Mehmet Ali Ates - Academia.edu (original) (raw)

Papers by Mehmet Ali Ates

Environmental Toxicology, 2019

In this study, the impact of alpha‐iron oxide (α‐Fe2O3, 20‐40 nm) and gamma iron oxide (γ‐Fe2O3, ... more In this study, the impact of alpha‐iron oxide (α‐Fe2O3, 20‐40 nm) and gamma iron oxide (γ‐Fe2O3, 20‐40 nm) nanoparticles (NPs) on phytoplankton species Selenastrum capricornutum and Nannochloropsis oculata was investigated Characterizations of the NPs were systematically carried out by TEM, dynamic light scattering, zeta potential, X‐ray diffraction, SEM, and Fourier transformation infrared spectroscopy. Acute toxicity was tested between 0.2 and 50 mg/L for each NP for a period of 72 hours exposure. γ‐Fe2O3 NP inhibited development of N oculata at the rate of 54% in 0.2 mg/L group with a high mortality rate of up to 82%. α‐Fe2O3 NPs were less toxic that induced 97% mortality on N oculata at 10 mg/L suspensions. In contrast, α‐Fe2O3 NP inhibited growth of S capricornutum strongly (73%) in 0.2 mg/L group. γ‐Fe2O3 NPs showed similar growth inhibition (72%) on S capricornutum in 10 mg/L suspensions. Despite the differential effects, the results indicated acute toxicity of α‐Fe2O3 and γ‐...

Pharmacology, biochemistry, and behavior, Jan 22, 2018

Empathy is the ability to recognize, process and respond to another's emotional state and emp... more Empathy is the ability to recognize, process and respond to another's emotional state and empathic functions have been linked with a multitude of cognitive and affective processes. Impaired empathy has been linked to aggression and criminal behavior in society. Acetaminophen (paracetamol) is among the most common nonprescription (over the counter) analgesics in the world and has been already linked to reducing empathic behavior in humans. The aim of this study is to investigate the effects of acetaminophen on empathy-like behavior in Sprague Dawley rats, and we further explored the underlying mechanisms by analyzing empathy related neurohormones, e.g. oxytocin and vasopressin, in association with acetaminophen exposure in rats. Empathic behavior was assessed 30 min following acetaminophen administration (100, 200, and 400 mg/kg). The impact of single and repeated acetaminophen administrations on empathy-like behavior and anxiety level were evaluated separately. Empathy-like beha...

Neuroscience letters, Jan 29, 2018

We have recently shown that regular voluntary aerobic exercised rats have low levels of anxiety. ... more We have recently shown that regular voluntary aerobic exercised rats have low levels of anxiety. Irisin is an exercise-induced myokine that is produced by many tissues; and the role it plays in anxiolytic behavior is unknown. In this study we aimed to investigate the correlation between anxiety like behavior and irisin levels following regular voluntary aerobic exercise in male mice. We've have shown that anxiety levels decreased in exercised mice, while irisin levels increased in the brain, brown adipose tissue, white adipose tissue, kidney, and pancreas tissues. No significant difference of irisin levels in the liver, muscle and serum were detected in the exercise group, when compared to controls. In addition, there was a strong positive correlation between brain irisin levels and activity in middle area of open field test and in the open arms of elevated plus maze test; both which are indicators of low anxiety levels. Our results suggest that decrease in anxiolytic behavior d...

Biological trace element research, Jan 21, 2018

Magnesium is an element of great importance functioning because of its association with many cell... more Magnesium is an element of great importance functioning because of its association with many cellular physiological functions. The magnesium content of foods is gradually decreasing due to food processing, and magnesium supplementation for healthy living has become increasingly popular. However, data is very limited on the bioavailability of various magnesium preparations. The aim of this study is to investigate the bioavailability of five different magnesium compounds (magnesium sulfate, magnesium oxide, magnesium acetyl taurate, magnesium citrate, and magnesium malate) in different tissues. Following a single dose 400 mg/70 kg magnesium administration to Sprague Dawley rats, bioavailability was evaluated by examining time-dependent absorption, tissue penetration, and the effects on the behavior of the animals. Pharmacokinetically, the area under the curve calculation is highest in the magnesium malate. The magnesium acetyl taurate was found to have the second highest area under th...

Behavioural brain research, Sep 3, 2018

Empathy defined as the ability to understand and the share the feelings, thoughts, and attitudes ... more Empathy defined as the ability to understand and the share the feelings, thoughts, and attitudes of another, is an important skill in survival and reproduction. Among many factors that affect empathy include psychological stress, anxiety states. The aim of this study was to investigate the impact of acute psychological stress on empathic behavior and its association with oxytocin and vasopressin levels in amygdala and prefrontal cortex. Rats were subjected to 0.2 mA (low) and 1.6 mA (high) intensity of foot shock stress for duration of 20 min. Empathic behavior was found to be improved as a response to low intensity stress, but not to high intensity stress. As a response to lower intensity stress, vasopressin was increased in prefrontal cortex and amygdala; oxytocin was increased in only prefrontal cortex, and corticosterone levels increased in general. Anxiety indicators did not change in low intensity stress group yet; high intensity stress group demonstrated a lesser degree of an...

Journal of Nanotoxicology and Nanomedicine, 2017

Knowledge of nanomaterial toxicity is critical to avoid adverse effects on human and environment ... more Knowledge of nanomaterial toxicity is critical to avoid adverse effects on human and environment health. In this study, the influences of crystal morphology on physico-chemical and toxic properties of nanoscale TiO2 (n- TiO2) were investigated. Artemia salina were exposed to anatase, rutile and mixture polymorphs of n-TiO2 in seawater. Short-term (24 h) and long-term (96 h) exposures were conducted in 1, 10 and 100 mg/L suspensions of n-TiO2 in the presence and absence of food. Anatase form had highest accumulation followed by mixture and rutile. Presence of food greatly reduced accumulation. n-TiO2 dissolution was not significant in seawater (p<0.05) nor was influenced from crystal structure. Highest toxic effects occurred in 96h exposure in the order of anatase>mixture>rutile. Mortality and oxidative stress levels increased with increasing n-TiO2 concentration and exposure time (p<0.05). Presence of food in the exposure medium alleviated the oxidative stress, indicatin...

Turkiye Klinikleri Cardiovascular Sciences, 2013

Aquatic toxicology (Amsterdam, Netherlands), Jan 11, 2016

Effects of chronic exposure to alpha and gamma iron oxide nanoparticles (α-Fe2O3 and γ-Fe2O3 NPs)... more Effects of chronic exposure to alpha and gamma iron oxide nanoparticles (α-Fe2O3 and γ-Fe2O3 NPs) were investigated through exposure of tilapia (Oreochromis niloticus) to 0.1, 0.5 and 1.0mg/L (9.2×10(-4), 4.6×10(-3) and 9.2×10(-3)mM) aqueous suspensions for 60days. Fish were then transferred to NP-free freshwater and allowed to eliminate ingested NPs for 30days. The organs, including gills, liver, kidney, intestine, brain, spleen, and muscle tissue of the fish were analyzed to determine the accumulation, physiological distribution and elimination of the Fe2O3 NPs. Largest accumulation occurred in spleen followed by intestine, kidney, liver, gills, brain and muscle tissue. Fish exposed to γ-Fe2O3 NPs possessed significantly higher Fe in all organs. Accumulation in spleen was fast and independent of NP concentration reaching to maximum levels by the end of the first sampling period (30th day). Dissolved Fe levels in water were very negligible ranging at 4-6μg/L for α-Fe2O3 and 17-21μg...

RSC Advances, 2015

Morphology-driven Li1.2Mn0.6Ni0.14Co0.06O2with excellent cycling stability.

Digest Journal of Nanomaterials and Biostructures, 2014

Nanotechnologies research has become a significant priority worldwide. Many engineered nano-sized... more Nanotechnologies research has become a significant priority worldwide. Many engineered nano-sized materials have been increasingly used in consumer products. But the adverse effects of these nanoparticles on the environment and organisms have recently drawn much attention. The present study investigated the effects of different concentrations of copper oxide nanoparticles (CuO NPs) on the sheepshead minnow (Cyprinodon variegatus) at different salinity regimes, since it is able to withstand a wide range of salinities. The results indicated that CuO NPs could cause behavioral changes in the fish, such as increased mucus secretion, less general activity and loss of equilibrium. No mortality was observed at the presence of CuO NPs during the experiments. But higher oxidative stress was determined at half strength seawater than seawater exposure medium, which can be associated with the decreasing toxicity of CuO NPs as salinity increases. In addition, Cu contents in the tissues of the fi...

Turkiye Klinikleri Journal of Medical Sciences, 2013

The aim of this study was to assess the efficacy and side effects of postoperative administration... more The aim of this study was to assess the efficacy and side effects of postoperative administration of amiodarone as a prophylaxis for or treatment of new onset atrial fibrillation after coronary artery bypass grafting surgery. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Between January 2010 and January 2012, we conducted a retrospective analysis on consecutive patients who underwent coronary artery bypass grafting surgery. Patients were grouped according to whether they received amiodarone for prophylaxis or for treatment of atrial fibrillation. In Group 1, amiodarone was given after new onset atrial fibrillation for treatment (Group 1; n=595; 378 males, 217 females; mean age 62.16±4.72 years; range 43-78 years). Group 2 received amiodarone for prevention of postoperative atrial fibrillation (Group 2; n=500; 344 males, 156 females; mean age 61.43±6.12 years; range 41-81 years). The patients were followed-up for arrhythmias and left ventricular function using electrocardiography and echocardiography. R Re es su ul lt ts s: : Preoperative patient characteristics and operative variables were similar in two groups. Patient recovery was significantly slower in Group 1. Postoperative atrial fibrillation occurred in 595 patients among 3500 patients (17%) who underwent coronary bypass surgery without amiodarone, and in 27 patients (5.40 %) receiving amiodarone as prophylaxis (p=0.0001). Mean pulmonary and liver function tests were not significantly different between two groups. Group 2 patients had shorter hospital stays compared to Group 1 patients (Group 2: 4.9+3.6 days vs. Group 1: 6.2+5.8 days, p=0.001). The in-hospital mortality was not different between the two groups (1.5% vs. 1.2%, p=0.176, respectively). C Co on nc cl lu us si io on n: : Postoperative prophylactic amiodarone therapy in patients undergoing coronary bypass surgery is well tolerated and significantly reduces the incidence of postoperative atrial arrhythmias while not affecting left ventricular function. K Ke ey y W Wo or rd ds s: : Coronary artery bypass; amiodaron; prevention and control Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı, koroner arter baypas operasyonlarından sonra başlayan atriyal fibrilasyonda, amiodaronun tedavi amaçlı veya proflaktik amaçlı kullanımının etkinlik ve yan etkilerini değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Ocak 2010 ile Ocak 2012 tarihleri arasında ardışık olarak koroner arter baypas cerrahisi uygulanan hastaların verileri geriye dönük olarak değerlendirildi. Hastalar atriyal fibrilasyonun tedavisi veya proflaktik amaçlı amiodaron kullanımına göre iki gruba ayrıldı. Yeni başlayan atriyal fibrilasyonun tedavisi amacıyla amiodaron uygulanan hastalardan elde edilen veriler Grup 1 içinde değerlendirildi (Grup 1; n=595; 378 erkek, 217 kadın; ortalama yaş 62,16±4,72 yıl; dağılım 43-78 yıl). Atriyal fibrilasyon gelişmeden proflaktik olarak amiodaron verilen hastalardan elde edilen veriler de Grup 2 içinde değerlendirildi (Grup 2; n=500; 344 erkek, 156 kadın; ortalama yaş 61,43±6,12 yıl; dağılım 41-81 yıl). Hastalar elektrokardiyografi ve ekokardiyografi ile aritmi ve ventrikül fonksiyonları bakımından değerlendirildi. B Bu ul lg gu ul la ar r: : Her iki gruptaki hastalar, hasta özellikleri ve operatif veriler açısından benzerdi. Hastaların iyileşme süreci Grup 1'de anlamlı şekilde daha yavaştı. Amiodaron verilmeyen hastalarda atriyal fibrilasyon görülme oranı %17 iken (3500 hastadan, 595 hasta), proflaktik olarak amiodaron verilen hastalarda bu oran %5,4 idi (27 hasta) (p=0,0001). Akciğer ve karaciğer fonksiyonlarına ait ortalama değerler her iki grupta da benzerdi. Grup 2'deki hastaların hastanede kalış süreleri, grup 1'e göre daha kısaydı (Grup 2; 4,9+3,6 gün iken, Grup 1; 6,2+5,8 gün, p=0,001). Hastane içi mortalite iki grupta da benzerdi (sırasıyla, %1,51 ve %1,2, p=0,176). S So on nu uç ç: : Koroner baypas cerrahisi uygulanan hastalarda postoperatif dönemde proflaktik amiodaron uygulaması iyi tolere edilir, postoperatif atriyal aritmi riskini anlamlı şekilde azaltır ve sol ventrikül fonksiyonlarını da etkilemez. A An na ah ht ta ar r K Ke el li im me el le er r: : Koroner arter baypas; amiodarone; önleme ve kontrol T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i

Turkiye Klinikleri Journal of Medical Sciences, 2013

The ne ces sity for an ind wel ling ar te ri al shunt du ring ca ro tid en dar te rec tomy (CE A)... more The ne ces sity for an ind wel ling ar te ri al shunt du ring ca ro tid en dar te rec tomy (CE A) is one of the most wi dely de ba ted and long-stan ding con tro ver si es in ca ro tid sur gery. We deve lo ped a mo di fi ed tech ni qu e for ca ro tid en dar te rec tomy wit ho ut using a shunt and ha ve ac hi e ved suc cess ful re sults with this pro ce du re. The aim of this study is to pre sent the se 352 iso la ted CE A cases and eva lu a te the re sults. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In our cli nic, 352 iso la ted CE A we re per for med on 320 con se cu ti ve pa ti ents wit ho ut using a shunt bet we en 2005 and 2012. In 32 of the ca ses, bi late ral CE A we re per for med. Among the pa ti ents, 36.8 % (n=118) we re ne u ro lo gi cally asym pto matic, and 63.2 % (n=202) we re sympto ma tic. Comp le te occ lu si on was pre sent in the con tra la te ral ca ro tid ar te ri es of 23 pa ti ents. All pa ti ents we re ope ra ted on un der ge ne ral anest he si a, and no intra lu mi nal shunts we re used. This ope ra ti ve tech ni qu e is a mo di fi ca ti on of an ever si on ca ro tid endar te rec tomy in which a lon gi tu di nal ar te ri o tomy is be gun on the com mon ca ro tid ar tery (CCA) and pur po sely ske wed to wards the ori gin of the ex ter nal ca ro tid ar tery. The me an cross-clamp time in our study was 12±4.62 mi nu tes. R Re e s su ul lt ts s: : The re was one ca se of pos to pe ra ti ve mor ta lity (0.28%) that was ca u sed by myo car di al in farc ti on. We ob ser ved 1 (0.28%) ca se of per ma nent ne u ro lo gic de fi cit, 27 (7.6%) ca ses of pe rip he ral ner ve da ma ge, 4 (1.1%) ca ses of early pos to pe ra ti ve tran si ent ne u ro lo gic at tack, 3 (0.85%) ca ses of ho ar se ness and 3 (0.85%) ca ses of ne u ro cog ni ti ve im pa ir ment. C Co on nc c l lu u s si i o on n: : The re sults in di ca te that this mi ni-mo di fi ed ever si on CE A sur gery per for med wit ho ut the use of a shunt can be suc cess ful for pa ti ents with ca ro tid ste no sis. K Ke ey y W Wo or rd ds s: : En dar te rec tomy, ca ro tid; isc he mic at tack, tran si ent; stro ke Ö ÖZ ZE ET T A Am ma aç ç: : Karotis arter endarterektomi (CEA) cerrahisinde şant kullanım gerekliliği, yama kullanımı, eversiyon ve konvansiyonel endarterektomi teknikleri halen tartışılan konulardır. Kliniğimizde CEA operasyonları şant kullanılmadan yapılmaktadır. Yine bu operasyonlarda kliniğimizde geliştirilmiş olan farklı bir arteriyotomi tekniği kullanılmaktadır. Bu çalışmada şant kullanılmadan gerçekleştirilen 352 izole CEA olgusu değerlendirilmiş ve kliniğimizce geliştirilmiş olan tekniğinin tarifi ve erken dönem sonuçları tartışılmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Kliniğimizde 2005-2012 yılları arasında 320 hastaya 32'si bilateral olmak üzere, toplam 352 izole CEA operasyonu uygulandı. Hastaların %36,8 (n=118)'i nörolojik olarak asemptomatik, %63,2 (n=202)'si ise semptomatik hastalardan oluşmaktaydı. Tüm hastalar genel anestezi altında ve şant kullanılmadan opere edildi. Endarterektomi, ana karotis arterden eksternal karotis artere longitudinal bir arteriyotomi insizyonu ile gerçekleştirildi. Ortalama kros klemp zamanı 12±4,62 dakika olarak ölçüldü. B Bu ul lg gu ul la ar r: : Genel anestezi altında ve şant kullanılmadan gerçekleştirilen CEA operasyonlarında oldukça iyi sonuçlar alınabildiği görülmüştür. Ayrıca, tarif ettiğimiz teknikte-uygun olgular için-aterosklerotik plağın kolayca çıkarılabildiği, internal karotis arterde dikiş hattı olmaması sayesinde yama kullanım gerekliliğinin olmadığı görülmüştür. T Ta ar rt tı ış şm ma a: : Olgularımızdan biri (%0,28) postoperatif dönemde gelişen akut myokardiyal infarktüs nedeniyle kaybedildi. Bir olguda (%0,28) kalıcı nörolojik defisit, 27 (%7,6) olguda ekstrakraniyal periferik sinir hasarı, 4 (%1,1) olguda erken post operatif geçici (transient) nörolojik atak, 3 olguda (%0,85) ses kısıklığı ve 3 olguda da (%0,85) geçici bilişsel bozukluk oluştuğu gözlemlendi. A An na ah h t ta ar r K Ke e l li i m me e l le er r: : En dar te rek to mi, ka ro tid; is ke mik atak, ge çi ci; in me, felç T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i

Journal of Nanomaterials, 2013

The increased use of nanosized materials is likely to result in the release of these particles in... more The increased use of nanosized materials is likely to result in the release of these particles into the environment. It is, however, unclear if these materials are harmful to aquatic animals. In this study, the sublethal effects of exposure of low and high concentrations of titanium dioxide nanoparticles (TiO2NPs) on goldfish (Carassius auratus) were investigated. Accumulation of TiO2NPs increased from 42.71 to 110.68 ppb in the intestine and from 4.10 to 9.86 ppb in the gills of the goldfish with increasing exposure dose from 10 to 100 mg/L TiO2NPs. No significant accumulation in the muscle and brain of the fish was detected. Malondialdehyde as a biomarker of lipid oxidation was detected in the liver of the goldfish. Moreover, TiO2NPs exposure inhibited growth of the goldfish. Although there was an increase (8.1%) in the body weights of the goldfish for the control group, in the low and high exposure groups 1.8% increase and 19.7% decrease were measured, respectively. The results o...

European Journal of Pediatric Surgery, 2014

Introduction Intestinal damage has been shown to occur when intra-amniotic meconium concentration... more Introduction Intestinal damage has been shown to occur when intra-amniotic meconium concentration exceeds threshold level. However, the mechanism of the meconium-induced intestinal damage is still unclear. Intestinal ischemia can cause intestinal damage in gastroschisis. This study was aimed to determine the effects of intra-amniotic meconium on the contractility of superior mesenteric artery (SMA). Materials and Methods Eighteen-day-old fertilized chick embryos (Gallus Domesticus) were extirpated and intestines were harvested. The SMA specimens were prepared as 4 mm segments in the organ bath with Krebs-Henseleit buffer. The isometric contraction responses of the SMA specimens were evaluated with norepinephrine, different meconium concentrations, and clear amniotic fluid. Maximum isometric contractions responses (MICR) of the SMA specimens were recorded with an amplifier system on a computer. Results In the norepinephrine group, MICR was found as 2.92 ± 0.57 mN. While MICR of the 1/100 meconium group (highest meconium concentration) was found as 1.56 ± 0.40 mN, MICR of the clear amniotic fluid group was 0.41 ± 0.07 mN. The MICR of the norepinephrine group was significantly increased compared with the 1/100 meconium and clear amniotic fluid groups. MICR of the 1/100 meconium group was also found to be significantly increased compared with clear amniotic fluid group. No statistically significant difference was found among the meconium subgroups. Conclusion Intra-amniotic meconium in fetuses with gastroschisis might cause ischemic intestinal damage by reducing the intestinal blood flow. Further studies are needed to show the outcomes of the vasoactive effect of meconium on the SMA blood flow.

Environ. Sci.: Processes Impacts, 2013

Brine shrimp (Artemia salina) larvae were exposed to different sizes of zinc (Zn) and zinc oxide ... more Brine shrimp (Artemia salina) larvae were exposed to different sizes of zinc (Zn) and zinc oxide (ZnO) nanoparticles (NPs) to evaluate their toxicity in marine aquatic ecosystems. Acute exposure was conducted in seawater with 10, 50 and 100 mg/L concentrations of the NPs for 24 h and 96 h. Phase contrast microscope images confirmed the accumulation of the NPs inside the guts. Artemia were unable to eliminate the ingested particles, which was thought to occur due the formation of massive particles in the guts. Although the suspensions of the NPs did not exhibit any significant acute toxicity within 24 h, mortalities increased remarkably in 96 h and escalated with increasing concentration of NP suspension to 42% for Zn NPs (40-60 nm) (LC 50 ~100 mg/L) and to about 34% for ZnO NPs (10-30 nm) (LC 50 >100 mg/L). The suspensions of Zn NPs were more toxic to Artemia than those of ZnO NPs under comparable regimes. This effect was attributed to higher Zn 2+ levels (ca. up to 8.9 mg L-1) released to the medium from Zn NPs in comparison to that measured in the suspensions of ZnO NPs (ca. 5.5 mg L-1). In addition, the size of the nanopowders appeared to contribute to the observed toxicities. Although the suspensions possessed aggregates of comparable sizes, smaller Zn NPs (40-60 nm) were relatively more toxic than larger Zn NPs (80-100 nm). Likewise, the suspensions of 10-30 nm ZnO NPs caused higher than those of 200 nm ZnO NPs. Lipid peroxidation levels were substantially higher in 96 h (p<0.05) indicating that the toxic effects were due to the oxidative stress.

Journal of Mood Disorders, 2012

Reboksetinle indüklenmiş ağrılı ejakülasyon: Bir olgu sunumu Cinsel işlev bozuklukları antidepres... more Reboksetinle indüklenmiş ağrılı ejakülasyon: Bir olgu sunumu Cinsel işlev bozuklukları antidepresan ilaçların önemli ve sık karşılaşılan yan etkilerinden olup bazen tedavinin erken bırakılmasına neden olabilir. Reboksetin önceleri cinsel yan etkisi olmayan bir ilaç olarak bilinmekteydi. Ancak, biz burada reboksetin tedavisine başladıktan kısa bir süre sonra ağrılı ejakülasyon geliştirmiş olan bir olguyu sunmaktayız. Kırk yaşındaki bu hastaya depresyonu nedeniyle reboksetin tedavisi başlanmıştı. Başlanan 4 mg/gün dozundaki reboksetin tedavisinden 3 hafta sonra hasta ağrılı ejakülasyondan şikayetçi olmaya başladı. Tedavinin kesilmesinden sonra hastanın ağrılı ejakülasyonu kendiliğinden düzeldi. Reboksetin ile erkek hastaların tedavisinde cinsel yan etkiler, özellikle de ağrılı ejakülasyon dahil ejakülasyon bozuklukları akılda bulundurulmalıdır.

Cardiovascular Journal Of Africa, 2013

Background: The aim of this study was to compare the effects of single-clamping and partial-clamp... more Background: The aim of this study was to compare the effects of single-clamping and partial-clamping techniques on postoperative stroke during coronary artery bypass surgery. Methods: Between December 2008 and December 2012, 2 000 patients who underwent coronary artery bypass grafting in two hospitals were analysed. Post-operative neurological complications were analysed retrospectively in these patients. The cases were divided into two groups: in group 1, 1 500 patients were analysed, in whom proximal anastomosis was performed with partial clamping in a beating heart (n = 1 500, 846 male, 654 female; mean age 63.25 ± 5.72 years; range 43-78 years). In group 2, 500 patients were analysed, in whom proximal anastomosis had been performed by other surgical teams in another hospital, with cross clamping in a resting heart with cardioplegia (n = 500, 296 male, 214 female; mean age 64.83 ± 8.12 years; range 41-81 years). During 30 days post-operatively, neurological deficits, stroke incidence and the relationship of the clinical situation to mortality were analysed. Results: For both groups, patients were similar in terms of patient characteristics. In group 2, cross-clamp duration and perfusion time were longer; however, time of hospital stay was similar in the two groups. Post-operative stroke was seen in 26 patients in group 1 (1.73%) and in nine in group 2 (1.8%). The difference between the two groups was not statistically significant (p = 0.92). All stroke patients were over the age of 55 years. Seven of the stroke patients died (21.1%). In total, 31 patients died because of multiple organ failure in the postoperative 30 days (group 1: 1.6%; group 2: 1.4%) (p = 0.91). Smoking, diabetes mellitus, hypertension, atrial fibrillation, peripheral vascular disease and hypercholesterolaemia were found to be factors that affected stroke development. Mean duration of hospital stay was 5.1 ± 2.8 days in group 1 and 4.9 ± 3.6 days in group 2 and the difference between the two groups was not statistically significant (p = 0.46). Conclusion: In patients without plaques in the aorta, performing partial clamping did not increase stroke incidence.

Journal of Hazardous Materials, 2011

Cadmium selenide nanoparticles (CdSe NPs) exhibit novel optoelectronic properties for potential b... more Cadmium selenide nanoparticles (CdSe NPs) exhibit novel optoelectronic properties for potential biomedical applications. However, their metabolic stability is not fully understood because of the difficulties in measurement of free Cd from biological tissues of exposed individuals. In this study, alkaline dissolution with tetramethylammonium hydroxide (TMAH) is demonstrated for selective determination of free Cd and intact NPs from liver and kidney samples of animals that were exposed to thiol-capped CdSe NPs. Aqueous suspensions of CdSe NPs (3.2 nm) were used to optimize the conditions for extracting free Cd without affecting NPs. Nanoparticles were found to aggregate when heated in TMAH without releasing any significant Cd to solution. Performance of the method in discriminating free Cd and intact NPs were verified by Dogfish Liver (DOLT-4) certified reference material. The samples from the animals were digested in 4 mL TMAH at 70 °C to extract free Cd followed by analysis of aqueous phase by ICP-MS. Both liver and kidney contained significant levels of free Cd. Total Cd was higher in the liver, while kidney accumulated mostly free Cd such that up to 47.9% of total Cd in the kidney was free Cd when NPs were exposed to UV-light before injection.

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014

Environmental Toxicology, 2019

In this study, the impact of alpha‐iron oxide (α‐Fe2O3, 20‐40 nm) and gamma iron oxide (γ‐Fe2O3, ... more In this study, the impact of alpha‐iron oxide (α‐Fe2O3, 20‐40 nm) and gamma iron oxide (γ‐Fe2O3, 20‐40 nm) nanoparticles (NPs) on phytoplankton species Selenastrum capricornutum and Nannochloropsis oculata was investigated Characterizations of the NPs were systematically carried out by TEM, dynamic light scattering, zeta potential, X‐ray diffraction, SEM, and Fourier transformation infrared spectroscopy. Acute toxicity was tested between 0.2 and 50 mg/L for each NP for a period of 72 hours exposure. γ‐Fe2O3 NP inhibited development of N oculata at the rate of 54% in 0.2 mg/L group with a high mortality rate of up to 82%. α‐Fe2O3 NPs were less toxic that induced 97% mortality on N oculata at 10 mg/L suspensions. In contrast, α‐Fe2O3 NP inhibited growth of S capricornutum strongly (73%) in 0.2 mg/L group. γ‐Fe2O3 NPs showed similar growth inhibition (72%) on S capricornutum in 10 mg/L suspensions. Despite the differential effects, the results indicated acute toxicity of α‐Fe2O3 and γ‐...

Pharmacology, biochemistry, and behavior, Jan 22, 2018

Empathy is the ability to recognize, process and respond to another's emotional state and emp... more Empathy is the ability to recognize, process and respond to another's emotional state and empathic functions have been linked with a multitude of cognitive and affective processes. Impaired empathy has been linked to aggression and criminal behavior in society. Acetaminophen (paracetamol) is among the most common nonprescription (over the counter) analgesics in the world and has been already linked to reducing empathic behavior in humans. The aim of this study is to investigate the effects of acetaminophen on empathy-like behavior in Sprague Dawley rats, and we further explored the underlying mechanisms by analyzing empathy related neurohormones, e.g. oxytocin and vasopressin, in association with acetaminophen exposure in rats. Empathic behavior was assessed 30 min following acetaminophen administration (100, 200, and 400 mg/kg). The impact of single and repeated acetaminophen administrations on empathy-like behavior and anxiety level were evaluated separately. Empathy-like beha...

Neuroscience letters, Jan 29, 2018

We have recently shown that regular voluntary aerobic exercised rats have low levels of anxiety. ... more We have recently shown that regular voluntary aerobic exercised rats have low levels of anxiety. Irisin is an exercise-induced myokine that is produced by many tissues; and the role it plays in anxiolytic behavior is unknown. In this study we aimed to investigate the correlation between anxiety like behavior and irisin levels following regular voluntary aerobic exercise in male mice. We've have shown that anxiety levels decreased in exercised mice, while irisin levels increased in the brain, brown adipose tissue, white adipose tissue, kidney, and pancreas tissues. No significant difference of irisin levels in the liver, muscle and serum were detected in the exercise group, when compared to controls. In addition, there was a strong positive correlation between brain irisin levels and activity in middle area of open field test and in the open arms of elevated plus maze test; both which are indicators of low anxiety levels. Our results suggest that decrease in anxiolytic behavior d...

Biological trace element research, Jan 21, 2018

Magnesium is an element of great importance functioning because of its association with many cell... more Magnesium is an element of great importance functioning because of its association with many cellular physiological functions. The magnesium content of foods is gradually decreasing due to food processing, and magnesium supplementation for healthy living has become increasingly popular. However, data is very limited on the bioavailability of various magnesium preparations. The aim of this study is to investigate the bioavailability of five different magnesium compounds (magnesium sulfate, magnesium oxide, magnesium acetyl taurate, magnesium citrate, and magnesium malate) in different tissues. Following a single dose 400 mg/70 kg magnesium administration to Sprague Dawley rats, bioavailability was evaluated by examining time-dependent absorption, tissue penetration, and the effects on the behavior of the animals. Pharmacokinetically, the area under the curve calculation is highest in the magnesium malate. The magnesium acetyl taurate was found to have the second highest area under th...

Behavioural brain research, Sep 3, 2018

Empathy defined as the ability to understand and the share the feelings, thoughts, and attitudes ... more Empathy defined as the ability to understand and the share the feelings, thoughts, and attitudes of another, is an important skill in survival and reproduction. Among many factors that affect empathy include psychological stress, anxiety states. The aim of this study was to investigate the impact of acute psychological stress on empathic behavior and its association with oxytocin and vasopressin levels in amygdala and prefrontal cortex. Rats were subjected to 0.2 mA (low) and 1.6 mA (high) intensity of foot shock stress for duration of 20 min. Empathic behavior was found to be improved as a response to low intensity stress, but not to high intensity stress. As a response to lower intensity stress, vasopressin was increased in prefrontal cortex and amygdala; oxytocin was increased in only prefrontal cortex, and corticosterone levels increased in general. Anxiety indicators did not change in low intensity stress group yet; high intensity stress group demonstrated a lesser degree of an...

Journal of Nanotoxicology and Nanomedicine, 2017

Knowledge of nanomaterial toxicity is critical to avoid adverse effects on human and environment ... more Knowledge of nanomaterial toxicity is critical to avoid adverse effects on human and environment health. In this study, the influences of crystal morphology on physico-chemical and toxic properties of nanoscale TiO2 (n- TiO2) were investigated. Artemia salina were exposed to anatase, rutile and mixture polymorphs of n-TiO2 in seawater. Short-term (24 h) and long-term (96 h) exposures were conducted in 1, 10 and 100 mg/L suspensions of n-TiO2 in the presence and absence of food. Anatase form had highest accumulation followed by mixture and rutile. Presence of food greatly reduced accumulation. n-TiO2 dissolution was not significant in seawater (p<0.05) nor was influenced from crystal structure. Highest toxic effects occurred in 96h exposure in the order of anatase>mixture>rutile. Mortality and oxidative stress levels increased with increasing n-TiO2 concentration and exposure time (p<0.05). Presence of food in the exposure medium alleviated the oxidative stress, indicatin...

Turkiye Klinikleri Cardiovascular Sciences, 2013

Aquatic toxicology (Amsterdam, Netherlands), Jan 11, 2016

Effects of chronic exposure to alpha and gamma iron oxide nanoparticles (α-Fe2O3 and γ-Fe2O3 NPs)... more Effects of chronic exposure to alpha and gamma iron oxide nanoparticles (α-Fe2O3 and γ-Fe2O3 NPs) were investigated through exposure of tilapia (Oreochromis niloticus) to 0.1, 0.5 and 1.0mg/L (9.2×10(-4), 4.6×10(-3) and 9.2×10(-3)mM) aqueous suspensions for 60days. Fish were then transferred to NP-free freshwater and allowed to eliminate ingested NPs for 30days. The organs, including gills, liver, kidney, intestine, brain, spleen, and muscle tissue of the fish were analyzed to determine the accumulation, physiological distribution and elimination of the Fe2O3 NPs. Largest accumulation occurred in spleen followed by intestine, kidney, liver, gills, brain and muscle tissue. Fish exposed to γ-Fe2O3 NPs possessed significantly higher Fe in all organs. Accumulation in spleen was fast and independent of NP concentration reaching to maximum levels by the end of the first sampling period (30th day). Dissolved Fe levels in water were very negligible ranging at 4-6μg/L for α-Fe2O3 and 17-21μg...

RSC Advances, 2015

Morphology-driven Li1.2Mn0.6Ni0.14Co0.06O2with excellent cycling stability.

Digest Journal of Nanomaterials and Biostructures, 2014

Nanotechnologies research has become a significant priority worldwide. Many engineered nano-sized... more Nanotechnologies research has become a significant priority worldwide. Many engineered nano-sized materials have been increasingly used in consumer products. But the adverse effects of these nanoparticles on the environment and organisms have recently drawn much attention. The present study investigated the effects of different concentrations of copper oxide nanoparticles (CuO NPs) on the sheepshead minnow (Cyprinodon variegatus) at different salinity regimes, since it is able to withstand a wide range of salinities. The results indicated that CuO NPs could cause behavioral changes in the fish, such as increased mucus secretion, less general activity and loss of equilibrium. No mortality was observed at the presence of CuO NPs during the experiments. But higher oxidative stress was determined at half strength seawater than seawater exposure medium, which can be associated with the decreasing toxicity of CuO NPs as salinity increases. In addition, Cu contents in the tissues of the fi...

Turkiye Klinikleri Journal of Medical Sciences, 2013

The aim of this study was to assess the efficacy and side effects of postoperative administration... more The aim of this study was to assess the efficacy and side effects of postoperative administration of amiodarone as a prophylaxis for or treatment of new onset atrial fibrillation after coronary artery bypass grafting surgery. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Between January 2010 and January 2012, we conducted a retrospective analysis on consecutive patients who underwent coronary artery bypass grafting surgery. Patients were grouped according to whether they received amiodarone for prophylaxis or for treatment of atrial fibrillation. In Group 1, amiodarone was given after new onset atrial fibrillation for treatment (Group 1; n=595; 378 males, 217 females; mean age 62.16±4.72 years; range 43-78 years). Group 2 received amiodarone for prevention of postoperative atrial fibrillation (Group 2; n=500; 344 males, 156 females; mean age 61.43±6.12 years; range 41-81 years). The patients were followed-up for arrhythmias and left ventricular function using electrocardiography and echocardiography. R Re es su ul lt ts s: : Preoperative patient characteristics and operative variables were similar in two groups. Patient recovery was significantly slower in Group 1. Postoperative atrial fibrillation occurred in 595 patients among 3500 patients (17%) who underwent coronary bypass surgery without amiodarone, and in 27 patients (5.40 %) receiving amiodarone as prophylaxis (p=0.0001). Mean pulmonary and liver function tests were not significantly different between two groups. Group 2 patients had shorter hospital stays compared to Group 1 patients (Group 2: 4.9+3.6 days vs. Group 1: 6.2+5.8 days, p=0.001). The in-hospital mortality was not different between the two groups (1.5% vs. 1.2%, p=0.176, respectively). C Co on nc cl lu us si io on n: : Postoperative prophylactic amiodarone therapy in patients undergoing coronary bypass surgery is well tolerated and significantly reduces the incidence of postoperative atrial arrhythmias while not affecting left ventricular function. K Ke ey y W Wo or rd ds s: : Coronary artery bypass; amiodaron; prevention and control Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı, koroner arter baypas operasyonlarından sonra başlayan atriyal fibrilasyonda, amiodaronun tedavi amaçlı veya proflaktik amaçlı kullanımının etkinlik ve yan etkilerini değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Ocak 2010 ile Ocak 2012 tarihleri arasında ardışık olarak koroner arter baypas cerrahisi uygulanan hastaların verileri geriye dönük olarak değerlendirildi. Hastalar atriyal fibrilasyonun tedavisi veya proflaktik amaçlı amiodaron kullanımına göre iki gruba ayrıldı. Yeni başlayan atriyal fibrilasyonun tedavisi amacıyla amiodaron uygulanan hastalardan elde edilen veriler Grup 1 içinde değerlendirildi (Grup 1; n=595; 378 erkek, 217 kadın; ortalama yaş 62,16±4,72 yıl; dağılım 43-78 yıl). Atriyal fibrilasyon gelişmeden proflaktik olarak amiodaron verilen hastalardan elde edilen veriler de Grup 2 içinde değerlendirildi (Grup 2; n=500; 344 erkek, 156 kadın; ortalama yaş 61,43±6,12 yıl; dağılım 41-81 yıl). Hastalar elektrokardiyografi ve ekokardiyografi ile aritmi ve ventrikül fonksiyonları bakımından değerlendirildi. B Bu ul lg gu ul la ar r: : Her iki gruptaki hastalar, hasta özellikleri ve operatif veriler açısından benzerdi. Hastaların iyileşme süreci Grup 1'de anlamlı şekilde daha yavaştı. Amiodaron verilmeyen hastalarda atriyal fibrilasyon görülme oranı %17 iken (3500 hastadan, 595 hasta), proflaktik olarak amiodaron verilen hastalarda bu oran %5,4 idi (27 hasta) (p=0,0001). Akciğer ve karaciğer fonksiyonlarına ait ortalama değerler her iki grupta da benzerdi. Grup 2'deki hastaların hastanede kalış süreleri, grup 1'e göre daha kısaydı (Grup 2; 4,9+3,6 gün iken, Grup 1; 6,2+5,8 gün, p=0,001). Hastane içi mortalite iki grupta da benzerdi (sırasıyla, %1,51 ve %1,2, p=0,176). S So on nu uç ç: : Koroner baypas cerrahisi uygulanan hastalarda postoperatif dönemde proflaktik amiodaron uygulaması iyi tolere edilir, postoperatif atriyal aritmi riskini anlamlı şekilde azaltır ve sol ventrikül fonksiyonlarını da etkilemez. A An na ah ht ta ar r K Ke el li im me el le er r: : Koroner arter baypas; amiodarone; önleme ve kontrol T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i

Turkiye Klinikleri Journal of Medical Sciences, 2013

The ne ces sity for an ind wel ling ar te ri al shunt du ring ca ro tid en dar te rec tomy (CE A)... more The ne ces sity for an ind wel ling ar te ri al shunt du ring ca ro tid en dar te rec tomy (CE A) is one of the most wi dely de ba ted and long-stan ding con tro ver si es in ca ro tid sur gery. We deve lo ped a mo di fi ed tech ni qu e for ca ro tid en dar te rec tomy wit ho ut using a shunt and ha ve ac hi e ved suc cess ful re sults with this pro ce du re. The aim of this study is to pre sent the se 352 iso la ted CE A cases and eva lu a te the re sults. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In our cli nic, 352 iso la ted CE A we re per for med on 320 con se cu ti ve pa ti ents wit ho ut using a shunt bet we en 2005 and 2012. In 32 of the ca ses, bi late ral CE A we re per for med. Among the pa ti ents, 36.8 % (n=118) we re ne u ro lo gi cally asym pto matic, and 63.2 % (n=202) we re sympto ma tic. Comp le te occ lu si on was pre sent in the con tra la te ral ca ro tid ar te ri es of 23 pa ti ents. All pa ti ents we re ope ra ted on un der ge ne ral anest he si a, and no intra lu mi nal shunts we re used. This ope ra ti ve tech ni qu e is a mo di fi ca ti on of an ever si on ca ro tid endar te rec tomy in which a lon gi tu di nal ar te ri o tomy is be gun on the com mon ca ro tid ar tery (CCA) and pur po sely ske wed to wards the ori gin of the ex ter nal ca ro tid ar tery. The me an cross-clamp time in our study was 12±4.62 mi nu tes. R Re e s su ul lt ts s: : The re was one ca se of pos to pe ra ti ve mor ta lity (0.28%) that was ca u sed by myo car di al in farc ti on. We ob ser ved 1 (0.28%) ca se of per ma nent ne u ro lo gic de fi cit, 27 (7.6%) ca ses of pe rip he ral ner ve da ma ge, 4 (1.1%) ca ses of early pos to pe ra ti ve tran si ent ne u ro lo gic at tack, 3 (0.85%) ca ses of ho ar se ness and 3 (0.85%) ca ses of ne u ro cog ni ti ve im pa ir ment. C Co on nc c l lu u s si i o on n: : The re sults in di ca te that this mi ni-mo di fi ed ever si on CE A sur gery per for med wit ho ut the use of a shunt can be suc cess ful for pa ti ents with ca ro tid ste no sis. K Ke ey y W Wo or rd ds s: : En dar te rec tomy, ca ro tid; isc he mic at tack, tran si ent; stro ke Ö ÖZ ZE ET T A Am ma aç ç: : Karotis arter endarterektomi (CEA) cerrahisinde şant kullanım gerekliliği, yama kullanımı, eversiyon ve konvansiyonel endarterektomi teknikleri halen tartışılan konulardır. Kliniğimizde CEA operasyonları şant kullanılmadan yapılmaktadır. Yine bu operasyonlarda kliniğimizde geliştirilmiş olan farklı bir arteriyotomi tekniği kullanılmaktadır. Bu çalışmada şant kullanılmadan gerçekleştirilen 352 izole CEA olgusu değerlendirilmiş ve kliniğimizce geliştirilmiş olan tekniğinin tarifi ve erken dönem sonuçları tartışılmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Kliniğimizde 2005-2012 yılları arasında 320 hastaya 32'si bilateral olmak üzere, toplam 352 izole CEA operasyonu uygulandı. Hastaların %36,8 (n=118)'i nörolojik olarak asemptomatik, %63,2 (n=202)'si ise semptomatik hastalardan oluşmaktaydı. Tüm hastalar genel anestezi altında ve şant kullanılmadan opere edildi. Endarterektomi, ana karotis arterden eksternal karotis artere longitudinal bir arteriyotomi insizyonu ile gerçekleştirildi. Ortalama kros klemp zamanı 12±4,62 dakika olarak ölçüldü. B Bu ul lg gu ul la ar r: : Genel anestezi altında ve şant kullanılmadan gerçekleştirilen CEA operasyonlarında oldukça iyi sonuçlar alınabildiği görülmüştür. Ayrıca, tarif ettiğimiz teknikte-uygun olgular için-aterosklerotik plağın kolayca çıkarılabildiği, internal karotis arterde dikiş hattı olmaması sayesinde yama kullanım gerekliliğinin olmadığı görülmüştür. T Ta ar rt tı ış şm ma a: : Olgularımızdan biri (%0,28) postoperatif dönemde gelişen akut myokardiyal infarktüs nedeniyle kaybedildi. Bir olguda (%0,28) kalıcı nörolojik defisit, 27 (%7,6) olguda ekstrakraniyal periferik sinir hasarı, 4 (%1,1) olguda erken post operatif geçici (transient) nörolojik atak, 3 olguda (%0,85) ses kısıklığı ve 3 olguda da (%0,85) geçici bilişsel bozukluk oluştuğu gözlemlendi. A An na ah h t ta ar r K Ke e l li i m me e l le er r: : En dar te rek to mi, ka ro tid; is ke mik atak, ge çi ci; in me, felç T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i

Journal of Nanomaterials, 2013

The increased use of nanosized materials is likely to result in the release of these particles in... more The increased use of nanosized materials is likely to result in the release of these particles into the environment. It is, however, unclear if these materials are harmful to aquatic animals. In this study, the sublethal effects of exposure of low and high concentrations of titanium dioxide nanoparticles (TiO2NPs) on goldfish (Carassius auratus) were investigated. Accumulation of TiO2NPs increased from 42.71 to 110.68 ppb in the intestine and from 4.10 to 9.86 ppb in the gills of the goldfish with increasing exposure dose from 10 to 100 mg/L TiO2NPs. No significant accumulation in the muscle and brain of the fish was detected. Malondialdehyde as a biomarker of lipid oxidation was detected in the liver of the goldfish. Moreover, TiO2NPs exposure inhibited growth of the goldfish. Although there was an increase (8.1%) in the body weights of the goldfish for the control group, in the low and high exposure groups 1.8% increase and 19.7% decrease were measured, respectively. The results o...

European Journal of Pediatric Surgery, 2014

Introduction Intestinal damage has been shown to occur when intra-amniotic meconium concentration... more Introduction Intestinal damage has been shown to occur when intra-amniotic meconium concentration exceeds threshold level. However, the mechanism of the meconium-induced intestinal damage is still unclear. Intestinal ischemia can cause intestinal damage in gastroschisis. This study was aimed to determine the effects of intra-amniotic meconium on the contractility of superior mesenteric artery (SMA). Materials and Methods Eighteen-day-old fertilized chick embryos (Gallus Domesticus) were extirpated and intestines were harvested. The SMA specimens were prepared as 4 mm segments in the organ bath with Krebs-Henseleit buffer. The isometric contraction responses of the SMA specimens were evaluated with norepinephrine, different meconium concentrations, and clear amniotic fluid. Maximum isometric contractions responses (MICR) of the SMA specimens were recorded with an amplifier system on a computer. Results In the norepinephrine group, MICR was found as 2.92 ± 0.57 mN. While MICR of the 1/100 meconium group (highest meconium concentration) was found as 1.56 ± 0.40 mN, MICR of the clear amniotic fluid group was 0.41 ± 0.07 mN. The MICR of the norepinephrine group was significantly increased compared with the 1/100 meconium and clear amniotic fluid groups. MICR of the 1/100 meconium group was also found to be significantly increased compared with clear amniotic fluid group. No statistically significant difference was found among the meconium subgroups. Conclusion Intra-amniotic meconium in fetuses with gastroschisis might cause ischemic intestinal damage by reducing the intestinal blood flow. Further studies are needed to show the outcomes of the vasoactive effect of meconium on the SMA blood flow.

Environ. Sci.: Processes Impacts, 2013

Brine shrimp (Artemia salina) larvae were exposed to different sizes of zinc (Zn) and zinc oxide ... more Brine shrimp (Artemia salina) larvae were exposed to different sizes of zinc (Zn) and zinc oxide (ZnO) nanoparticles (NPs) to evaluate their toxicity in marine aquatic ecosystems. Acute exposure was conducted in seawater with 10, 50 and 100 mg/L concentrations of the NPs for 24 h and 96 h. Phase contrast microscope images confirmed the accumulation of the NPs inside the guts. Artemia were unable to eliminate the ingested particles, which was thought to occur due the formation of massive particles in the guts. Although the suspensions of the NPs did not exhibit any significant acute toxicity within 24 h, mortalities increased remarkably in 96 h and escalated with increasing concentration of NP suspension to 42% for Zn NPs (40-60 nm) (LC 50 ~100 mg/L) and to about 34% for ZnO NPs (10-30 nm) (LC 50 >100 mg/L). The suspensions of Zn NPs were more toxic to Artemia than those of ZnO NPs under comparable regimes. This effect was attributed to higher Zn 2+ levels (ca. up to 8.9 mg L-1) released to the medium from Zn NPs in comparison to that measured in the suspensions of ZnO NPs (ca. 5.5 mg L-1). In addition, the size of the nanopowders appeared to contribute to the observed toxicities. Although the suspensions possessed aggregates of comparable sizes, smaller Zn NPs (40-60 nm) were relatively more toxic than larger Zn NPs (80-100 nm). Likewise, the suspensions of 10-30 nm ZnO NPs caused higher than those of 200 nm ZnO NPs. Lipid peroxidation levels were substantially higher in 96 h (p<0.05) indicating that the toxic effects were due to the oxidative stress.

Journal of Mood Disorders, 2012

Reboksetinle indüklenmiş ağrılı ejakülasyon: Bir olgu sunumu Cinsel işlev bozuklukları antidepres... more Reboksetinle indüklenmiş ağrılı ejakülasyon: Bir olgu sunumu Cinsel işlev bozuklukları antidepresan ilaçların önemli ve sık karşılaşılan yan etkilerinden olup bazen tedavinin erken bırakılmasına neden olabilir. Reboksetin önceleri cinsel yan etkisi olmayan bir ilaç olarak bilinmekteydi. Ancak, biz burada reboksetin tedavisine başladıktan kısa bir süre sonra ağrılı ejakülasyon geliştirmiş olan bir olguyu sunmaktayız. Kırk yaşındaki bu hastaya depresyonu nedeniyle reboksetin tedavisi başlanmıştı. Başlanan 4 mg/gün dozundaki reboksetin tedavisinden 3 hafta sonra hasta ağrılı ejakülasyondan şikayetçi olmaya başladı. Tedavinin kesilmesinden sonra hastanın ağrılı ejakülasyonu kendiliğinden düzeldi. Reboksetin ile erkek hastaların tedavisinde cinsel yan etkiler, özellikle de ağrılı ejakülasyon dahil ejakülasyon bozuklukları akılda bulundurulmalıdır.

Cardiovascular Journal Of Africa, 2013

Background: The aim of this study was to compare the effects of single-clamping and partial-clamp... more Background: The aim of this study was to compare the effects of single-clamping and partial-clamping techniques on postoperative stroke during coronary artery bypass surgery. Methods: Between December 2008 and December 2012, 2 000 patients who underwent coronary artery bypass grafting in two hospitals were analysed. Post-operative neurological complications were analysed retrospectively in these patients. The cases were divided into two groups: in group 1, 1 500 patients were analysed, in whom proximal anastomosis was performed with partial clamping in a beating heart (n = 1 500, 846 male, 654 female; mean age 63.25 ± 5.72 years; range 43-78 years). In group 2, 500 patients were analysed, in whom proximal anastomosis had been performed by other surgical teams in another hospital, with cross clamping in a resting heart with cardioplegia (n = 500, 296 male, 214 female; mean age 64.83 ± 8.12 years; range 41-81 years). During 30 days post-operatively, neurological deficits, stroke incidence and the relationship of the clinical situation to mortality were analysed. Results: For both groups, patients were similar in terms of patient characteristics. In group 2, cross-clamp duration and perfusion time were longer; however, time of hospital stay was similar in the two groups. Post-operative stroke was seen in 26 patients in group 1 (1.73%) and in nine in group 2 (1.8%). The difference between the two groups was not statistically significant (p = 0.92). All stroke patients were over the age of 55 years. Seven of the stroke patients died (21.1%). In total, 31 patients died because of multiple organ failure in the postoperative 30 days (group 1: 1.6%; group 2: 1.4%) (p = 0.91). Smoking, diabetes mellitus, hypertension, atrial fibrillation, peripheral vascular disease and hypercholesterolaemia were found to be factors that affected stroke development. Mean duration of hospital stay was 5.1 ± 2.8 days in group 1 and 4.9 ± 3.6 days in group 2 and the difference between the two groups was not statistically significant (p = 0.46). Conclusion: In patients without plaques in the aorta, performing partial clamping did not increase stroke incidence.

Journal of Hazardous Materials, 2011

Cadmium selenide nanoparticles (CdSe NPs) exhibit novel optoelectronic properties for potential b... more Cadmium selenide nanoparticles (CdSe NPs) exhibit novel optoelectronic properties for potential biomedical applications. However, their metabolic stability is not fully understood because of the difficulties in measurement of free Cd from biological tissues of exposed individuals. In this study, alkaline dissolution with tetramethylammonium hydroxide (TMAH) is demonstrated for selective determination of free Cd and intact NPs from liver and kidney samples of animals that were exposed to thiol-capped CdSe NPs. Aqueous suspensions of CdSe NPs (3.2 nm) were used to optimize the conditions for extracting free Cd without affecting NPs. Nanoparticles were found to aggregate when heated in TMAH without releasing any significant Cd to solution. Performance of the method in discriminating free Cd and intact NPs were verified by Dogfish Liver (DOLT-4) certified reference material. The samples from the animals were digested in 4 mL TMAH at 70 °C to extract free Cd followed by analysis of aqueous phase by ICP-MS. Both liver and kidney contained significant levels of free Cd. Total Cd was higher in the liver, while kidney accumulated mostly free Cd such that up to 47.9% of total Cd in the kidney was free Cd when NPs were exposed to UV-light before injection.

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014