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Papers by Muhammad Alamsyah Aziz

Poster Presentations, 2019

Journal of South Asian Federation of Obstetrics and Gynaecology

Objectives: Severe acute respiratory syndrome-coronavirus 2/COVID-19 infection is still a global ... more Objectives: Severe acute respiratory syndrome-coronavirus 2/COVID-19 infection is still a global concern, with pregnant women are considered as vulnerable population. Until now, the characteristics of pregnant women in Indonesia who are infected with COVID-19, as well as pregnancy and neonatal outcomes, are still unknown. This study aims to obtain national data, which are expected to be useful for the prevention and management of COVID-19 in pregnant women in Indonesia. Methods: There were 1,427 patients recruited in this retrospective multicenter study. This study involved 11 hospitals in 10 provinces in Indonesia and was carried out using secondary patient data from April 2020 to July 2021. COVID-19 severity was differentiated into asymptomatic-to-mild symptoms and moderate-to-severe symptoms. The collected data include maternal characteristics, laboratory examinations, imaging, pregnancy outcomes, and neonatal outcomes. Results: Leukocyte, platelets, basophil, neutrophils segment, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, alanine aminotransferase (ALT), aspartate aminotransferase (AST), C-reactive protein (CRP), urea, and creatinine were found to be significantly associated with severity differences (p < 0.05). Moderate-severe symptoms of COVID-19 also shown to have suggestive pneumonia findings on chest X-ray findings. Patients with asymptomatic-to-mild symptoms had significantly (p < 0.001) higher recovery rate, shorter hospital stay, less intensive care unit (ICU) admission, and had more vaginal delivery. Neonates from mother with mild symptoms also had significantly (p < 0.001) higher survival rate, higher birth weight, and higher APGAR score. Conclusion: Several laboratory and radiology components, as well as maternal and neonatal outcomes are related to the severity of COVID-19 in pregnant women in Indonesia

Indonesian Journal of Obstetrics & Gynecology Science, 2021

Tujuan : Penelitian ini dilakukan untuk mengetahui gambaran karakteristik dan luaran maternal... more Tujuan : Penelitian ini dilakukan untuk mengetahui gambaran karakteristik dan luaran maternal pasien obstetri yang dirawat di ruang perawatan intensif RSUP Dr. Hasan Sadikin selama periode tahun 2017–2018. Metode : Penelitian ini menggunakan metode studi retrospektif deskriptif. Hasil : Sebanyak 173 pasien obstetri yang dirawat di ruang perawatan intensif dengan luaran maternal hidup 159 pasien dan kasus meninggal 14 kasus. Luaran maternal hidup dengan penyakit penyerta terbanyak yaitu hipertensi dalam kehamilan, seperti eklamsia 36 (22,6%), impending eklamsia 12 (7,5%) dan PEB 52 (32,7%). Selain itu terdapat penyakit jantung sebanyak 31 (19,5%). Luaran maternal meninggal terbanyak dengan penyakit jantung sebanyak 5 pasien (35,7%), eklamsia sebanyak 4 pasien (28,6%). Kesimpulan : Indikasi rawat ruang intensif terbanyak adalah hipertensi maligna 62 (39,0%). Jenis persalinan terbanyak yaitu seksio sesarea 135 (78,0%). Pasien dengan lama perawatan selama 10 har...

Indonesian Journal of Obstetrics & Gynecology Science, 2021

Abstrak Tujuan : Penelitian ini akan dilakukan untuk identifikasi prevalensi dan faktor risiko ib... more Abstrak Tujuan : Penelitian ini akan dilakukan untuk identifikasi prevalensi dan faktor risiko ibu terhadap angka kejadian IUGR di Rumah Sakit Umum Penidikan (RSUP) Dr. Hasan Sadikin Bandung. Metode : Penelitian ini menggunakan desain deskriptif retrospektif menggunakan data sekunder dengan melihat data rekam medik rawat inap pasien hamil dengan IUGR yang lahir di RSUP Dr. Hasan Sadikin Bandung periode bulan Januari 2018 – Desember 2019 berdasarkan kriteria inklusi dan eksklusi. Hasil : Prevalensi kasus IUGR di RSUP Hasan Sadikin Bandung adalah 76,16 orang per 1000 kehamilan. Karakteristik pasien dengan diagnosis IUGR terbanyak pada usia 21-34 tahun (64,32%), dengan paritas paling banyak pada primipara dengan total 147 kasus (79,45%). Faktor Risiko IUGR terdiri dari nilai BMI terbanyak dengan 86 subjek (46.5%) memiliki nilai BMI di atas batas normal. Tiga puluh lima subjek penelitian (18.9%) memiliki riwayat merokok, sementara 15 pasien (8.1%) memiliki riwayat mengonsumsi alkohol. P...

Tujuan : Mengevaluasi penggunaan antibiotik dengan metode Gyssens pada pasien seksio sesarea di R... more Tujuan : Mengevaluasi penggunaan antibiotik dengan metode Gyssens pada pasien seksio sesarea di RSUP Hasan Sadikin Bandung pada periode Januari–Desember 2018. Mengevaluasi ketepatan waktu penggunaan antibiotik profilaksis pada pasien seksio sesarea di RSUP Hasan Sadikin Bandung pada periode Januari–Desember 2018. Mengetahui keuntungan penghematan yang diperoleh jika metode Gyssens digunakan pada periode Januari– Desember 2018. Metode : Penelitian ini merupakan penelitian deskriptif eksploratif retrospektif yang dilaksanakan di RSUP dr. Hasan Sadikin Bandung pada pasien yang dilakukan seksio sesarea. Data diambil dari rekam medis bulan Januari–Desember 2018 Hasil : Pasien yang sesuai dengan metode Gyssens sebanyak 451 atau sebesar 59,5%. Untuk pasien yang menggunakan antibiotik profilaksis pre-op sebanyak 722 atau sebesar 95,3%. Sedangkan ketepatan antibiotik profilaksis yang diberikan 30 menit sebelum operasi seksio sesarea 618 pasien atau 81,5%. Penghematan yang dapat diperoleh sel...

Indonesian Journal of Obstetrics & Gynecology Science, 2018

Menganalisis korelasi antara kadar 25 hidroksi vitamin D3 dengan kekuatan kontraksi levator ani p... more Menganalisis korelasi antara kadar 25 hidroksi vitamin D3 dengan kekuatan kontraksi levator ani pada primipara 42 hari pasca persalinan spontan. Metode : Penelitian observasional analitik dilakukan pada primipara pasca persalinan spontan yang memenuhi kriteria inklusi penelitian (n=48).

Open Journal of Obstetrics and Gynecology, 2016

Preeclampsia is still a major cause of maternal death in pregnancy which needs efforts to prevent... more Preeclampsia is still a major cause of maternal death in pregnancy which needs efforts to prevent and early detection. Nitric oxide and Corticotrophin Releasing Hormone has an important role in the pathogenesis of preeclampsia to determine differences in concentrations of NO and CRH in normal pregnancy and preeclampsia, as well as to study the correlation both on the incidence of preeclampsia. This is a cross sectional study. Blood samples obtained from patients with preeclampsia (30 samples) and normal pregnancies as controls (30 samples) in accordance with inclusion and exclusion criteria. NO concentration was examined with essay protocol, and CRH concentrations with ELISA method. Then be calculated by statistical analysis: chi square, t test, Mann-Whitney, and Spearman Rank correlation coefficient. Based on statistical analysis, there was no significant difference (p > 0.05) from the characteristics of maternal age, pregnancy weeks, and parity in both study groups, so the two groups of homogeneous and comparable. The mean concentration of NO in preeclampsia was lower (3.780 µM) compared with normal pregnancy (13.360 µM). There was significant correlation between NO and CRH concentrations in normal pregnancy and preeclampsia (p < 0.001). The involvement of NO/c-GMP pathway is very possible in the pathogenesis of preeclampsia.

Majalah Kedokteran Bandung, 2018

Kelahiran preterm (kurang bulan) merupakan salah satu penyebab kematian bayi yang hingga kini men... more Kelahiran preterm (kurang bulan) merupakan salah satu penyebab kematian bayi yang hingga kini menjadi permasalahan di seluruh dunia. Salah satu mekanisme patofisiologis yang menyebabkan kelahiran kurang bulan adalah aktivitas sumbu hipotalamus-pituitari-adrenal (HPA) pada ibu dan janin. Stres maternal biologis berupa hipoksia merupakan salah satu penyebab terjadi mekanisme kelahiran kurang bulan melalui jalur aktivasi sumbu HPA ibu dan sebagai respons terhadap reactive oxygen species (ROS). Vitamin D 3 sebagai salah satu sumber ion Ca 2+ dibutuhkan untuk mekanisme kontraksi dan relaksasi otot halus miometrium. Selain itu, vitamin D diduga berpengaruh terhadap kerja sumbu HPA. Tujuan penelitian ini adalah mengetahui pengaruh penambahan vitamin D 3 pada sel lini PHM1-41 yang menjadi model in vitro dari kontraksi miometrium pada ibu hamil yang mengalami stres hipoksia terhadap kadar ROS intraseluler sel PHM1-41. Penelitian dilakukan di Laboratorium penelitian Aretha Medika Utama, Biomolecular and Biomedical Research Centre dengan kurun waktu penelitian dari bulan Desember 2017 hingga Februari 2018. Sel PHM1-41 yang telah dikultur dengan keadaan hipoksia selama 24 jam diberi penambahan vitamin D 3 , kemudian diukur kadar ROS intraselulernya. Hasil menunjukkan bahwa kadar ROS menurun signifikan pada kelompok sel yang diberi penambahan vitamin D 3 dengan konsentrasi 150 nM dibanding dengan kelompok sel kontrol hipoksia. Hal ini menunjukkan bahwa penambahan vitamin D 3 150 nM memiliki potensi mencegah kelahiran kurang bulan.

International Journal of Integrated Health Sciences, Sep 29, 2017

Objective: To discover the factors affecting the occurrence of maternal deaths. The high maternal... more Objective: To discover the factors affecting the occurrence of maternal deaths. The high maternal mortality rate (MMR) in Indonesia is still a common problem which needs urgent solution. Methods: This is an analytic observational, cross-sectional study using a case control approach Fifty two cases were selected as cases, another 52 were selected as control. The sampling was performed by simple random sampling. The instruments used in this study were the medical records of mothers who gave birth in Dr. Hasan Sadikin General Hospital Bandung from 1 January 2009-31 December 2013. Data analysis was performed using chi-square test. Results: In this study, the results showed that the risk factors contributing to maternal deaths were pregnancy complication (p<0.001), delivery complication (p<0.001), puerpural complication (p=0.022), age (p=0.030), parity (p=0.427), prior medical history (p<0.001), antenatal care (p=0.007), maternal education (p=0.527), and area of residence (p=0.049). Conclusions: The risk factors that contribute to maternal deaths include pregnancy complication, delivery complication, puerpural complication, maternal age, prior medical history, antenatal care, and area of residence.

Background: Depomedroxyprogesteron acetate (DMPA) is the most popular contraception in the world.... more Background: Depomedroxyprogesteron acetate (DMPA) is the most popular contraception in the world. The used of this contraception can be caused osteoporotic. Objective this research was to compare the bone mineral density (BMD) of DMPA users and non-users, and its correlation with the length of use DMPA. Methods: Cross-sectional study was done on 32 DMPA users and 31 non-users as control, who met the inclusion criteria, at Department of Obstetrics and Gynecology Hasan Sadikin General Hospital, from January to December 2005. To be noted: age, height, weight, body mass index (BMI), marital age, parity, graduated marital status, and ethnicity. Analysis was done by chi-square test, t-test, exact Fisher test, Mann-Whitney test, and rank Spearman correlation analysis. Results: Characteristics of DMPA users were: (28.8 + 4.9) years, height (154 + 4.8) cm, weight (51.2 + 7.1) kg, body mass index (21.5 + 2.7) kg/m2, marital age (20.8 + 3.8) years, parity >1 (96.87%), senior high school (56.25%), married (96.87%) and sundanese (100%), and on the control group were: age (32.8 + 4.2) years, height (154.3 + 5.1) cm, weight (53.4 + 9.7) kg, BMI (22.4 + 3.7) kg/m2, marital age (23 + 3.4) years, parity >1 (87.1%), senior high school (51.62%), married (93.55%), and sundanese (100%). The characteristics in both groups were homogeneous (p>0.05). The average of BMD in both group was significantly different (p<0.001), (1.025 + 0.394) g/cm2 versus (1,184 + 0.0166) g/cm2. The difference between each measured value was 0.159 g/cm2. The mean length of DMPA use was (54.8 + 33.8) months and its correlation with bone mineral density (BMD) was significantly different (p>0.05). The correlation between DMPA use and BMD was very significant (p<0.001) in the youngest group (20-24 years), but there was no significant correlation between body mass index (BMI) and BMD (p>0.05). Conclusions: BMD in DMPA users is lower than that in non-users. There is no correlation between the length of DMPA use and the BMD.

Poster Presentations, 2019

Journal of South Asian Federation of Obstetrics and Gynaecology

Objectives: Severe acute respiratory syndrome-coronavirus 2/COVID-19 infection is still a global ... more Objectives: Severe acute respiratory syndrome-coronavirus 2/COVID-19 infection is still a global concern, with pregnant women are considered as vulnerable population. Until now, the characteristics of pregnant women in Indonesia who are infected with COVID-19, as well as pregnancy and neonatal outcomes, are still unknown. This study aims to obtain national data, which are expected to be useful for the prevention and management of COVID-19 in pregnant women in Indonesia. Methods: There were 1,427 patients recruited in this retrospective multicenter study. This study involved 11 hospitals in 10 provinces in Indonesia and was carried out using secondary patient data from April 2020 to July 2021. COVID-19 severity was differentiated into asymptomatic-to-mild symptoms and moderate-to-severe symptoms. The collected data include maternal characteristics, laboratory examinations, imaging, pregnancy outcomes, and neonatal outcomes. Results: Leukocyte, platelets, basophil, neutrophils segment, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, alanine aminotransferase (ALT), aspartate aminotransferase (AST), C-reactive protein (CRP), urea, and creatinine were found to be significantly associated with severity differences (p < 0.05). Moderate-severe symptoms of COVID-19 also shown to have suggestive pneumonia findings on chest X-ray findings. Patients with asymptomatic-to-mild symptoms had significantly (p < 0.001) higher recovery rate, shorter hospital stay, less intensive care unit (ICU) admission, and had more vaginal delivery. Neonates from mother with mild symptoms also had significantly (p < 0.001) higher survival rate, higher birth weight, and higher APGAR score. Conclusion: Several laboratory and radiology components, as well as maternal and neonatal outcomes are related to the severity of COVID-19 in pregnant women in Indonesia

Indonesian Journal of Obstetrics & Gynecology Science, 2021

Tujuan : Penelitian ini dilakukan untuk mengetahui gambaran karakteristik dan luaran maternal... more Tujuan : Penelitian ini dilakukan untuk mengetahui gambaran karakteristik dan luaran maternal pasien obstetri yang dirawat di ruang perawatan intensif RSUP Dr. Hasan Sadikin selama periode tahun 2017–2018. Metode : Penelitian ini menggunakan metode studi retrospektif deskriptif. Hasil : Sebanyak 173 pasien obstetri yang dirawat di ruang perawatan intensif dengan luaran maternal hidup 159 pasien dan kasus meninggal 14 kasus. Luaran maternal hidup dengan penyakit penyerta terbanyak yaitu hipertensi dalam kehamilan, seperti eklamsia 36 (22,6%), impending eklamsia 12 (7,5%) dan PEB 52 (32,7%). Selain itu terdapat penyakit jantung sebanyak 31 (19,5%). Luaran maternal meninggal terbanyak dengan penyakit jantung sebanyak 5 pasien (35,7%), eklamsia sebanyak 4 pasien (28,6%). Kesimpulan : Indikasi rawat ruang intensif terbanyak adalah hipertensi maligna 62 (39,0%). Jenis persalinan terbanyak yaitu seksio sesarea 135 (78,0%). Pasien dengan lama perawatan selama 10 har...

Indonesian Journal of Obstetrics & Gynecology Science, 2021

Abstrak Tujuan : Penelitian ini akan dilakukan untuk identifikasi prevalensi dan faktor risiko ib... more Abstrak Tujuan : Penelitian ini akan dilakukan untuk identifikasi prevalensi dan faktor risiko ibu terhadap angka kejadian IUGR di Rumah Sakit Umum Penidikan (RSUP) Dr. Hasan Sadikin Bandung. Metode : Penelitian ini menggunakan desain deskriptif retrospektif menggunakan data sekunder dengan melihat data rekam medik rawat inap pasien hamil dengan IUGR yang lahir di RSUP Dr. Hasan Sadikin Bandung periode bulan Januari 2018 – Desember 2019 berdasarkan kriteria inklusi dan eksklusi. Hasil : Prevalensi kasus IUGR di RSUP Hasan Sadikin Bandung adalah 76,16 orang per 1000 kehamilan. Karakteristik pasien dengan diagnosis IUGR terbanyak pada usia 21-34 tahun (64,32%), dengan paritas paling banyak pada primipara dengan total 147 kasus (79,45%). Faktor Risiko IUGR terdiri dari nilai BMI terbanyak dengan 86 subjek (46.5%) memiliki nilai BMI di atas batas normal. Tiga puluh lima subjek penelitian (18.9%) memiliki riwayat merokok, sementara 15 pasien (8.1%) memiliki riwayat mengonsumsi alkohol. P...

Tujuan : Mengevaluasi penggunaan antibiotik dengan metode Gyssens pada pasien seksio sesarea di R... more Tujuan : Mengevaluasi penggunaan antibiotik dengan metode Gyssens pada pasien seksio sesarea di RSUP Hasan Sadikin Bandung pada periode Januari–Desember 2018. Mengevaluasi ketepatan waktu penggunaan antibiotik profilaksis pada pasien seksio sesarea di RSUP Hasan Sadikin Bandung pada periode Januari–Desember 2018. Mengetahui keuntungan penghematan yang diperoleh jika metode Gyssens digunakan pada periode Januari– Desember 2018. Metode : Penelitian ini merupakan penelitian deskriptif eksploratif retrospektif yang dilaksanakan di RSUP dr. Hasan Sadikin Bandung pada pasien yang dilakukan seksio sesarea. Data diambil dari rekam medis bulan Januari–Desember 2018 Hasil : Pasien yang sesuai dengan metode Gyssens sebanyak 451 atau sebesar 59,5%. Untuk pasien yang menggunakan antibiotik profilaksis pre-op sebanyak 722 atau sebesar 95,3%. Sedangkan ketepatan antibiotik profilaksis yang diberikan 30 menit sebelum operasi seksio sesarea 618 pasien atau 81,5%. Penghematan yang dapat diperoleh sel...

Indonesian Journal of Obstetrics & Gynecology Science, 2018

Menganalisis korelasi antara kadar 25 hidroksi vitamin D3 dengan kekuatan kontraksi levator ani p... more Menganalisis korelasi antara kadar 25 hidroksi vitamin D3 dengan kekuatan kontraksi levator ani pada primipara 42 hari pasca persalinan spontan. Metode : Penelitian observasional analitik dilakukan pada primipara pasca persalinan spontan yang memenuhi kriteria inklusi penelitian (n=48).

Open Journal of Obstetrics and Gynecology, 2016

Preeclampsia is still a major cause of maternal death in pregnancy which needs efforts to prevent... more Preeclampsia is still a major cause of maternal death in pregnancy which needs efforts to prevent and early detection. Nitric oxide and Corticotrophin Releasing Hormone has an important role in the pathogenesis of preeclampsia to determine differences in concentrations of NO and CRH in normal pregnancy and preeclampsia, as well as to study the correlation both on the incidence of preeclampsia. This is a cross sectional study. Blood samples obtained from patients with preeclampsia (30 samples) and normal pregnancies as controls (30 samples) in accordance with inclusion and exclusion criteria. NO concentration was examined with essay protocol, and CRH concentrations with ELISA method. Then be calculated by statistical analysis: chi square, t test, Mann-Whitney, and Spearman Rank correlation coefficient. Based on statistical analysis, there was no significant difference (p > 0.05) from the characteristics of maternal age, pregnancy weeks, and parity in both study groups, so the two groups of homogeneous and comparable. The mean concentration of NO in preeclampsia was lower (3.780 µM) compared with normal pregnancy (13.360 µM). There was significant correlation between NO and CRH concentrations in normal pregnancy and preeclampsia (p < 0.001). The involvement of NO/c-GMP pathway is very possible in the pathogenesis of preeclampsia.

Majalah Kedokteran Bandung, 2018

Kelahiran preterm (kurang bulan) merupakan salah satu penyebab kematian bayi yang hingga kini men... more Kelahiran preterm (kurang bulan) merupakan salah satu penyebab kematian bayi yang hingga kini menjadi permasalahan di seluruh dunia. Salah satu mekanisme patofisiologis yang menyebabkan kelahiran kurang bulan adalah aktivitas sumbu hipotalamus-pituitari-adrenal (HPA) pada ibu dan janin. Stres maternal biologis berupa hipoksia merupakan salah satu penyebab terjadi mekanisme kelahiran kurang bulan melalui jalur aktivasi sumbu HPA ibu dan sebagai respons terhadap reactive oxygen species (ROS). Vitamin D 3 sebagai salah satu sumber ion Ca 2+ dibutuhkan untuk mekanisme kontraksi dan relaksasi otot halus miometrium. Selain itu, vitamin D diduga berpengaruh terhadap kerja sumbu HPA. Tujuan penelitian ini adalah mengetahui pengaruh penambahan vitamin D 3 pada sel lini PHM1-41 yang menjadi model in vitro dari kontraksi miometrium pada ibu hamil yang mengalami stres hipoksia terhadap kadar ROS intraseluler sel PHM1-41. Penelitian dilakukan di Laboratorium penelitian Aretha Medika Utama, Biomolecular and Biomedical Research Centre dengan kurun waktu penelitian dari bulan Desember 2017 hingga Februari 2018. Sel PHM1-41 yang telah dikultur dengan keadaan hipoksia selama 24 jam diberi penambahan vitamin D 3 , kemudian diukur kadar ROS intraselulernya. Hasil menunjukkan bahwa kadar ROS menurun signifikan pada kelompok sel yang diberi penambahan vitamin D 3 dengan konsentrasi 150 nM dibanding dengan kelompok sel kontrol hipoksia. Hal ini menunjukkan bahwa penambahan vitamin D 3 150 nM memiliki potensi mencegah kelahiran kurang bulan.

International Journal of Integrated Health Sciences, Sep 29, 2017

Objective: To discover the factors affecting the occurrence of maternal deaths. The high maternal... more Objective: To discover the factors affecting the occurrence of maternal deaths. The high maternal mortality rate (MMR) in Indonesia is still a common problem which needs urgent solution. Methods: This is an analytic observational, cross-sectional study using a case control approach Fifty two cases were selected as cases, another 52 were selected as control. The sampling was performed by simple random sampling. The instruments used in this study were the medical records of mothers who gave birth in Dr. Hasan Sadikin General Hospital Bandung from 1 January 2009-31 December 2013. Data analysis was performed using chi-square test. Results: In this study, the results showed that the risk factors contributing to maternal deaths were pregnancy complication (p<0.001), delivery complication (p<0.001), puerpural complication (p=0.022), age (p=0.030), parity (p=0.427), prior medical history (p<0.001), antenatal care (p=0.007), maternal education (p=0.527), and area of residence (p=0.049). Conclusions: The risk factors that contribute to maternal deaths include pregnancy complication, delivery complication, puerpural complication, maternal age, prior medical history, antenatal care, and area of residence.

Background: Depomedroxyprogesteron acetate (DMPA) is the most popular contraception in the world.... more Background: Depomedroxyprogesteron acetate (DMPA) is the most popular contraception in the world. The used of this contraception can be caused osteoporotic. Objective this research was to compare the bone mineral density (BMD) of DMPA users and non-users, and its correlation with the length of use DMPA. Methods: Cross-sectional study was done on 32 DMPA users and 31 non-users as control, who met the inclusion criteria, at Department of Obstetrics and Gynecology Hasan Sadikin General Hospital, from January to December 2005. To be noted: age, height, weight, body mass index (BMI), marital age, parity, graduated marital status, and ethnicity. Analysis was done by chi-square test, t-test, exact Fisher test, Mann-Whitney test, and rank Spearman correlation analysis. Results: Characteristics of DMPA users were: (28.8 + 4.9) years, height (154 + 4.8) cm, weight (51.2 + 7.1) kg, body mass index (21.5 + 2.7) kg/m2, marital age (20.8 + 3.8) years, parity >1 (96.87%), senior high school (56.25%), married (96.87%) and sundanese (100%), and on the control group were: age (32.8 + 4.2) years, height (154.3 + 5.1) cm, weight (53.4 + 9.7) kg, BMI (22.4 + 3.7) kg/m2, marital age (23 + 3.4) years, parity >1 (87.1%), senior high school (51.62%), married (93.55%), and sundanese (100%). The characteristics in both groups were homogeneous (p>0.05). The average of BMD in both group was significantly different (p<0.001), (1.025 + 0.394) g/cm2 versus (1,184 + 0.0166) g/cm2. The difference between each measured value was 0.159 g/cm2. The mean length of DMPA use was (54.8 + 33.8) months and its correlation with bone mineral density (BMD) was significantly different (p>0.05). The correlation between DMPA use and BMD was very significant (p<0.001) in the youngest group (20-24 years), but there was no significant correlation between body mass index (BMI) and BMD (p>0.05). Conclusions: BMD in DMPA users is lower than that in non-users. There is no correlation between the length of DMPA use and the BMD.