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Papers by Nensi Lalic

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

To compare Nd: YAG laser resection with Nd: YAG laser plus brachytherapy and external beam radiot... more To compare Nd: YAG laser resection with Nd: YAG laser plus brachytherapy and external beam radiotherapy (EBRT) in the palliation of malignant central airway obstruction symptoms due to lung cancer. In this prospective non-randomized study we evaluated the effects of Nd:YAG laser photoresection alone vs. Nd:YAG laser resection in combination with brachytherapy and EBRT on cough, dyspnoea, thoracic pain, haemoptysis, body weight loss, atelectasis, postobstructive pneumonia, endoscopic findings, disease-free period and survival rate in lung cancer patients. Only patients with Karnofsky index (KI) < or =50 were included. Sixty-four patients were divided into 2 groups: group I patients ( = 20) were treated only with Nd: YAG laser, and group II patients (n = 44) were treated with Nd: YAG laser followed by brachytherapy and EBRT. Group I patients showed statistically significant improvement in all investigated parameters but cough. Group II patients achieved significant improvement in a...

The Journal of Infection in Developing Countries

Introduction: In October 2022, after almost two years, tuberculosis reclaimed its first place as ... more Introduction: In October 2022, after almost two years, tuberculosis reclaimed its first place as the world's deadliest infectious disease, replacing COVID-19. Since knowledge is the most powerful tool to combat any disease, the primary goal of our study was to assess patients' knowledge of tuberculosis and its relationship to their socio-demographic status. Methodology: This cross-sectional study included 1,067 respiratory patients who were surveyed between November 2021 and June 2022 at the Institute for Pulmonary Diseases of Vojvodina (Serbia). They completed a questionnaire designed for this study. Results: The majority of patients (53.7%) were female; over two-thirds (70.8%) were ≥ 60 years; every fifth (23.2%) was either with or without primary school; every third (33.3%) was financially poor. Although the majority of patients (97.8%) were aware that tuberculosis is an infectious disease, only 44.2% knew the etiology. Around 3/4 (72.6%) were aware of a tuberculosis vacc...

Medicina

Background and Objectives: Treatment of advanced lung cancer (LC) has become increasingly persona... more Background and Objectives: Treatment of advanced lung cancer (LC) has become increasingly personalized over the past decade due to an improved understanding of tumor molecular biology and antitumor immunity. The main task of a pulmonologist oncologist is to establish a tumor diagnosis and, ideally, to confirm the stage of the disease with the least invasive technique possible. Materials and Methods: The paper will summarize published reviews and original papers, as well as published clinical studies and case reports, which studied the role and compared the methods of invasive pulmonology diagnostics to obtain adequate tumor tissue samples for molecular analysis, thereby determining the most effective molecular treatments. Results: Bronchoscopy is often recommended as the initial diagnostic procedure for LC. If the tumor is endoscopically visible, the biopsy sample is susceptible to molecular testing, the same as tumor tissue samples obtained from surgical resection and mediastinosco...

Medicina

Background and Objectives: Reducing time of treatment during COVID-19 outbreaks has been recommen... more Background and Objectives: Reducing time of treatment during COVID-19 outbreaks has been recommended by the leading Radiation Oncology societies. Still minimizing radiation induced tissue toxicity is one of the most important issues in breast cancer patients. The study aimed to investigate compliance, clinical and dosimetry normal tissue toxicity, and cosmetic results between moderated and ultra-fractionated regimes for breast cancer patients during COVID-19 pandemic. Materials and Methods: This pilot prospective randomized study included 60 patients with early breast cancer after preserving surgery, 27 patients advocated to ultra-hypofractionated whole-breast three dimensional (3D) conformal radiotherapy of 26 Gy in 5 fractions over 1 week and 33 patients with moderate fractionated breast 3D conformal radiotherapy patients between March 2020 and July 2020, during the COVID pandemic outbreak. The compliance to treatment, dosimetric parameters, acute and late skin toxicity, subcutane...

Hui D et al. Impact of timing and setting of palliative care referral on quality of end-of-life c... more Hui D et al. Impact of timing and setting of palliative care referral on quality of end-of-life care in cancer patients, 2014

Medicinski pregled, 2018

Introduction. Determinants of asthma and its clinical course include the interaction between vari... more Introduction. Determinants of asthma and its clinical course include the interaction between various intrinsic and extrinsic factors, of which exposure to harmful tobacco particles is one of the most important preventable causes of increased morbidity and mortality related to asthma. However, it is surprising that the prevalence of cigarette smoking among patients with asthma is equivalent to prevalence among the general population. Smoking as a Risk Factor for Development of Asthma. Exposure to tobacco smoke stimulates the immune response that can co-occur with asthma, lead to the development of bronchial hyperactivity and chronic inflammation of the respiratory tract, thus favoring the onset of asthma during childhood, as well as adulthood. Asthma Control in Relation to Smoking Habits. Continuous exposure to noxious particles of tobacco smoke, dysfunction of small airways as well as an altered inflammatory response result in irreversible changes. The worsening symptoms and signs of illness can easily remain unnoticed since they develop gradually, so the patients are often unaware of the severity of illness. The Prevalence of Asthma Symptoms Among Smokers. Compared to non-smokers, smokers have more prevalent and severe symptoms at all stages of disease, which is usually related to body weight and overall duration of smoking. Cigarette Smoking as a Risk Factor for Asthma Exacerbation. Current and former smokers are almost twice as likely to have asthma exacerbations and frequent relapses over a short period of time which increases the risk of requiring intensive care treatment The Effect of Smoking on Lung Function. Reduced airway sensitivity to the application of standardized inhalation therapy and the need for additional medications to achieve disease control can lead to irreversible changes and the development of fixed bronchial obstruction.

American Journal of Roentgenology, 2006

OBJECTIVE. The purpose of our study was to evaluate clinical findings and sonographic features of... more OBJECTIVE. The purpose of our study was to evaluate clinical findings and sonographic features of abdominal wall endometriosis and also to report its CT and MR appearance. MATERIALS AND METHODS. A computerized search of our institution's database over a 5-year period was performed, yielding 12 surgically proven cases of abdominal wall endometriosis that were retrospectively studied. All patients had undergone sonography including power Doppler examination. Additional CT was performed in one patient and MRI in four. Pathologic material was preoperatively obtained by sonographically guided puncture in six patients. The clinical data were analyzed, and the imaging studies were reviewed by two radiologists working in consensus. RESULTS. All patients had a history of at least one prior cesarean section. All presented with focal pain near the surgical scar, which was cyclic in three patients. Nine patients presented with a palpable mass near the scar. Sonography detected 11 lesions within the abdominal wall, with a mean diameter of 25 mm. All lesions were hypoechoic, vascular, and solid, with some cystic changes in one. The calculated frequency of abdominal wall endometriosis is approximately 0.8% of all women who had a cesarean delivery. CONCLUSION. Abdominal wall endometriosis frequently presents with noncyclic symptoms. Imaging findings of a solid mass near a cesarean section scar strongly suggest its diagnosis.

Srpski arhiv za celokupno lekarstvo

Introduction. Lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis are the most c... more Introduction. Lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis are the most common pulmonary cystic diseases. Although they differ in pathogenesis, they share several features. The aim of this paper is to present the similarities and differences between these diseases, as well as to describe two cases from our practice. Outlines of cases. The patient with lymphangioleiomyomatosis (43 years old) had pulmonary changes detected during a regular examination within the underlying disease ? tuberous sclerosis. Four years after starting therapy with everolimus, she was still respiratory asymptomatic, a slight radiological deterioration of cystic changes was registered, the diffusion capacity was declining (by 12%). The second patient (23 years old) was admitted due to bilateral radiological lung changes and symptoms in the form of dry cough, quick fatigue, and chest pain. Pathohistological examination of the transbronchial biopsy showed numerous large-core histiocytes, ...

Background Narrow Band Imaging (NBI) videobronchoscopy is a new technique for visualization of mi... more Background Narrow Band Imaging (NBI) videobronchoscopy is a new technique for visualization of microvascular changes in bronchial mucosa. The primary aim of this study was to evaluate relation between vascular patterns visualized by NBI and histology of lung cancer.

Journal of Thoracic Disease, 2012

In recent years rapid development of technology led to the increase in number of interventional b... more In recent years rapid development of technology led to the increase in number of interventional bronchology techniques available for use in respiratory endoscopy units (REU). Many of techniques are not readily available for routine use in bronchology, however their appliance significantly increases diagnostic and therapeutic efficacy of bronchoscopy. Among diagnostic interventional bronchoscopy techniques recently advanced in REU of the Institute for pulmonary diseases of Vojvodina most facilitating are autofluorescence videobronchoscopy (AFI), narrow band imaging videobronchoscopy (NBI), radial and linear endobronchial ultrasound (EBUS). In recent years REU team published several significant clinical trials in domain of AFI, NBI and EBUS. These techniques became routine diagnostic tools for detection of lung cancer, tuberculosis, sarcoidosis, and other respiratory disorders. Therapeutic interventional bronchoscopy techniques routinely used in treatment of malignant and non-malignan...

Journal of Thoracic Disease, 2012

Lung cancer is not any more on the first place regarding incidence in some countries among malign... more Lung cancer is not any more on the first place regarding incidence in some countries among malignant diseases, but is still the leading cause of death. Also, it is notable that incidence of lung cancer among men in some West European and Scandinavian countries is decreasing. Unfortunately, in other countries, especially in Southeast European countries, age-adjusted rate for men is still increasing, or at least, has been reached a plateau. Even worse situation is among female in this region, with constant incidence increase. The proportion of adenocarcinoma has been increasing over time. In Vojvodina, the northern part of Serbia, all of this mentioned changes has been noticed: adenocarcinoma is leading type of lung cancer nowadays, overcoming squamous cell carcinoma also among men, number of lung cancer among female is increasing, reaching the rate men to women 2.7:1, the number of nonsmokers is slightly increasing among male patients with adenocarcinoma, and notable among female pat...

Srpski arhiv za celokupno lekarstvo, 2021

Introduction/Objective. Chronic obstructive pulmonary disease (COPD) is a primary lung disease. T... more Introduction/Objective. Chronic obstructive pulmonary disease (COPD) is a primary lung disease. Today, pulmonary rehabilitation (PR) is the basis for non-pharmacological treatment of these patients, with numerous confirmed effects on the most significant symptoms of the disease and the quality of life (QoL). The aim of this study was to determine the relationship between certain risk factors and the outcome of PR, as well as to determine the percentage of respondents who had a positive outcome of PR. Methods. The study included 500 patients with COPD, determined according to the Global Initiative for Chronic Obstructive Lung Disease guidelines, all stages (I?IV), in the stable phase of the disease, who completed the outpatient PR program. Disease stage, comorbidities, forced expiratory volume in the first second, six-minute walk test (6MWT), COPD Assessment Test (CAT), and Medical Research Council dyspnea scale, body mass index, airflow obstruction, dyspnea and exercise capacity (BO...

Medical review, 2018

Percutaneous tracheostomy is a commonly carried out procedure in patients in the Intensive Care U... more Percutaneous tracheostomy is a commonly carried out procedure in patients in the Intensive Care Unit. Percutaneous dilatational tracheostomy consists of the introduction of a tracheal cannula from the front of the neck, through blunt dissection of the pretracheal tissues, using a guide by Seldinger technique. When percutaneous dilatational tracheostomy procedure was introduced in routine clinical practice in the Clinical Center of Vojvodina, procedural protocol was established. This Protocol includes: 1. indications, contraindications and timing for percutaneous dilatational tracheostomy, 2. assessment of the patient, 3. preparation of the patient and equipment, 4. procedure description, 5. potential complications and complication management. At our institution percutaneous dilatational tracheostomy is performed on an individual patient basis assessment within 5-7 days following translaryngeal intubation. Routinely the platelet count, activated prothrombin time and prothrombin time ...

Medical review, 2018

Introduction. Complementary and alternative medicine is used more and more in the communities but... more Introduction. Complementary and alternative medicine is used more and more in the communities but there are differences in attitudes, beliefs and knowledge about it among and within different medical professions. The aims of this study are to determine the attitude of nurses and medical technicians towards methods of complementary and alternative medicine and to determine the levels of personal use and willingness to recommend their patients methods of complementary and alternative medicine that have been adopted by the Health Ministry of the Republic of Serbia. Material and Methods. The research included 126 nurses and technicians. The survey was conducted at the General Hospital in Subotica. The Complementary and alternative medicine Health Belief Questionnaire was used to determine the attitudes of nurses and technicians towards complementary and alternative medicine. A custom questionnaire was designed for this study in order to determine the willingness to recommend complementa...

Medical review, 2018

Introduction. Healthcare workers should check if an oncology patient would like to be visited by ... more Introduction. Healthcare workers should check if an oncology patient would like to be visited by a priest and if there are any religious rituals that would ease the treatment and eliminate the stress of people close to them. The aims of study have been to check if a lung cancer patient requires help from a priest during palliative oncological treatment and if a team for palliative care requires the presence of a priest. Material and Methods. The study included 200 lung cancer patients treated between 2015 and 2017 at the Institute for Pulmonary Diseases of Vojvodina. The sample was divided into two groups: patients with I, II, IIIA stage of carcinoma and the other with stadium of IIIB and IV. The research was performed by using a questionnaire to be completed by the patients. Results. A statistical significance was determined for the question ?Do you think that the priest can participate in your treatment?? The percentage of male and female patients who answered positively was 38.9%...

Srpski arhiv za celokupno lekarstvo, 2019

Introduction/Objective. The chronic obstructive pulmonary disease (COPD) exacerbations have a maj... more Introduction/Objective. The chronic obstructive pulmonary disease (COPD) exacerbations have a major impact on outcomes of COPD patients. Pulmonary rehabilitation (PR) interrupts the vicious circle caused by exacerbations. It has not been widely implemented as standard of COPD treatment yet. The aim of study was to examine the effectiveness of PR in prevention of exacerbations. Method. The prospective observation study included stable COPD patients between January 2015 and December 2018. The effects of PR on exacerbation rates were evaluated using univariate and multivariate logistic regression analysis, taking into account age, comorbidity, vaccination status (against seasonal flu), body mass index (BMI). Results. Study included 1,674 patients (956 males, age 65.93 ?} 8.45, current or ex-smokers 94.9%; 21 ? BMI 1,406 patients, 84%, FEV1 < 80% 1,448 patients, 86.5%). The PR rate was 48.1%. There was significant difference in PR status with respect to age (p = 0.020), comorbidities...

Srpski arhiv za celokupno lekarstvo, 2019

Introduction/Objective. Breast cancer surgery is associated with the risk of developing functiona... more Introduction/Objective. Breast cancer surgery is associated with the risk of developing functional constraints that may negatively affect the quality of patients? lives. The objective of the study was to determine the impact of early postoperative exercises three months after surgery on functional recovery and the quality of life of patients who were operated on. Methods. A group of 149 patients was tested, divided by the type of surgery into two groups. The assessment of the quality of life by the SF-36 questionnaire and functional testing were done three months after surgery; the extent of movement in the shoulder joint and of the limbs was measured as well. Results. On basic measurements of the quality of life, the average results of SF-36 showed the highest values in the domain of physical functioning, while the lowest value was in the vitality and energy domain. After the realized rehabilitation activities, the results of the SF-36 questionnaire indicated the increase in all do...

Srpski arhiv za celokupno lekarstvo, 2019

Introduction. Lung carcinoids are considered a rare and uncommon group of lung tumors, making abo... more Introduction. Lung carcinoids are considered a rare and uncommon group of lung tumors, making about 1% of all primary lung tumors. Atypical carcinoids are more aggressive than typical ones, with higher metastatic potential and worse prognosis and a 10-year survival rate of less than 60%. Case outline. In 2012, a 61-year-old male underwent the right lower lobectomy and the histopathological finding was an atypical lung carcinoid tumor. At the beginning of 2016, radiological and bronchoscopic progression of the disease was reported. Magnetic resonance imaging revealed enhanced nodular lesions compatible with liver metastases. The patient received endoluminal brachytherapy. Subsequently, the first line chemotherapy according to the cisplatin/etoposide (PE) protocol was applied. In August 2016, the somatostatin receptor scintigraphy (SRS) revealed secondary deposits with somatostatin receptor (SR) expression in the liver and lungs. The treatment with lanreotide injections was initiated....

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

To compare Nd: YAG laser resection with Nd: YAG laser plus brachytherapy and external beam radiot... more To compare Nd: YAG laser resection with Nd: YAG laser plus brachytherapy and external beam radiotherapy (EBRT) in the palliation of malignant central airway obstruction symptoms due to lung cancer. In this prospective non-randomized study we evaluated the effects of Nd:YAG laser photoresection alone vs. Nd:YAG laser resection in combination with brachytherapy and EBRT on cough, dyspnoea, thoracic pain, haemoptysis, body weight loss, atelectasis, postobstructive pneumonia, endoscopic findings, disease-free period and survival rate in lung cancer patients. Only patients with Karnofsky index (KI) < or =50 were included. Sixty-four patients were divided into 2 groups: group I patients ( = 20) were treated only with Nd: YAG laser, and group II patients (n = 44) were treated with Nd: YAG laser followed by brachytherapy and EBRT. Group I patients showed statistically significant improvement in all investigated parameters but cough. Group II patients achieved significant improvement in a...

The Journal of Infection in Developing Countries

Introduction: In October 2022, after almost two years, tuberculosis reclaimed its first place as ... more Introduction: In October 2022, after almost two years, tuberculosis reclaimed its first place as the world's deadliest infectious disease, replacing COVID-19. Since knowledge is the most powerful tool to combat any disease, the primary goal of our study was to assess patients' knowledge of tuberculosis and its relationship to their socio-demographic status. Methodology: This cross-sectional study included 1,067 respiratory patients who were surveyed between November 2021 and June 2022 at the Institute for Pulmonary Diseases of Vojvodina (Serbia). They completed a questionnaire designed for this study. Results: The majority of patients (53.7%) were female; over two-thirds (70.8%) were ≥ 60 years; every fifth (23.2%) was either with or without primary school; every third (33.3%) was financially poor. Although the majority of patients (97.8%) were aware that tuberculosis is an infectious disease, only 44.2% knew the etiology. Around 3/4 (72.6%) were aware of a tuberculosis vacc...

Medicina

Background and Objectives: Treatment of advanced lung cancer (LC) has become increasingly persona... more Background and Objectives: Treatment of advanced lung cancer (LC) has become increasingly personalized over the past decade due to an improved understanding of tumor molecular biology and antitumor immunity. The main task of a pulmonologist oncologist is to establish a tumor diagnosis and, ideally, to confirm the stage of the disease with the least invasive technique possible. Materials and Methods: The paper will summarize published reviews and original papers, as well as published clinical studies and case reports, which studied the role and compared the methods of invasive pulmonology diagnostics to obtain adequate tumor tissue samples for molecular analysis, thereby determining the most effective molecular treatments. Results: Bronchoscopy is often recommended as the initial diagnostic procedure for LC. If the tumor is endoscopically visible, the biopsy sample is susceptible to molecular testing, the same as tumor tissue samples obtained from surgical resection and mediastinosco...

Medicina

Background and Objectives: Reducing time of treatment during COVID-19 outbreaks has been recommen... more Background and Objectives: Reducing time of treatment during COVID-19 outbreaks has been recommended by the leading Radiation Oncology societies. Still minimizing radiation induced tissue toxicity is one of the most important issues in breast cancer patients. The study aimed to investigate compliance, clinical and dosimetry normal tissue toxicity, and cosmetic results between moderated and ultra-fractionated regimes for breast cancer patients during COVID-19 pandemic. Materials and Methods: This pilot prospective randomized study included 60 patients with early breast cancer after preserving surgery, 27 patients advocated to ultra-hypofractionated whole-breast three dimensional (3D) conformal radiotherapy of 26 Gy in 5 fractions over 1 week and 33 patients with moderate fractionated breast 3D conformal radiotherapy patients between March 2020 and July 2020, during the COVID pandemic outbreak. The compliance to treatment, dosimetric parameters, acute and late skin toxicity, subcutane...

Hui D et al. Impact of timing and setting of palliative care referral on quality of end-of-life c... more Hui D et al. Impact of timing and setting of palliative care referral on quality of end-of-life care in cancer patients, 2014

Medicinski pregled, 2018

Introduction. Determinants of asthma and its clinical course include the interaction between vari... more Introduction. Determinants of asthma and its clinical course include the interaction between various intrinsic and extrinsic factors, of which exposure to harmful tobacco particles is one of the most important preventable causes of increased morbidity and mortality related to asthma. However, it is surprising that the prevalence of cigarette smoking among patients with asthma is equivalent to prevalence among the general population. Smoking as a Risk Factor for Development of Asthma. Exposure to tobacco smoke stimulates the immune response that can co-occur with asthma, lead to the development of bronchial hyperactivity and chronic inflammation of the respiratory tract, thus favoring the onset of asthma during childhood, as well as adulthood. Asthma Control in Relation to Smoking Habits. Continuous exposure to noxious particles of tobacco smoke, dysfunction of small airways as well as an altered inflammatory response result in irreversible changes. The worsening symptoms and signs of illness can easily remain unnoticed since they develop gradually, so the patients are often unaware of the severity of illness. The Prevalence of Asthma Symptoms Among Smokers. Compared to non-smokers, smokers have more prevalent and severe symptoms at all stages of disease, which is usually related to body weight and overall duration of smoking. Cigarette Smoking as a Risk Factor for Asthma Exacerbation. Current and former smokers are almost twice as likely to have asthma exacerbations and frequent relapses over a short period of time which increases the risk of requiring intensive care treatment The Effect of Smoking on Lung Function. Reduced airway sensitivity to the application of standardized inhalation therapy and the need for additional medications to achieve disease control can lead to irreversible changes and the development of fixed bronchial obstruction.

American Journal of Roentgenology, 2006

OBJECTIVE. The purpose of our study was to evaluate clinical findings and sonographic features of... more OBJECTIVE. The purpose of our study was to evaluate clinical findings and sonographic features of abdominal wall endometriosis and also to report its CT and MR appearance. MATERIALS AND METHODS. A computerized search of our institution's database over a 5-year period was performed, yielding 12 surgically proven cases of abdominal wall endometriosis that were retrospectively studied. All patients had undergone sonography including power Doppler examination. Additional CT was performed in one patient and MRI in four. Pathologic material was preoperatively obtained by sonographically guided puncture in six patients. The clinical data were analyzed, and the imaging studies were reviewed by two radiologists working in consensus. RESULTS. All patients had a history of at least one prior cesarean section. All presented with focal pain near the surgical scar, which was cyclic in three patients. Nine patients presented with a palpable mass near the scar. Sonography detected 11 lesions within the abdominal wall, with a mean diameter of 25 mm. All lesions were hypoechoic, vascular, and solid, with some cystic changes in one. The calculated frequency of abdominal wall endometriosis is approximately 0.8% of all women who had a cesarean delivery. CONCLUSION. Abdominal wall endometriosis frequently presents with noncyclic symptoms. Imaging findings of a solid mass near a cesarean section scar strongly suggest its diagnosis.

Srpski arhiv za celokupno lekarstvo

Introduction. Lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis are the most c... more Introduction. Lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis are the most common pulmonary cystic diseases. Although they differ in pathogenesis, they share several features. The aim of this paper is to present the similarities and differences between these diseases, as well as to describe two cases from our practice. Outlines of cases. The patient with lymphangioleiomyomatosis (43 years old) had pulmonary changes detected during a regular examination within the underlying disease ? tuberous sclerosis. Four years after starting therapy with everolimus, she was still respiratory asymptomatic, a slight radiological deterioration of cystic changes was registered, the diffusion capacity was declining (by 12%). The second patient (23 years old) was admitted due to bilateral radiological lung changes and symptoms in the form of dry cough, quick fatigue, and chest pain. Pathohistological examination of the transbronchial biopsy showed numerous large-core histiocytes, ...

Background Narrow Band Imaging (NBI) videobronchoscopy is a new technique for visualization of mi... more Background Narrow Band Imaging (NBI) videobronchoscopy is a new technique for visualization of microvascular changes in bronchial mucosa. The primary aim of this study was to evaluate relation between vascular patterns visualized by NBI and histology of lung cancer.

Journal of Thoracic Disease, 2012

In recent years rapid development of technology led to the increase in number of interventional b... more In recent years rapid development of technology led to the increase in number of interventional bronchology techniques available for use in respiratory endoscopy units (REU). Many of techniques are not readily available for routine use in bronchology, however their appliance significantly increases diagnostic and therapeutic efficacy of bronchoscopy. Among diagnostic interventional bronchoscopy techniques recently advanced in REU of the Institute for pulmonary diseases of Vojvodina most facilitating are autofluorescence videobronchoscopy (AFI), narrow band imaging videobronchoscopy (NBI), radial and linear endobronchial ultrasound (EBUS). In recent years REU team published several significant clinical trials in domain of AFI, NBI and EBUS. These techniques became routine diagnostic tools for detection of lung cancer, tuberculosis, sarcoidosis, and other respiratory disorders. Therapeutic interventional bronchoscopy techniques routinely used in treatment of malignant and non-malignan...

Journal of Thoracic Disease, 2012

Lung cancer is not any more on the first place regarding incidence in some countries among malign... more Lung cancer is not any more on the first place regarding incidence in some countries among malignant diseases, but is still the leading cause of death. Also, it is notable that incidence of lung cancer among men in some West European and Scandinavian countries is decreasing. Unfortunately, in other countries, especially in Southeast European countries, age-adjusted rate for men is still increasing, or at least, has been reached a plateau. Even worse situation is among female in this region, with constant incidence increase. The proportion of adenocarcinoma has been increasing over time. In Vojvodina, the northern part of Serbia, all of this mentioned changes has been noticed: adenocarcinoma is leading type of lung cancer nowadays, overcoming squamous cell carcinoma also among men, number of lung cancer among female is increasing, reaching the rate men to women 2.7:1, the number of nonsmokers is slightly increasing among male patients with adenocarcinoma, and notable among female pat...

Srpski arhiv za celokupno lekarstvo, 2021

Introduction/Objective. Chronic obstructive pulmonary disease (COPD) is a primary lung disease. T... more Introduction/Objective. Chronic obstructive pulmonary disease (COPD) is a primary lung disease. Today, pulmonary rehabilitation (PR) is the basis for non-pharmacological treatment of these patients, with numerous confirmed effects on the most significant symptoms of the disease and the quality of life (QoL). The aim of this study was to determine the relationship between certain risk factors and the outcome of PR, as well as to determine the percentage of respondents who had a positive outcome of PR. Methods. The study included 500 patients with COPD, determined according to the Global Initiative for Chronic Obstructive Lung Disease guidelines, all stages (I?IV), in the stable phase of the disease, who completed the outpatient PR program. Disease stage, comorbidities, forced expiratory volume in the first second, six-minute walk test (6MWT), COPD Assessment Test (CAT), and Medical Research Council dyspnea scale, body mass index, airflow obstruction, dyspnea and exercise capacity (BO...

Medical review, 2018

Percutaneous tracheostomy is a commonly carried out procedure in patients in the Intensive Care U... more Percutaneous tracheostomy is a commonly carried out procedure in patients in the Intensive Care Unit. Percutaneous dilatational tracheostomy consists of the introduction of a tracheal cannula from the front of the neck, through blunt dissection of the pretracheal tissues, using a guide by Seldinger technique. When percutaneous dilatational tracheostomy procedure was introduced in routine clinical practice in the Clinical Center of Vojvodina, procedural protocol was established. This Protocol includes: 1. indications, contraindications and timing for percutaneous dilatational tracheostomy, 2. assessment of the patient, 3. preparation of the patient and equipment, 4. procedure description, 5. potential complications and complication management. At our institution percutaneous dilatational tracheostomy is performed on an individual patient basis assessment within 5-7 days following translaryngeal intubation. Routinely the platelet count, activated prothrombin time and prothrombin time ...

Medical review, 2018

Introduction. Complementary and alternative medicine is used more and more in the communities but... more Introduction. Complementary and alternative medicine is used more and more in the communities but there are differences in attitudes, beliefs and knowledge about it among and within different medical professions. The aims of this study are to determine the attitude of nurses and medical technicians towards methods of complementary and alternative medicine and to determine the levels of personal use and willingness to recommend their patients methods of complementary and alternative medicine that have been adopted by the Health Ministry of the Republic of Serbia. Material and Methods. The research included 126 nurses and technicians. The survey was conducted at the General Hospital in Subotica. The Complementary and alternative medicine Health Belief Questionnaire was used to determine the attitudes of nurses and technicians towards complementary and alternative medicine. A custom questionnaire was designed for this study in order to determine the willingness to recommend complementa...

Medical review, 2018

Introduction. Healthcare workers should check if an oncology patient would like to be visited by ... more Introduction. Healthcare workers should check if an oncology patient would like to be visited by a priest and if there are any religious rituals that would ease the treatment and eliminate the stress of people close to them. The aims of study have been to check if a lung cancer patient requires help from a priest during palliative oncological treatment and if a team for palliative care requires the presence of a priest. Material and Methods. The study included 200 lung cancer patients treated between 2015 and 2017 at the Institute for Pulmonary Diseases of Vojvodina. The sample was divided into two groups: patients with I, II, IIIA stage of carcinoma and the other with stadium of IIIB and IV. The research was performed by using a questionnaire to be completed by the patients. Results. A statistical significance was determined for the question ?Do you think that the priest can participate in your treatment?? The percentage of male and female patients who answered positively was 38.9%...

Srpski arhiv za celokupno lekarstvo, 2019

Introduction/Objective. The chronic obstructive pulmonary disease (COPD) exacerbations have a maj... more Introduction/Objective. The chronic obstructive pulmonary disease (COPD) exacerbations have a major impact on outcomes of COPD patients. Pulmonary rehabilitation (PR) interrupts the vicious circle caused by exacerbations. It has not been widely implemented as standard of COPD treatment yet. The aim of study was to examine the effectiveness of PR in prevention of exacerbations. Method. The prospective observation study included stable COPD patients between January 2015 and December 2018. The effects of PR on exacerbation rates were evaluated using univariate and multivariate logistic regression analysis, taking into account age, comorbidity, vaccination status (against seasonal flu), body mass index (BMI). Results. Study included 1,674 patients (956 males, age 65.93 ?} 8.45, current or ex-smokers 94.9%; 21 ? BMI 1,406 patients, 84%, FEV1 < 80% 1,448 patients, 86.5%). The PR rate was 48.1%. There was significant difference in PR status with respect to age (p = 0.020), comorbidities...

Srpski arhiv za celokupno lekarstvo, 2019

Introduction/Objective. Breast cancer surgery is associated with the risk of developing functiona... more Introduction/Objective. Breast cancer surgery is associated with the risk of developing functional constraints that may negatively affect the quality of patients? lives. The objective of the study was to determine the impact of early postoperative exercises three months after surgery on functional recovery and the quality of life of patients who were operated on. Methods. A group of 149 patients was tested, divided by the type of surgery into two groups. The assessment of the quality of life by the SF-36 questionnaire and functional testing were done three months after surgery; the extent of movement in the shoulder joint and of the limbs was measured as well. Results. On basic measurements of the quality of life, the average results of SF-36 showed the highest values in the domain of physical functioning, while the lowest value was in the vitality and energy domain. After the realized rehabilitation activities, the results of the SF-36 questionnaire indicated the increase in all do...

Srpski arhiv za celokupno lekarstvo, 2019

Introduction. Lung carcinoids are considered a rare and uncommon group of lung tumors, making abo... more Introduction. Lung carcinoids are considered a rare and uncommon group of lung tumors, making about 1% of all primary lung tumors. Atypical carcinoids are more aggressive than typical ones, with higher metastatic potential and worse prognosis and a 10-year survival rate of less than 60%. Case outline. In 2012, a 61-year-old male underwent the right lower lobectomy and the histopathological finding was an atypical lung carcinoid tumor. At the beginning of 2016, radiological and bronchoscopic progression of the disease was reported. Magnetic resonance imaging revealed enhanced nodular lesions compatible with liver metastases. The patient received endoluminal brachytherapy. Subsequently, the first line chemotherapy according to the cisplatin/etoposide (PE) protocol was applied. In August 2016, the somatostatin receptor scintigraphy (SRS) revealed secondary deposits with somatostatin receptor (SR) expression in the liver and lungs. The treatment with lanreotide injections was initiated....