A. Neria - Academia.edu (original) (raw)
Papers by A. Neria
Veterinary Immunology and Immunopathology, 1992
Brenner, J., Neria, A., Askenazy, G., Paz, R., Meirom, R., Ungar-Waron, H. and Trainin, Z., 1992.... more Brenner, J., Neria, A., Askenazy, G., Paz, R., Meirom, R., Ungar-Waron, H. and Trainin, Z., 1992. A lactogenic-immune-deficiency-syndrome in cows: unexplained phenomenon. Vet. lmmunol. Immunopathol., The majority of adult cows in a certain dairy herd, were found to have very low levels of immunoglobulins (Igs) in their colostrum. This phenomenon was defined by us as Lactogenic-lmmune-Deficiency-Syndrome (LIDS). The mean IgG levels were 44.5 and 57.2 mg ml-~ respectively (on two different occasions) as compared to that of a control group which was 103.4 mg ml-~. The levels of lgs in the colostra of heifers from the same herd were found to be higher than those of adult cows. The degree of LIDS was found to be closely related to the age of cows in the herd. The low levels of lgs in the colostra were not directly linked to their concentrations in the sera of the affected cows. The relatively low amount of lgA in the affected colostra suggests that the local production in the lymph tissue associated with the mammary glands is impaired as well.
Blood, 2009
Since the earliest days of the HIV epidemic, the number of CD4(+) T cells per unit volume of bloo... more Since the earliest days of the HIV epidemic, the number of CD4(+) T cells per unit volume of blood has been recognized as a major prognostic factor for the development of AIDS in persons with HIV infection. It has also been generally accepted that approximately 2% of total body lymphocytes circulate in the blood. In the present study, we have used a nondepleting humanized anti-CD4 monoclonal antibody labeled with the gamma emitter indium-111 to visualize the CD4(+) T-cell pool in vivo in nonhuman primates with simian HIV infection. A strong correlation was noted between radiotracer uptake in spleen, tonsil, axillary lymph nodes, and peripheral blood CD4 T-cell counts (rho = 0.75, 0.93, and 0.85, respectively, P < .005). The relationship between radiotracer retention in lymphoid tissues and CD4(+) T-cell counts in the circulation was governed by an exponential law. These data provide an estimate for the total number of lymphocytes in the body as being between 1.9 and 2.9 x 10(12) and suggest that the partition between peripheral blood and lymphoid tissue is between 0.3% and 0.5%.
Veterinary Immunology and Immunopathology, 1992
Brenner, J., Neria, A., Askenazy, G., Paz, R., Meirom, R., Ungar-Waron, H. and Trainin, Z., 1992.... more Brenner, J., Neria, A., Askenazy, G., Paz, R., Meirom, R., Ungar-Waron, H. and Trainin, Z., 1992. A lactogenic-immune-deficiency-syndrome in cows: unexplained phenomenon. Vet. lmmunol. Immunopathol., The majority of adult cows in a certain dairy herd, were found to have very low levels of immunoglobulins (Igs) in their colostrum. This phenomenon was defined by us as Lactogenic-lmmune-Deficiency-Syndrome (LIDS). The mean IgG levels were 44.5 and 57.2 mg ml-~ respectively (on two different occasions) as compared to that of a control group which was 103.4 mg ml-~. The levels of lgs in the colostra of heifers from the same herd were found to be higher than those of adult cows. The degree of LIDS was found to be closely related to the age of cows in the herd. The low levels of lgs in the colostra were not directly linked to their concentrations in the sera of the affected cows. The relatively low amount of lgA in the affected colostra suggests that the local production in the lymph tissue associated with the mammary glands is impaired as well.
Blood, 2009
Since the earliest days of the HIV epidemic, the number of CD4(+) T cells per unit volume of bloo... more Since the earliest days of the HIV epidemic, the number of CD4(+) T cells per unit volume of blood has been recognized as a major prognostic factor for the development of AIDS in persons with HIV infection. It has also been generally accepted that approximately 2% of total body lymphocytes circulate in the blood. In the present study, we have used a nondepleting humanized anti-CD4 monoclonal antibody labeled with the gamma emitter indium-111 to visualize the CD4(+) T-cell pool in vivo in nonhuman primates with simian HIV infection. A strong correlation was noted between radiotracer uptake in spleen, tonsil, axillary lymph nodes, and peripheral blood CD4 T-cell counts (rho = 0.75, 0.93, and 0.85, respectively, P < .005). The relationship between radiotracer retention in lymphoid tissues and CD4(+) T-cell counts in the circulation was governed by an exponential law. These data provide an estimate for the total number of lymphocytes in the body as being between 1.9 and 2.9 x 10(12) and suggest that the partition between peripheral blood and lymphoid tissue is between 0.3% and 0.5%.