Minh Dinh - Academia.edu (original) (raw)

Papers by Minh Dinh

2021 IEEE 17th International Conference on Wearable and Implantable Body Sensor Networks (BSN)

Breathing rate is an important vital sign and an indicator of overall health and fitness. Traditi... more Breathing rate is an important vital sign and an indicator of overall health and fitness. Traditionally breathing is monitored using specialized devices such as chestband or spirometers which are uncomfortable for daily use. Recent works show the feasibility of estimating breathing rate using earbuds' motion sensors. However, non-breathing head motion is one of the biggest challenges for breathing rate estimation using earbuds. In this paper, we propose algorithms to estimate breathing rate in presence of non-breathing head motion using inertial sensors embedded in commodity earbuds. Using the chestband as a reference device, we show that our algorithms can estimate breathing rate in resting positions with error rate 2.34 breaths per minute (BPM). Our algorithms can handle passive head motion and reduce the error by 27.78%. Furthermore, our algorithms can handle active head motion and help reduce the error by 45.70% when intentional non-breathing head motion is present in the data segment. It can be a big stride towards passive breathing monitoring in daily life using commodity earbuds.

ICASSP 2022 - 2022 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)

2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021

Respiration rate is considered as a critical vital sign, and daily monitoring of respiration rate... more Respiration rate is considered as a critical vital sign, and daily monitoring of respiration rate could provide helpful information about any acute condition in the human body. While researchers have been exploring mobile devices for respiration rate monitoring, passive and continuous monitoring is still not feasible due to many usability challenges (e.g., active participation) in existing approaches. This paper presents an end-to-end system called RRMonitor that leverages the movement sensors from commodity earbuds to continuously monitor the respiration rate in near real-time. While developing the systems, we extensively explored some key parameters, algorithms, and approaches from existing literature that are better suited for continuous and passive respiration rate monitoring. RRMonitor can passively track the respiration rate with a mean absolute error as low as 1.64 cycles per minute without requiring active participation from the user. Clinical relevance-This work enables continuous monitoring of respiration rate during daily life that has significant potential for detecting abnormal changes in respiration rate.

HemaSphere, 2019

7030 Background: Bromodomain and extra-terminal (BET) proteins bind to acetyllysines and upregula... more 7030 Background: Bromodomain and extra-terminal (BET) proteins bind to acetyllysines and upregulate oncogenic target genes. Mivebresib (ABBV-075) is a pan-BET inhibitor with antitumor activity in vitro and xenograft models of AML. This 2-part phase 1 study evaluates the safety and pharmacokinetics of mivebresib at monotherapy or combination dosing schedules in patients with solid tumors (part 1) and acute myeloid leukemia (AML; part 2) (NCT02391480). Here, we report preliminary data from part 2 in patients with relapsed/refractory (RR) AML. Methods: Mivebresib monotherapy (MIV-mono), or combined with venetoclax (MIV-VEN), were administered daily to adult patients with AML. The dose-limiting toxicity (DLT) period was 28 d. Results: As of Dec 2018, 41 patients (median age: 69 y [range, 29–84]; 19 patients had > 2 prior therapies) were enrolled: 19 in MIV-mono (5 of whom switched to MIV-combo) and 22 who began treatment in MIV-VEN cohorts. 23 patients had high cytogenetic risk. Median time on treatment was 28 d (range, 8–562). There were no DLTs. All patients experienced a treatment-emergent adverse event (AE), most commonly (≥40% patient incidence), fatigue (56%), dysgeusia (46%), decreased appetite (44%), diarrhoea (42%), nausea (42%), vomiting (42%). 40 patients had grade ≥3 AEs (febrile neutropenia (37%), anemia (34%) and thrombocytopenia (32%). 33 patients had serious AEs, most commonly febrile neutropenia (19%). 25 deaths were reported; 15 patients died of causes unrelated to mivebresib and 10 patients due to AML progression. The median best % bone marrow blast change for 26 evaluable patients was -20% (range, -98% to +300%). Gene expression analysis in pre- and post-treatment peripheral blood samples showed that HEXIM1, DCXR and CD93 genes were reliable PD biomarkers of ABBV-075 which were consistently modulated in a dose-dependent manner. At the cutoff date, median overall survival for all patients was 2.6 m. Conclusions: Mivebresib was well tolerated and showed antileukemic effects in patients with RR AML. Clinical trial information: NCT02391480.

Journal of Clinical Oncology, 2018

SUMMARY The level of the ground water has been constantly lowering and the urbanization has been ... more SUMMARY The level of the ground water has been constantly lowering and the urbanization has been rapidly developing during the last decades due to the strong groundwater extraction has led to the subsidence of some areas in the Ho Chi Minh City. Land deformation at the rate of few centimetres per year can be measured at the heavy ground water pumping stations. Most existing techniques for monitoring ground subsidence base on using methods of precise leveling, and more recently the GPS. These methods are generally expensive and inefficient for monitoring large areas. Besides, sparsely distributed data points are often insufficient to provide information on every localized ground subsidence. Recent advances in the SAR interferometry, especially with the Permanent Scatterer InSAR (PSInSAR) is an appropriate remote sensing technique for measuring ground subsidence in urban areas at high accuracy and low costs. Results demonstrate the effectiveness of employing the PSInSARTechnique for l...

AIDS Patient Care and STDs, 2009

The incidence of Burkitt&... more The incidence of Burkitt's lymphoma, a rare and aggressive form of non-Hodgkin's lymphoma, remains unaffected by immune reconstitution in HIV-infected individuals. We report a case of a 45-year-old patient with HIV on highly active antiretroviral therapy (HAART) who presented with symptoms of rectal pain. After two misdiagnoses, a computed tomography (CT) scan showed marked rectal wall thickening and lymphadenopathy. A flexible sigmoidoscopy with biopsy of the rectum and peripheral blood smear with bone marrow examination revealed immunophenotypic and cytogenic findings diagnostic of Burkitt's lymphoma of the rectum. The patient has initiated an intensive chemotherapy regimen with good clinical response. There have been significantly fewer reports of colorectal lymphomas in the HAART era, although HIV-infected patients are still at higher risk for developing uncommon manifestations of these types of malignancies.

2021 IEEE 17th International Conference on Wearable and Implantable Body Sensor Networks (BSN)

Breathing rate is an important vital sign and an indicator of overall health and fitness. Traditi... more Breathing rate is an important vital sign and an indicator of overall health and fitness. Traditionally breathing is monitored using specialized devices such as chestband or spirometers which are uncomfortable for daily use. Recent works show the feasibility of estimating breathing rate using earbuds' motion sensors. However, non-breathing head motion is one of the biggest challenges for breathing rate estimation using earbuds. In this paper, we propose algorithms to estimate breathing rate in presence of non-breathing head motion using inertial sensors embedded in commodity earbuds. Using the chestband as a reference device, we show that our algorithms can estimate breathing rate in resting positions with error rate 2.34 breaths per minute (BPM). Our algorithms can handle passive head motion and reduce the error by 27.78%. Furthermore, our algorithms can handle active head motion and help reduce the error by 45.70% when intentional non-breathing head motion is present in the data segment. It can be a big stride towards passive breathing monitoring in daily life using commodity earbuds.

ICASSP 2022 - 2022 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)

2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021

Respiration rate is considered as a critical vital sign, and daily monitoring of respiration rate... more Respiration rate is considered as a critical vital sign, and daily monitoring of respiration rate could provide helpful information about any acute condition in the human body. While researchers have been exploring mobile devices for respiration rate monitoring, passive and continuous monitoring is still not feasible due to many usability challenges (e.g., active participation) in existing approaches. This paper presents an end-to-end system called RRMonitor that leverages the movement sensors from commodity earbuds to continuously monitor the respiration rate in near real-time. While developing the systems, we extensively explored some key parameters, algorithms, and approaches from existing literature that are better suited for continuous and passive respiration rate monitoring. RRMonitor can passively track the respiration rate with a mean absolute error as low as 1.64 cycles per minute without requiring active participation from the user. Clinical relevance-This work enables continuous monitoring of respiration rate during daily life that has significant potential for detecting abnormal changes in respiration rate.

HemaSphere, 2019

7030 Background: Bromodomain and extra-terminal (BET) proteins bind to acetyllysines and upregula... more 7030 Background: Bromodomain and extra-terminal (BET) proteins bind to acetyllysines and upregulate oncogenic target genes. Mivebresib (ABBV-075) is a pan-BET inhibitor with antitumor activity in vitro and xenograft models of AML. This 2-part phase 1 study evaluates the safety and pharmacokinetics of mivebresib at monotherapy or combination dosing schedules in patients with solid tumors (part 1) and acute myeloid leukemia (AML; part 2) (NCT02391480). Here, we report preliminary data from part 2 in patients with relapsed/refractory (RR) AML. Methods: Mivebresib monotherapy (MIV-mono), or combined with venetoclax (MIV-VEN), were administered daily to adult patients with AML. The dose-limiting toxicity (DLT) period was 28 d. Results: As of Dec 2018, 41 patients (median age: 69 y [range, 29–84]; 19 patients had > 2 prior therapies) were enrolled: 19 in MIV-mono (5 of whom switched to MIV-combo) and 22 who began treatment in MIV-VEN cohorts. 23 patients had high cytogenetic risk. Median time on treatment was 28 d (range, 8–562). There were no DLTs. All patients experienced a treatment-emergent adverse event (AE), most commonly (≥40% patient incidence), fatigue (56%), dysgeusia (46%), decreased appetite (44%), diarrhoea (42%), nausea (42%), vomiting (42%). 40 patients had grade ≥3 AEs (febrile neutropenia (37%), anemia (34%) and thrombocytopenia (32%). 33 patients had serious AEs, most commonly febrile neutropenia (19%). 25 deaths were reported; 15 patients died of causes unrelated to mivebresib and 10 patients due to AML progression. The median best % bone marrow blast change for 26 evaluable patients was -20% (range, -98% to +300%). Gene expression analysis in pre- and post-treatment peripheral blood samples showed that HEXIM1, DCXR and CD93 genes were reliable PD biomarkers of ABBV-075 which were consistently modulated in a dose-dependent manner. At the cutoff date, median overall survival for all patients was 2.6 m. Conclusions: Mivebresib was well tolerated and showed antileukemic effects in patients with RR AML. Clinical trial information: NCT02391480.

Journal of Clinical Oncology, 2018

SUMMARY The level of the ground water has been constantly lowering and the urbanization has been ... more SUMMARY The level of the ground water has been constantly lowering and the urbanization has been rapidly developing during the last decades due to the strong groundwater extraction has led to the subsidence of some areas in the Ho Chi Minh City. Land deformation at the rate of few centimetres per year can be measured at the heavy ground water pumping stations. Most existing techniques for monitoring ground subsidence base on using methods of precise leveling, and more recently the GPS. These methods are generally expensive and inefficient for monitoring large areas. Besides, sparsely distributed data points are often insufficient to provide information on every localized ground subsidence. Recent advances in the SAR interferometry, especially with the Permanent Scatterer InSAR (PSInSAR) is an appropriate remote sensing technique for measuring ground subsidence in urban areas at high accuracy and low costs. Results demonstrate the effectiveness of employing the PSInSARTechnique for l...

AIDS Patient Care and STDs, 2009

The incidence of Burkitt&... more The incidence of Burkitt's lymphoma, a rare and aggressive form of non-Hodgkin's lymphoma, remains unaffected by immune reconstitution in HIV-infected individuals. We report a case of a 45-year-old patient with HIV on highly active antiretroviral therapy (HAART) who presented with symptoms of rectal pain. After two misdiagnoses, a computed tomography (CT) scan showed marked rectal wall thickening and lymphadenopathy. A flexible sigmoidoscopy with biopsy of the rectum and peripheral blood smear with bone marrow examination revealed immunophenotypic and cytogenic findings diagnostic of Burkitt's lymphoma of the rectum. The patient has initiated an intensive chemotherapy regimen with good clinical response. There have been significantly fewer reports of colorectal lymphomas in the HAART era, although HIV-infected patients are still at higher risk for developing uncommon manifestations of these types of malignancies.