Misa Nishimoto - Academia.edu (original) (raw)

Papers by Misa Nishimoto

Research paper thumbnail of Corrigendum to “Oral Frailty Index-8 in the risk assessment of new-onset oral frailty and functional disability among community-dwelling older adults” Archives of Gerontology and Geriatrics, Volume 94 (2021) 104340

Archives of Gerontology and Geriatrics, Sep 1, 2021

Research paper thumbnail of Impact of Local Drug Delivery of Minocycline on the Subgingival Microbiota during Supportive Periodontal Therapy: A Randomized Controlled Pilot Study

Dentistry journal, Oct 27, 2020

Research paper thumbnail of Severe Periodontitis Increases the Risk of Oral Frailty: A Six-Year Follow-Up Study from Kashiwa Cohort Study

Geriatrics, Feb 13, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Social Frailty as a Predictor of 5-YEAR Disability and Mortality in Physically Non-Frail Adults

Innovation in Aging, Nov 1, 2018

Research paper thumbnail of Health Literacy and Oral Health Behaviors Decrease the Risk of Oral Frailty in Japanese Elderly

Innovation in Aging, Nov 1, 2018

VAS). 204 patients were included in the analysis (77.5 ± 6.3 years, 59.8% women). 106 (52.0%) pat... more VAS). 204 patients were included in the analysis (77.5 ± 6.3 years, 59.8% women). 106 (52.0%) patients were at nutritional risk and 97 (47.5%) were malnourished. Malnourished patients were more often frail than those at risk (60 (30.8%) vs. 30 (15.4%), p<0.001). Self-reported functional limitations were more pronounced in malnourished patients (17.3 ± 6.2 vs. 14.3 ± 5.6 from max 30 points, p=0.001), while quality of life did not differ (EQ5D5L-Index and EQ-VAS). The majority of patients reported having problems in all dimensions of the EQ5D5L. Malnourished patients had objectively measured as well as subjectively reported limitations at hospital discharge but did not differ in quality of life compared to patients with nutritional risk.

Research paper thumbnail of Severe Periodontitis Increases the Risk of Oral Frailty: A Six-Year Follow-Up Study from Kashiwa Cohort Study

Geriatrics

Oral frailty, overlapping a decline in multi-faceted oral functions and often seen in older adult... more Oral frailty, overlapping a decline in multi-faceted oral functions and often seen in older adults, increases risks of adverse health outcomes, thereby necessitating earlier measures. Tooth loss, a major element of oral frailty, is mainly caused by periodontal disease and is an irreversible event. Therefore, this study aimed to clarify whether advanced periodontal disease increases the risks of “new-onset” oral frailty through a longitudinal analysis based on the 2012 baseline survey of the Kashiwa cohort and the follow-up assessments conducted in 2013, 2014, 2016, and 2018. The participants were disability-free, non-orally frail older adults living in Kashiwa City. Of the 1234 participants (72.2 ± 5.1 years old; 50.8% men) analyzed in this study, oral frailty occurred in 23.1% within the six-year period. The group with Community Periodontal Index (CPI) ≥ 3 at baseline had no significant difference in the risk of oral frailty compared with CPI ≤ 2; however, CPI4 at baseline was rela...

Research paper thumbnail of Corrigendum to “Oral Frailty Index-8 in the risk assessment of new-onset oral frailty and functional disability among community-dwelling older adults” Archives of Gerontology and Geriatrics, Volume 94 (2021) 104340

Archives of Gerontology and Geriatrics, 2021

Research paper thumbnail of Oral Frailty Index-8 in the risk assessment of new-onset oral frailty and functional disability among community-dwelling older adults

Archives of Gerontology and Geriatrics, 2021

BACKGROUND Oral frailty is associated with the loss of oral function and increased care needs. We... more BACKGROUND Oral frailty is associated with the loss of oral function and increased care needs. We have previously developed an Oral Frailty Index (OFI-8) to identify older adults at risk of oral frailty. Herein, we aimed to examine whether OFI-8 scores are indicative of oral frailty or functional disability risk in community-dwelling older adults. METHODS A total of 2,011 individuals (51% women; mean age, 73.0 ± 5.5 years) participated in the 2012 baseline survey (last follow-up wave 2018). Oral frailty was assessed at each time point, based on tooth status, oral function, and other subjective measures. Functional disability was defined as long-term care certification granted during 2012-2019. The OFI-8 items were assessed at baseline. RESULTS The prevalence and incidence rates of oral frailty at baseline and 6 years were 16% and 24%, respectively. The area under the receiver operating characteristic curve of OFI-8 was 0.88 with 95% confidence interval of 0.86-0.90 for oral frailty. The OFI-8 score of ≥4 points maximized the sum of sensitivity and specificity values. The corresponding positive rate, sensitivity, specificity, positive, and negative predictive values were 30%, 80%, 80%, 43%, and 95%, respectively, for baseline oral frailty. A 1-point increase in the OFI-8 score corresponded to a 1.3-fold increase in the risk of new-onset oral frailty and 1.1-fold increase in the risk of disability. CONCLUSIONS OFI-8 may help identify individuals at risk of oral frailty and functional disability. It may also increase the awareness of oral care and facilitate its uptake.

Research paper thumbnail of Oral Frailty is Associated with Multifaceted Frailty in Elderly Outpatients at Community Dental Clinics

Innovation in Aging, 2019

Aim For achieving healthy aging, frailty prevention is essential. Because it is reported that acc... more Aim For achieving healthy aging, frailty prevention is essential. Because it is reported that accumulated declines in multiple oral functions (i.e. oral frailty) could lead to frailty progression, detailed countermeasures for oral frailty are currently required. However, dentists of community dental clinics don’t even know a prevalence of oral frailty among outpatients. Thus, we aimed to identify the prevalence of oral frailty and to examine the association with frailty in outpatients at community dental clinics. Methods The subjects were elderly outpatients at dental clinics in Kanagawa, Japan. Frailty was assessed using the Kihon checklists (KCL); those with ≥8 KCL score were classified as frailty. Furthermore, multiple functions (physical, nutrition, and oral) were assessed using subscale of the KCL. Oral frailty was defined as ≥3 deteriorations out of 5 oral status (remaining teeth, chewing ability, articulatory oral motor skill, subjective difficulties in eating and swallowing)...

Research paper thumbnail of Is Oral Frailty Related To Meal Satisfaction

Journal of Aging Science, 2021

Oral frailty causes nutritional imbalance, subsequently leading to malnutrition in older adults. ... more Oral frailty causes nutritional imbalance, subsequently leading to malnutrition in older adults. Herein, we examined the relationship between oral frailty and meal satisfaction among community-dwelling older adults. Meal satisfaction was evaluated using self-administered questionnaires. Oral conditions were assessed based on the number of remaining teeth and oral frailty. Of the 940 subjects in the Kashiwa study, which was conducted in the Kashiwa city, Chiba prefecture, Japan, 71% responded that their meals were “tasty” and 96% responded “enjoyable”. Moreover, 23% responded that the amount of meal was “large,” and 63% responded “normal” - While the number of teeth was not significantly associated with meal satisfaction, there was a negative association between oral frailty and meal satisfaction. Our finding indicates that it is important to consider and manage oral functions, other than the number of remaining teeth, to maintain healthy eating habits in older adults.

Research paper thumbnail of Oral frailty is associated with food satisfaction in community-dwelling older adults

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2020

Research paper thumbnail of Corrigendum to “Oral Frailty Index-8 in the risk assessment of new-onset oral frailty and functional disability among community-dwelling older adults” Archives of Gerontology and Geriatrics, Volume 94 (2021) 104340

Archives of Gerontology and Geriatrics, Sep 1, 2021

Research paper thumbnail of Impact of Local Drug Delivery of Minocycline on the Subgingival Microbiota during Supportive Periodontal Therapy: A Randomized Controlled Pilot Study

Dentistry journal, Oct 27, 2020

Research paper thumbnail of Severe Periodontitis Increases the Risk of Oral Frailty: A Six-Year Follow-Up Study from Kashiwa Cohort Study

Geriatrics, Feb 13, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Social Frailty as a Predictor of 5-YEAR Disability and Mortality in Physically Non-Frail Adults

Innovation in Aging, Nov 1, 2018

Research paper thumbnail of Health Literacy and Oral Health Behaviors Decrease the Risk of Oral Frailty in Japanese Elderly

Innovation in Aging, Nov 1, 2018

VAS). 204 patients were included in the analysis (77.5 ± 6.3 years, 59.8% women). 106 (52.0%) pat... more VAS). 204 patients were included in the analysis (77.5 ± 6.3 years, 59.8% women). 106 (52.0%) patients were at nutritional risk and 97 (47.5%) were malnourished. Malnourished patients were more often frail than those at risk (60 (30.8%) vs. 30 (15.4%), p<0.001). Self-reported functional limitations were more pronounced in malnourished patients (17.3 ± 6.2 vs. 14.3 ± 5.6 from max 30 points, p=0.001), while quality of life did not differ (EQ5D5L-Index and EQ-VAS). The majority of patients reported having problems in all dimensions of the EQ5D5L. Malnourished patients had objectively measured as well as subjectively reported limitations at hospital discharge but did not differ in quality of life compared to patients with nutritional risk.

Research paper thumbnail of Severe Periodontitis Increases the Risk of Oral Frailty: A Six-Year Follow-Up Study from Kashiwa Cohort Study

Geriatrics

Oral frailty, overlapping a decline in multi-faceted oral functions and often seen in older adult... more Oral frailty, overlapping a decline in multi-faceted oral functions and often seen in older adults, increases risks of adverse health outcomes, thereby necessitating earlier measures. Tooth loss, a major element of oral frailty, is mainly caused by periodontal disease and is an irreversible event. Therefore, this study aimed to clarify whether advanced periodontal disease increases the risks of “new-onset” oral frailty through a longitudinal analysis based on the 2012 baseline survey of the Kashiwa cohort and the follow-up assessments conducted in 2013, 2014, 2016, and 2018. The participants were disability-free, non-orally frail older adults living in Kashiwa City. Of the 1234 participants (72.2 ± 5.1 years old; 50.8% men) analyzed in this study, oral frailty occurred in 23.1% within the six-year period. The group with Community Periodontal Index (CPI) ≥ 3 at baseline had no significant difference in the risk of oral frailty compared with CPI ≤ 2; however, CPI4 at baseline was rela...

Research paper thumbnail of Corrigendum to “Oral Frailty Index-8 in the risk assessment of new-onset oral frailty and functional disability among community-dwelling older adults” Archives of Gerontology and Geriatrics, Volume 94 (2021) 104340

Archives of Gerontology and Geriatrics, 2021

Research paper thumbnail of Oral Frailty Index-8 in the risk assessment of new-onset oral frailty and functional disability among community-dwelling older adults

Archives of Gerontology and Geriatrics, 2021

BACKGROUND Oral frailty is associated with the loss of oral function and increased care needs. We... more BACKGROUND Oral frailty is associated with the loss of oral function and increased care needs. We have previously developed an Oral Frailty Index (OFI-8) to identify older adults at risk of oral frailty. Herein, we aimed to examine whether OFI-8 scores are indicative of oral frailty or functional disability risk in community-dwelling older adults. METHODS A total of 2,011 individuals (51% women; mean age, 73.0 ± 5.5 years) participated in the 2012 baseline survey (last follow-up wave 2018). Oral frailty was assessed at each time point, based on tooth status, oral function, and other subjective measures. Functional disability was defined as long-term care certification granted during 2012-2019. The OFI-8 items were assessed at baseline. RESULTS The prevalence and incidence rates of oral frailty at baseline and 6 years were 16% and 24%, respectively. The area under the receiver operating characteristic curve of OFI-8 was 0.88 with 95% confidence interval of 0.86-0.90 for oral frailty. The OFI-8 score of ≥4 points maximized the sum of sensitivity and specificity values. The corresponding positive rate, sensitivity, specificity, positive, and negative predictive values were 30%, 80%, 80%, 43%, and 95%, respectively, for baseline oral frailty. A 1-point increase in the OFI-8 score corresponded to a 1.3-fold increase in the risk of new-onset oral frailty and 1.1-fold increase in the risk of disability. CONCLUSIONS OFI-8 may help identify individuals at risk of oral frailty and functional disability. It may also increase the awareness of oral care and facilitate its uptake.

Research paper thumbnail of Oral Frailty is Associated with Multifaceted Frailty in Elderly Outpatients at Community Dental Clinics

Innovation in Aging, 2019

Aim For achieving healthy aging, frailty prevention is essential. Because it is reported that acc... more Aim For achieving healthy aging, frailty prevention is essential. Because it is reported that accumulated declines in multiple oral functions (i.e. oral frailty) could lead to frailty progression, detailed countermeasures for oral frailty are currently required. However, dentists of community dental clinics don’t even know a prevalence of oral frailty among outpatients. Thus, we aimed to identify the prevalence of oral frailty and to examine the association with frailty in outpatients at community dental clinics. Methods The subjects were elderly outpatients at dental clinics in Kanagawa, Japan. Frailty was assessed using the Kihon checklists (KCL); those with ≥8 KCL score were classified as frailty. Furthermore, multiple functions (physical, nutrition, and oral) were assessed using subscale of the KCL. Oral frailty was defined as ≥3 deteriorations out of 5 oral status (remaining teeth, chewing ability, articulatory oral motor skill, subjective difficulties in eating and swallowing)...

Research paper thumbnail of Is Oral Frailty Related To Meal Satisfaction

Journal of Aging Science, 2021

Oral frailty causes nutritional imbalance, subsequently leading to malnutrition in older adults. ... more Oral frailty causes nutritional imbalance, subsequently leading to malnutrition in older adults. Herein, we examined the relationship between oral frailty and meal satisfaction among community-dwelling older adults. Meal satisfaction was evaluated using self-administered questionnaires. Oral conditions were assessed based on the number of remaining teeth and oral frailty. Of the 940 subjects in the Kashiwa study, which was conducted in the Kashiwa city, Chiba prefecture, Japan, 71% responded that their meals were “tasty” and 96% responded “enjoyable”. Moreover, 23% responded that the amount of meal was “large,” and 63% responded “normal” - While the number of teeth was not significantly associated with meal satisfaction, there was a negative association between oral frailty and meal satisfaction. Our finding indicates that it is important to consider and manage oral functions, other than the number of remaining teeth, to maintain healthy eating habits in older adults.

Research paper thumbnail of Oral frailty is associated with food satisfaction in community-dwelling older adults

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2020