Md BL Manik Islam - Academia.edu (original) (raw)
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Papers by Md BL Manik Islam
Bioequivalence & Bioavailability International Journal, 2017
Clopidogrel is a potent anti-platelets and antithrombotic drug. It is film coated and 75 mg table... more Clopidogrel is a potent anti-platelets and antithrombotic drug. It is film coated and 75 mg tablet. The objective of our study was to evaluate the quality parameters of some marketed clopidrogel tablet and to compare the parameters among them. To assess the quality, nine different marketed clopidogrel 75 mg tablet were selected and in-vitro dissolution test, potency, disintegration time were carried out. Other general quality parameters of these tablets like weight variation, hardness, friability were also determined according to established protocols. All the brands comply the requirements of ''United State Pharmacopoeia'' as they showed acceptable weight variation range. Friability of all brands was less than 1%. No significant differences were founding disintegration time as they disintegrated within 15 minutes. In case of dissolution profile all brands showed better dissolution time as they released more than 75% of drug in 45 minute. The hardness of one brand was within the range 40-60N. The limitation of the potency must be within 95-105%. All three brands meet this specification. This study suggested that most commercially available clopidogrel tablet in Bangladesh maintain the quality and comply with the USP specifications which are essential for better therapeutic activity of these anti-platelet drug.
Journal of Experimental Therapeutics and Oncology, 2002
Genetics have and will continue to have a strong and often controversial impact on our lives. Sin... more Genetics have and will continue to have a strong and often controversial impact on our lives. Since the first human gene therapy in l989, data from some 400 officially approved trials have been reported; only a handful appears promising. Of course, one must discern between gene replacements that correct inherited genetic disorders for life and the specific replacement of mutant genes that initiate or maintain the malignant phenotype with a correct gene copy. A truly reliable, safe, and efficient gene delivery system is not yet available, and many techniques have serious limitations or may be outright dangerous. Nevertheless, strong scientific and economic forces keep driving genetic research in cancer, with the promise of immortal fame (and even greater monetary rewards).
Bioequivalence & Bioavailability International Journal, 2017
Clopidogrel is a potent anti-platelets and antithrombotic drug. It is film coated and 75 mg table... more Clopidogrel is a potent anti-platelets and antithrombotic drug. It is film coated and 75 mg tablet. The objective of our study was to evaluate the quality parameters of some marketed clopidrogel tablet and to compare the parameters among them. To assess the quality, nine different marketed clopidogrel 75 mg tablet were selected and in-vitro dissolution test, potency, disintegration time were carried out. Other general quality parameters of these tablets like weight variation, hardness, friability were also determined according to established protocols. All the brands comply the requirements of ''United State Pharmacopoeia'' as they showed acceptable weight variation range. Friability of all brands was less than 1%. No significant differences were founding disintegration time as they disintegrated within 15 minutes. In case of dissolution profile all brands showed better dissolution time as they released more than 75% of drug in 45 minute. The hardness of one brand was within the range 40-60N. The limitation of the potency must be within 95-105%. All three brands meet this specification. This study suggested that most commercially available clopidogrel tablet in Bangladesh maintain the quality and comply with the USP specifications which are essential for better therapeutic activity of these anti-platelet drug.
Journal of Experimental Therapeutics and Oncology, 2002
Genetics have and will continue to have a strong and often controversial impact on our lives. Sin... more Genetics have and will continue to have a strong and often controversial impact on our lives. Since the first human gene therapy in l989, data from some 400 officially approved trials have been reported; only a handful appears promising. Of course, one must discern between gene replacements that correct inherited genetic disorders for life and the specific replacement of mutant genes that initiate or maintain the malignant phenotype with a correct gene copy. A truly reliable, safe, and efficient gene delivery system is not yet available, and many techniques have serious limitations or may be outright dangerous. Nevertheless, strong scientific and economic forces keep driving genetic research in cancer, with the promise of immortal fame (and even greater monetary rewards).