Ngô Thủy - Academia.edu (original) (raw)
Papers by Ngô Thủy
Tạp chí Khoa học, 2020
Trong bài báo này, chúng tôi tổng hợp hạt vi cầu Y-90 dạng hạt thủy tinh và hạt gel trên Lò phả... more Trong bài báo này, chúng tôi tổng hợp hạt vi cầu Y-90 dạng hạt thủy tinh và hạt gel trên Lò phản ứng Hạt nhân Đà Lạt ứng dụng trong điều trị ung thư gan tại Việt Nam. Kích thước và hình thái học của hạt vi cầu Y-90 được kiểm tra bằng phương pháp kính hiển vi điện tử quét phân giải cao (FE-SEM), độ tinh khiết hóa học được kiểm tra bằng phổ tán sắc năng lượng tia X (EDX), độ tinh khiết hạt nhân phóng xạ kiểm tra bằng phổ kế gamma Canberra-GC-3019-7500SL, độ tinh khiết hóa phóng xạ kiểm tra bằng sắc kí lớp mỏng, độc tố kim loại nặng kiểm tra bằng phương pháp ICP-MS, độ vô khuẩn, nội độc tố vi khuẩn, và độ ổn định của sản phẩm theo thời gian kiểm tra theo Dược điển Anh 2016. Kết quả cho thấy hạt vi cầu phóng xạ Y-90 dạng hạt thủy tinh và hạt gel có kích thước hạt từ 20-30 µm, có hoạt độ riêng cao đáp ứng các chỉ tiêu chất lượng của thuốc phóng xạ theo Dược điển Anh 2016. Đây là sản phẩm thuốc phóng xạ đầy hứa hẹn trong điều trị ung thư gan nguyên phát và thứ phát bằng phương pháp tắc ...
Tạp chí Y học Việt Nam, 2022
Remdesivir là thuốc kháng virus đã được chấp thuận trong điều trị bệnh nhân COVID-19 nhập viện ở ... more Remdesivir là thuốc kháng virus đã được chấp thuận trong điều trị bệnh nhân COVID-19 nhập viện ở nhiều nước trên thế giới, trong đó có Việt Nam. Tuy nhiên, hiện chưa có nghiên cứu nào về remdesivir được công bố tại Việt Nam. Chính vì thế, nghiên cứu được thực hiện để phân tích kết quả điều trị và độ an toàn của remdesivir trên bệnh nhân COVID-19 tại Việt Nam. Nghiên cứu hồi cứu, mô tả thực hiện trên bệnh nhân COVID-19 từ 12 tuổi trở lên có chỉ định nhập viện và được điều trị với ít nhất một liều remdesivir từ ngày 10/08/2021 đến ngày 10/09/2021 tại Bệnh viện đa khoa quốc tế Vinmec Central Park. Kết quả điều trị được đánh giá theo thang WHO 6 điểm, biến cố thở máy ngày 14 và tử vong tại thời điểm ngày 28. Độ an toàn của remdesivir được đánh giá dựa trên tỷ lệ biến cố không mong muốn ghi nhận theo thang AIDS 2017.Kết quả: Nghiên cứu thu thập được 152 bệnh nhân COVID -19 được điều trị bằng remdesivir, trong đó hơn 50% có ít nhất 1 bệnh lý nền, chủ yếu là bệnh lý tim mạch hoặc đái tháo ...
Tạp chí Y học Dự phòng, 2021
Nghiên cứu nhằm mô tả hoạt động và kết quả của hệ thống giám sát liệt mềm cấp/bại liệt (LMC/BL) t... more Nghiên cứu nhằm mô tả hoạt động và kết quả của hệ thống giám sát liệt mềm cấp/bại liệt (LMC/BL) tại Việt Nam trong giai đoạn 2015 - 2019. Đối tượng là trẻ dưới 15 tuổi trên toàn quốc bị LMC được ghi nhận trên phần mềm giám sát của Ban giám sát BL Quốc gia. Kết quả cho thấy tỷ lệ phát hiện LMC/100.000 dân và tỷ lệ LMC lấy đủ 2 mẫu phân đúng quy định vượt yêu cầu của Tổ chức Y tế thế giới (WHO) trong cả giai đoạn 2015 - 2019. LMC chủ yếu được phát hiện ở trẻ < 5 tuổi (81,2%). Tỷ lệ LMC ở nam (58,9%) cao hơn ở nữ (41,1%). Hơn 90% các trường hợp LMC uống ít nhất 3 liều vắc xin bại liệt dạng uống (OPV). Không phân lập được trường hợp vi rút bại liệt hoang dại trong mẫu phân của các trường hợp LMC, 12% dương tính với các vi rút đường ruột khác. Việt Nam vẫn duy trì hệ thống giám sát LMC/BL đạt chất lượng cao trong giai đoạn 2015 - 2019. Hệ thống này cần tiếp tục đảm bảo chất lượng giám sát, tìm kiếm tích cực các trường hợp LMC, không bỏ sót trường hợp bệnh, đồng thời tăng cường công tá...
From the ethyl acetate extract of Maclura cochinchinenis six flavonoids: kaempferol, dihydrokaemp... more From the ethyl acetate extract of Maclura cochinchinenis six flavonoids: kaempferol, dihydrokaempferol, quercetin, 6- p -hydroxybenzyl-dihydrokaempferol (gericudranin E), oxyresveratrol and 2',4',5,7-tetrahydroxy-flavanone (steppogenin) were isolated. Their structures were established by analysis of the NMR and mass spectra. Compound 6-p-hydroxybenzyl-dihydroquercetin was isolated for the first time from M. cochinchinenis .
SUMMARY Clinical observation suggests thatdeliberate violence against thepersonis increasing inbo... more SUMMARY Clinical observation suggests thatdeliberate violence against thepersonis increasing inbothincidence andseverity inthecommunity. Overasix-year periodtherewas a trendtowards an annualincrease inthenumberof attendances attheWaveneyHospital astheresult ofassaults. A retrospective studyfora six- monthperiod (August 1987toJanuary 1988)defined the pattemofattendance, injuries andtreatment for284cases. Mostofthevictims wereyoungmaleswhopresented outside normalworking hourswithsuperficial injuries. Admission wasrequired in12% ofpatients.
Tạp chí Nhi khoa, 2021
Đặt vấn đề/ Mục tiêu: Viêm nhiễm virus hợp bào hô hấp RSV (Respiratory Syncytial virus) là một tr... more Đặt vấn đề/ Mục tiêu: Viêm nhiễm virus hợp bào hô hấp RSV (Respiratory Syncytial virus) là một trong những nguyên nhân phổ biến gây bệnh đường hô hấp. Nghiên cứu này được thực hiện nhằm bước đầu khảo sát tác dụng hỗ trợ điều trị của sản phẩm probiotic LiveSpo® Navax dạng nước chứa bào tử lợi khuẩn Bacillus thế hệ LS-III ở nồng độ cao trên đối tượng trẻ em bị bệnh đường hô hấp cấp do nhiễm RSV tại bệnh viện Nhi Trung ương. Phương pháp: Bước đầu đánh giá trên 30 bệnh nhân được chẩn đoán bị bệnh viêm tiểu phế quản do nhiễm RSV tham gia vào nghiên cứu thử nghiệm lâm sàng ngẫu nhiên có đối chứng mù. Bệnh nhân được chia ngẫu nhiên vào 2 nhóm (n =15/nhóm): nhóm sử dụng LiveSpo® Navax (nhóm Navax) và nhóm sử dụng nước muối sinh lý NaCl 0,9% (nhóm Chứng), được hướng dẫn xịt mũi với tần suất 3 lần/ngày trong 6 ngày liên tục, kết hợp với sử dụng thuốc điều trị thường quy tại bệnh viện. Bệnh nhân được tiến hành theo dõi các chỉ số lâm sàng (khò khè, khó thở, độ bão hòa oxy,...) trong suốt thời ...
Sensors, 2020
Over the last decade industrial and academic communities have increased their focus on sentiment ... more Over the last decade industrial and academic communities have increased their focus on sentiment analysis techniques, especially applied to tweets. State-of-the-art results have been recently achieved using language models trained from scratch on corpora made up exclusively of tweets, in order to better handle the Twitter jargon. This work aims to introduce a different approach for Twitter sentiment analysis based on two steps. Firstly, the tweet jargon, including emojis and emoticons, is transformed into plain text, exploiting procedures that are language-independent or easily applicable to different languages. Secondly, the resulting tweets are classified using the language model BERT, but pre-trained on plain text, instead of tweets, for two reasons: (1) pre-trained models on plain text are easily available in many languages, avoiding resource- and time-consuming model training directly on tweets from scratch; (2) available plain text corpora are larger than tweet-only ones, ther...
Journal of the American College of Radiology, 2019
OBJECTIVE Increased utilization of CT pulmonary angiography (CTPA) for the evaluation of pulmonar... more OBJECTIVE Increased utilization of CT pulmonary angiography (CTPA) for the evaluation of pulmonary embolism has been associated with decreasing diagnostic yields and rising concerns about the harms of unnecessary testing. The objective of this study was to determine whether clinical decision support (CDS) use would be associated with increased imaging yields after controlling for selection bias. METHODS We performed a retrospective cohort study in the emergency departments of two tertiary care hospitals of all CTPAs performed between August 2015 and September 2018. Providers ordering a CTPA are routed to an optional CDS tool, which allows them to use Wells' Criteria for pulmonary embolism. After propensity score matching, CTPA yield was calculated for the CDS-use and CDS-dismissal groups and stratified by provider type. RESULTS A total of 7,367 CTPAs were ordered during the study period. Of those, providers used the CDS tool in 2,568 (35%) cases and did not use the tool in 4,799 (65%) of cases. After propensity score matching, CTPA yield was 11.99% in the CDS-use group and 8.70% in the CDS-dismissal group (P < .001). Attending physicians, residents, and physician assistant CDS users demonstrated a 56.5% (P = .006), 38.7% (P = .01), and 16.7% (P = .03) increased yield compared with those who dismissed the tool, respectively. DISCUSSION Diagnostic yield was 38% higher for CTPAs when the provider used the CDS tool, after controlling for selection bias. Yields were higher for every provider type. Further research is needed to discover successful strategies to increase provider use of these important tools.
Academic Radiology, 2019
Background: The benefits of computed tomography pulmonary angiography (CTPA) for pulmonary emboli... more Background: The benefits of computed tomography pulmonary angiography (CTPA) for pulmonary embolism (PE) diagnosis must be weighed against its risks, radiation-induced malignancy, and contrast-induced nephropathy. Appropriate use of CTPA can be assessed by monitoring yield, the percentage of tests positive for PE. We identify factors that are associated low CTPA yield, which may predict overtesting. Methods: This was a retrospective cohort study of six emergency departments between June 2014 and February 2017. The electronic health record was queried for CTPAs ordered for adult patients in the emergency department. We assessed the following patient factors: age, gender, body mass index, number of comorbidities, race, and ethnicity, provider factors: type (resident, fellow, attending, physician assistant) and environment factors: test time of day, season of visit, and crowdedness of the department. Results: A total of 14,782 CTPAs were reviewed, of which 1366 were found to be positive for PE, resulting in an overall CTPA yield of 9.24%. Provider type was not associated with a difference in yield. Testing was less likely to be positive in younger patients, females, those with lower body mass indexes and those identifying as Asian or Hispanic. Testing was also less likely to be positive when ordered during the overnight shift and during the winter and spring seasons. Conclusion: Our study identified several patient and environmental factors associated with low CTPA yield suggesting potential targets for overtesting. Targeting education and clinical decision support to assist providers in these circumstances may meaningfully improve yields.
JMIR medical informatics, Jan 25, 2018
Use of computed tomography pulmonary angiography (CTPA) in the assessment of pulmonary embolism (... more Use of computed tomography pulmonary angiography (CTPA) in the assessment of pulmonary embolism (PE) has markedly increased over the past two decades. While this technology has improved the accuracy of radiological testing for PE, CTPA also carries the risk of substantial iatrogenic harm. Each CTPA carries a 14% risk of contrast-induced nephropathy and a lifetime malignancy risk that can be as high as 2.76%. The appropriate use of CTPA can be estimated by monitoring the CTPA yield, the percentage of tests positive for PE. This is the first study to propose and validate a computerized method for measuring the CTPA yield in the emergency department (ED). The objective of our study was to assess the validity of a novel computerized method of calculating the CTPA yield in the ED. The electronic health record databases at two tertiary care academic hospitals were queried for CTPA orders completed in the ED over 1-month periods. These visits were linked with an inpatient admission with a ...
Geriatrics & gerontology international, 2018
We sought to explore the relationship between the number of medications at hospital discharge and... more We sought to explore the relationship between the number of medications at hospital discharge and 30-day rehospitalization in older adults aged >65 years. This was a multicenter cohort study to determine whether an increased number of medications was associated with 30-day rehospitalization in patients aged >65 years. We explored the relationship between rehospitalization and other risk factors. Data were collected from a large health system in the New York metropolitan area from September 2011 to January 2013. The primary outcome was 30-day hospital readmission from the index hospitalization. Patients had a mean ± SD age of 78 ± 9 years; 55% were women. The average length of stay after discharge from the hospital was 6 days. An increased number of medications was significantly associated with unplanned 30-day hospital readmission (P < 0.05). For each medication, the risk of rehospitalization increased by 4% (OR 1.04, 95% CI 1.03, 1.05). Patients discharged to rehabilitatio...
Journal for healthcare quality : official publication of the National Association for Healthcare Quality, Jan 30, 2018
This study examined the prognostic value of the Charlson Comorbidity Index (CCI) in predicting sh... more This study examined the prognostic value of the Charlson Comorbidity Index (CCI) in predicting short-term clinical outcomes in hospitalized older adults. We conducted a retrospective cohort study of patients, older than 75 years, admitted to the medicine service at a large tertiary hospital (New York). We used the Enhanced International Classification of Disease, 9th Revision, Clinical Modification adaptation to abstract the CCI from electronic medical records. The CCI scores were compared, using the standard Deyo version and the Schneeweiss version. Outcome measures included in-hospital mortality, length of stay (LOS), and 30-day readmissions. When comparing Charlson/Deyo and Charlson/Deyo/Schneeweiss with and without age, we found similar significant association with regard to in-hospital mortality, with a moderate predictive ability (area under the curve [AUC]: 0.5906-0.6433). However, for 30-day readmissions and LOS, the predictive ability was poor (AUC: 0.5598-0.6106 and ρ: 0.1...
Southern medical journal, Apr 1, 2018
Hospitalization-associated disability affects up to 60% of older adults; however, standardized me... more Hospitalization-associated disability affects up to 60% of older adults; however, standardized measures of function are not routinely used and documented. We sought to determine whether nursing documentation in electronic medical records can be used to determine mobility status and associated clinical outcomes. A retrospective study of 2383 medical patients aged 75 years and older was conducted at a large academic tertiary hospital in New York. Mobility (low, intermediate, and high) was the primary variable of interest. Short-term clinical outcomes, including length of stay (LOS), discharge disposition, and readmissions, were the primary outcome variables. Average age and Charlson Comorbidity Index were 84.7 (range 74-107) and 6.46, respectively; 84.5% of patients were documented to have been ambulatory before admission. More than half (52.8%) of the subjects with in-hospital mortality were in the low mobility group (27.2 vs 0.27 vs 0, < 0.0001). Low mobility was associated with ...
Journal of the American Geriatrics Society, Jan 20, 2017
Whereas opiate prescribing patterns have been well described in outpatient and emergency departme... more Whereas opiate prescribing patterns have been well described in outpatient and emergency department settings, they have been less defined in hospitalized older adults. The objective was to describe patterns of opiate prescribing and associated outcomes in hospitalized older adults. Retrospective cohort study. Tertiary care facility. Hospitalized medical patients aged 65 and older (N = 9,245; mean age 80.3, 55.2% female, 72.3% white, 90.8% non-Hispanic). Opiate exposure and duration of action, concurrent use of potentially inappropriate medications (PIMs), adverse events, discharge disposition, length of stay (LOS), and 30-day readmissions. There was no difference in sex, race, ethnicity, or Charlson Comorbidity Index between opiate exposure groups. Participants who had never received opiates had a significantly shorter mean LOS than prior and new opiate users (5.2, 6.8, 7.7 days; P < .001) and were more likely to be discharged home (88.6%, 82.8%, 82.5%; P < .001) and significa...
Expert Systems with Applications, 2021
Abstract Social media offer a big amount of information, to exploit in many fields of research. H... more Abstract Social media offer a big amount of information, to exploit in many fields of research. However, while methods for Natural Language Processing are being developed with good results when applied to well-formed datasets made of written text with a clear syntax, these sources present text written in informal language, unstructured syntax, and with peculiar symbols; therefore, particular approaches are required for text processing in this case. In this paper, the task of sentiment analysis of tweets is regarded. In particular, in order to avoid noise constituted by some web constructs like URLs and mentions and by other text fragments, and to exploit information hidden in symbols like emoticons, emojis and hashtags, the pre-processing of tweets is analyzed. More in detail, a number of experiments, performed by a state-of-the-art classification model (BERT), are designed, to evaluate many currently available operations for pre-processing tweets, in terms of the statistical significance of their influence on sentiment analysis performances. Moreover, available data in two languages are considered, i.e., English and Italian, in order to also evaluate dependence on the language. Results allow to individuate the most convenient strategy to pre-process tweets, and thus to improve the state of the art in both languages for the considered task of sentiment analysis.
Tạp chí Khoa học, 2020
Trong bài báo này, chúng tôi tổng hợp hạt vi cầu Y-90 dạng hạt thủy tinh và hạt gel trên Lò phả... more Trong bài báo này, chúng tôi tổng hợp hạt vi cầu Y-90 dạng hạt thủy tinh và hạt gel trên Lò phản ứng Hạt nhân Đà Lạt ứng dụng trong điều trị ung thư gan tại Việt Nam. Kích thước và hình thái học của hạt vi cầu Y-90 được kiểm tra bằng phương pháp kính hiển vi điện tử quét phân giải cao (FE-SEM), độ tinh khiết hóa học được kiểm tra bằng phổ tán sắc năng lượng tia X (EDX), độ tinh khiết hạt nhân phóng xạ kiểm tra bằng phổ kế gamma Canberra-GC-3019-7500SL, độ tinh khiết hóa phóng xạ kiểm tra bằng sắc kí lớp mỏng, độc tố kim loại nặng kiểm tra bằng phương pháp ICP-MS, độ vô khuẩn, nội độc tố vi khuẩn, và độ ổn định của sản phẩm theo thời gian kiểm tra theo Dược điển Anh 2016. Kết quả cho thấy hạt vi cầu phóng xạ Y-90 dạng hạt thủy tinh và hạt gel có kích thước hạt từ 20-30 µm, có hoạt độ riêng cao đáp ứng các chỉ tiêu chất lượng của thuốc phóng xạ theo Dược điển Anh 2016. Đây là sản phẩm thuốc phóng xạ đầy hứa hẹn trong điều trị ung thư gan nguyên phát và thứ phát bằng phương pháp tắc ...
Tạp chí Y học Việt Nam, 2022
Remdesivir là thuốc kháng virus đã được chấp thuận trong điều trị bệnh nhân COVID-19 nhập viện ở ... more Remdesivir là thuốc kháng virus đã được chấp thuận trong điều trị bệnh nhân COVID-19 nhập viện ở nhiều nước trên thế giới, trong đó có Việt Nam. Tuy nhiên, hiện chưa có nghiên cứu nào về remdesivir được công bố tại Việt Nam. Chính vì thế, nghiên cứu được thực hiện để phân tích kết quả điều trị và độ an toàn của remdesivir trên bệnh nhân COVID-19 tại Việt Nam. Nghiên cứu hồi cứu, mô tả thực hiện trên bệnh nhân COVID-19 từ 12 tuổi trở lên có chỉ định nhập viện và được điều trị với ít nhất một liều remdesivir từ ngày 10/08/2021 đến ngày 10/09/2021 tại Bệnh viện đa khoa quốc tế Vinmec Central Park. Kết quả điều trị được đánh giá theo thang WHO 6 điểm, biến cố thở máy ngày 14 và tử vong tại thời điểm ngày 28. Độ an toàn của remdesivir được đánh giá dựa trên tỷ lệ biến cố không mong muốn ghi nhận theo thang AIDS 2017.Kết quả: Nghiên cứu thu thập được 152 bệnh nhân COVID -19 được điều trị bằng remdesivir, trong đó hơn 50% có ít nhất 1 bệnh lý nền, chủ yếu là bệnh lý tim mạch hoặc đái tháo ...
Tạp chí Y học Dự phòng, 2021
Nghiên cứu nhằm mô tả hoạt động và kết quả của hệ thống giám sát liệt mềm cấp/bại liệt (LMC/BL) t... more Nghiên cứu nhằm mô tả hoạt động và kết quả của hệ thống giám sát liệt mềm cấp/bại liệt (LMC/BL) tại Việt Nam trong giai đoạn 2015 - 2019. Đối tượng là trẻ dưới 15 tuổi trên toàn quốc bị LMC được ghi nhận trên phần mềm giám sát của Ban giám sát BL Quốc gia. Kết quả cho thấy tỷ lệ phát hiện LMC/100.000 dân và tỷ lệ LMC lấy đủ 2 mẫu phân đúng quy định vượt yêu cầu của Tổ chức Y tế thế giới (WHO) trong cả giai đoạn 2015 - 2019. LMC chủ yếu được phát hiện ở trẻ < 5 tuổi (81,2%). Tỷ lệ LMC ở nam (58,9%) cao hơn ở nữ (41,1%). Hơn 90% các trường hợp LMC uống ít nhất 3 liều vắc xin bại liệt dạng uống (OPV). Không phân lập được trường hợp vi rút bại liệt hoang dại trong mẫu phân của các trường hợp LMC, 12% dương tính với các vi rút đường ruột khác. Việt Nam vẫn duy trì hệ thống giám sát LMC/BL đạt chất lượng cao trong giai đoạn 2015 - 2019. Hệ thống này cần tiếp tục đảm bảo chất lượng giám sát, tìm kiếm tích cực các trường hợp LMC, không bỏ sót trường hợp bệnh, đồng thời tăng cường công tá...
From the ethyl acetate extract of Maclura cochinchinenis six flavonoids: kaempferol, dihydrokaemp... more From the ethyl acetate extract of Maclura cochinchinenis six flavonoids: kaempferol, dihydrokaempferol, quercetin, 6- p -hydroxybenzyl-dihydrokaempferol (gericudranin E), oxyresveratrol and 2',4',5,7-tetrahydroxy-flavanone (steppogenin) were isolated. Their structures were established by analysis of the NMR and mass spectra. Compound 6-p-hydroxybenzyl-dihydroquercetin was isolated for the first time from M. cochinchinenis .
SUMMARY Clinical observation suggests thatdeliberate violence against thepersonis increasing inbo... more SUMMARY Clinical observation suggests thatdeliberate violence against thepersonis increasing inbothincidence andseverity inthecommunity. Overasix-year periodtherewas a trendtowards an annualincrease inthenumberof attendances attheWaveneyHospital astheresult ofassaults. A retrospective studyfora six- monthperiod (August 1987toJanuary 1988)defined the pattemofattendance, injuries andtreatment for284cases. Mostofthevictims wereyoungmaleswhopresented outside normalworking hourswithsuperficial injuries. Admission wasrequired in12% ofpatients.
Tạp chí Nhi khoa, 2021
Đặt vấn đề/ Mục tiêu: Viêm nhiễm virus hợp bào hô hấp RSV (Respiratory Syncytial virus) là một tr... more Đặt vấn đề/ Mục tiêu: Viêm nhiễm virus hợp bào hô hấp RSV (Respiratory Syncytial virus) là một trong những nguyên nhân phổ biến gây bệnh đường hô hấp. Nghiên cứu này được thực hiện nhằm bước đầu khảo sát tác dụng hỗ trợ điều trị của sản phẩm probiotic LiveSpo® Navax dạng nước chứa bào tử lợi khuẩn Bacillus thế hệ LS-III ở nồng độ cao trên đối tượng trẻ em bị bệnh đường hô hấp cấp do nhiễm RSV tại bệnh viện Nhi Trung ương. Phương pháp: Bước đầu đánh giá trên 30 bệnh nhân được chẩn đoán bị bệnh viêm tiểu phế quản do nhiễm RSV tham gia vào nghiên cứu thử nghiệm lâm sàng ngẫu nhiên có đối chứng mù. Bệnh nhân được chia ngẫu nhiên vào 2 nhóm (n =15/nhóm): nhóm sử dụng LiveSpo® Navax (nhóm Navax) và nhóm sử dụng nước muối sinh lý NaCl 0,9% (nhóm Chứng), được hướng dẫn xịt mũi với tần suất 3 lần/ngày trong 6 ngày liên tục, kết hợp với sử dụng thuốc điều trị thường quy tại bệnh viện. Bệnh nhân được tiến hành theo dõi các chỉ số lâm sàng (khò khè, khó thở, độ bão hòa oxy,...) trong suốt thời ...
Sensors, 2020
Over the last decade industrial and academic communities have increased their focus on sentiment ... more Over the last decade industrial and academic communities have increased their focus on sentiment analysis techniques, especially applied to tweets. State-of-the-art results have been recently achieved using language models trained from scratch on corpora made up exclusively of tweets, in order to better handle the Twitter jargon. This work aims to introduce a different approach for Twitter sentiment analysis based on two steps. Firstly, the tweet jargon, including emojis and emoticons, is transformed into plain text, exploiting procedures that are language-independent or easily applicable to different languages. Secondly, the resulting tweets are classified using the language model BERT, but pre-trained on plain text, instead of tweets, for two reasons: (1) pre-trained models on plain text are easily available in many languages, avoiding resource- and time-consuming model training directly on tweets from scratch; (2) available plain text corpora are larger than tweet-only ones, ther...
Journal of the American College of Radiology, 2019
OBJECTIVE Increased utilization of CT pulmonary angiography (CTPA) for the evaluation of pulmonar... more OBJECTIVE Increased utilization of CT pulmonary angiography (CTPA) for the evaluation of pulmonary embolism has been associated with decreasing diagnostic yields and rising concerns about the harms of unnecessary testing. The objective of this study was to determine whether clinical decision support (CDS) use would be associated with increased imaging yields after controlling for selection bias. METHODS We performed a retrospective cohort study in the emergency departments of two tertiary care hospitals of all CTPAs performed between August 2015 and September 2018. Providers ordering a CTPA are routed to an optional CDS tool, which allows them to use Wells' Criteria for pulmonary embolism. After propensity score matching, CTPA yield was calculated for the CDS-use and CDS-dismissal groups and stratified by provider type. RESULTS A total of 7,367 CTPAs were ordered during the study period. Of those, providers used the CDS tool in 2,568 (35%) cases and did not use the tool in 4,799 (65%) of cases. After propensity score matching, CTPA yield was 11.99% in the CDS-use group and 8.70% in the CDS-dismissal group (P < .001). Attending physicians, residents, and physician assistant CDS users demonstrated a 56.5% (P = .006), 38.7% (P = .01), and 16.7% (P = .03) increased yield compared with those who dismissed the tool, respectively. DISCUSSION Diagnostic yield was 38% higher for CTPAs when the provider used the CDS tool, after controlling for selection bias. Yields were higher for every provider type. Further research is needed to discover successful strategies to increase provider use of these important tools.
Academic Radiology, 2019
Background: The benefits of computed tomography pulmonary angiography (CTPA) for pulmonary emboli... more Background: The benefits of computed tomography pulmonary angiography (CTPA) for pulmonary embolism (PE) diagnosis must be weighed against its risks, radiation-induced malignancy, and contrast-induced nephropathy. Appropriate use of CTPA can be assessed by monitoring yield, the percentage of tests positive for PE. We identify factors that are associated low CTPA yield, which may predict overtesting. Methods: This was a retrospective cohort study of six emergency departments between June 2014 and February 2017. The electronic health record was queried for CTPAs ordered for adult patients in the emergency department. We assessed the following patient factors: age, gender, body mass index, number of comorbidities, race, and ethnicity, provider factors: type (resident, fellow, attending, physician assistant) and environment factors: test time of day, season of visit, and crowdedness of the department. Results: A total of 14,782 CTPAs were reviewed, of which 1366 were found to be positive for PE, resulting in an overall CTPA yield of 9.24%. Provider type was not associated with a difference in yield. Testing was less likely to be positive in younger patients, females, those with lower body mass indexes and those identifying as Asian or Hispanic. Testing was also less likely to be positive when ordered during the overnight shift and during the winter and spring seasons. Conclusion: Our study identified several patient and environmental factors associated with low CTPA yield suggesting potential targets for overtesting. Targeting education and clinical decision support to assist providers in these circumstances may meaningfully improve yields.
JMIR medical informatics, Jan 25, 2018
Use of computed tomography pulmonary angiography (CTPA) in the assessment of pulmonary embolism (... more Use of computed tomography pulmonary angiography (CTPA) in the assessment of pulmonary embolism (PE) has markedly increased over the past two decades. While this technology has improved the accuracy of radiological testing for PE, CTPA also carries the risk of substantial iatrogenic harm. Each CTPA carries a 14% risk of contrast-induced nephropathy and a lifetime malignancy risk that can be as high as 2.76%. The appropriate use of CTPA can be estimated by monitoring the CTPA yield, the percentage of tests positive for PE. This is the first study to propose and validate a computerized method for measuring the CTPA yield in the emergency department (ED). The objective of our study was to assess the validity of a novel computerized method of calculating the CTPA yield in the ED. The electronic health record databases at two tertiary care academic hospitals were queried for CTPA orders completed in the ED over 1-month periods. These visits were linked with an inpatient admission with a ...
Geriatrics & gerontology international, 2018
We sought to explore the relationship between the number of medications at hospital discharge and... more We sought to explore the relationship between the number of medications at hospital discharge and 30-day rehospitalization in older adults aged >65 years. This was a multicenter cohort study to determine whether an increased number of medications was associated with 30-day rehospitalization in patients aged >65 years. We explored the relationship between rehospitalization and other risk factors. Data were collected from a large health system in the New York metropolitan area from September 2011 to January 2013. The primary outcome was 30-day hospital readmission from the index hospitalization. Patients had a mean ± SD age of 78 ± 9 years; 55% were women. The average length of stay after discharge from the hospital was 6 days. An increased number of medications was significantly associated with unplanned 30-day hospital readmission (P < 0.05). For each medication, the risk of rehospitalization increased by 4% (OR 1.04, 95% CI 1.03, 1.05). Patients discharged to rehabilitatio...
Journal for healthcare quality : official publication of the National Association for Healthcare Quality, Jan 30, 2018
This study examined the prognostic value of the Charlson Comorbidity Index (CCI) in predicting sh... more This study examined the prognostic value of the Charlson Comorbidity Index (CCI) in predicting short-term clinical outcomes in hospitalized older adults. We conducted a retrospective cohort study of patients, older than 75 years, admitted to the medicine service at a large tertiary hospital (New York). We used the Enhanced International Classification of Disease, 9th Revision, Clinical Modification adaptation to abstract the CCI from electronic medical records. The CCI scores were compared, using the standard Deyo version and the Schneeweiss version. Outcome measures included in-hospital mortality, length of stay (LOS), and 30-day readmissions. When comparing Charlson/Deyo and Charlson/Deyo/Schneeweiss with and without age, we found similar significant association with regard to in-hospital mortality, with a moderate predictive ability (area under the curve [AUC]: 0.5906-0.6433). However, for 30-day readmissions and LOS, the predictive ability was poor (AUC: 0.5598-0.6106 and ρ: 0.1...
Southern medical journal, Apr 1, 2018
Hospitalization-associated disability affects up to 60% of older adults; however, standardized me... more Hospitalization-associated disability affects up to 60% of older adults; however, standardized measures of function are not routinely used and documented. We sought to determine whether nursing documentation in electronic medical records can be used to determine mobility status and associated clinical outcomes. A retrospective study of 2383 medical patients aged 75 years and older was conducted at a large academic tertiary hospital in New York. Mobility (low, intermediate, and high) was the primary variable of interest. Short-term clinical outcomes, including length of stay (LOS), discharge disposition, and readmissions, were the primary outcome variables. Average age and Charlson Comorbidity Index were 84.7 (range 74-107) and 6.46, respectively; 84.5% of patients were documented to have been ambulatory before admission. More than half (52.8%) of the subjects with in-hospital mortality were in the low mobility group (27.2 vs 0.27 vs 0, < 0.0001). Low mobility was associated with ...
Journal of the American Geriatrics Society, Jan 20, 2017
Whereas opiate prescribing patterns have been well described in outpatient and emergency departme... more Whereas opiate prescribing patterns have been well described in outpatient and emergency department settings, they have been less defined in hospitalized older adults. The objective was to describe patterns of opiate prescribing and associated outcomes in hospitalized older adults. Retrospective cohort study. Tertiary care facility. Hospitalized medical patients aged 65 and older (N = 9,245; mean age 80.3, 55.2% female, 72.3% white, 90.8% non-Hispanic). Opiate exposure and duration of action, concurrent use of potentially inappropriate medications (PIMs), adverse events, discharge disposition, length of stay (LOS), and 30-day readmissions. There was no difference in sex, race, ethnicity, or Charlson Comorbidity Index between opiate exposure groups. Participants who had never received opiates had a significantly shorter mean LOS than prior and new opiate users (5.2, 6.8, 7.7 days; P < .001) and were more likely to be discharged home (88.6%, 82.8%, 82.5%; P < .001) and significa...
Expert Systems with Applications, 2021
Abstract Social media offer a big amount of information, to exploit in many fields of research. H... more Abstract Social media offer a big amount of information, to exploit in many fields of research. However, while methods for Natural Language Processing are being developed with good results when applied to well-formed datasets made of written text with a clear syntax, these sources present text written in informal language, unstructured syntax, and with peculiar symbols; therefore, particular approaches are required for text processing in this case. In this paper, the task of sentiment analysis of tweets is regarded. In particular, in order to avoid noise constituted by some web constructs like URLs and mentions and by other text fragments, and to exploit information hidden in symbols like emoticons, emojis and hashtags, the pre-processing of tweets is analyzed. More in detail, a number of experiments, performed by a state-of-the-art classification model (BERT), are designed, to evaluate many currently available operations for pre-processing tweets, in terms of the statistical significance of their influence on sentiment analysis performances. Moreover, available data in two languages are considered, i.e., English and Italian, in order to also evaluate dependence on the language. Results allow to individuate the most convenient strategy to pre-process tweets, and thus to improve the state of the art in both languages for the considered task of sentiment analysis.