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Papers by Nazim Uddin Ahmed

SSRN Electronic Journal

Plant seeds are the resources of many different bioactive components. The chemical composition of... more Plant seeds are the resources of many different bioactive components. The chemical composition of the different crude extracts from Benincasa hispida (White pumpkin) and Cucurbita moschata (Pumpkin) seeds with three different polarity-based solvents (n-hexane, n-hexane-chloroform (2:1), and methanol) was analyzed to identify the biologically active compounds. Each of the extracts was analyzed by gas chromatography-mass spectrometry. Different extracts of targeted seeds showed different biologically active compounds that have different pharmacological potentialities. 9, 12-Octadecadienoic acid (ZZ) was the most potent bioactive compound present in three different extracts of both B. hispida and C. moschata. Another bioactive compound comparatively low percentage present in both plants was n-hexadecanoic acid. Other major pharmacologically active compounds present in both plants were 9-Octadecenoic acid (Z)-, methyl ester, and 9, 12-Octadecadienoic acid methyl ester (E, E). Besides these compounds, a few more biologically active compounds were present in the two plants separately. The findings of this study support the use of these seeds in modern functional foods, nutraceuticals, and medicinal purposes, and the whole seeds would give better health benefits rather than use any extract. Although further pharmacological examinations should be carried out to conclude the medicinal application of the seeds of these two plants as well as to understand the mechanism of the potential health benefits.

International Journal of Applied Pharmaceutics, 2022

The current treatment approaches for allergic rhinitis are practiced over decades, but the patien... more The current treatment approaches for allergic rhinitis are practiced over decades, but the patient quality of life has not yet changed so much. The reasons are research gaps in pathophysiology of the disease, proper management of the disease. Fexofenadine HCl is a second-generation antihistamine drug which has a half-life of about 14.4 h. It is useful in the management of common symptoms like sneezing, itchy throat, and red eyes in individuals suffering from allergic rhinitis. Fexofenadine immediate release or sustained release formulations are available in the market as suspension, tablet and capsule. In this research paper, we have discussed the symptoms associated with allergic rhinitis and treatment approaches. Fexofenadine HCl is being used for the treatment of this disease. But as it has a long half-life, we have discussed the importance of the introduction of sustained-release microsphere formulation of Fexofenadine HCl in the market.

Journal of Antioxidant Activity, 2017

The use of herbal medicine is becoming popular day by day due to toxicity and side effects of all... more The use of herbal medicine is becoming popular day by day due to toxicity and side effects of allopathic medicines. Considering the medicinal importance of the plant Murraya koenigii Linn (Curry leaf), the antioxidant activity (AC), total phenolic content (TPC), total flavonoid content (TFC), of different fractions of methanolic extract (DIA-ion resin adsorbed fraction, chloroform, Ethyl acetate and petroleum ether) of M. koenigii were investigated. Among the fractions, DIA-ion resin-adsorbed fraction showed the highest total antioxidant activity with absorbance 2.320±06 and petroleum ether fraction showed the lowest total antioxidant activity with absorbance 1.944 at 100 mg/ml concentration. The TPC were found range between 13.285 to 17.52 mg GAE/g while the highest amount of TFC recorded among the extracts was 16.65 mg CatE/g. DPPH free radical scavenging activity of different extracts of leaves was also measured where DIA-ion resin-adsorbed fraction had the highest free radical scavenging activity with IC 50 value 15.53 µg/ml. In the present study phenolic compound were found to be the predominant components in the leaves of M. koenigii indicating that they are potent antioxidant.

The present study was carried out to investigate the antidiabetic and antioxidant effect with phy... more The present study was carried out to investigate the antidiabetic and antioxidant effect with phytochemical screening of ethanol extract of Saurauia roxburghii. The ethanol extract of Saurauia roxburghii was evaluated for its antidiabetic activities in alloxan induced diabetic rats. The significant reduction in blood glucose levels of the ethanol extract at 2g/kg dose exhibited a peak effect of 53.51% using glucometer. It gives the lowering blood glucose effects. The DPPH free radical scavenging effect of the ethanol extract was compared with standard antioxidant ascorbic acid. IC 50 values were found 37.844 µg/ml for the extract and 0.661 µg/ml for ascorbic acid. The ethanol extract was screened phytochemically for its chemical components. This revealed the presence of alkaloids, carbohydrates, cardiac glycosides, flavonoids, saponins, terpenes and steroids in moderate concentration. This study shows a possible beneficial effect of Saurauia roxburghii in the management of non-insul...

International Journal of Food Properties, 2015

This study investigated the quantitative phytochemical contents, total phenolics, total flavonoid... more This study investigated the quantitative phytochemical contents, total phenolics, total flavonoids, total carotenoids, antioxidative capacity, tannin, proanthocyanidins, lycopene, chlorophyll a, and chlorophyll b of the Stephania japonica extract. Comprehensive antioxidative effects of the extract were also investigated. Quantitative assays were conducted through both spectrophotometric and high-performance liquid chromatographic methods. Antioxidative effects were measured through FeCl3 reducing power, metal chelating power, reducing power, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) scavenging activity, N, N-dimethyl-1,4-diaminobenzene free radical scavenging activity, superoxide radical scavenging activity, and nitric oxide scavenging effect. The contents of total phenolics, total flavonoids, total carotenoids, total antioxidative capacity, tannin, proanthocyanidins, lycopene, chlorophyll a, and chlorophyll b were found to be 47.32 ± 0.75 mg tannic acid equivalent, 61.41 ± 1.58 mg catechin equivalent, 63.29 ± 2.21 mg, 22.85 ± 0.70 mg ascorbic acid equivalent, 76.17 ± 0.97 mg tannic acid equivalent, 94.96 ± 4.49 mg catechin equivalent, 22.19 ± 0.79 µg, 22.19 ± 0.79 µg, 7.52 ± 1.24 mg, and 10.43 ± 2.11 mg, respectively, in 1 g of ethanol extract. A high concentration of epicatechin, p-coumaric acid, and rutin hydrate and moderate concentration of caffeic acid and quercetin was detected in the extract. The IC50 value for ferric reducing power assay, metal chelating assay, reducing power assay, ABTS scavenging assay, N, N-dimethyl-1,4-diaminobenzene scavenging assay, superoxide scavenging assay and nitric oxide (NO) assay were 465.06 ± 7.32 µmol ascorbic acid/g, 1656.52, 270.55, 457.27, 632.74, 217.5, and 464.00 µg/mL, respectively. No beta carotene was detected in the extract. The extract was demonstrated to be a very potential source of antioxidative metabolites.

African Journal of Pharmacy and Pharmacology, 2012

This study was designed to investigate the analgesic and anti-inflammatory effects of Ageratum co... more This study was designed to investigate the analgesic and anti-inflammatory effects of Ageratum conyzoides and Emilia sonchifolia alcoholic extracts in animal models. Analgesic effects have been investigated in acetic acid induced writhing model and formalin induced licking model of Swiss albino mice. Anti-inflammatory effect was investigated in carrageenan induced anti-inflammatory paw edema model of Wistar albino rat. Data were analyzed by one-way analysis of variance (ANOVA), followed by Tukey's post hoc test for multiple comparisons. In a dose-dependent response, A. conyzoides and E. sonchifolia extracts inhibited 49.85 and 39.47% of acetic acid induced pain at the highest dose 2.0 g/kg body weight (BW). These effects were statistically significant (P < 0.05) as compared to the reference drug, diclofenac sodium (40 mg/kg). A. conyzoides reduced 35.48% and E. sonchifolia reduced 38.70% of formalin induced pain by 2.0 g/kg which were also statistically significant (P < 0.05) as compared to morphine (0.5 mg/kg). In a time-dependent inhibition of carrageenan induced paw edema model, the extracts of A. conyzoides and E. sonchifolia promoted 50.23 and 48.11% inhibition of paw edema at the 4th hour of administration, respectively and the effects were statistically significant (P < 0.05). No mortality was observed in acute toxicity test. Observed results demonstrate an effective analgesic and anti-inflammatory potentials of the extracts to be used as complementary and alternative therapy.

IOSR Journal of Pharmacy and Biological Sciences, 2013

The present study was undertaken to evaluate the antidiabetic properties with phytochemical scree... more The present study was undertaken to evaluate the antidiabetic properties with phytochemical screening of the ethanol leaves extracts of two common indigenous medicinal plants of Bangladesh-Azadirachta indica (Neem) and Andrographis peniculata (Kalomegh) on experimental animal model. Hypoglycemic activity of the concentrated ethanolic (90%) extract of Azadirachta indica and Andrographis peniculata were studied compared with that of a reference antidiabetic drug glimeperide in both glucose loaded and alloxan induced diabetic rats. The acute toxicity of these two plants extract was also studied. Experimental results showed that ethanol leaves extract (1 gm/kg) of Azadirachta indica and Andrographis peniculata significantly (P<0.01) reduced the elevated blood glucose level by 36.91 % and 40.65 % respectively in glucose loaded rats and 30.20 % and 32.18 % respectively in alloxan induced diabetic rats compared to the respective diabetic control group. This study strongly suggested that ethanol leaves extracts of Azadirachta indica and Andrographis peniculata possess significant antidiabetic activity and could be a potential source for treatment of diabetes mellitus.

Journal of Scientific Research, 2011

The aim of the study was to evaluate the analgesic and anti-inflammatory effects of Clausena suff... more The aim of the study was to evaluate the analgesic and anti-inflammatory effects of Clausena suffruticosa root extract. The effect of different concentrations of ethanolic root extract were studied in animal model using acetic acid induced writhing response, formalin induced pain, hot plate method for analgesic activity in Swiss Albino mice and carrageenan induced paw edema for anti-inflammatory action in Wister Albino rat. The extract reduced writhing response 20% by 0.5g/kg, 57.6% by 1.5g/kg and 78% by 2 g/kg and showed significant analgesic activity as determined by formalin induced pain and hot plate method. In the carrageenan induced paw edema, the extract at a dose of 0.5, 1.0 and 2.0 g/kg showed the highest inhibition 17.23%, 26.30% and 42.46%, respectively, at the 4th hour of administration. The results indicate that the extract shows promising analgesic effect in chemical models of nociception (not related to the opioid system) and anti-inflammatory effect.

Bangladesh Journal of Scientific and Industrial Research, 2012

Medicinal plants like Curcuma longa, Curcuma zedoaria, Streblus asper, Enhydra fluctunas and Scop... more Medicinal plants like Curcuma longa, Curcuma zedoaria, Streblus asper, Enhydra fluctunas and Scoparia dulcis are commonly available in Bangladesh. This study investigated the effect of ethanol extracts from these five medicinal plants on the viability of Brine Shrimp larvae. The lethal concentrations (LC50 values) of the extracts were determined. LC50 values of C. longa, C. zedoaria and S. asper were less than 250?g/ml and that of E. fluctunas was greater than 250 ?g/ml. Among five plants tested, one (S. dulcis) appear to be inactive. Results indicate that C. longa, C. zedoaria and S. asper could be potential sources of bio-active compounds DOI: http://dx.doi.org/10.3329/bjsir.v47i1.10724 Bangladesh J. Sci. Ind. Res. 47(1), 133-136, 2012

Journal of Biologically Active Products from Nature, 2012

ABSTRACT Essential oil of Alpinia calcarata Rosc. rhizome was studied for anti-inflammatory and a... more ABSTRACT Essential oil of Alpinia calcarata Rosc. rhizome was studied for anti-inflammatory and anti-nociceptive effects in animal models. Anti-inflammatory effect was investigated in carrageenan-induced paw edema model in Albino rat with the doses of 100, 200 and 400 mg/kg BW. Anti-nociceptive effect was measured in acetic acid-induced pain, formalin-induced pain and thermal pain (hot plate test) models in Albino mice with the doses of 200, 400 and 600 mg/kg BW. Significant (pth min of treatment in hot plate model. Results evidenced that essential oil from Alpinia calcarata could be processed to use as an alternative source of inflammatory and nociceptive treatment.

Asian Pacific journal of tropical medicine, 2012

To investigate the antilithiatic effect of the whole Leea macrophylla (L. macrophylla) Roxb (Leea... more To investigate the antilithiatic effect of the whole Leea macrophylla (L. macrophylla) Roxb (Leeaceae) ethanol extract in ethylene glycol-induced urolithiasis model of rats. Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely: preventive (n=18) and therapeutic (n=24). Preventive group was further subdivided into 3 groups of 6 rats namely: preventive control (PC), preventive lithiatic control (PLC) and preventive lithiatic L. macrophylla (PLLM). Similarly, therapeutic group was also subdivided into 4 groups of 6 rats namely: therapeutic control (TC), therapeutic lithiatic control (TLC), therapeutic lithitatic L. macrophylla (TLLM) and therapeutic lithiatic cystone (TLCYS). The lithiasis was induced by 0.75% (v/v) ethylene glycol in the drinking water of all groups except the PC and TC groups. The urinary ionic parameters such as calcium, inorganic phosphate, oxalate, magnesium & creatinine and renal morphology were altered by ethylene ...

International Journal of Life Sciences, 2012

The hypocholesterolemic effect of the ethanol extract of Ananas comosas (Pineapple) was investiga... more The hypocholesterolemic effect of the ethanol extract of Ananas comosas (Pineapple) was investigated in 5 groups of albino rats, 7 in each group. Group I rat received only distilled water and served as normal control. Groups II, III, IV and V were made hypercholesterolemic by feeding cholesterol orally suspended in 2% cholic acid mixed soybean oil (1 ml/kg bw) at a dose of 100 mg/kg bw daily up to 60 days. Group II rat received 1 ml distilled water while animals of Group III , IV and V received ethanol extract of Ananas comosas at the dose of 1000 mg/kg, 500 mg/kg and 100 mg/kg body weight respectively daily up to 60 days in addition to cholesterol as above. At the end of 60th day animals were sacrificed and blood samples were collected for measurement of lipid profiles using enzymatic kit. Administration of cholesterol caused a significant rise (p<0.001) in the serum levels of total cholesterol, LDL-cholesterol and triglycerides. Simultaneous administration of three different d...

Bangladesh Journal of Pharmacology, 2009

The ethanolic bark extract of Mitragyna diversifolia showed significant (p<0.05) antidiarrheal ac... more The ethanolic bark extract of Mitragyna diversifolia showed significant (p<0.05) antidiarrheal activity on gastrointestinal motility with barium sulfate milk model and castor oil-induced diarrheal model in rats. These results revealed that the bark extract possess pharmacological activity against diarrhea and may possibly explain the use of the plant in traditional medicine.

Bangladesh Journal of Scientific and Industrial Research, 2009

The present study was carried out to investigate the anti-inflammatory, antinociceptive and antip... more The present study was carried out to investigate the anti-inflammatory, antinociceptive and antipyretic activities of the crude ethanol extract of Azadirachta indica leaves on experimental animal model at three different dose level- 1g/kg, 500 mg/kg and 100 mg/kg. For evaluation of the anti-inflammatory property carrageenan induced paw edema served as acute model and cotton pellet induced granuloma formation served as chronic model in rats. The acetic acid induced writhing response and hot plate test were used to assess antinociceptive activity in mice. The antipyretic activity was evaluated on yeast-induced pyrexia in rats. Acute toxicity test was also performed in rats after administration of the extract orally at high dose level (4g/kg). Oral administration of the ethanol extract of A. indica leaves significantly (P<0.05) suppressed the paw edema induced by carrageenan as well as granulomatous tissue formation induced by cotton pellet in rats at high dose level (1g/kg) but no ...

Bangladesh Journal of Microbiology, 2012

Antibacterial effect of Crinum asiaticum bulb extract (1mg/disc) was tested on four Gram- positiv... more Antibacterial effect of Crinum asiaticum bulb extract (1mg/disc) was tested on four Gram- positive and six Gram-negative bacteria by disc diffusion method using kanamycin (30 ìg/disc) as standard antibiotic disc. The bulb extract (250-1000mg/disc) showed significant zone of inhibition against all Gram-positive and Gram-negative bacteria ranging from 12-14 mm in diameter. Antioxidant potential of the same extract was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging method. The extract showed remarkable free radical scavenging effect (95.96%) providing the IC50 value of 5.62 for the bulb extract and 5.46 for ascorbic acid (standard antioxidant) at the concentration of 1000 ìg/ml. The bulb extract was found to be (LC50 value 94.06 ?g/ml) in Brine-Shrimp lethality test. DOI: http://dx.doi.org/10.3329/bjm.v28i1.11801 Bangladesh J Microbiol, Volume 28, Number 1, June 2011, pp 1-5

Int J Biol Med …, 2010

This study was subjected to investigate antioxidant, cytotoxic and antimicrobial (antibacterial a... more This study was subjected to investigate antioxidant, cytotoxic and antimicrobial (antibacterial and antifungal) properties of Eclipta alba ethanol extract. The antioxidant and cytotoxic properties of the extract were assessed by DPPH free radical scavenging method and brine shrimp ...

1, 2,3,4,5,6,8,9,10 Bangladesh Council of Scientific & Industrial Research (BCSIR) Laboratories R... more 1, 2,3,4,5,6,8,9,10 Bangladesh Council of Scientific & Industrial Research (BCSIR) Laboratories Rajshahi, Binodpur, Rajshahi6206 7 Designated Reference Institute for Chemical Measurements (DRiCM), BCSIR, Dr. Qudrat-i-Khuda Road, Dhanmondi, Dhaka-1205.,of Bangladesh Council of Scientific & Industrial Research (BCSIR) *Correspondence to: Md. Abdul Khaleque, Fibre and Polymer Research Division, Bangladesh Council of Scientific & Industrial Research (BCSIR) Laboratories Rajshahi, Binodpur, Rajshahi-6206, E-mail: khalequebcsirraj@gmail.com, Mob:+88-01718280108, Pho:+880721750757, :+880721750851, Fax:+88-0721750851