Michał Pawlak - Academia.edu (original) (raw)
Papers by Michał Pawlak
Infrared Physics & Technology
Blood, 2020
The development and progression of multiple myeloma (MM) depend on the formation and perpetual ev... more The development and progression of multiple myeloma (MM) depend on the formation and perpetual evolution of an immunosuppressive and hypervascular bone marrow microenvironment. MM undergoes an angiogenic switch during its early progression stages and initiates the secretion of proangiogenic proteins, such as VEGFA and Galectin-1. Following their engagement with the VEGF receptor 2 on the surface of the endothelium, quiescent endothelial cells (ECs) rapidly switch to an activated state, thus gaining the ability to create sprouts, migrate and proliferate. However, chronic angiogenic stimulation results in the formation of a dense and leaky network of pathological vessels, which in the case of MM also serves as a major source of prosurvival paracrine signals. Since PIM kinases are known modulators of cytokine signaling, owing to their ability to activate NFκB, JAK/STAT and mTOR pathways, we analyzed the expression pattern of PIM1, PIM2 and PIM3 in multiple myeloma bone marrow samples u...
Proceedings of the 17th International Conference on Advances in Mobile Computing & Multimedia, 2019
There exist many voting solutions, which have different benefits and issues. The most significant... more There exist many voting solutions, which have different benefits and issues. The most significant difficulties faced by such systems are lack of transparency and auditability. Recently developed blockchain technology may be a solution to these issues. The paper describes the use of intelligent agents and multi-agent system concept for Auditable Blockchain Voting System (ABVS), which integrates e-voting process with blockchain technology into one supervised non-remote internet voting system which is end-to-end verifiable.
The integrity of data transmission is an important issue of data security. There are many methods... more The integrity of data transmission is an important issue of data security. There are many methods to secure the stored and exchanged data and some of them use the cryptographic techniques. However, such techniques require an additional time for encryption and decryption of data and for trusted subject (CA).
International Journal of Web and Grid Services, 2020
Reports of Practical Oncology & Radiotherapy, 2019
Aim: The main goal of this investigation was to evaluate the influence of positive beta haemolyti... more Aim: The main goal of this investigation was to evaluate the influence of positive beta haemolytic streptococci culture from the genital tract on patients receiving radiation therapy who suffer from cervical cancer. The other aim was to observe radiation therapy complications. Background: Group B streptococci (GBS), group C streptococci (GCS) and group G streptococci (GGS) have been described as frequent invasive pathogens in elderly patients, often in association with underlying medical conditions including immunodeficiency and cancer. Materials and methods: In the years 2006-2015, vaginal swabs from 452 patients were examined. A total of 118 women with positive beta haemolytic streptococci (BHS) groups A, B, C, F, G cultures were analysed, of whom 111 were diagnosed with cervix cancer of IB to IVA degree according to the FIGO 1988 clinical classification. Results: Of the 452 patients suffering from cervix cancer 26.1% were positive for A, B, C, F or G group BHS isolated from the genital tract. All of the 114 examined strains were sensitive to beta-lactam antibiotics. The antimicrobials for which resistance was noted were erythromycin, clindamycin, ciprofloxacin and tetracycline. Conclusions: Positive cultures of BHS from the genital tract were demonstrated to occur in patients with cervix cancer. Complications were found during radiotherapy in 30 (27%) of these patients, including 20 (18%) patients suffering from clinical symptoms of inflammation. When beta-lactam antibiotics are not recommended because of allergy, sensitivity tests to other drugs are necessary.
The Astrophysical Journal, 2019
We analyze the gravitational binary-lensing event OGLE-2016-BLG-0156, for which the lensing light... more We analyze the gravitational binary-lensing event OGLE-2016-BLG-0156, for which the lensing light curve displays pronounced deviations induced by microlens-parallax effects. The light curve exhibits 3 distinctive widely-separated peaks and we find that the multiple-peak feature provides a very tight constraint on the microlens-parallax effect, enabling us to precisely measure the microlens parallax π E. All the peaks are densely and continuously covered from high-cadence survey observations using globally located telescopes and the analysis of the peaks leads to the precise measurement of the angular Einstein radius θ E. From the combination of the measured π E and θ E , we determine the physical parameters of the lens. It is found that the lens is a binary composed of two M dwarfs with masses M 1 = 0.18 ± 0.01 M ⊙ and M 2 = 0.16 ± 0.01 M ⊙ located at a distance D L = 1.35 ± 0.09 kpc. According to the estimated lens mass and distance, the flux from the lens comprises an important fraction, ∼ 25%, of the blended flux. The bright nature of the lens combined with the high relative lens-source motion, µ = 6.94 ± 0.50 mas yr −1 , suggests that the lens can be directly observed from future high-resolution follow-up observations.
Infrared Physics & Technology, 2018
The radiative lifetimes of chromium transitions in ZnSe:Cr crystal were determined by the modulat... more The radiative lifetimes of chromium transitions in ZnSe:Cr crystal were determined by the modulated infrared radiometry method and the accuracy of the obtained data were analysed together with the recently studied from ZnTe:Cr crystal. The radiative lifetimes of chromium transitions in ZnSe:Cr crystal can be estimated from the photoluminescence response, additionally filtered out using an Inrasil window, with very good precision. Studying the influence of the light intensity on the estimation of the lifetime it was observed that with increasing light intensity the lifetime decreases. Also in ZnTe:Cr crystal it had been found, that with increasing light intensity the lifetimes decrease. However, whereas in ZnSe:Cr the accuracy of estimation error is independent on the light intensity in ZnTe:Cr the estimation error increases with the increasing light intensity.
Information System in Management, 2018
Software testing is a very broad term that includes a wide variety of topics. They range from tec... more Software testing is a very broad term that includes a wide variety of topics. They range from technical like testing techniques and measurements, to more organizational like planning and management of testing. Ability to plan, design and create efficient tests is the most critical ability for any good tester. The paper presents Kungfu Testing, which is a testing approach based on advice and best practices advocated by experts in the field of testing. The method is intended to provide a step-by-step instruction of managing testing activities in a project environment. The presented approach was designed to work with and complement the agile development methodologies due to their widespread use and popularity.
Applied Physics A, 2014
This paper presents experimental results that characterize implanted layers in silicon being the ... more This paper presents experimental results that characterize implanted layers in silicon being the result of a high energy implantation of O ?6 ions. We propose a simple relation between attenuation of photothermal radiometry and/ or modulated free carrier absorption amplitudes, the implanted layer thickness and its optical absorption coefficient. The thickness of the implanted layers was determined from capacitance-voltage characteristics and computations with the TRIM program. The obtained results allowed to estimate changes of the optical absorption coefficient of the oxygen implanted layers indicating the amorfization of the layers.
Nature Astronomy, 2017
Regular intrinsic brightness variations observed in many stars are caused by pulsations. These pu... more Regular intrinsic brightness variations observed in many stars are caused by pulsations. These pulsations provide information on the global and structural parameters of the star. The pulsation periods range from seconds to years, depending on the compactness of the star and properties of the matter that forms its outer layers. Here, we report the discovery of more than a dozen of previously unknown short-period variable stars: blue large-amplitude pulsators. These objects show very regular brightness variations with periods in the range of 20-40 min and amplitudes of 0.2-0.4 mag in the optical passbands. The phased light curves have a characteristic sawtooth shape, similar to the shape of classical Cepheids and RR Lyrae-type stars pulsating in the fundamental mode. The objects are significantly bluer than main sequence stars observed in the same fields, which indicates that all of them are hot stars. Follow-up spectroscopy confirms a high surface temperature of about 30,000 K. Temperature and colour changes over the cycle prove the pulsational nature of the variables. However, large-amplitude pulsations at such short periods are not observed in any known type of stars, including hot objects. Long-term photometric observations show that the variable stars are very stable over time. Derived rates of period change are of the order of 10 −7 per year and, in most cases, they
Infrared Physics & Technology, 2016
Abstract In this work we investigated the photoluminescence response in the frequency domain modu... more Abstract In this work we investigated the photoluminescence response in the frequency domain modulated infrared radiometry signal observed of ZnTe:Cr bulk crystal. In mid-infrared range, three characteristic phenomena are observed in ZnTe:Cr crystal: absorption and emission of IR photons (2–3 μm) and the free carrier absorption. This implies that the modulated infrared radiometry signal yields information about the effective infrared absorption coefficient (photothermal response) as well about the recombination lifetime of carriers related with the infrared photoluminescence emission. In this paper, the frequency equivalence of the two-term independent exponential photoluminescence decay model in order to explain the measured frequency characteristics is proposed. The measured recombination lifetimes (2.3 μs for two exponential decay model and 1.5 μs for one exponential decay model) are in good agreement with the values given by other authors (about 2.5–3.0 μs). Moreover, we found that the photothermal response is uncorrelated with the photoluminescence one, in contrast, to the photocarrier response.
Journal of Applied Physics, 2016
Nature, Aug 24, 2017
Planet formation theories predict that some planets may be ejected from their parent systems as r... more Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have been discovered by infrared surveys of young stellar clusters and star-forming regions as well as wide-field surveys, but these studies are incomplete for objects below five Jupiter masses. Gravitational microlensing is the only method capable of exploring the entire population of free-floating planets down to Mars-mass objects, because the microlensing signal does not depend on the brightness of the lensing object. A characteristic timescale of microlensing events depends on the mass of the lens: the less massive the lens, the shorter the microlensing event. A previous analysis of 474 microlensing events found an excess of ten very short events (1-2 days)-more than know...
Monthly Notices of the Royal Astronomical Society, 2015
There are by now ten published detections of fast radio bursts (FRBs)-single bright GHz-band mill... more There are by now ten published detections of fast radio bursts (FRBs)-single bright GHz-band millisecond pulses of unknown origin. Proposed explanations cover a broad range from exotic processes at cosmological distances to atmospheric and terrestrial sources. Loeb, Maoz, and Shvartzvald have previously suggested that FRB sources could be nearby flare stars, and pointed out the presence of a W-UMa-type contact binary within the beam of one out of three FRB fields that they examined. To further test the flare-star hypothesis, we use time-domain optical photometry and spectroscopy, and now find possible flare stars in additional FRB fields, with one to three such cases among all eight FRB fields studied. We evaluate the chance probabilities of these possible associations to be in the range ∼ 0.1% to 9%, depending on the input assumptions. Further, we re-analyze the probability that two FRBs recently discovered 3 years apart within the same radio beam are unrelated. Contrary to other claims, we conclude with 99% confidence that the two events are from the same repeating source. The different dispersion measures between the two bursts then rule out a cosmological intergalactic-medium origin for the dispersion measure, but are consistent with the flare-star scenario with a varying plasma blanket between bursts. Finally, we review some theoretical objections that have been raised against a local flare-star FRB origin, and show that they are incorrect.
Psychiatria Polska, 2015
CelOcena częstości występowania zaburzeń ciągłości snu u kobiet w okresie przekwitania, ocena zal... more CelOcena częstości występowania zaburzeń ciągłości snu u kobiet w okresie przekwitania, ocena zależności pomiędzy występowaniem zaburzeń ciągłości snu a stopniem nasilenia zespołu klimakterycznego i występowaniem poszczególnych objawów zespołu klimakterycznego, jak również ocena zależności pomiędzy występowaniem problemów ze snem a stężeniem gonadotropin, prolaktyny i hormonów płciowych w surowicy.MetodaZbadanych zostało 140 kobiet (średni wiek 54,4 ± 4,7 lat), które kolejno zgłosiły się do Kliniki Endokrynologii Ginekologicznej z powodu objawów zespołu klimakterycznego. Do oceny typu i nasilenia zaburzeń ciągłości snu użyto pytań o jakość snu ze Skali Depresji Hamiltona. Nasilenie objawów zespołu klimakterycznego oceniano przy użyciu indeksu Kuppermana. U wszystkich badanych oznaczono stężenia hormonów: follikulotropiny (FSH), lutropiny (LH), 17β-estradiolu, prolaktyny (PRL), testosteronu całkowitego, siarczanu dehydroepiandrosteronu (DHEAS) oraz globuliny wiążącej hormony płciowe ...
Ginekologia polska, 2006
THE OBJECTIVES: The aim of this study was to evaluate the clinical value of blood flow indicies f... more THE OBJECTIVES: The aim of this study was to evaluate the clinical value of blood flow indicies for differentiating between benign and malignant ovarian tumours. Realisation of the aim was based on the analysis of examinations' results of 686 ovarian tumors. For each recorded blood flow wave the followind parameters of examined tumor vessels were analysed: pulsatility index (PI), resistance index (RI), peak systolic velocity (PSV), time-averaged maximum velocity (TAMXV) and maximum and diastolic velocity (MEDV). Apart from conditional probabilities we also presented assessing areas under the ROC curves, which introducted information over practical usefulness of each test. Vascular perfusion was observed in 100% of malignant tumors and 92% of non-malignant tumors. In group of patients with malignant tumors PI and RI were significantly lower; and PSV, TAMXV and MEDV were higher than in group with non-malignant tumors. (p<0.05) Transvaginal ultrasonography with the Doppler techn...
Infrared Physics & Technology
Blood, 2020
The development and progression of multiple myeloma (MM) depend on the formation and perpetual ev... more The development and progression of multiple myeloma (MM) depend on the formation and perpetual evolution of an immunosuppressive and hypervascular bone marrow microenvironment. MM undergoes an angiogenic switch during its early progression stages and initiates the secretion of proangiogenic proteins, such as VEGFA and Galectin-1. Following their engagement with the VEGF receptor 2 on the surface of the endothelium, quiescent endothelial cells (ECs) rapidly switch to an activated state, thus gaining the ability to create sprouts, migrate and proliferate. However, chronic angiogenic stimulation results in the formation of a dense and leaky network of pathological vessels, which in the case of MM also serves as a major source of prosurvival paracrine signals. Since PIM kinases are known modulators of cytokine signaling, owing to their ability to activate NFκB, JAK/STAT and mTOR pathways, we analyzed the expression pattern of PIM1, PIM2 and PIM3 in multiple myeloma bone marrow samples u...
Proceedings of the 17th International Conference on Advances in Mobile Computing & Multimedia, 2019
There exist many voting solutions, which have different benefits and issues. The most significant... more There exist many voting solutions, which have different benefits and issues. The most significant difficulties faced by such systems are lack of transparency and auditability. Recently developed blockchain technology may be a solution to these issues. The paper describes the use of intelligent agents and multi-agent system concept for Auditable Blockchain Voting System (ABVS), which integrates e-voting process with blockchain technology into one supervised non-remote internet voting system which is end-to-end verifiable.
The integrity of data transmission is an important issue of data security. There are many methods... more The integrity of data transmission is an important issue of data security. There are many methods to secure the stored and exchanged data and some of them use the cryptographic techniques. However, such techniques require an additional time for encryption and decryption of data and for trusted subject (CA).
International Journal of Web and Grid Services, 2020
Reports of Practical Oncology & Radiotherapy, 2019
Aim: The main goal of this investigation was to evaluate the influence of positive beta haemolyti... more Aim: The main goal of this investigation was to evaluate the influence of positive beta haemolytic streptococci culture from the genital tract on patients receiving radiation therapy who suffer from cervical cancer. The other aim was to observe radiation therapy complications. Background: Group B streptococci (GBS), group C streptococci (GCS) and group G streptococci (GGS) have been described as frequent invasive pathogens in elderly patients, often in association with underlying medical conditions including immunodeficiency and cancer. Materials and methods: In the years 2006-2015, vaginal swabs from 452 patients were examined. A total of 118 women with positive beta haemolytic streptococci (BHS) groups A, B, C, F, G cultures were analysed, of whom 111 were diagnosed with cervix cancer of IB to IVA degree according to the FIGO 1988 clinical classification. Results: Of the 452 patients suffering from cervix cancer 26.1% were positive for A, B, C, F or G group BHS isolated from the genital tract. All of the 114 examined strains were sensitive to beta-lactam antibiotics. The antimicrobials for which resistance was noted were erythromycin, clindamycin, ciprofloxacin and tetracycline. Conclusions: Positive cultures of BHS from the genital tract were demonstrated to occur in patients with cervix cancer. Complications were found during radiotherapy in 30 (27%) of these patients, including 20 (18%) patients suffering from clinical symptoms of inflammation. When beta-lactam antibiotics are not recommended because of allergy, sensitivity tests to other drugs are necessary.
The Astrophysical Journal, 2019
We analyze the gravitational binary-lensing event OGLE-2016-BLG-0156, for which the lensing light... more We analyze the gravitational binary-lensing event OGLE-2016-BLG-0156, for which the lensing light curve displays pronounced deviations induced by microlens-parallax effects. The light curve exhibits 3 distinctive widely-separated peaks and we find that the multiple-peak feature provides a very tight constraint on the microlens-parallax effect, enabling us to precisely measure the microlens parallax π E. All the peaks are densely and continuously covered from high-cadence survey observations using globally located telescopes and the analysis of the peaks leads to the precise measurement of the angular Einstein radius θ E. From the combination of the measured π E and θ E , we determine the physical parameters of the lens. It is found that the lens is a binary composed of two M dwarfs with masses M 1 = 0.18 ± 0.01 M ⊙ and M 2 = 0.16 ± 0.01 M ⊙ located at a distance D L = 1.35 ± 0.09 kpc. According to the estimated lens mass and distance, the flux from the lens comprises an important fraction, ∼ 25%, of the blended flux. The bright nature of the lens combined with the high relative lens-source motion, µ = 6.94 ± 0.50 mas yr −1 , suggests that the lens can be directly observed from future high-resolution follow-up observations.
Infrared Physics & Technology, 2018
The radiative lifetimes of chromium transitions in ZnSe:Cr crystal were determined by the modulat... more The radiative lifetimes of chromium transitions in ZnSe:Cr crystal were determined by the modulated infrared radiometry method and the accuracy of the obtained data were analysed together with the recently studied from ZnTe:Cr crystal. The radiative lifetimes of chromium transitions in ZnSe:Cr crystal can be estimated from the photoluminescence response, additionally filtered out using an Inrasil window, with very good precision. Studying the influence of the light intensity on the estimation of the lifetime it was observed that with increasing light intensity the lifetime decreases. Also in ZnTe:Cr crystal it had been found, that with increasing light intensity the lifetimes decrease. However, whereas in ZnSe:Cr the accuracy of estimation error is independent on the light intensity in ZnTe:Cr the estimation error increases with the increasing light intensity.
Information System in Management, 2018
Software testing is a very broad term that includes a wide variety of topics. They range from tec... more Software testing is a very broad term that includes a wide variety of topics. They range from technical like testing techniques and measurements, to more organizational like planning and management of testing. Ability to plan, design and create efficient tests is the most critical ability for any good tester. The paper presents Kungfu Testing, which is a testing approach based on advice and best practices advocated by experts in the field of testing. The method is intended to provide a step-by-step instruction of managing testing activities in a project environment. The presented approach was designed to work with and complement the agile development methodologies due to their widespread use and popularity.
Applied Physics A, 2014
This paper presents experimental results that characterize implanted layers in silicon being the ... more This paper presents experimental results that characterize implanted layers in silicon being the result of a high energy implantation of O ?6 ions. We propose a simple relation between attenuation of photothermal radiometry and/ or modulated free carrier absorption amplitudes, the implanted layer thickness and its optical absorption coefficient. The thickness of the implanted layers was determined from capacitance-voltage characteristics and computations with the TRIM program. The obtained results allowed to estimate changes of the optical absorption coefficient of the oxygen implanted layers indicating the amorfization of the layers.
Nature Astronomy, 2017
Regular intrinsic brightness variations observed in many stars are caused by pulsations. These pu... more Regular intrinsic brightness variations observed in many stars are caused by pulsations. These pulsations provide information on the global and structural parameters of the star. The pulsation periods range from seconds to years, depending on the compactness of the star and properties of the matter that forms its outer layers. Here, we report the discovery of more than a dozen of previously unknown short-period variable stars: blue large-amplitude pulsators. These objects show very regular brightness variations with periods in the range of 20-40 min and amplitudes of 0.2-0.4 mag in the optical passbands. The phased light curves have a characteristic sawtooth shape, similar to the shape of classical Cepheids and RR Lyrae-type stars pulsating in the fundamental mode. The objects are significantly bluer than main sequence stars observed in the same fields, which indicates that all of them are hot stars. Follow-up spectroscopy confirms a high surface temperature of about 30,000 K. Temperature and colour changes over the cycle prove the pulsational nature of the variables. However, large-amplitude pulsations at such short periods are not observed in any known type of stars, including hot objects. Long-term photometric observations show that the variable stars are very stable over time. Derived rates of period change are of the order of 10 −7 per year and, in most cases, they
Infrared Physics & Technology, 2016
Abstract In this work we investigated the photoluminescence response in the frequency domain modu... more Abstract In this work we investigated the photoluminescence response in the frequency domain modulated infrared radiometry signal observed of ZnTe:Cr bulk crystal. In mid-infrared range, three characteristic phenomena are observed in ZnTe:Cr crystal: absorption and emission of IR photons (2–3 μm) and the free carrier absorption. This implies that the modulated infrared radiometry signal yields information about the effective infrared absorption coefficient (photothermal response) as well about the recombination lifetime of carriers related with the infrared photoluminescence emission. In this paper, the frequency equivalence of the two-term independent exponential photoluminescence decay model in order to explain the measured frequency characteristics is proposed. The measured recombination lifetimes (2.3 μs for two exponential decay model and 1.5 μs for one exponential decay model) are in good agreement with the values given by other authors (about 2.5–3.0 μs). Moreover, we found that the photothermal response is uncorrelated with the photoluminescence one, in contrast, to the photocarrier response.
Journal of Applied Physics, 2016
Nature, Aug 24, 2017
Planet formation theories predict that some planets may be ejected from their parent systems as r... more Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have been discovered by infrared surveys of young stellar clusters and star-forming regions as well as wide-field surveys, but these studies are incomplete for objects below five Jupiter masses. Gravitational microlensing is the only method capable of exploring the entire population of free-floating planets down to Mars-mass objects, because the microlensing signal does not depend on the brightness of the lensing object. A characteristic timescale of microlensing events depends on the mass of the lens: the less massive the lens, the shorter the microlensing event. A previous analysis of 474 microlensing events found an excess of ten very short events (1-2 days)-more than know...
Monthly Notices of the Royal Astronomical Society, 2015
There are by now ten published detections of fast radio bursts (FRBs)-single bright GHz-band mill... more There are by now ten published detections of fast radio bursts (FRBs)-single bright GHz-band millisecond pulses of unknown origin. Proposed explanations cover a broad range from exotic processes at cosmological distances to atmospheric and terrestrial sources. Loeb, Maoz, and Shvartzvald have previously suggested that FRB sources could be nearby flare stars, and pointed out the presence of a W-UMa-type contact binary within the beam of one out of three FRB fields that they examined. To further test the flare-star hypothesis, we use time-domain optical photometry and spectroscopy, and now find possible flare stars in additional FRB fields, with one to three such cases among all eight FRB fields studied. We evaluate the chance probabilities of these possible associations to be in the range ∼ 0.1% to 9%, depending on the input assumptions. Further, we re-analyze the probability that two FRBs recently discovered 3 years apart within the same radio beam are unrelated. Contrary to other claims, we conclude with 99% confidence that the two events are from the same repeating source. The different dispersion measures between the two bursts then rule out a cosmological intergalactic-medium origin for the dispersion measure, but are consistent with the flare-star scenario with a varying plasma blanket between bursts. Finally, we review some theoretical objections that have been raised against a local flare-star FRB origin, and show that they are incorrect.
Psychiatria Polska, 2015
CelOcena częstości występowania zaburzeń ciągłości snu u kobiet w okresie przekwitania, ocena zal... more CelOcena częstości występowania zaburzeń ciągłości snu u kobiet w okresie przekwitania, ocena zależności pomiędzy występowaniem zaburzeń ciągłości snu a stopniem nasilenia zespołu klimakterycznego i występowaniem poszczególnych objawów zespołu klimakterycznego, jak również ocena zależności pomiędzy występowaniem problemów ze snem a stężeniem gonadotropin, prolaktyny i hormonów płciowych w surowicy.MetodaZbadanych zostało 140 kobiet (średni wiek 54,4 ± 4,7 lat), które kolejno zgłosiły się do Kliniki Endokrynologii Ginekologicznej z powodu objawów zespołu klimakterycznego. Do oceny typu i nasilenia zaburzeń ciągłości snu użyto pytań o jakość snu ze Skali Depresji Hamiltona. Nasilenie objawów zespołu klimakterycznego oceniano przy użyciu indeksu Kuppermana. U wszystkich badanych oznaczono stężenia hormonów: follikulotropiny (FSH), lutropiny (LH), 17β-estradiolu, prolaktyny (PRL), testosteronu całkowitego, siarczanu dehydroepiandrosteronu (DHEAS) oraz globuliny wiążącej hormony płciowe ...
Ginekologia polska, 2006
THE OBJECTIVES: The aim of this study was to evaluate the clinical value of blood flow indicies f... more THE OBJECTIVES: The aim of this study was to evaluate the clinical value of blood flow indicies for differentiating between benign and malignant ovarian tumours. Realisation of the aim was based on the analysis of examinations' results of 686 ovarian tumors. For each recorded blood flow wave the followind parameters of examined tumor vessels were analysed: pulsatility index (PI), resistance index (RI), peak systolic velocity (PSV), time-averaged maximum velocity (TAMXV) and maximum and diastolic velocity (MEDV). Apart from conditional probabilities we also presented assessing areas under the ROC curves, which introducted information over practical usefulness of each test. Vascular perfusion was observed in 100% of malignant tumors and 92% of non-malignant tumors. In group of patients with malignant tumors PI and RI were significantly lower; and PSV, TAMXV and MEDV were higher than in group with non-malignant tumors. (p<0.05) Transvaginal ultrasonography with the Doppler techn...