Nesrin Ceylan - Academia.edu (original) (raw)

Papers by Nesrin Ceylan

Turkish Journal of Medical Sciences, 2022

Background/aim: Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a ra... more Background/aim: Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a rare clinicoradiological syndrome that typically presents with central nervous system symptoms such as loss of consciousness, seizure, headache, and ophthalmoparesis. Materials and methods: Here, we highlight the characteristics of this syndrome together with the clinical and MRI findings of 6 pediatric patients with MERS. Results: Between January 2017 and October 2020, 6 patients with MERS (3 boys and 3 girls) presented to our center. The mean age was 122 ± 54.6 (min-max: 44-180) months. None of the patients had a chronic disease. In our study, infectious agents were detected in 4 patients (66.6%), while noninfectious causes (one seizure and the other hyponatremia) were detected in two patients. All of our cases were discharged without any sequelae after an average of 12.1 ± 7 (min-max: 4-20) days of hospitalization. In 1 patient (case 6), control MRI could not be performed, and the radiological recovery of our other patients was shown to be between 14 days and 2 months. Conclusion: MERS is an acute encephalopathy with good prognosis and should be considered by neurologists in differential diagnosis due to its variable clinical presentation and specific MRI findings.

Genel Tıp Dergisi, 2023

Introduction: Despite the developments in pharmacologic treatments, traditional and complementary... more Introduction: Despite the developments in pharmacologic treatments, traditional and complementary therapies have recently gained popularity in our country, as well as around the world. Aim: To question complementary and alternative medicine practices CAMP during clinical visits of pediatric neurology patients, to raise awareness of families and patients about the use of complementary and alternative medicine, and to prevent possible negative interactions. Methods: This prospective survey study was conducted with the parents of 300 pediatric patients aged between 6 months and 18 years, who were being treated at the Child Neurology Clinic between March 1st and May 30th, 2020. For the study, 360 patients’ parents who came to the Pediatric Neurology clinic for treatment were randomly selected, and a face-to-face survey lasting 2 minutes was conducted with 300 patients’ parents who agreed to participate in the study. This study was approved with the decision number E-20-12-62 at the meet...

Neurophysiologie Clinique

European review for medical and pharmacological sciences, 2015

To investigate serum concentration of nesfatin-1 in underweight children who have poor appetite, ... more To investigate serum concentration of nesfatin-1 in underweight children who have poor appetite, and its association with anthropometric markers of malnutrition. We recruited 50 underweight children and adolescents (aged 2-18 years) who presented with loss of appetite. Thirty age- and sex-matched controls were also included in the study. Fasting serum nesfatin-1 concentrations were measured by using Enzyme-Linked Immunosorbent Assay (ELISA) technique. Mean nesfatin-1 level was significantly higher in underweight children when compared to controls (p<0.001). There was no correlation between serum nesfatin-1 levels and anthropometrics markers. Our results suggest that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of loss of appetite in children.

East African medical journal, 2002

... Titre du document / Document title. Rubella seroprevalence in adolescent girls in the eastern... more ... Titre du document / Document title. Rubella seroprevalence in adolescent girls in the eastern region of Turkey. Auteur(s) / Author(s). CAKSEN H. ; CEYLAN A. ; CEYLAN N. ; ARSLAN S. ; ÖNER AF ; KIRIMI E. ; Revue / Journal Title. ...

Medical Science and Discovery, 2016

Objective: Celiac disease is seen by increasing rates in the whole world. It may have a silent co... more Objective: Celiac disease is seen by increasing rates in the whole world. It may have a silent course besides having classical symptoms. It may result in serious complications if the diagnosis is delayed such as anemia, fatigue, vitamin K deficiency, excessive bruising and bleeding. The aim of this study is to detect celiac patients who have not been diagnosed yet in healthy school children. Materials and Methods: Present study performed was in 1003 school children who are between 5-18 years old in Van city, east of Turkey. Celiac disease was investigated via rapid celiac testing (BiocardTM stick test). Results: Percentages of the cases, 51.2% were female and 48.8% male. Test was positive in two (0.2%) patients. Ten (1%) patients had immunoglobulin A deficiency. In addition to these patients, one patient had been diagnosed as celiac disease beforehand. Conclusion: The prevalence of celiac disease in Van city, east of Turkey in our study, shows a lower prevalence than in study which performed in our country previously

Genel tıp dergisi, Apr 29, 2022

It was aimed to examine the pattern visual evoked potentials (P-VEP) of children with neurofibrom... more It was aimed to examine the pattern visual evoked potentials (P-VEP) of children with neurofibromatosis type 1 (NF type 1) and to evaluate the correlation of P-VEP results with optical gliomas and unidentified bright objects (UBO) associated with NF Type 1. Materials and Methods: P-VEP and P100 latencies of 28 children including 16 (%57) boys, who were followed up with the diagnosis of NF Type 1 in the Pediatric Neurology Outpatient Clinic of xxxxxxxxxxxxx between 2017 and 2020, with a mean age of 9.61 ± 3.7 years of age were compared with the P100 latencies of a control group consisting of 28 healthy children of similar age and gender. Results: Unidentified bright objects were found in the brain of 82% of the patients by using magnetic resonance imaging, and optic glioma was found in 21% of the patients. P100 latencies were significantly longer in the patient group than in the control group (p = 0.013, p = 0.043). Patients with optic glioma were found to have significantly longer P100 latencies than patients without optic glioma, consistent with the anatomical location of the optic glioma (p = 0.042, p = 0.025). Conclusion: With this study, it has been shown that the P-VEP test is an objective electrophysiological test that can be used in the functional assessment of visual pathways in children with NF Type 1. We think that the use of the P-VEP test in the clinical follow-up of children with NF Type 1 may be particularly useful in the early detection of optic gliomas.

Journal of Medical Microbiology, 2004

A PCR assay for the detection of Bordetella pertussis and Bordetella parapertussis was compared w... more A PCR assay for the detection of Bordetella pertussis and Bordetella parapertussis was compared with the conventional culture method under routine laboratory conditions. Detection of B. pertussis was based on the amplification of a section of the IS481 insertion sequence and confirmation of positive results was based on a sequence of the pertussis toxin promoter region. Detection of B. parapertussis was based on the amplification of a section of the IS1001 insertion sequence. An internal control was included. Data were available for the period 28 November 2000 to 9 July 2003. In this period, 3096 patients were examined for infection with B. pertussis and B. parapertussis by culture and PCR on the same day. B. pertussis was found in 496 (16 %) patients; 208 (42 %) were diagnosed by PCR alone whereas 17 (3 %) were diagnosed by culture alone. B. parapertussis was found in 64 (2 %) patients. The sensitivity of the PCR was 97 % and of culture 58 %. The specificity of PCR was 93 % when regarding culture as 100 % sensitive. There was a significant relationship between laboratory method and age, as the superiority of PCR was most marked in the age group 0. 5-3 years. The PCR assay proved highly sensitive for the diagnosis of pertussis. The specificity estimate of the PCR assay suffers from the influence of a gold-standard method with a low sensitivity. The PCR assay is considered highly specific due to the amplification of two different sequences in two separate assays.

Acta Veterinaria Brno, 2007

IgG-antibody response in aborting sheep and in apparently healthy sheep in a flock against acidgl... more IgG-antibody response in aborting sheep and in apparently healthy sheep in a flock against acidglycine- extracted antigens from three strains for each C. fetus subsp. fetus and C. jejuni were analysed by Western blot. One strain of C. fetus subsp. fetus was isolated from aborting sheep. Western blot analysis of the sera revealed the presence of IgG antibody binding to the common antigens including proteins with the Mw of 63 kDa and 54 kDa in extracts from both C. fetus subsp. fetus and C. jejuni strains. In addition, IgG antibodies in sera from aborting sheep reacted more strongly with the antigens from C. fetus subsp. fetus strains with Mw of approximately 100, 95 and 86.5 kDa than those of apparently healthy sheep. The binding profile of the antibodies with these antigens appeared to be unique for each C. fetus subsp. fetus strain. On the other hand, IgG antibodies only in sera from aborting sheep recognized strongly the antigens of each C. fetus subsp. fetus strain at the Mw rang...

Clinical & Experimental Allergy, 2013

Background-Atopic dermatitis (AD) is common in children; however, persistence of AD with or witho... more Background-Atopic dermatitis (AD) is common in children; however, persistence of AD with or without asthma, is less common. Longitudinal studies remain limited in their ability to characterize how IgE antibody responses evolve in AD, and their relationship to asthma. Objective-To use a cross-sectional study design of children with active AD to analyze agerelated differences in IgE antibodies and relation to wheeze. Methods-IgE antibodies to food and inhalant allergens were measured in children with active AD (5 months to 15 years of age, n=66), with and without history of wheeze. Results-Whereas IgE antibodies to foods persisted at a similar prevalence and titer throughout childhood, IgE antibodies to all aeroallergens rose sharply into adolescence. From birth, the chance of sensitization for any aeroallergen increased for each 12-month increment in age (OR≥1.21, p≤0.01), with the largest effect observed for dust mite (OR=1.56, p<0.001). A steeper age-related rise in IgE antibody titer to dust mite, but no other allergen, was associated with more severe disease. Despite this, sensitization to cat was more strongly associated with wheeze (OR=4.5, p<0.01), and linked to Fel d 1 and Fel d 4, but not Fel d 2. Comparison of cat allergic children with AD to those without, revealed higher titers to Fel d 2 and Fel d 4 (p<0.05), but not Fel d 1. Conclusions and Clinical Relevance-Differences in sensitization to cat and dust mite among young children with AD may aid in identifying those at increased risk for disease progression and development of asthma. Early sensitization to cat and risk for wheeze among children with AD may be linked to an increased risk for sensitization to a broader spectrum of allergen components from early life. Collectively, our findings argue for early intervention strategies designed to mitigate skin inflammation in children with AD.

Kafkas Universitesi Veteriner Fakultesi Dergisi, 2021

Background and Aim: Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) a r... more Background and Aim: Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) a rare clinicoradiological syndrome that typically presents with central nervous system symptoms such as loss of consciousness, seizure, headache, and ophthalmoparesis Methods: Here, we highlight the characteristics of this syndrome together with the clinical and MRI findings of 6 pediatric patients with MERS.

Amac: Yenidogan bebeklerin en sik karsilasilan sorunlarindan biri indirekt hiperbilirubinemidir. ... more Amac: Yenidogan bebeklerin en sik karsilasilan sorunlarindan biri indirekt hiperbilirubinemidir. Bu retrospektif calismada patolojik indirekt hiperbilirubinemi ve uzamis sarilik nedeniyle izlenen term yenidoganlarin etiyolojisi, klinik ve demografik ozellikleri, uygulanan tedavi yontemleri ve gelisen komplikasyonlar degerlendirildi. Gerec ve Yontem : Patolojik indirekt hiperbilirubinemi ve uzamis sarilik tanisi ile 1 Ocak 2013 - 31 Aralik 2014 tarihleri arasinda Yuzuncu Yil Universitesi Tip Fakultesi yenidogan unitesinde izlenen 237 term yenidogan calismaya alindi. Bulgular: Calismaya alinan yenidoganlarin % 57.8’i erkek, ortalama dogum agirliklari 2870 ±505 g, gebelik haftalari 38.4 ± 1. hafta, basvuruda bilirubin degerleri 21.6 ± 5.6 mg/dL (13-49), vaginal dogum orani % 55.7, annenin yasayan 1. cocugu olanlar % 34.2, anne sutuyle beslenme %98 oraninda saptandi. Hastalarin 95’inde (% 40.1) neden bulunamaz iken, 72’inde (% 30.4) ABO uygunsuzlugu, 24’unde (% 10.1) Rh uygunsuzlugu ve...

Turkish Journal of Pediatric Disease, 2021

Objective: Cases of Cytomegalovirus (CMV) infection are encountered in the early stages of life i... more Objective: Cases of Cytomegalovirus (CMV) infection are encountered in the early stages of life in developing countries. The aim of this study is to specify the seroprevalence of CMV-IgM and IgG in pediatric patients and to indicate its relationship with certain hematological, serological, and biochemical parameters. Material and Methods: Serological test results of CMV-IgM and CMV-IgG in children aged 0-14 with CMV as a causative agent were analyzed retrospectively in the blood samples sent to the Microbiology Laboratory of Dursun Odabas Medical Center of Van Yuzuncu Yil University between 2013 and 2015. The relationship with hematological and biochemical parameters was investigated in the cases with positive CMV-IgM results. Results: CMV-IgM and IgG tests were studied in 1.385 children. It was determined that 58% of these children were boys and 42% were girls. A total of 112 (8.2%) of the 1.363 patients who were tested for CMV-IgM were found to be positive. The decrease in IgM with age was found to be statistically significant (p<0.01). It was determined that 707 (95.3%) of 742 patients who were tested for CMV-IgG were positive. Similarly, the increase in IgG parallel to age was found to be statistically significant (p<0.05). The correlation between positivity values of CMV-IgM-positive patients and patients' hematological, serological, and biochemical parameters were calculated separately. It was noted that the significant value in the correlation was C-reactive protein with 0.49 (p<0.01). Conclusion: CMV-IgG seroprevalence was found to be higher compared with studies conducted in developed countries. Accordingly, we think that increased C-reactive protein levels will be useful in the diagnosis of CMV.

Japanese Journal of Pharmacology, 1998

The Belle II experiment, located at the SuperKEKB collider at the high-energy research facility K... more The Belle II experiment, located at the SuperKEKB collider at the high-energy research facility KEK in Tsukuba, Japan, started operation in 2018. Compared to the predecessor experiment Belle, Belle II plans to increase the peak luminosity by a factor of about 40, by employing nano-beam technology in the interaction region. In particular the new, innermost sub-detector of Belle II-the Pixel Vertex Detector (PXD)-is in close proximity to the interaction point. This allows for the detection of particles, which do not leave a signal in the outer sub-detectors. Among these, Highly Ionizing Particles (HIPs) encounter a characteristically high energy loss, limiting their penetration depth into the detector. Anti-deuterons and magnetic monopoles as possible HIPs are considered. Without a signal in the outer sub-detectors, no track trigger is issued, resulting in possible information loss. The possibility of identifying HIPs solely with information provided by the PXD is presented, by using neural network algorithms operating in a multidimensional parameter space of PXD cluster data.

Eastern Journal Of Medicine, 2016

Severe hyperlipidemia is a rare presentation usually associated with acute myeloid leukemia. 2-mo... more Severe hyperlipidemia is a rare presentation usually associated with acute myeloid leukemia. 2-month-old girl complaining of discomfort. Her skin and conjunctivae were pale, abdominal distention and 5 cm hepatosplenomegaly were determined. Blood count revealed anemia (10 g/dL) and thrombocytopenia (41x10 9 /L). Total leukocyte count was 24x10 9 /L, and on blood smear, 58% blast and 42% lymphocytes were seen. Bone marrow aspirate revealed diffuse infiltration with blast cells consistent with acute monoblastic leukemia. Her plasma had a milky appearance. In the laboratory examination, triglyceride level was 1428 mg/dl, cholesterol level was 1291 mg/dl. This case report illustrate that the hematological malignancies may present with severe hypertriglyceridemia.

Case Reports in Medicine, 2016

Ecthyma gangrenosum is a cutaneous lesion often associated with pseudomonas aeruginosa bacteremia... more Ecthyma gangrenosum is a cutaneous lesion often associated with pseudomonas aeruginosa bacteremia, even though it may develop without bacteremia and may originate from other bacterial and fungal organisms. Pseudomonas aeruginosa bacteremia or sepsis, which mainly affects immunocompromised patients, frequently occurs in hospitals. This lesion typically occurs on the extremities and gluteal and perineal regions. In this report we present a case of ecthyma gangrenosum in a premature newborn occurring secondary to pseudomonas sepsis causing sucking dysfunction due to tissue loss in the lip, soft palate, and tongue.