Nahid rezaei - Academia.edu (original) (raw)

Papers by Nahid rezaei

مجله دانشکده پزشکی اصفهان, 2018

Saffron or Crocus sativus is a member of Iridacea which traditionally has been used as flavor and... more Saffron or Crocus sativus is a member of Iridacea which traditionally has been used as flavor and color in foods. Studies indicated that saffron has different pharmacological effects such as anti-inflammatory, antioxidant, antiproliferative, and apoptosis. Although, numerous in-vitro and in-vivo studies have been done to find the different effects of this herbal drug, however, clinical usage of it is very limited. Since using herbal drugs in treatment of disease is very popular, it should be more attention on the beneficial effects of saffron which lead to clinical usage of it. In this study, to understand more about the beneficial effects of this herbal drug, we reviewed clinical studies which have been done on saffron so far.

Introduction: Extended liver resection has increased during the last decades. However, hepatic he... more Introduction: Extended liver resection has increased during the last decades. However, hepatic hemodynamic changes after resection and the consequent complications like small for size syndrome are still a challenging issue. The aim of this study was to systematically evaluate the role of sequential [for full text, please go to the a.m. URL]

Scientific Reports, 2022

The aim of this study was to evaluate whether the portocaval shunt (PCS) corrects these unwanted ... more The aim of this study was to evaluate whether the portocaval shunt (PCS) corrects these unwanted changes in transhepatic flow after extended hepatectomy (EH). Forty female Landrace pigs were divided into two main groups: (A) EH (75%) and (B) no EH. Group A was divided into 3 subgroups: (A1) EH without PCS; (A2) EH with side-to-side PCS; and (A3) EH with end-to-side PCS. Group B was divided into 2 subgroups: (B1) side-to-side PCS and (B2) end-to-side PCS. HAF, PVF, and PVP were measured in each animal before and after the surgical procedure. EH increased the PVF/100 g (173%, p < 0.001) and PVP (68%, p < 0.001) but reduced the HAF/100 g (22%, p = 0.819). Following EH, side-to-side PCS reduced the increased PVF (78%, p < 0.001) and PVP (38%, p = 0.001). Without EH, side-to-side PCS reduced the PVF/100 g (68%, p < 0.001) and PVP (12%, p = 0.237). PVP was reduced by end-to-side PCS following EH by 48% (p < 0.001) and without EH by 21% (p = 0.075). PCS can decrease and corr...

Escherichia coli is the gram negative bacilli of Entrobacteriaceae family that commonly found in... more Escherichia coli is the gram negative bacilli of Entrobacteriaceae family that commonly found in intestinal infections and many infections outside the intestine, like urinary tract infections (UTI), cholecystitis, wound infections, meningitis, septicemia, pulmonary infections, and many more. Plants are rich sources of bioactive compounds, hence they can be effective in a wide variety of diseases. The pandemic spread of multidrug-resistant (MDR) bacteria (i.e., extended-spectrum b-lactamase-producing Enterobacteriaceae (ESBLPE), Carbapenemase-producing Enterobacteriaceae (CPE)) threaten healthcare Worldwide. The present review is a report of the most effective medicinal plants against E . coli . In this research, the required online database searches were conducted using the key words such as bacteria, E. coli and medicinal plants. Databases of Web of Science, PubMed, Scopus, Google Scholar, and ScienceDirect were explored to find and explore related articles. Since the incidence of...

Escherichia coli is the gram negative bacilli of Entrobacteriaceae family that commonly found in ... more Escherichia coli is the gram negative bacilli of Entrobacteriaceae family that commonly found in intestinal infections and many infections outside the intestine, like urinary tract infections (UTI), cholecystitis, wound infections, meningitis, septicemia, pulmonary infections, and many more. Plants are rich sources of bioactive compounds, hence they can be effective in a wide variety of diseases. The pandemic spread of multidrug-resistant (MDR) bacteria (i.e., extended-spectrum b-lactamase-producing Enterobacteriaceae (ESBLPE). Carbapenemase-producing Enterobacteriaceae (CPE),) threaten healthcare Worldwide. The present review is a report of the most effective medicinal plants against E. coli. In this research, the required online database searches were conducted using the key words such as bacteria, E. coli and medicinal plants. Databases of Web of Science, PubMed, Scopus, Google Scholar, and ScienceDirect were explored to find and explore related articles. Since the incidence of E...

Oral diseases such as tooth decay, gum disease, and tooth loss can significantly affect the overa... more Oral diseases such as tooth decay, gum disease, and tooth loss can significantly affect the overall health of the individual. Tooth decay is a polymicrobial disease in which nutrition, microbial infection and host response play an important role. Enterococcus faecalis is one of these bacterial agents. Medicinal plants have fewer side effects compared to chemical drugs. Those have been easy to access from the past and have been used as drugs in the treatment of various diseases. This natural source has effective ingredients which cure diseases. The efforts in this reviewing study were on reporting anti-Enterococcusfaecalis medicinal plants. Searching for articles in this reviewing study were done with words such as Enterococcusfaecalis, Medicinal plants, dental diseases and phytotherapy. Search was done from databases such as Scopus, ISC, SID, Magiran and some other databases. Accordingly, 13 medical plants which are effective on Streptococcus faecalis are used. According to the obta...

Biotechnology Reports, 2021

Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid... more Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core (HBc) antigen is capable of assembling into VLPs that can elicit strong immune responses and has been licensed as a commercial vaccine against Hepatitis B. The HBc VLPs have also been employed as a platform for the presentation of foreign epitopes to the immune system and have been used to develop vaccines against, for example, influenza A and Foot-and-mouth disease. Plant expression systems are rapid, scalable and safe, and are capable of providing correct post-translational modifications and reducing upstream production costs. The production of HBc-based virus-like particles in plants would thus greatly increase the efficiency of vaccine production. This review investigates the application of plant-based HBc VLP as a platform for vaccine production.

Land of Andalusia once was as a Mecca for scientists and it is important to discuss about it. Fac... more Land of Andalusia once was as a Mecca for scientists and it is important to discuss about it. Factors for fall of Andalusia are in twelve reasons in the analytical history of Andalusia book, but in this study, the behavior of the Bani Ahmar’s princes that followed by the final fall of Andalusia in the Bani Ahmar period, will be discussed in detail, with the descriptive analytical method. Analytical History of Andalusia book has stated the hypothesis, which the incompetence and negligence of the Bani Nasr’s government caused the final fall of Andalusia. There is in this article, that tolerance and trust the enemy and their involvement in the Civil War and the secret pact continuedtheir involvement in the Andalusia and the rebellion of Bani Nasr’s princes, instabled the Granada’s situation. Christian governments, including Aragon and Castellae used this opportunity and surrounded Granada cities andramparts. And with the capture of Gibraltar, the connection between Granada with the W...

Asian Journal of Research in Business Economics and Management, 2014

This study is aimed at studying the effects of economic sanctions on the financial statements of ... more This study is aimed at studying the effects of economic sanctions on the financial statements of companies accepted in Iran's Stock Exchange. This study investigates the difference in the stock price and the operating profit of companies accepted in Iran's Stock Exchange before and after the economic sanction years. The research method is that of correlation and in general, 144 companies from different industries have been selected in the systemic omission method between the years 2006 and 2011. All research hypotheses were separately examines. The research findings show that the stock price decreases in small companies after the economic sanction, and it increases in big companies after the economic sanction. The operating profit decreases in big and small companies after the economic sanction.

The most common cause of gum disease is lack of observance of oral hygiene and the accumulation o... more The most common cause of gum disease is lack of observance of oral hygiene and the accumulation of bacterial plaque, followed by dental mass, food intake and dental restorations. Bacterial agents which cause dental plaque formation and ultimately cause tooth decay. Streptococcus mitis is the greatest bacterial agent isolated from dental plaque. Medicinal plants are rich in substances whose pharmacological properties are applied through potent antioxidant and bioactive substances. We tried to report medicinal plants with anti-Streptococcus mitis properties in this reviewing study. Searching in this reviewing study was done with words such as Streptococcus mitis, dental diseases, medical plants and phytotherapy. Searching was done from databases such as Scopus, ISC, SID, Magiran and several other databases. Accordingly, 9 medical plants effective on Streptococcus mitis are used. According to obtained results, it was determined that Cinnamomum cassia, Spilanthes calva, Azardirachta ind...

Background: Toxoplasma gondii (T. gondii) is an intracellular protozoan parasite capable of infec... more Background: Toxoplasma gondii (T. gondii) is an intracellular protozoan parasite capable of infecting approximately one-third of the world human population. In this study, the seroprevalence of Toxoplasma gondii (T. gondii) antibodies in Iranian patients with rheumatoid arthritis was investigated, given the lack of information on the magnitude of toxoplasmosis in these patients. Methods: The serum was collected from patients with rheumatoid arthritis (n = 93) and a healthy control group (n = 93) from central parts of Iran to investigate the prevalence of anti-T. gondii IgG and IgM antibodies. Results: Anti-T. gondii IgG was detected among 76 of 93 patients with rheumatoid arthritis (81.72%) versus 37 of 93 healthy control group (39.80%), and it was higher among patients with rheumatoid arthritis than controls. The seroprevalence of anti-T. gondii IgM was significantly higher in patients with rheumatoid arthritis (36 of 93; 38.70%) compared to the healthy control group (2 of 93; 2.1%...

Physics of Fluids, 2021

Jet fans are increasingly preferred over traditional ducted systems as a means of ventilating pol... more Jet fans are increasingly preferred over traditional ducted systems as a means of ventilating pollutants in large environments such as underground car parks. The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—which causes the novel coronavirus disease—through the jet fans in underground car parks has been considered a matter of key concern. A quantitative understanding of the propagation of respiratory droplets/particles/aerosols containing the virus is important. However, to date, studies have yet to demonstrate viral (e.g., SARS-CoV-2) transmission in underground car parks equipped with jet fans. In this paper, numerical simulation has been performed to assess the effects of jet fans on the spreading of viruses inside underground car parks.

Scientific Reports, 2020

The aim of this study was to assess and compare the discriminatory performance of well-known risk... more The aim of this study was to assess and compare the discriminatory performance of well-known risk assessment scores in predicting mortality risk after extended hepatectomy (EH). A series of 250 patients who underwent EH (≥5 segments resection) were evaluated. Aspartate aminotransferase-to-platelet ratio index (APRI), albumin to bilirubin (ALBI) grade, predictive score developed by Breitenstein et al., liver fibrosis (FIB-4) index, and Heidelberg reference lines charting were used to compute cut-off values, and the sensitivity and specificity of each risk assessment score for predicting mortality were also calculated. Major morbidity and 90-day mortality after EH increased with increasing risk scores. APRI (86%), ALBI (86%), Heidelberg score (81%), and FIB-4 index (79%) had the highest sensitivity for 90-day mortality. However, only the FIB-4 index and Heidelberg score had an acceptable specificity (70% and 65%, respectively). A two-stage risk assessment strategy (Heidelberg–FIB-4 mo...

Bangladesh Journal of Medical Science, 2019

In nephro-urologic field, extent of approach to causes of lower urinary tract complaints in fourt... more In nephro-urologic field, extent of approach to causes of lower urinary tract complaints in fourth decade or more of life is challenging matter. Physicians must notice to alarm signs in diagnosis of patients to prevent misdiagnosis of important causes. in practice, combination of hematuria and constipation accompany weight loss are red flags. Bladder neoplasm is a malignant cause of above symptoms that sometime originate from neighboring organ. Bladder metastases are very rare in colorectal cancers (CRC). Symptoms of primary tumor may be precede or coincide with urinary symptoms. The present study describes an unusual case of symptomatic bladder involvement from sigmoid adenocarcinoma. A 68-year-old man with complaints of dysuria, frequency, microscopic-hematuria, nausea, vomiting, and abdominal pain was diagnosed as adenocarcinoma of sigmoid colon metastatic to the bladder. This case underlined the need to prompt and careful attention to patients with hematuria-dysuria in adult age...

Multiple Sclerosis and Related Disorders, 2019

Background: Multiple sclerosis is a chronic inflammatory demyelinating disease of the central ner... more Background: Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS) characterized by immune-mediated demyelination and axonal injury. Myelin-reactive IFN-γ-producing Th1 cells has been shown to play an important role in the development of MS. MicroRNAs (miRNAs) are a new class of small non-coding RNA molecules about 22 nucleotides long which regulate gene expression post-transcriptionally by binding to 3′ UTR of their mRNA targets, and resulting in degradation or transcriptional repression of the targeted mRNA. Accumulating evidence supports that miRNA dysregulation is linked to the pathogenesis of autoimmune diseases that include MS. miR-29b expression has been shown to be upregulated in memory CD4+T cells from relapsing-remitting MS (RR-MS) patients, which may reflect chronic Th1 inflammation. Interferon beta (IFN-β) benefits patients with MS and reduces symptoms of the RR-MS. MxA is induced by type I interferon and predicts IFN-β response in MS patients. The aim of this study was to evaluate miR-29b variants and MxA expression and serum IFN-γ level in responders and non-responders to IFN-β treatment. Methods: A total of 70 IFN-β treated RR-MS patients including 35 responders and 35 non-responders were enrolled. We analyzed the expression level of miR-29b variants and MxA using the peripheral blood of MS patients treated with IFN-β for more than one year. Real-time RT-PCR was performed to analyze miR-29b variants and MxA expression one year after initiation of IFN-β therapy. Serum cytokine level was measured by ELISA. Results: The results indicated that the expression level of miR-29b-3p changed related to IFN-β response. Moreover, miR-29b-5p was downregulated under IFN-β treatment in responders versus non-responders. MxA level was significantly decreased in the responders. There was no change in IFN-γ level following treatment with IFN-β in the MS patients. Conclusions: Our results might provide fundamentals for the development of new markers of the biological effects of IFN-β therapy.

Microbiologia Medica, 2017

Background and aims: Staphylococcus aureus is known as one of the most important nosocomial patho... more Background and aims: Staphylococcus aureus is known as one of the most important nosocomial pathogens, which may lead to several infections. The aim of this study was determining the enterotoxins A, C, and TSST-1 and molecular characterization of S. aureus strains with PFGE and MLST typing methods. Materials and methods: In the present study during the sixmonths sampling, fifty S. aureus strains were isolated from patients admitted to Al-Zahra university hospital. Antimicrobial susceptibility testing, Multiplex PCR for detection of enterotoxin A, C and TSST-1, pulse field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were used for molecular typing. Results: In antibiogram the highest and lowest percentage of resistance was belonged to tetracycline and rifampin respectively. Multiplex PCR indicated that 30% of the strains harbored sea and 34% harbored sec genes. However, only 4% of our collected isolates had tsst gene. In PFGE method analysis on all S. aureus strai...

Frontiers in Immunology, 2019

Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a growth factor ... more Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a growth factor that induces the differentiation and proliferation of myeloid progenitors in the bone marrow. GM-CSF also has an important cytokine effect in chronic inflammatory diseases by stimulating the activation and migration of myeloid cells to inflammation sites, promoting survival of target cells and stimulating the renewal of effector granulocytes and macrophages. Because of these pro-cellular effects, an imbalance in GM-CSF production/signaling may lead to harmful inflammatory conditions. In this context, GM-CSF has a pathogenic role in autoimmune diseases that are dependent on cellular immune responses such as multiple sclerosis (MS) and rheumatoid arthritis (RA). Conversely, a protective role has also been described in other autoimmune diseases where humoral responses are detrimental such as myasthenia gravis (MG), Hashimoto's thyroiditis (HT), inflammatory bowel disease (IBD), and systemic lupus erythematosus (SLE). In this review, we aimed for a comprehensive analysis of literature data on the multiple roles of GM-CSF in autoimmue diseases and possible therapeutic strategies that target GM-CSF production.

Inflammation, 2018

Dysregulation of microRNAs (miRNAs) has been linked to the progress of a number of autoimmune dis... more Dysregulation of microRNAs (miRNAs) has been linked to the progress of a number of autoimmune diseases including multiple sclerosis (MS), and its animal model, experimental autoimmune encephalomyelitis (EAE). IFN-γ-producing Th1 cells are major players in MS/EAE pathogenesis. It is known that differentiation of T cells towards the Th1 phenotype is influenced by various factors including miRNAs. The miR-92a shows substantial upregulation in MS; however, little is known about its role in the development of autoimmune and inflammatory responses. Herein, we investigated the role of miR-92a in the pathogenesis of MS, focusing on its potential effects on differentiation of Th1 cells. The expression levels of miR-92a were assessed in the spinal cord tissues and splenocytes from mice with EAE using real-time RT-PCR. Next, using transfection with miR-92a mimic sequences, the potential involvement of miR-92a in Th1 polarization was investigated by flow cytometric analysis. Moreover, the expression levels of miR-92a targets were explored in spinal cord tissues of EAE mice. miR-92a expression was enhanced in mouse spinal cord samples at the peak of EAE disease. Overexpression of miR-92a in splenocytes led to increased differentiation of Th1 cells compared with cells transfected with negative control sequences. Enhanced miR-92a expression was accompanied by reduced expression TSC1 or DUSP10, predicted miR-92a targets, in EAE spinal cords. Our data point to a potential role for miR-92a in neuroinflammatory responses in EAE. Our results indicate that miR-92a might affect Th1 differentiation, likely due to downregulation of TSC1 and DUSP10

Iranian journal of microbiology, 2015

Staphylococcus aureus is one of the main causatives of bovine mastitis. Resistance of some strain... more Staphylococcus aureus is one of the main causatives of bovine mastitis. Resistance of some strains to methicillin, can complicate the treatment of its infections. On the other hand, enterotoxin production is also important. Therefore, the aim of our study was to investigate the methicillin resistance and enterotoxin production in S. aureus isolates caused bovine mastitis. Four hundred and fifty milk samples were collected. After isolation of Staphylococcus aureus, MRSA strains were detected by cefoxitin disc diffusion and oxacillin agar screening methods. DNA was extracted by phenol - chloroform method and PCR was applied for mecA, sea and seb genes. SCCmec types of mecA gene were identified using multiplex-PCR. Fifty-four (12%) S. aureus were isolated. Out of these, 10 and 9 MRSA strains identified by cefoxitin disc diffusion and oxacillin agar screening methods, respectively. All 10 MRSA isolates identified by cefoxitin disc diffusion, were positive for mecA gene and all of them b...

مجله دانشکده پزشکی اصفهان, 2018

Saffron or Crocus sativus is a member of Iridacea which traditionally has been used as flavor and... more Saffron or Crocus sativus is a member of Iridacea which traditionally has been used as flavor and color in foods. Studies indicated that saffron has different pharmacological effects such as anti-inflammatory, antioxidant, antiproliferative, and apoptosis. Although, numerous in-vitro and in-vivo studies have been done to find the different effects of this herbal drug, however, clinical usage of it is very limited. Since using herbal drugs in treatment of disease is very popular, it should be more attention on the beneficial effects of saffron which lead to clinical usage of it. In this study, to understand more about the beneficial effects of this herbal drug, we reviewed clinical studies which have been done on saffron so far.

Introduction: Extended liver resection has increased during the last decades. However, hepatic he... more Introduction: Extended liver resection has increased during the last decades. However, hepatic hemodynamic changes after resection and the consequent complications like small for size syndrome are still a challenging issue. The aim of this study was to systematically evaluate the role of sequential [for full text, please go to the a.m. URL]

Scientific Reports, 2022

The aim of this study was to evaluate whether the portocaval shunt (PCS) corrects these unwanted ... more The aim of this study was to evaluate whether the portocaval shunt (PCS) corrects these unwanted changes in transhepatic flow after extended hepatectomy (EH). Forty female Landrace pigs were divided into two main groups: (A) EH (75%) and (B) no EH. Group A was divided into 3 subgroups: (A1) EH without PCS; (A2) EH with side-to-side PCS; and (A3) EH with end-to-side PCS. Group B was divided into 2 subgroups: (B1) side-to-side PCS and (B2) end-to-side PCS. HAF, PVF, and PVP were measured in each animal before and after the surgical procedure. EH increased the PVF/100 g (173%, p < 0.001) and PVP (68%, p < 0.001) but reduced the HAF/100 g (22%, p = 0.819). Following EH, side-to-side PCS reduced the increased PVF (78%, p < 0.001) and PVP (38%, p = 0.001). Without EH, side-to-side PCS reduced the PVF/100 g (68%, p < 0.001) and PVP (12%, p = 0.237). PVP was reduced by end-to-side PCS following EH by 48% (p < 0.001) and without EH by 21% (p = 0.075). PCS can decrease and corr...

Escherichia coli is the gram negative bacilli of Entrobacteriaceae family that commonly found in... more Escherichia coli is the gram negative bacilli of Entrobacteriaceae family that commonly found in intestinal infections and many infections outside the intestine, like urinary tract infections (UTI), cholecystitis, wound infections, meningitis, septicemia, pulmonary infections, and many more. Plants are rich sources of bioactive compounds, hence they can be effective in a wide variety of diseases. The pandemic spread of multidrug-resistant (MDR) bacteria (i.e., extended-spectrum b-lactamase-producing Enterobacteriaceae (ESBLPE), Carbapenemase-producing Enterobacteriaceae (CPE)) threaten healthcare Worldwide. The present review is a report of the most effective medicinal plants against E . coli . In this research, the required online database searches were conducted using the key words such as bacteria, E. coli and medicinal plants. Databases of Web of Science, PubMed, Scopus, Google Scholar, and ScienceDirect were explored to find and explore related articles. Since the incidence of...

Escherichia coli is the gram negative bacilli of Entrobacteriaceae family that commonly found in ... more Escherichia coli is the gram negative bacilli of Entrobacteriaceae family that commonly found in intestinal infections and many infections outside the intestine, like urinary tract infections (UTI), cholecystitis, wound infections, meningitis, septicemia, pulmonary infections, and many more. Plants are rich sources of bioactive compounds, hence they can be effective in a wide variety of diseases. The pandemic spread of multidrug-resistant (MDR) bacteria (i.e., extended-spectrum b-lactamase-producing Enterobacteriaceae (ESBLPE). Carbapenemase-producing Enterobacteriaceae (CPE),) threaten healthcare Worldwide. The present review is a report of the most effective medicinal plants against E. coli. In this research, the required online database searches were conducted using the key words such as bacteria, E. coli and medicinal plants. Databases of Web of Science, PubMed, Scopus, Google Scholar, and ScienceDirect were explored to find and explore related articles. Since the incidence of E...

Oral diseases such as tooth decay, gum disease, and tooth loss can significantly affect the overa... more Oral diseases such as tooth decay, gum disease, and tooth loss can significantly affect the overall health of the individual. Tooth decay is a polymicrobial disease in which nutrition, microbial infection and host response play an important role. Enterococcus faecalis is one of these bacterial agents. Medicinal plants have fewer side effects compared to chemical drugs. Those have been easy to access from the past and have been used as drugs in the treatment of various diseases. This natural source has effective ingredients which cure diseases. The efforts in this reviewing study were on reporting anti-Enterococcusfaecalis medicinal plants. Searching for articles in this reviewing study were done with words such as Enterococcusfaecalis, Medicinal plants, dental diseases and phytotherapy. Search was done from databases such as Scopus, ISC, SID, Magiran and some other databases. Accordingly, 13 medical plants which are effective on Streptococcus faecalis are used. According to the obta...

Biotechnology Reports, 2021

Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid... more Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core (HBc) antigen is capable of assembling into VLPs that can elicit strong immune responses and has been licensed as a commercial vaccine against Hepatitis B. The HBc VLPs have also been employed as a platform for the presentation of foreign epitopes to the immune system and have been used to develop vaccines against, for example, influenza A and Foot-and-mouth disease. Plant expression systems are rapid, scalable and safe, and are capable of providing correct post-translational modifications and reducing upstream production costs. The production of HBc-based virus-like particles in plants would thus greatly increase the efficiency of vaccine production. This review investigates the application of plant-based HBc VLP as a platform for vaccine production.

Land of Andalusia once was as a Mecca for scientists and it is important to discuss about it. Fac... more Land of Andalusia once was as a Mecca for scientists and it is important to discuss about it. Factors for fall of Andalusia are in twelve reasons in the analytical history of Andalusia book, but in this study, the behavior of the Bani Ahmar’s princes that followed by the final fall of Andalusia in the Bani Ahmar period, will be discussed in detail, with the descriptive analytical method. Analytical History of Andalusia book has stated the hypothesis, which the incompetence and negligence of the Bani Nasr’s government caused the final fall of Andalusia. There is in this article, that tolerance and trust the enemy and their involvement in the Civil War and the secret pact continuedtheir involvement in the Andalusia and the rebellion of Bani Nasr’s princes, instabled the Granada’s situation. Christian governments, including Aragon and Castellae used this opportunity and surrounded Granada cities andramparts. And with the capture of Gibraltar, the connection between Granada with the W...

Asian Journal of Research in Business Economics and Management, 2014

This study is aimed at studying the effects of economic sanctions on the financial statements of ... more This study is aimed at studying the effects of economic sanctions on the financial statements of companies accepted in Iran's Stock Exchange. This study investigates the difference in the stock price and the operating profit of companies accepted in Iran's Stock Exchange before and after the economic sanction years. The research method is that of correlation and in general, 144 companies from different industries have been selected in the systemic omission method between the years 2006 and 2011. All research hypotheses were separately examines. The research findings show that the stock price decreases in small companies after the economic sanction, and it increases in big companies after the economic sanction. The operating profit decreases in big and small companies after the economic sanction.

The most common cause of gum disease is lack of observance of oral hygiene and the accumulation o... more The most common cause of gum disease is lack of observance of oral hygiene and the accumulation of bacterial plaque, followed by dental mass, food intake and dental restorations. Bacterial agents which cause dental plaque formation and ultimately cause tooth decay. Streptococcus mitis is the greatest bacterial agent isolated from dental plaque. Medicinal plants are rich in substances whose pharmacological properties are applied through potent antioxidant and bioactive substances. We tried to report medicinal plants with anti-Streptococcus mitis properties in this reviewing study. Searching in this reviewing study was done with words such as Streptococcus mitis, dental diseases, medical plants and phytotherapy. Searching was done from databases such as Scopus, ISC, SID, Magiran and several other databases. Accordingly, 9 medical plants effective on Streptococcus mitis are used. According to obtained results, it was determined that Cinnamomum cassia, Spilanthes calva, Azardirachta ind...

Background: Toxoplasma gondii (T. gondii) is an intracellular protozoan parasite capable of infec... more Background: Toxoplasma gondii (T. gondii) is an intracellular protozoan parasite capable of infecting approximately one-third of the world human population. In this study, the seroprevalence of Toxoplasma gondii (T. gondii) antibodies in Iranian patients with rheumatoid arthritis was investigated, given the lack of information on the magnitude of toxoplasmosis in these patients. Methods: The serum was collected from patients with rheumatoid arthritis (n = 93) and a healthy control group (n = 93) from central parts of Iran to investigate the prevalence of anti-T. gondii IgG and IgM antibodies. Results: Anti-T. gondii IgG was detected among 76 of 93 patients with rheumatoid arthritis (81.72%) versus 37 of 93 healthy control group (39.80%), and it was higher among patients with rheumatoid arthritis than controls. The seroprevalence of anti-T. gondii IgM was significantly higher in patients with rheumatoid arthritis (36 of 93; 38.70%) compared to the healthy control group (2 of 93; 2.1%...

Physics of Fluids, 2021

Jet fans are increasingly preferred over traditional ducted systems as a means of ventilating pol... more Jet fans are increasingly preferred over traditional ducted systems as a means of ventilating pollutants in large environments such as underground car parks. The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—which causes the novel coronavirus disease—through the jet fans in underground car parks has been considered a matter of key concern. A quantitative understanding of the propagation of respiratory droplets/particles/aerosols containing the virus is important. However, to date, studies have yet to demonstrate viral (e.g., SARS-CoV-2) transmission in underground car parks equipped with jet fans. In this paper, numerical simulation has been performed to assess the effects of jet fans on the spreading of viruses inside underground car parks.

Scientific Reports, 2020

The aim of this study was to assess and compare the discriminatory performance of well-known risk... more The aim of this study was to assess and compare the discriminatory performance of well-known risk assessment scores in predicting mortality risk after extended hepatectomy (EH). A series of 250 patients who underwent EH (≥5 segments resection) were evaluated. Aspartate aminotransferase-to-platelet ratio index (APRI), albumin to bilirubin (ALBI) grade, predictive score developed by Breitenstein et al., liver fibrosis (FIB-4) index, and Heidelberg reference lines charting were used to compute cut-off values, and the sensitivity and specificity of each risk assessment score for predicting mortality were also calculated. Major morbidity and 90-day mortality after EH increased with increasing risk scores. APRI (86%), ALBI (86%), Heidelberg score (81%), and FIB-4 index (79%) had the highest sensitivity for 90-day mortality. However, only the FIB-4 index and Heidelberg score had an acceptable specificity (70% and 65%, respectively). A two-stage risk assessment strategy (Heidelberg–FIB-4 mo...

Bangladesh Journal of Medical Science, 2019

In nephro-urologic field, extent of approach to causes of lower urinary tract complaints in fourt... more In nephro-urologic field, extent of approach to causes of lower urinary tract complaints in fourth decade or more of life is challenging matter. Physicians must notice to alarm signs in diagnosis of patients to prevent misdiagnosis of important causes. in practice, combination of hematuria and constipation accompany weight loss are red flags. Bladder neoplasm is a malignant cause of above symptoms that sometime originate from neighboring organ. Bladder metastases are very rare in colorectal cancers (CRC). Symptoms of primary tumor may be precede or coincide with urinary symptoms. The present study describes an unusual case of symptomatic bladder involvement from sigmoid adenocarcinoma. A 68-year-old man with complaints of dysuria, frequency, microscopic-hematuria, nausea, vomiting, and abdominal pain was diagnosed as adenocarcinoma of sigmoid colon metastatic to the bladder. This case underlined the need to prompt and careful attention to patients with hematuria-dysuria in adult age...

Multiple Sclerosis and Related Disorders, 2019

Background: Multiple sclerosis is a chronic inflammatory demyelinating disease of the central ner... more Background: Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS) characterized by immune-mediated demyelination and axonal injury. Myelin-reactive IFN-γ-producing Th1 cells has been shown to play an important role in the development of MS. MicroRNAs (miRNAs) are a new class of small non-coding RNA molecules about 22 nucleotides long which regulate gene expression post-transcriptionally by binding to 3′ UTR of their mRNA targets, and resulting in degradation or transcriptional repression of the targeted mRNA. Accumulating evidence supports that miRNA dysregulation is linked to the pathogenesis of autoimmune diseases that include MS. miR-29b expression has been shown to be upregulated in memory CD4+T cells from relapsing-remitting MS (RR-MS) patients, which may reflect chronic Th1 inflammation. Interferon beta (IFN-β) benefits patients with MS and reduces symptoms of the RR-MS. MxA is induced by type I interferon and predicts IFN-β response in MS patients. The aim of this study was to evaluate miR-29b variants and MxA expression and serum IFN-γ level in responders and non-responders to IFN-β treatment. Methods: A total of 70 IFN-β treated RR-MS patients including 35 responders and 35 non-responders were enrolled. We analyzed the expression level of miR-29b variants and MxA using the peripheral blood of MS patients treated with IFN-β for more than one year. Real-time RT-PCR was performed to analyze miR-29b variants and MxA expression one year after initiation of IFN-β therapy. Serum cytokine level was measured by ELISA. Results: The results indicated that the expression level of miR-29b-3p changed related to IFN-β response. Moreover, miR-29b-5p was downregulated under IFN-β treatment in responders versus non-responders. MxA level was significantly decreased in the responders. There was no change in IFN-γ level following treatment with IFN-β in the MS patients. Conclusions: Our results might provide fundamentals for the development of new markers of the biological effects of IFN-β therapy.

Microbiologia Medica, 2017

Background and aims: Staphylococcus aureus is known as one of the most important nosocomial patho... more Background and aims: Staphylococcus aureus is known as one of the most important nosocomial pathogens, which may lead to several infections. The aim of this study was determining the enterotoxins A, C, and TSST-1 and molecular characterization of S. aureus strains with PFGE and MLST typing methods. Materials and methods: In the present study during the sixmonths sampling, fifty S. aureus strains were isolated from patients admitted to Al-Zahra university hospital. Antimicrobial susceptibility testing, Multiplex PCR for detection of enterotoxin A, C and TSST-1, pulse field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were used for molecular typing. Results: In antibiogram the highest and lowest percentage of resistance was belonged to tetracycline and rifampin respectively. Multiplex PCR indicated that 30% of the strains harbored sea and 34% harbored sec genes. However, only 4% of our collected isolates had tsst gene. In PFGE method analysis on all S. aureus strai...

Frontiers in Immunology, 2019

Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a growth factor ... more Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a growth factor that induces the differentiation and proliferation of myeloid progenitors in the bone marrow. GM-CSF also has an important cytokine effect in chronic inflammatory diseases by stimulating the activation and migration of myeloid cells to inflammation sites, promoting survival of target cells and stimulating the renewal of effector granulocytes and macrophages. Because of these pro-cellular effects, an imbalance in GM-CSF production/signaling may lead to harmful inflammatory conditions. In this context, GM-CSF has a pathogenic role in autoimmune diseases that are dependent on cellular immune responses such as multiple sclerosis (MS) and rheumatoid arthritis (RA). Conversely, a protective role has also been described in other autoimmune diseases where humoral responses are detrimental such as myasthenia gravis (MG), Hashimoto's thyroiditis (HT), inflammatory bowel disease (IBD), and systemic lupus erythematosus (SLE). In this review, we aimed for a comprehensive analysis of literature data on the multiple roles of GM-CSF in autoimmue diseases and possible therapeutic strategies that target GM-CSF production.

Inflammation, 2018

Dysregulation of microRNAs (miRNAs) has been linked to the progress of a number of autoimmune dis... more Dysregulation of microRNAs (miRNAs) has been linked to the progress of a number of autoimmune diseases including multiple sclerosis (MS), and its animal model, experimental autoimmune encephalomyelitis (EAE). IFN-γ-producing Th1 cells are major players in MS/EAE pathogenesis. It is known that differentiation of T cells towards the Th1 phenotype is influenced by various factors including miRNAs. The miR-92a shows substantial upregulation in MS; however, little is known about its role in the development of autoimmune and inflammatory responses. Herein, we investigated the role of miR-92a in the pathogenesis of MS, focusing on its potential effects on differentiation of Th1 cells. The expression levels of miR-92a were assessed in the spinal cord tissues and splenocytes from mice with EAE using real-time RT-PCR. Next, using transfection with miR-92a mimic sequences, the potential involvement of miR-92a in Th1 polarization was investigated by flow cytometric analysis. Moreover, the expression levels of miR-92a targets were explored in spinal cord tissues of EAE mice. miR-92a expression was enhanced in mouse spinal cord samples at the peak of EAE disease. Overexpression of miR-92a in splenocytes led to increased differentiation of Th1 cells compared with cells transfected with negative control sequences. Enhanced miR-92a expression was accompanied by reduced expression TSC1 or DUSP10, predicted miR-92a targets, in EAE spinal cords. Our data point to a potential role for miR-92a in neuroinflammatory responses in EAE. Our results indicate that miR-92a might affect Th1 differentiation, likely due to downregulation of TSC1 and DUSP10

Iranian journal of microbiology, 2015

Staphylococcus aureus is one of the main causatives of bovine mastitis. Resistance of some strain... more Staphylococcus aureus is one of the main causatives of bovine mastitis. Resistance of some strains to methicillin, can complicate the treatment of its infections. On the other hand, enterotoxin production is also important. Therefore, the aim of our study was to investigate the methicillin resistance and enterotoxin production in S. aureus isolates caused bovine mastitis. Four hundred and fifty milk samples were collected. After isolation of Staphylococcus aureus, MRSA strains were detected by cefoxitin disc diffusion and oxacillin agar screening methods. DNA was extracted by phenol - chloroform method and PCR was applied for mecA, sea and seb genes. SCCmec types of mecA gene were identified using multiplex-PCR. Fifty-four (12%) S. aureus were isolated. Out of these, 10 and 9 MRSA strains identified by cefoxitin disc diffusion and oxacillin agar screening methods, respectively. All 10 MRSA isolates identified by cefoxitin disc diffusion, were positive for mecA gene and all of them b...