Meike Wiechert - Academia.edu (original) (raw)

Papers by Meike Wiechert

Research paper thumbnail of Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study

International journal of obesity, Jun 26, 2024

BACKGROUND/OBJECTIVES: Weight loss outcomes vary individually. Magnetic resonance imaging (MRI)-b... more BACKGROUND/OBJECTIVES: Weight loss outcomes vary individually. Magnetic resonance imaging (MRI)-based evaluation of adipose tissue (AT) might help to identify AT characteristics that predict AT loss. This study aimed to assess the impact of an 8-week low-calorie diet (LCD) on different AT depots and to identify predictors of short-term AT loss using MRI in adults with obesity. METHODS: Eighty-one adults with obesity (mean BMI 34.08 ± 2.75 kg/m², mean age 46.3 ± 10.97 years, 49 females) prospectively underwent baseline MRI (liver dome to femoral head) and anthropometric measurements (BMI, waist-to-hip-ratio, body fat), followed by a post-LCD-examination. Visceral and subcutaneous AT (VAT and SAT) volumes and AT fat fraction were extracted from the MRI data. Apparent lipid volumes based on MRI were calculated as approximation for the lipid contained in the AT. SAT and VAT volumes were subdivided into equidistant thirds along the craniocaudal axis and normalized by length of the segmentation. T-tests compared baseline and follow-up measurements and sex differences. Effect sizes on subdivided AT volumes were compared. Spearman Rank correlation explored associations between baseline parameters and AT loss. Multiple regression analysis identified baseline predictors for AT loss. RESULTS: Following the LCD, participants exhibited significant weight loss (11.61 ± 3.07 kg, p < 0.01) and reductions in all MRI-based AT parameters (p < 0.01). Absolute SAT loss exceeded VAT loss, while relative apparent lipid loss was higher in VAT (both p < 0.01). The lower abdominopelvic third showed the most significant SAT and VAT reduction. The predictor of most AT and apparent lipid losses was the normalized baseline SAT volume in the lower abdominopelvic third, with smaller volumes favoring greater AT loss (p < 0.01 for SAT and VAT loss and SAT apparent lipid volume loss). CONCLUSIONS: The LCD primarily reduces lower abdominopelvic SAT and VAT. Furthermore, lower abdominopelvic SAT volume was detected as a potential predictor for short-term AT loss in persons with obesity.

Research paper thumbnail of Assoziation zwischen der postprandialen Glukose- oder Insulinantwort und der Veränderung anthropometrischer Parameter nach einer 8-wöchigen Formuladiät – Daten aus der LION-Studie

Abstracts des Gemeinsamen Kongresses der Deutschen Adipositas-Gesellschaft (DAG) und Deutsche Gesellschaft für Essstörungen (DGESS)

Research paper thumbnail of Pancreatic PDFF in persons with obesity: change during weight loss and correlations with adipose tissue PDFF

ISMRM Annual Meeting

Risk stratification strategies in patients with metabolic diseases are urgently needed for the se... more Risk stratification strategies in patients with metabolic diseases are urgently needed for the selection of appropriate lifestyle interventions. Pancreatic fat content has been shown to be associated with the metabolic syndrome and type 2 diabetes mellitus. MRI-based proton density fat fraction (PDFF) mapping based on a multi-echo gradient echo acquisition is the method of choice for non-invasive pancreatic fat quantification. This study evaluates how the PDFF of the pancreas correlates to adipose tissue PDFF and evolves after an 8-week weight loss intervention.

Research paper thumbnail of Subcutaneous adipose tissue water fraction increases with weight loss in persons with obesity

ISMRM Annual Meeting

Subcutaneous adipose tissue (SAT) dysfunction is key in defining high-risk individuals in obesity... more Subcutaneous adipose tissue (SAT) dysfunction is key in defining high-risk individuals in obesity. A change in adipose tissue water fraction with weight loss may reflect improvement in blood flow or changes in microstructure of adipose tissue. Single-voxel STEAM Magnetic Resonance Spectroscopy (MRS) and chemical shift encoded-based water-fat separation are non-invasive methods to assess the water fraction and proton density fat fraction (PDFF) of adipose tissue. The present work aims to investigate the feasibility of MRS and water-fat separation to quantify PDFF and evaluate the changes in SAT water fraction in persons with obesity undergoing an 8-week weight loss intervention.

Research paper thumbnail of Association between the Postprandial Glucose and Insulin Response and Changes in Anthropometric Parameters after an 8-Week Formula Diet—Data from the Lifestyle Intervention Study

Background and Objectives: There is a high inter-individual variability in the postprandial respo... more Background and Objectives: There is a high inter-individual variability in the postprandial response to an oral glucose tolerance test (OGTT). However, there is limited evidence on whether the individual postprandial response is associated with the success of a weight management intervention. This work examines postprandial glucose and insulin response to an OGTT as predictors for changes in anthropometric parameters after a standardized weight loss intervention. Methods: Adults (18-65 years) with a body mass index (BMI) between 30.0 and 39.9 kg/m 2 were recruited for the Lifestyle Intervention (LION) study (NCT04023942). Blood samples were taken before the start of the 8-week formula diet and during an OGTT. Several parameters describing the postprandial glucose and insulin response (e.g., area under the curve, peak time, and concentration) were calculated. Anthropometric parameters (e.g., body weight, fat mass) were collected before and after the 8-week formula diet. Finally, regression analyses adjusted for age and sex were fitted. Results: A total of 272 participants (mean age 45 ± 11 years, BMI 34.5 ± 2.9 kg/m 2 , 64% women) were included in the analysis. The formula diet resulted in an average weight loss of 11.8 ± 3.5 kg body weight and 8.2 ± 2.5 kg (4.1 ± 2.2%) fat mass. Postprandial parameters describing the glucose or insulin response from a total of 161 OGTTs showed no significant associations with changes in anthropometric parameters. Discussion: The examined postprandial glucose or insulin responses are not associated with weight loss success after an 8-week formula diet.

Research paper thumbnail of Veränderungen des Körperbildes nach einer 8-wöchigen Formula-Diät bei Personen mit Adipositas in Abhängigkeit von Gewichtsverlust und Lebensqualität (#74)

Abstracts des Adipositas-Kongresses 2022 zur 38. Jahrestagung der Deutschen Adipositas Gesellschaft e.V. DAG

Research paper thumbnail of Veränderung des Ruheenergieverbrauchs durch eine Gewichtsreduktion und deren Einflussfaktoren – Ergebnisse aus der LION-Studie (#78)

Abstracts des Adipositas-Kongresses 2022 zur 38. Jahrestagung der Deutschen Adipositas Gesellschaft e.V. DAG

Research paper thumbnail of Nutrition Concepts for the Treatment of Obesity in Adults

Nutrients, 2021

Obesity caused by a positive energy balance is a serious health burden. Studies have shown that o... more Obesity caused by a positive energy balance is a serious health burden. Studies have shown that obesity is the major risk factor for many diseases like type 2 diabetes mellitus, coronary heart diseases, or various types of cancer. Therefore, the prevention and treatment of increased body weight are key. Different evidence-based treatment approaches considering weight history, body mass index (BMI) category, and co-morbidities are available: lifestyle intervention, formula diet, drugs, and bariatric surgery. For all treatment approaches, behaviour change techniques, reduction in energy intake, and increasing energy expenditure are required. Self-monitoring of diet and physical activity provides an effective behaviour change technique for weight management. Digital tools increase engagement rates for self-monitoring and have the potential to improve weight management. The objective of this narrative review is to summarize current available treatment approaches for obesity, to provide ...

Research paper thumbnail of Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study

International journal of obesity, Jun 26, 2024

BACKGROUND/OBJECTIVES: Weight loss outcomes vary individually. Magnetic resonance imaging (MRI)-b... more BACKGROUND/OBJECTIVES: Weight loss outcomes vary individually. Magnetic resonance imaging (MRI)-based evaluation of adipose tissue (AT) might help to identify AT characteristics that predict AT loss. This study aimed to assess the impact of an 8-week low-calorie diet (LCD) on different AT depots and to identify predictors of short-term AT loss using MRI in adults with obesity. METHODS: Eighty-one adults with obesity (mean BMI 34.08 ± 2.75 kg/m², mean age 46.3 ± 10.97 years, 49 females) prospectively underwent baseline MRI (liver dome to femoral head) and anthropometric measurements (BMI, waist-to-hip-ratio, body fat), followed by a post-LCD-examination. Visceral and subcutaneous AT (VAT and SAT) volumes and AT fat fraction were extracted from the MRI data. Apparent lipid volumes based on MRI were calculated as approximation for the lipid contained in the AT. SAT and VAT volumes were subdivided into equidistant thirds along the craniocaudal axis and normalized by length of the segmentation. T-tests compared baseline and follow-up measurements and sex differences. Effect sizes on subdivided AT volumes were compared. Spearman Rank correlation explored associations between baseline parameters and AT loss. Multiple regression analysis identified baseline predictors for AT loss. RESULTS: Following the LCD, participants exhibited significant weight loss (11.61 ± 3.07 kg, p < 0.01) and reductions in all MRI-based AT parameters (p < 0.01). Absolute SAT loss exceeded VAT loss, while relative apparent lipid loss was higher in VAT (both p < 0.01). The lower abdominopelvic third showed the most significant SAT and VAT reduction. The predictor of most AT and apparent lipid losses was the normalized baseline SAT volume in the lower abdominopelvic third, with smaller volumes favoring greater AT loss (p < 0.01 for SAT and VAT loss and SAT apparent lipid volume loss). CONCLUSIONS: The LCD primarily reduces lower abdominopelvic SAT and VAT. Furthermore, lower abdominopelvic SAT volume was detected as a potential predictor for short-term AT loss in persons with obesity.

Research paper thumbnail of Assoziation zwischen der postprandialen Glukose- oder Insulinantwort und der Veränderung anthropometrischer Parameter nach einer 8-wöchigen Formuladiät – Daten aus der LION-Studie

Abstracts des Gemeinsamen Kongresses der Deutschen Adipositas-Gesellschaft (DAG) und Deutsche Gesellschaft für Essstörungen (DGESS)

Research paper thumbnail of Pancreatic PDFF in persons with obesity: change during weight loss and correlations with adipose tissue PDFF

ISMRM Annual Meeting

Risk stratification strategies in patients with metabolic diseases are urgently needed for the se... more Risk stratification strategies in patients with metabolic diseases are urgently needed for the selection of appropriate lifestyle interventions. Pancreatic fat content has been shown to be associated with the metabolic syndrome and type 2 diabetes mellitus. MRI-based proton density fat fraction (PDFF) mapping based on a multi-echo gradient echo acquisition is the method of choice for non-invasive pancreatic fat quantification. This study evaluates how the PDFF of the pancreas correlates to adipose tissue PDFF and evolves after an 8-week weight loss intervention.

Research paper thumbnail of Subcutaneous adipose tissue water fraction increases with weight loss in persons with obesity

ISMRM Annual Meeting

Subcutaneous adipose tissue (SAT) dysfunction is key in defining high-risk individuals in obesity... more Subcutaneous adipose tissue (SAT) dysfunction is key in defining high-risk individuals in obesity. A change in adipose tissue water fraction with weight loss may reflect improvement in blood flow or changes in microstructure of adipose tissue. Single-voxel STEAM Magnetic Resonance Spectroscopy (MRS) and chemical shift encoded-based water-fat separation are non-invasive methods to assess the water fraction and proton density fat fraction (PDFF) of adipose tissue. The present work aims to investigate the feasibility of MRS and water-fat separation to quantify PDFF and evaluate the changes in SAT water fraction in persons with obesity undergoing an 8-week weight loss intervention.

Research paper thumbnail of Association between the Postprandial Glucose and Insulin Response and Changes in Anthropometric Parameters after an 8-Week Formula Diet—Data from the Lifestyle Intervention Study

Background and Objectives: There is a high inter-individual variability in the postprandial respo... more Background and Objectives: There is a high inter-individual variability in the postprandial response to an oral glucose tolerance test (OGTT). However, there is limited evidence on whether the individual postprandial response is associated with the success of a weight management intervention. This work examines postprandial glucose and insulin response to an OGTT as predictors for changes in anthropometric parameters after a standardized weight loss intervention. Methods: Adults (18-65 years) with a body mass index (BMI) between 30.0 and 39.9 kg/m 2 were recruited for the Lifestyle Intervention (LION) study (NCT04023942). Blood samples were taken before the start of the 8-week formula diet and during an OGTT. Several parameters describing the postprandial glucose and insulin response (e.g., area under the curve, peak time, and concentration) were calculated. Anthropometric parameters (e.g., body weight, fat mass) were collected before and after the 8-week formula diet. Finally, regression analyses adjusted for age and sex were fitted. Results: A total of 272 participants (mean age 45 ± 11 years, BMI 34.5 ± 2.9 kg/m 2 , 64% women) were included in the analysis. The formula diet resulted in an average weight loss of 11.8 ± 3.5 kg body weight and 8.2 ± 2.5 kg (4.1 ± 2.2%) fat mass. Postprandial parameters describing the glucose or insulin response from a total of 161 OGTTs showed no significant associations with changes in anthropometric parameters. Discussion: The examined postprandial glucose or insulin responses are not associated with weight loss success after an 8-week formula diet.

Research paper thumbnail of Veränderungen des Körperbildes nach einer 8-wöchigen Formula-Diät bei Personen mit Adipositas in Abhängigkeit von Gewichtsverlust und Lebensqualität (#74)

Abstracts des Adipositas-Kongresses 2022 zur 38. Jahrestagung der Deutschen Adipositas Gesellschaft e.V. DAG

Research paper thumbnail of Veränderung des Ruheenergieverbrauchs durch eine Gewichtsreduktion und deren Einflussfaktoren – Ergebnisse aus der LION-Studie (#78)

Abstracts des Adipositas-Kongresses 2022 zur 38. Jahrestagung der Deutschen Adipositas Gesellschaft e.V. DAG

Research paper thumbnail of Nutrition Concepts for the Treatment of Obesity in Adults

Nutrients, 2021

Obesity caused by a positive energy balance is a serious health burden. Studies have shown that o... more Obesity caused by a positive energy balance is a serious health burden. Studies have shown that obesity is the major risk factor for many diseases like type 2 diabetes mellitus, coronary heart diseases, or various types of cancer. Therefore, the prevention and treatment of increased body weight are key. Different evidence-based treatment approaches considering weight history, body mass index (BMI) category, and co-morbidities are available: lifestyle intervention, formula diet, drugs, and bariatric surgery. For all treatment approaches, behaviour change techniques, reduction in energy intake, and increasing energy expenditure are required. Self-monitoring of diet and physical activity provides an effective behaviour change technique for weight management. Digital tools increase engagement rates for self-monitoring and have the potential to improve weight management. The objective of this narrative review is to summarize current available treatment approaches for obesity, to provide ...