Mrs Pooja Bhandare - Academia.edu (original) (raw)

Papers by Mrs Pooja Bhandare

Zenodo (CERN European Organization for Nuclear Research), Jul 20, 2023

The synthesis of 4-thiazolidinones of 2-amino-5-chloropyridine was performed by novel method of s... more The synthesis of 4-thiazolidinones of 2-amino-5-chloropyridine was performed by novel method of stirring involving the cyclocondensation of the appropriate Schiff's bases (2a-c) with thioglycolic acid, followed by the addition of zinc chloride in the presence of molecular sieves. Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques-Solubility,Thin Layer Chromatographic studies, UltraViolet studies,Rotational and vibrational studies (FT-IR), 1 H-NMR studies. The compounds were investigated for their Anticonvulsant activity by isoniazid induced convulsions in mice model.Compound3-(5-chloropyridin-2-yl)-2-(4-fluorophenyl) thiazolidin-4-one(3c)was found to be the most activeand compound 3-(5-chloropyridin-2-yl)-2-(2-hydroxyphenyl) thiazolidin-4-one (3a) was found to be less active among the tested compound according to pharmacological evaluation exhibited anticonvulsant activity.

International journal of current advanced research, Apr 28, 2017

Objective: The present study was undertaken to investigate the anti-gouty arthritic activity of A... more Objective: The present study was undertaken to investigate the anti-gouty arthritic activity of Adhatoda vasica Nees aqueous leaves extract (AVLE) using potassium oxonate-induced hyperuricemia in mice. Material and methods: Potassium oxonate (PO) induced hyperuricemia in mice were determined by in vivo experiments. PO causes hyperuricemia in one hour after i.p. administration. Thus mice were administered PO followed by AVLE and standard drug treatment of allopurinol study conducted for 7 days finally measuring the serum levels of uric acid, xanthine oxidase, and xanthine dehydrogenase etc. Results: The evaluation of anti-gouty arthritic potential by oral administration of AVLE (100-400 mg/kg) evoked a significantly decrease in the serum levels of uric acid, xanthine oxidase (XOD), xanthine dehydrogenase (XDH) in treated mice. Finally, the study concluded that in AVLE the flavonoid constituents impart enzyme inhibitory activity thus reducing levels of xanthine oxidase, xanthine dehydrogenase, and serum uric acid. Conclusions: The results obtained in this study indicate that AVLE possesses potential anti-gouty arthritic activity.

Zenodo (CERN European Organization for Nuclear Research), Dec 11, 2019

The current work aimed to formulate a stable w/o cream containing Glycyrrhiza glabra extract and ... more The current work aimed to formulate a stable w/o cream containing Glycyrrhiza glabra extract and studying its effects on skin pigment. Glycyrrhiza glabra Extract obtained by concentrating the alcoholic extract of Glycyrrhiza glabra roots was entrapped in the inner aqueous phase of W/O emulsion. Base containing no active material and a formulation containing ethanolic extract of Glycyrrhiza glabra (1%) were prepared. Samples of base and formulation were stored at different accelerated conditions (8°C, 25°C, 40°C, 40°C+75%RH) for four weeks to predict the stability of creams. Base and formulation were stable at all accelerated conditions regarding color, liquefaction and phase separation. Both creams were good for sensory evaluation.

International Journal of Advanced Research

The synthesis of 4-thiazolidinones of 2-amino-5-chloropyridine was performed by novel method of s... more The synthesis of 4-thiazolidinones of 2-amino-5-chloropyridine was performed by novel method of stirring involving the cyclocondensation of the appropriate Schiffs bases (2a–c) with thioglycolic acid, followed by the addition of zinc chloride in the presence of molecular sieves. Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques- Solubility,Thin Layer Chromatographic studies, Ultra-Violet studies,Rotational and vibrational studies (FT-IR), 1H-NMR studies. The compounds were investigated for their Anticonvulsant activity by isoniazid induced convulsions in mice model.Compound3-(5-chloropyridin-2-yl)-2-(4-fluorophenyl) thiazolidin-4-one(3c)was found to be the most activeand compound 3-(5-chloropyridin-2-yl)-2-(2-hydroxyphenyl) thiazolidin-4-one (3a) was found to be less active among the tested compound according to pharmacological evaluation exhibited anticonvulsant activity.

Annona squamosa L is a multipurpose tree with edible fruits and is a source of the medicinal and ... more Annona squamosa L is a multipurpose tree with edible fruits and is a source of the medicinal and industrial products. It is used as an antioxidant, antidiabetics, hepatoprotective, cytotoxic, genetoxic, anti tumor, anti lice agent etc.Annona squamosa L belongs to the family Annonaceae commonly known as custard apple. Antimicrobial activity of combined methanolic leaf and seed extract of A.squamosa were evaluated against four bacteria Bacillus subtilis, Styphaloccocus aureus gram positive and E.coli, Pseudomonas aerogenosa by using cup and plate method. Maximum inhibition was found with 20mg ml concentration of combined extract as compare to separate leaf and seed extract against all the tested organism under investigation. The study suggest that maximum antibacterial activity was observed against gram negative organism i.e., E.coli and P.aerogenosa. Ms. Chetana D. Patil | Ms. Nikita Pawar | Mrs. Pooja S. Bhandare "A Comparative in Vitro Antimicrobial Activity of Annona Squamosa...

Identification and selection of patient suffering from Renal Failure-To explore the patient treat... more Identification and selection of patient suffering from Renal Failure-To explore the patient treatment for renal failure, its catogries either acute or chronic, then to study about the haematological, renal or biochemical profile of the patient and the family history. The detailed study about the pathological test performed by the patient. Then, the medications administered to the patient. The future treatment to be carried out either dialysis or kidney transplantation.

–Helminthes or worm infection is one of the most prevalent disease and one of the most serious pr... more –Helminthes or worm infection is one of the most prevalent disease and one of the most serious problems in the world. It contributes to malnutrition anemia, eosinophilia and pneumonia. Various numbers of plants available for anthelmintic activity a new lead for helminth control is much desirable and has promoted studies of traditionally used anthelmintic plants, which are generally considered to be important sources of bioactive substances [10]. Anthelmintics derived from plant source can be an answer to this world wide problem as they form secure and non-toxic with a modified site of action. Ocimum sanctum Linn (Ocimum tenuiflorum) known as Tulsi in India, is a sacred plant for hindus known from centuries being used in Ayurveda for its varied healing properties. In the present study different species of tulsi were studied for their anthelminthic activity using earthworms as they have physiological resemblance to the worms or helminthes using standard drug Albendazole Keywords––Helminthiasis, tulsi, anthelmintic, albendazole

–The main objective of the work was to formulate a mosquito repellent cream naturally obtained fr... more –The main objective of the work was to formulate a mosquito repellent cream naturally obtained from medicinal plants instead of commonly available synthetic insecticides and repellents such as N-Diethyl3methylbenzamide (DEET), which are carcinogenic and non eco-friendly. Essential oils of Lemongrass and extract of Neem leaves were used in the cream formulation and evaluated for various parameters. The formulated cream had smooth texture and spreadability with a pH 7.2 which is non irritant and suitable for the skin. From the present work it was concluded that the formulated mosquito repellent cream using essential oil is natural, safe, effective, usable for the skin to afford mosquito repellent action. Keywords––Mosquito repellent cream, neem(azadirachta indica), Lemongrass(cymbopogon flexuousus) INTRODUCTION The role of natural mosquito repellent is to mask human scent. An alarming increase in the range of mosquitoes is mainly due to deforestation, industrialized farming and stagnant water [1]. Thus, special products like mosquito repellents for combating mosquitoes are required. The products used for mosquito repellency show varying degrees of effectiveness [2]. A number of natural mosquito repellents were studied in many research papers and review papers[3-6] that work to repel mosquitoes. Mosquito repellents based on chemicals has a designed with remarkable safety profile, but even then they are toxic against the skin and nervous system and usually cause rashes, swelling and sometimes eye irritation. Hence, natural mosquito repellents are preferred over chemical products. Lemongrass (Cymbopogon citrates. L) the leaves have a lemon like odor because they contain an essential oil having citral as main constituent, same as what is present in lemon peel. Leading phytochemical compounds in lemongrass leaf are terpineol, Dipentene, Limonene, αterpineol, citronellol, methyl heptenone, dipentene, geraniol, limonene, nerol, farnesol, mainly (triterpenoids). Fig. 1: Cymbopogon Flexuousus and Azadirachta Indica. MATERIALS AND METHOD Collection of plant material Leaves of Cymbopogon flexuousus and Azadirachta indica were collected from shirgaon, in satara district. The leaves during the month of July in the year 2017 and authenticated by Dept. of Botany, Y.C.I.S, Satara, Maharashtra, India. Procedure of extraction using soxhlet apparatus[7-12] The soxhlet assembly is a continous extactor which is generally suitable for the extaction from powderd plant material with the help of organic solvent. In this instance, the powderd drug is packed loosely in the thimble of the soxhlet apparatus; and the organic solvent affords a deep penetration of the moist drug therapy allowing the greatest possible extraction of the sutaible contain from exposed surface of the cell and tissue of the crude drug. Once, the extraction is as presumed to have completed, the solvent is evaporated in a electrical water bath and residue is collected. Extraction of neem leaves Leaves of azadirachta indica were screened and unwanted leaves were removed. A leaves were dried for 15 days in shade, powdered and sieved to get a fine powder. Then 50 g of fine powdered sample was taken in 200 mL of ehanol at 50 0 -60 0 C for 18 hours by using soxhlet apparatus. Samle was dried by using electrical waterbath for evaporation. Fig. 2: Figure of neem leaves extract. Formulation and evaluation of mosquito repellent cream using lemongrass and neem leaves Bhandare et al. www.ijeid.com {IJEID © 2019} All Rights Reserved Page | 9 Extraction for Lemongrass oil The extraction Lemongrass oil was carried by using a 150 g of of the fresh leaves of Cymbopogon flexuousus and 250 mL of distilled water by using steam distillation .When water reached 100 0 C started boiling ripping of essential oil from Lemongrass leaves. The volatile oil generated were collected after passing through condenser, in separate flask. The mixture of oil and water obtained from steam ditillation was separated with separating funnel. Extracted oil was stored in an sample bottles at a temperature of 4 0 C till the period of formulation. Fig. 3: Steam distillation. Macroscopic Characteristic The macroscopy of Cymbopogon flexuousus and Azadirachta indica were studied according to standard methods[13-14]. Physical Evaluation The ash values, extractive values and loss on drying were performed according to the officinal methods prescribed in Indian pharmacopeia [15]. Fluorescence analysis was carried out according to the method of Chase and Pratt [16] and Kokoski [17]. Determination of total ash The total ash value of crude powder of Cymbopogon flexuousus and Azadirachta indica was determined by incinerating 2 gm of accurately weighed crude powder in a tarred silica crucible. It was incinerated in a muffle furnace at a temperature not exceeding 45oC until free from carbon, then cooled and weighed. a. Determination of total ash The total ash value of Cymbopogon flexuousus and Azadirachta indica was…

International Journal of Trend in Scientific Research and Development, 2019

The current work aimed to formulate a stable w o cream containing Glycyrrhiza glabra extract and ... more The current work aimed to formulate a stable w o cream containing Glycyrrhiza glabra extract and studying its effects on skin pigment. Glycyrrhiza glabra Extract obtained by concentrating the alcoholic extract of Glycyrrhiza glabra roots was entrapped in the inner aqueous phase of W O emulsion. Base containing no active material and a formulation containing ethanolic extract of Glycyrrhiza glabra 1 were prepared. Samples of base and formulation were stored at different accelerated conditions 8°C, 25°C, 40°C, 40°C 75 RH for four weeks to predict the stability of creams. Base and formulation were stable at all accelerated conditions regarding color, liquefaction and phase separation. Both creams were good for sensory evaluation. Ms. Chetana D. Patil | Ms. Rutika U. More | Mrs. Pooja S. Bhandare "Hydrotropic Cream Preparation from Licorice Extract" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26435.pdf Paper URL https://www.ijtsrd.com/pharmacy/pharmacognosy-/26435/hydrotropic-cream-preparation-from-licorice-extract/ms-chetana-d-patil

Suspensions may be defined as preparations containing finely divided drug particles (the suspenso... more Suspensions may be defined as preparations containing finely divided drug particles (the suspensoid) distributed somewhat uniformly throughout a vehicle with or without stabilizers and other additives in which drug exhibits a minimum degree of solubility hence conventional oral suspension can be administered immediately (ready to use form) and not requiring reconstitution at the time of dispensing are simply designated as “Oral Suspension”. There is an important category of suspension that are available as dry powders intended for suspension in liquid vehicles. These are dry mixtures containing the drug and suitable suspending and dispersing agents to be diluted and agitated with a specific quantity of vehicle, most often purified water. Drugs that are instable if maintained for extended periods in the presence of aqueous vehicle (eg., many antibiotic drugs) are frequently supplied as dry powder mixtures for reconstitution at the time of dispensing. This type of preparation is desig...

International Journal of Current Advanced Research, Apr 28, 2017

Objective: The present study was undertaken to investigate the anti-gouty arthritic activity of A... more Objective: The present study was undertaken to investigate the anti-gouty arthritic activity of Adhatoda vasica Nees aqueous leaves extract (AVLE) using potassium oxonate-induced hyperuricemia in mice. Material and methods: Potassium oxonate (PO) induced hyperuricemia in mice were determined by in vivo experiments. PO causes hyperuricemia in one hour after i.p. administration. Thus mice were administered PO followed by AVLE and standard drug treatment of allopurinol study conducted for 7 days finally measuring the serum levels of uric acid, xanthine oxidase, and xanthine dehydrogenase etc. Results: The evaluation of anti-gouty arthritic potential by oral administration of AVLE (100-400 mg/kg) evoked a significantly decrease in the serum levels of uric acid, xanthine oxidase (XOD), xanthine dehydrogenase (XDH) in treated mice. Finally, the study concluded that in AVLE the flavonoid constituents impart enzyme inhibitory activity thus reducing levels of xanthine oxidase, xanthine dehydrogenase, and serum uric acid. Conclusions: The results obtained in this study indicate that AVLE possesses potential anti-gouty arthritic activity.

Zenodo (CERN European Organization for Nuclear Research), Jul 20, 2023

The synthesis of 4-thiazolidinones of 2-amino-5-chloropyridine was performed by novel method of s... more The synthesis of 4-thiazolidinones of 2-amino-5-chloropyridine was performed by novel method of stirring involving the cyclocondensation of the appropriate Schiff's bases (2a-c) with thioglycolic acid, followed by the addition of zinc chloride in the presence of molecular sieves. Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques-Solubility,Thin Layer Chromatographic studies, UltraViolet studies,Rotational and vibrational studies (FT-IR), 1 H-NMR studies. The compounds were investigated for their Anticonvulsant activity by isoniazid induced convulsions in mice model.Compound3-(5-chloropyridin-2-yl)-2-(4-fluorophenyl) thiazolidin-4-one(3c)was found to be the most activeand compound 3-(5-chloropyridin-2-yl)-2-(2-hydroxyphenyl) thiazolidin-4-one (3a) was found to be less active among the tested compound according to pharmacological evaluation exhibited anticonvulsant activity.

International journal of current advanced research, Apr 28, 2017

Objective: The present study was undertaken to investigate the anti-gouty arthritic activity of A... more Objective: The present study was undertaken to investigate the anti-gouty arthritic activity of Adhatoda vasica Nees aqueous leaves extract (AVLE) using potassium oxonate-induced hyperuricemia in mice. Material and methods: Potassium oxonate (PO) induced hyperuricemia in mice were determined by in vivo experiments. PO causes hyperuricemia in one hour after i.p. administration. Thus mice were administered PO followed by AVLE and standard drug treatment of allopurinol study conducted for 7 days finally measuring the serum levels of uric acid, xanthine oxidase, and xanthine dehydrogenase etc. Results: The evaluation of anti-gouty arthritic potential by oral administration of AVLE (100-400 mg/kg) evoked a significantly decrease in the serum levels of uric acid, xanthine oxidase (XOD), xanthine dehydrogenase (XDH) in treated mice. Finally, the study concluded that in AVLE the flavonoid constituents impart enzyme inhibitory activity thus reducing levels of xanthine oxidase, xanthine dehydrogenase, and serum uric acid. Conclusions: The results obtained in this study indicate that AVLE possesses potential anti-gouty arthritic activity.

Zenodo (CERN European Organization for Nuclear Research), Dec 11, 2019

The current work aimed to formulate a stable w/o cream containing Glycyrrhiza glabra extract and ... more The current work aimed to formulate a stable w/o cream containing Glycyrrhiza glabra extract and studying its effects on skin pigment. Glycyrrhiza glabra Extract obtained by concentrating the alcoholic extract of Glycyrrhiza glabra roots was entrapped in the inner aqueous phase of W/O emulsion. Base containing no active material and a formulation containing ethanolic extract of Glycyrrhiza glabra (1%) were prepared. Samples of base and formulation were stored at different accelerated conditions (8°C, 25°C, 40°C, 40°C+75%RH) for four weeks to predict the stability of creams. Base and formulation were stable at all accelerated conditions regarding color, liquefaction and phase separation. Both creams were good for sensory evaluation.

International Journal of Advanced Research

The synthesis of 4-thiazolidinones of 2-amino-5-chloropyridine was performed by novel method of s... more The synthesis of 4-thiazolidinones of 2-amino-5-chloropyridine was performed by novel method of stirring involving the cyclocondensation of the appropriate Schiffs bases (2a–c) with thioglycolic acid, followed by the addition of zinc chloride in the presence of molecular sieves. Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques- Solubility,Thin Layer Chromatographic studies, Ultra-Violet studies,Rotational and vibrational studies (FT-IR), 1H-NMR studies. The compounds were investigated for their Anticonvulsant activity by isoniazid induced convulsions in mice model.Compound3-(5-chloropyridin-2-yl)-2-(4-fluorophenyl) thiazolidin-4-one(3c)was found to be the most activeand compound 3-(5-chloropyridin-2-yl)-2-(2-hydroxyphenyl) thiazolidin-4-one (3a) was found to be less active among the tested compound according to pharmacological evaluation exhibited anticonvulsant activity.

Annona squamosa L is a multipurpose tree with edible fruits and is a source of the medicinal and ... more Annona squamosa L is a multipurpose tree with edible fruits and is a source of the medicinal and industrial products. It is used as an antioxidant, antidiabetics, hepatoprotective, cytotoxic, genetoxic, anti tumor, anti lice agent etc.Annona squamosa L belongs to the family Annonaceae commonly known as custard apple. Antimicrobial activity of combined methanolic leaf and seed extract of A.squamosa were evaluated against four bacteria Bacillus subtilis, Styphaloccocus aureus gram positive and E.coli, Pseudomonas aerogenosa by using cup and plate method. Maximum inhibition was found with 20mg ml concentration of combined extract as compare to separate leaf and seed extract against all the tested organism under investigation. The study suggest that maximum antibacterial activity was observed against gram negative organism i.e., E.coli and P.aerogenosa. Ms. Chetana D. Patil | Ms. Nikita Pawar | Mrs. Pooja S. Bhandare "A Comparative in Vitro Antimicrobial Activity of Annona Squamosa...

Identification and selection of patient suffering from Renal Failure-To explore the patient treat... more Identification and selection of patient suffering from Renal Failure-To explore the patient treatment for renal failure, its catogries either acute or chronic, then to study about the haematological, renal or biochemical profile of the patient and the family history. The detailed study about the pathological test performed by the patient. Then, the medications administered to the patient. The future treatment to be carried out either dialysis or kidney transplantation.

–Helminthes or worm infection is one of the most prevalent disease and one of the most serious pr... more –Helminthes or worm infection is one of the most prevalent disease and one of the most serious problems in the world. It contributes to malnutrition anemia, eosinophilia and pneumonia. Various numbers of plants available for anthelmintic activity a new lead for helminth control is much desirable and has promoted studies of traditionally used anthelmintic plants, which are generally considered to be important sources of bioactive substances [10]. Anthelmintics derived from plant source can be an answer to this world wide problem as they form secure and non-toxic with a modified site of action. Ocimum sanctum Linn (Ocimum tenuiflorum) known as Tulsi in India, is a sacred plant for hindus known from centuries being used in Ayurveda for its varied healing properties. In the present study different species of tulsi were studied for their anthelminthic activity using earthworms as they have physiological resemblance to the worms or helminthes using standard drug Albendazole Keywords––Helminthiasis, tulsi, anthelmintic, albendazole

–The main objective of the work was to formulate a mosquito repellent cream naturally obtained fr... more –The main objective of the work was to formulate a mosquito repellent cream naturally obtained from medicinal plants instead of commonly available synthetic insecticides and repellents such as N-Diethyl3methylbenzamide (DEET), which are carcinogenic and non eco-friendly. Essential oils of Lemongrass and extract of Neem leaves were used in the cream formulation and evaluated for various parameters. The formulated cream had smooth texture and spreadability with a pH 7.2 which is non irritant and suitable for the skin. From the present work it was concluded that the formulated mosquito repellent cream using essential oil is natural, safe, effective, usable for the skin to afford mosquito repellent action. Keywords––Mosquito repellent cream, neem(azadirachta indica), Lemongrass(cymbopogon flexuousus) INTRODUCTION The role of natural mosquito repellent is to mask human scent. An alarming increase in the range of mosquitoes is mainly due to deforestation, industrialized farming and stagnant water [1]. Thus, special products like mosquito repellents for combating mosquitoes are required. The products used for mosquito repellency show varying degrees of effectiveness [2]. A number of natural mosquito repellents were studied in many research papers and review papers[3-6] that work to repel mosquitoes. Mosquito repellents based on chemicals has a designed with remarkable safety profile, but even then they are toxic against the skin and nervous system and usually cause rashes, swelling and sometimes eye irritation. Hence, natural mosquito repellents are preferred over chemical products. Lemongrass (Cymbopogon citrates. L) the leaves have a lemon like odor because they contain an essential oil having citral as main constituent, same as what is present in lemon peel. Leading phytochemical compounds in lemongrass leaf are terpineol, Dipentene, Limonene, αterpineol, citronellol, methyl heptenone, dipentene, geraniol, limonene, nerol, farnesol, mainly (triterpenoids). Fig. 1: Cymbopogon Flexuousus and Azadirachta Indica. MATERIALS AND METHOD Collection of plant material Leaves of Cymbopogon flexuousus and Azadirachta indica were collected from shirgaon, in satara district. The leaves during the month of July in the year 2017 and authenticated by Dept. of Botany, Y.C.I.S, Satara, Maharashtra, India. Procedure of extraction using soxhlet apparatus[7-12] The soxhlet assembly is a continous extactor which is generally suitable for the extaction from powderd plant material with the help of organic solvent. In this instance, the powderd drug is packed loosely in the thimble of the soxhlet apparatus; and the organic solvent affords a deep penetration of the moist drug therapy allowing the greatest possible extraction of the sutaible contain from exposed surface of the cell and tissue of the crude drug. Once, the extraction is as presumed to have completed, the solvent is evaporated in a electrical water bath and residue is collected. Extraction of neem leaves Leaves of azadirachta indica were screened and unwanted leaves were removed. A leaves were dried for 15 days in shade, powdered and sieved to get a fine powder. Then 50 g of fine powdered sample was taken in 200 mL of ehanol at 50 0 -60 0 C for 18 hours by using soxhlet apparatus. Samle was dried by using electrical waterbath for evaporation. Fig. 2: Figure of neem leaves extract. Formulation and evaluation of mosquito repellent cream using lemongrass and neem leaves Bhandare et al. www.ijeid.com {IJEID © 2019} All Rights Reserved Page | 9 Extraction for Lemongrass oil The extraction Lemongrass oil was carried by using a 150 g of of the fresh leaves of Cymbopogon flexuousus and 250 mL of distilled water by using steam distillation .When water reached 100 0 C started boiling ripping of essential oil from Lemongrass leaves. The volatile oil generated were collected after passing through condenser, in separate flask. The mixture of oil and water obtained from steam ditillation was separated with separating funnel. Extracted oil was stored in an sample bottles at a temperature of 4 0 C till the period of formulation. Fig. 3: Steam distillation. Macroscopic Characteristic The macroscopy of Cymbopogon flexuousus and Azadirachta indica were studied according to standard methods[13-14]. Physical Evaluation The ash values, extractive values and loss on drying were performed according to the officinal methods prescribed in Indian pharmacopeia [15]. Fluorescence analysis was carried out according to the method of Chase and Pratt [16] and Kokoski [17]. Determination of total ash The total ash value of crude powder of Cymbopogon flexuousus and Azadirachta indica was determined by incinerating 2 gm of accurately weighed crude powder in a tarred silica crucible. It was incinerated in a muffle furnace at a temperature not exceeding 45oC until free from carbon, then cooled and weighed. a. Determination of total ash The total ash value of Cymbopogon flexuousus and Azadirachta indica was…

International Journal of Trend in Scientific Research and Development, 2019

The current work aimed to formulate a stable w o cream containing Glycyrrhiza glabra extract and ... more The current work aimed to formulate a stable w o cream containing Glycyrrhiza glabra extract and studying its effects on skin pigment. Glycyrrhiza glabra Extract obtained by concentrating the alcoholic extract of Glycyrrhiza glabra roots was entrapped in the inner aqueous phase of W O emulsion. Base containing no active material and a formulation containing ethanolic extract of Glycyrrhiza glabra 1 were prepared. Samples of base and formulation were stored at different accelerated conditions 8°C, 25°C, 40°C, 40°C 75 RH for four weeks to predict the stability of creams. Base and formulation were stable at all accelerated conditions regarding color, liquefaction and phase separation. Both creams were good for sensory evaluation. Ms. Chetana D. Patil | Ms. Rutika U. More | Mrs. Pooja S. Bhandare "Hydrotropic Cream Preparation from Licorice Extract" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26435.pdf Paper URL https://www.ijtsrd.com/pharmacy/pharmacognosy-/26435/hydrotropic-cream-preparation-from-licorice-extract/ms-chetana-d-patil

Suspensions may be defined as preparations containing finely divided drug particles (the suspenso... more Suspensions may be defined as preparations containing finely divided drug particles (the suspensoid) distributed somewhat uniformly throughout a vehicle with or without stabilizers and other additives in which drug exhibits a minimum degree of solubility hence conventional oral suspension can be administered immediately (ready to use form) and not requiring reconstitution at the time of dispensing are simply designated as “Oral Suspension”. There is an important category of suspension that are available as dry powders intended for suspension in liquid vehicles. These are dry mixtures containing the drug and suitable suspending and dispersing agents to be diluted and agitated with a specific quantity of vehicle, most often purified water. Drugs that are instable if maintained for extended periods in the presence of aqueous vehicle (eg., many antibiotic drugs) are frequently supplied as dry powder mixtures for reconstitution at the time of dispensing. This type of preparation is desig...

International Journal of Current Advanced Research, Apr 28, 2017

Objective: The present study was undertaken to investigate the anti-gouty arthritic activity of A... more Objective: The present study was undertaken to investigate the anti-gouty arthritic activity of Adhatoda vasica Nees aqueous leaves extract (AVLE) using potassium oxonate-induced hyperuricemia in mice. Material and methods: Potassium oxonate (PO) induced hyperuricemia in mice were determined by in vivo experiments. PO causes hyperuricemia in one hour after i.p. administration. Thus mice were administered PO followed by AVLE and standard drug treatment of allopurinol study conducted for 7 days finally measuring the serum levels of uric acid, xanthine oxidase, and xanthine dehydrogenase etc. Results: The evaluation of anti-gouty arthritic potential by oral administration of AVLE (100-400 mg/kg) evoked a significantly decrease in the serum levels of uric acid, xanthine oxidase (XOD), xanthine dehydrogenase (XDH) in treated mice. Finally, the study concluded that in AVLE the flavonoid constituents impart enzyme inhibitory activity thus reducing levels of xanthine oxidase, xanthine dehydrogenase, and serum uric acid. Conclusions: The results obtained in this study indicate that AVLE possesses potential anti-gouty arthritic activity.