Natchiappan Senthilkumar - Academia.edu (original) (raw)
Papers by Natchiappan Senthilkumar
Shikimic acid is a lead compound in the manufacture of the drug oseltamivir phosphate, commercial... more Shikimic acid is a lead compound in the manufacture of the drug oseltamivir phosphate, commercially known as Tamiflu ®, which is an oral antiviral used to treat influenza viruses, as a H5N1(avian influenza) and a H1N1(swine influenza). The major bottleneck in Tamiflu production is the availability of shikimic acid. The only source for the extraction of shikimic acid is fruits of Chinese star anise, Illicium verum (Hook. f.). However, it takes almost six years after plantation to get fruits of star anise. Therefore, search of alternative source for shikimic acid is warranted. The water hyacinth, Eichhornia crassipes (Mart.) Solms. (Pontederiaceae) is considered as one of the most productive plants on earth, and an aquatic weed, which causes serious environmental problems. In this study, E. crassipes is considered as an alternative renewable source of shikimic acid since, n-hexane extract of leaves of E. crassipes was found to have more shikimic acid content (3.25%) than that of star anise (1.77%), hence, it may be considered as an alternate renewable source of shikimic acid.
Two new species of the Genus, Trigonocorypha Stal 1873 (Orthoptera: Tettigoniidae: Phaneropterina... more Two new species of the Genus, Trigonocorypha Stal 1873 (Orthoptera: Tettigoniidae: Phaneropterinae) as Trigonocorpha ponmaniae sp. nov. and Trigonocorpha divyae sp. nov. collected from Coimbatore and Thiruvannamalai districts of Tamil Nadu respectively are described with morphological characteristics of the other four species reported from India. A key to identify the species of the reported Genus, Trigonocorpha of India has been provided.
IJPBA, 2019
The physicochemical characterization of oil extracts from Simarouba glauca DC. seeds collected in... more The physicochemical characterization of oil extracts from Simarouba glauca DC. seeds collected in Southern states of India was performed. Among the organic solvents used for oil extraction n-hexane was found promising with high oil yield of 32%.Maximum oil yield was observed in the accession KD 23 with 34% collected from Nallampalli, Dharmapuri. Phytochemical screening of seed oil of S. glauca showed the presence of Steroids and Terpenoids. High saponification value indicated that the free fatty acids are low and saponifiable fats are more especially high triglycerol content hence, the seed oil has been converted into FAME for further characterization. The genetic source KD 23 yielded appreciably high oil and rich storehouse of bioactive constituents (secondary metabolites), with high saponifiable matters (252), and unsaponifiable matters (6%) which could be tapped for use as insecticide.
Objective: To characterize anthocyanin from Tamarindus indica var rhodocarpa using spectral analy... more Objective: To characterize anthocyanin from Tamarindus indica var rhodocarpa using spectral analysis for use in food colourants. Results: Nutritional parameters such as carbohydrate and protein contents were high in Red Tamarind unripen fruit extract with the values of 8.6g and 12.61g respectively. Low fat level with nil Cholesterol (BDL) is present in the extract. Other minerals and vitamins such as iron, calcium, vitamins A &C are rich in the extract. TLC separation of unripen fruit extract of red tamarind matched with the authentic anthocyanins pigments namely, cyaniding-3-glucoside, delphidin and pelargonidin. HPLC analysis also confirmed the presence of major anthocyanin pigments, cyaniding-3-glucoside, delphidin and pelargonidin. Conclusion: Anthocyanins are the important polyphenolic compounds present in Red Tamarind. The characterization of anthocyanins using TLC and HPLC analysis revealed the presence of three major anthocyanins pigments v: z., cyanidin-3-glucoside, pelargonidin, delphinidin. The red colour of the unripen fruit extracts of red tamarind is due to presence of cyaniding-3-glucoside with higher quantity of 94.21%. The pH of the extract is 2. Analysis of nutritional parameters revealed that the extract contains high level of protein and carbohydrate; rich in minerals and vitamins with low level of fat which support the daily human intake values, hence it may be considered to use as food colourant. Therefore, it is concluded that the presence of anthocyanin pigments cyaniding-3-glucoside in unripen fruit of red tamarind is responsible for red colour which is depending on the pH.
Acta Anaesthesiologica Scandinavica, 2000
GC-MS-MS analysis was carried out for the identification of phytochemicals present in the n-hexan... more GC-MS-MS analysis was carried out for the identification of phytochemicals present in the n-hexane leaf extract of C. papaya variety CO7. It indicates that the leaf extract is rich in alkaloids, phenolics, fatty acids, and flavonoids. All compounds identified by GC/MS/MS screening were assessed for their anticancerous, antimicrobial, antioxidant and insecticidal property using physico-chemical property calculations according to Tice Rules. The phytochemicals such as Clausamine G, Galactitol, Ibogamine are found to have anticancer property. Garveatin D, N-Methylaspartic acid were reported as antimicrobial metabolites.
Effect of coir pith and vermiculite based media inoculated with various bioinoculants PGPRs, PPFM... more Effect of coir pith and vermiculite based media inoculated with various bioinoculants PGPRs, PPFM, AM fungi along with vermicompost, farmyard manure, effluent compost, decomposed green manure, neem seed kernel cake, aegle seed cake etc., were critically examined at different mixing ratio as an integrated bio-nutrient management for the quality production of seedling of Eucalyptus tereticornis. It was demonstrated that some of the bioinoculant application could appreciably improve the germination behaviour (24-100%) in our nursery experiments as the supplement of primary/micronutrients like protein, chlorophyll, Ca, N, Ph, Mg, K and organic carbon , and thus reducing the need for fertilizers. The inoculated seedlings shown better performance of biomass with reference to seedling survival, shoot length, collar diameter at 30-60 days after application.
GC-MS analysis of methanolic extract of aerial parts of Eichhornia crassipes revealed the presenc... more GC-MS analysis of methanolic extract of aerial parts of Eichhornia crassipes revealed the presence of 26 compounds. The identified compounds such as Goniothalamicin, Arborescidine were reported to have anticancer properties. Compounds such as 1, 8 Dipropoxyanthraquinone (91.33%) reported to have antioxidant property. Ambrosial, Camarolide and trace amount of Muricin were also recorded and reported as antimicrobial compounds. Therefore methanol extract of E.crassipes proves as a potential source of bioactive compounds of pharmacological importance.
Plant secondary metabolites derived from weeds, medicinal and aromatic plants have been found to ... more Plant secondary metabolites derived from weeds, medicinal and aromatic plants have been found to be a protective biopesticidal agent, cost effective and safe to ecosystem & public health. In the present investigation, the essential oil of Lantana camara collected from the different agro-climatic conditions of Tamilnadu regions has proven to be interesting source of terpenoid derivatives for their biopesticidal properties against some of the defoliators of forestry tree species. Bioassay confirmation of those terpenoids identified from the essential oil was tested on the target pests such as Hyblaea puera, Eligma narcissus and Atteva fabriciella at different concentrations both in the laboratory and field conditions. The bioactivity interms of larval mortality was observed when the early instars were exposed to preformulated oil applications.
The present study investigated the physicochemical properties and phytochemical constituents of s... more The present study investigated the physicochemical properties and phytochemical constituents of seed oil of Semecarpus anacardium L. to understand its biopesticidal and therapeutic potential. Preliminary phytochemical studies showed the presence of polyphenolic compounds, flavonoids, tannins, saponins, steroids in seed oil which is extracted using various organic solvents such as n-hexane, petroleum ether, methanol and acetone. 34 to 44 percent of oil was extracted using the said solvents. Physicochemical properties such as saponification value, iodine value, peroxide value, acid value, viscosity, pH, relative density of seed oil of S. anacardium were determined. The results suggest that the seed oils of S. anacardium and their physicochemical properties and phytochemical constituents are found suitable to develop biopesticide formulation for the management of insect pests and fungi. Hence the seed oil of S. anacardium could be considered as an effective biopesticide.
![Research paper thumbnail of ANTICANCER ACTIVITY OF WATER HYACINTH [EICHHORNIA CRASSIPES (MART) SOLMS] ON HUMAN CERVICAL CANCER CELL LINE](https://attachments.academia-assets.com/44621485/thumbnails/1.jpg)
](Eichhornia crassipes (Mart) Solms commonly known as water hyacinth is native to Brazil. It is one... more Eichhornia crassipes (Mart) Solms commonly known as water hyacinth is native to Brazil. It is one of the most productive plants on earth and is considered the world's worst aquatic weed which causes serious environmental issues. In the current study the methanol extract of this plant have been tested for anticancer activity. The in-vitro anticancer studies were performed against human cancer cell line (HeLa). MTT assay was used to analyze the cell growth inhibition. The methanol extract of E. crassipes resulted in mild anticancer activity on HeLa cell line.
GC-MS analysis of methanolic extract of aerial parts of Eichhornia crassipes revealed the presenc... more GC-MS analysis of methanolic extract of aerial parts of Eichhornia crassipes revealed the presence of 26 compounds. The identified compounds such as Goniothalamicin, Arborescidine were reported to have anticancer properties. Compounds such as 1, 8 Dipropoxyanthraquinone (91.33%) reported to have antioxidant property. Ambrosial, Camarolide and trace amount of Muricin were also recorded and reported as antimicrobial compounds. Therefore methanol extract of E.crassipes proves as a potential source of bioactive compounds of pharmacological importance.
Plant secondary metabolites derived from weeds, medicinal and aromatic plants have been found to ... more Plant secondary metabolites derived from weeds, medicinal and aromatic plants have been found to be a protective
biopesticidal agent, cost effective and safe to ecosystem & public health. In the present investigation, the essential
oil of Lantana camara collected from the different agro-climatic conditions of Tamilnadu regions has proven to be
interesting source of terpenoid derivatives for their biopesticidal properties against some of the defoliators of
forestry tree species. Bioassay confirmation of those terpenoids identified from the essential oil was tested on the
target pests such as Hyblaea puera, Eligma narcissus and Atteva fabriciella at different concentrations both in the
laboratory and field conditions. The bioactivity interms of larval mortality was observed when the early instars
were exposed to preformulated oil applications.
Shikimic acid is a lead compound in the manufacture of the drug oseltamivir phosphate, commercial... more Shikimic acid is a lead compound in the manufacture of the drug oseltamivir phosphate, commercially known as Tamiflu ®, which is an oral antiviral used to treat influenza viruses, as a H5N1(avian influenza) and a H1N1(swine influenza). The major bottleneck in Tamiflu production is the availability of shikimic acid. The only source for the extraction of shikimic acid is fruits of Chinese star anise, Illicium verum (Hook. f.). However, it takes almost six years after plantation to get fruits of star anise. Therefore, search of alternative source for shikimic acid is warranted. The water hyacinth, Eichhornia crassipes (Mart.) Solms. (Pontederiaceae) is considered as one of the most productive plants on earth, and an aquatic weed, which causes serious environmental problems. In this study, E. crassipes is considered as an alternative renewable source of shikimic acid since, n-hexane extract of leaves of E. crassipes was found to have more shikimic acid content (3.25%) than that of star anise (1.77%), hence, it may be considered as an alternate renewable source of shikimic acid.
Two new species of the Genus, Trigonocorypha Stal 1873 (Orthoptera: Tettigoniidae: Phaneropterina... more Two new species of the Genus, Trigonocorypha Stal 1873 (Orthoptera: Tettigoniidae: Phaneropterinae) as Trigonocorpha ponmaniae sp. nov. and Trigonocorpha divyae sp. nov. collected from Coimbatore and Thiruvannamalai districts of Tamil Nadu respectively are described with morphological characteristics of the other four species reported from India. A key to identify the species of the reported Genus, Trigonocorpha of India has been provided.
IJPBA, 2019
The physicochemical characterization of oil extracts from Simarouba glauca DC. seeds collected in... more The physicochemical characterization of oil extracts from Simarouba glauca DC. seeds collected in Southern states of India was performed. Among the organic solvents used for oil extraction n-hexane was found promising with high oil yield of 32%.Maximum oil yield was observed in the accession KD 23 with 34% collected from Nallampalli, Dharmapuri. Phytochemical screening of seed oil of S. glauca showed the presence of Steroids and Terpenoids. High saponification value indicated that the free fatty acids are low and saponifiable fats are more especially high triglycerol content hence, the seed oil has been converted into FAME for further characterization. The genetic source KD 23 yielded appreciably high oil and rich storehouse of bioactive constituents (secondary metabolites), with high saponifiable matters (252), and unsaponifiable matters (6%) which could be tapped for use as insecticide.
Objective: To characterize anthocyanin from Tamarindus indica var rhodocarpa using spectral analy... more Objective: To characterize anthocyanin from Tamarindus indica var rhodocarpa using spectral analysis for use in food colourants. Results: Nutritional parameters such as carbohydrate and protein contents were high in Red Tamarind unripen fruit extract with the values of 8.6g and 12.61g respectively. Low fat level with nil Cholesterol (BDL) is present in the extract. Other minerals and vitamins such as iron, calcium, vitamins A &C are rich in the extract. TLC separation of unripen fruit extract of red tamarind matched with the authentic anthocyanins pigments namely, cyaniding-3-glucoside, delphidin and pelargonidin. HPLC analysis also confirmed the presence of major anthocyanin pigments, cyaniding-3-glucoside, delphidin and pelargonidin. Conclusion: Anthocyanins are the important polyphenolic compounds present in Red Tamarind. The characterization of anthocyanins using TLC and HPLC analysis revealed the presence of three major anthocyanins pigments v: z., cyanidin-3-glucoside, pelargonidin, delphinidin. The red colour of the unripen fruit extracts of red tamarind is due to presence of cyaniding-3-glucoside with higher quantity of 94.21%. The pH of the extract is 2. Analysis of nutritional parameters revealed that the extract contains high level of protein and carbohydrate; rich in minerals and vitamins with low level of fat which support the daily human intake values, hence it may be considered to use as food colourant. Therefore, it is concluded that the presence of anthocyanin pigments cyaniding-3-glucoside in unripen fruit of red tamarind is responsible for red colour which is depending on the pH.
Acta Anaesthesiologica Scandinavica, 2000
GC-MS-MS analysis was carried out for the identification of phytochemicals present in the n-hexan... more GC-MS-MS analysis was carried out for the identification of phytochemicals present in the n-hexane leaf extract of C. papaya variety CO7. It indicates that the leaf extract is rich in alkaloids, phenolics, fatty acids, and flavonoids. All compounds identified by GC/MS/MS screening were assessed for their anticancerous, antimicrobial, antioxidant and insecticidal property using physico-chemical property calculations according to Tice Rules. The phytochemicals such as Clausamine G, Galactitol, Ibogamine are found to have anticancer property. Garveatin D, N-Methylaspartic acid were reported as antimicrobial metabolites.
Effect of coir pith and vermiculite based media inoculated with various bioinoculants PGPRs, PPFM... more Effect of coir pith and vermiculite based media inoculated with various bioinoculants PGPRs, PPFM, AM fungi along with vermicompost, farmyard manure, effluent compost, decomposed green manure, neem seed kernel cake, aegle seed cake etc., were critically examined at different mixing ratio as an integrated bio-nutrient management for the quality production of seedling of Eucalyptus tereticornis. It was demonstrated that some of the bioinoculant application could appreciably improve the germination behaviour (24-100%) in our nursery experiments as the supplement of primary/micronutrients like protein, chlorophyll, Ca, N, Ph, Mg, K and organic carbon , and thus reducing the need for fertilizers. The inoculated seedlings shown better performance of biomass with reference to seedling survival, shoot length, collar diameter at 30-60 days after application.
GC-MS analysis of methanolic extract of aerial parts of Eichhornia crassipes revealed the presenc... more GC-MS analysis of methanolic extract of aerial parts of Eichhornia crassipes revealed the presence of 26 compounds. The identified compounds such as Goniothalamicin, Arborescidine were reported to have anticancer properties. Compounds such as 1, 8 Dipropoxyanthraquinone (91.33%) reported to have antioxidant property. Ambrosial, Camarolide and trace amount of Muricin were also recorded and reported as antimicrobial compounds. Therefore methanol extract of E.crassipes proves as a potential source of bioactive compounds of pharmacological importance.
Plant secondary metabolites derived from weeds, medicinal and aromatic plants have been found to ... more Plant secondary metabolites derived from weeds, medicinal and aromatic plants have been found to be a protective biopesticidal agent, cost effective and safe to ecosystem & public health. In the present investigation, the essential oil of Lantana camara collected from the different agro-climatic conditions of Tamilnadu regions has proven to be interesting source of terpenoid derivatives for their biopesticidal properties against some of the defoliators of forestry tree species. Bioassay confirmation of those terpenoids identified from the essential oil was tested on the target pests such as Hyblaea puera, Eligma narcissus and Atteva fabriciella at different concentrations both in the laboratory and field conditions. The bioactivity interms of larval mortality was observed when the early instars were exposed to preformulated oil applications.
The present study investigated the physicochemical properties and phytochemical constituents of s... more The present study investigated the physicochemical properties and phytochemical constituents of seed oil of Semecarpus anacardium L. to understand its biopesticidal and therapeutic potential. Preliminary phytochemical studies showed the presence of polyphenolic compounds, flavonoids, tannins, saponins, steroids in seed oil which is extracted using various organic solvents such as n-hexane, petroleum ether, methanol and acetone. 34 to 44 percent of oil was extracted using the said solvents. Physicochemical properties such as saponification value, iodine value, peroxide value, acid value, viscosity, pH, relative density of seed oil of S. anacardium were determined. The results suggest that the seed oils of S. anacardium and their physicochemical properties and phytochemical constituents are found suitable to develop biopesticide formulation for the management of insect pests and fungi. Hence the seed oil of S. anacardium could be considered as an effective biopesticide.
Eichhornia crassipes (Mart) Solms commonly known as water hyacinth is native to Brazil. It is one... more Eichhornia crassipes (Mart) Solms commonly known as water hyacinth is native to Brazil. It is one of the most productive plants on earth and is considered the world's worst aquatic weed which causes serious environmental issues. In the current study the methanol extract of this plant have been tested for anticancer activity. The in-vitro anticancer studies were performed against human cancer cell line (HeLa). MTT assay was used to analyze the cell growth inhibition. The methanol extract of E. crassipes resulted in mild anticancer activity on HeLa cell line.
GC-MS analysis of methanolic extract of aerial parts of Eichhornia crassipes revealed the presenc... more GC-MS analysis of methanolic extract of aerial parts of Eichhornia crassipes revealed the presence of 26 compounds. The identified compounds such as Goniothalamicin, Arborescidine were reported to have anticancer properties. Compounds such as 1, 8 Dipropoxyanthraquinone (91.33%) reported to have antioxidant property. Ambrosial, Camarolide and trace amount of Muricin were also recorded and reported as antimicrobial compounds. Therefore methanol extract of E.crassipes proves as a potential source of bioactive compounds of pharmacological importance.
Plant secondary metabolites derived from weeds, medicinal and aromatic plants have been found to ... more Plant secondary metabolites derived from weeds, medicinal and aromatic plants have been found to be a protective
biopesticidal agent, cost effective and safe to ecosystem & public health. In the present investigation, the essential
oil of Lantana camara collected from the different agro-climatic conditions of Tamilnadu regions has proven to be
interesting source of terpenoid derivatives for their biopesticidal properties against some of the defoliators of
forestry tree species. Bioassay confirmation of those terpenoids identified from the essential oil was tested on the
target pests such as Hyblaea puera, Eligma narcissus and Atteva fabriciella at different concentrations both in the
laboratory and field conditions. The bioactivity interms of larval mortality was observed when the early instars
were exposed to preformulated oil applications.