Nikita Chauhan - Academia.edu (original) (raw)

Papers by Nikita Chauhan

International Conference on Computing, Communication & Automation, 2015

With the broadening followers of wireless communication technology current technology for radio o... more With the broadening followers of wireless communication technology current technology for radio or wireless network is required to be enhanced in terms of managing the present provided resources. There is a committing encouraging technology that can enhance the usage of wireless spectrum. The basic approach for this is to combine hardware as well as software framework to built a architecture that meets the requirements of the spectrum and comply with the enforcements of spectrum policy rule. In this paper, we propose a rational supervisory technique for cognitive radio called as cognitive spectrum management framework. This framework is able to deal with various environmental circumstances. It assigns channels, rearranges radio distribution parameters, assures fidelity of three main layers : Interface layer, decision layer and enforcement layer. Cognitive spectrum management technique is implemented on a USRP N210 that is connected to MATLAB. Spectrum Sensing and physical parameters are collected with the help of network sniffer and later optimization procedure handles the behavior of transmission.

International Journal of Advanced Research, Apr 30, 2018

Background:Uterine rupture is a rare obstetrical complication associated with disastrous outcome.... more Background:Uterine rupture is a rare obstetrical complication associated with disastrous outcome. Since the rate of caesarean deliveries has increased in the past decades, the risk of scar rupture is also expected to increase. The incidence of uterine rupture is inversely proportional to quality of obstetric care being provided. In the developing world, uterine rupture can have devastating maternal and/or fetal outcomes due to delayed recognition and/or intervention Materials and Methods:This is a retrospective study of patients with uterine rupture from January 2017 to December 2017, admitted in Rajendra Institute of Medical Sciences, Ranchi in the Department of Obstetrics and Gynecology. All the cases of uterine rupture were included and detailed study of their case history, obstetric history, surgical history was done. Details of their referral, duration & augmentation of labor, diagnosis on admission, site of rupture, surgical intervention requiring hysterectomy or repair and fe...

Introduction: Obstructed labor continues to plague thousands of women each year, accounting for a... more Introduction: Obstructed labor continues to plague thousands of women each year, accounting for about 8% of all maternal deaths in developing countries like India. It is the leading cause of hospitalization, comprising up to 39% of all obstetric patients in developing countries. Obstructed labor is the single most important cause of maternal death and is one of the three leading causes of perinatal mortality with the case fatality rate of 87%100%. Materials and Methods: This Retrospective study of obstructed labour was conducted from January 2019 to December 2020 in the Department of obstetrics and Gynaecology of Hazaribagh Medical College, Hazaribagh, Jharkhand. All patients admitted with obstructed labour were included in the study. Detailed history regarding age, socioeconomic status, parity, previous obstetric history, past history, antenatal care, duration of labour, details of referral and management were recorded. During admission, the general condition of mother was assessed...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2020

Background: Gestational Trophoblastic Diseases (GTD) encompass a wide spectrum of proliferative d... more Background: Gestational Trophoblastic Diseases (GTD) encompass a wide spectrum of proliferative disorders of trophoblast tissue, which hold a good prognosis if diagnosed and treated on time. A close understanding of the disease spectrum is therefore needed to reduce morbidity and mortality.Methods: This is an observational study (both prospective and retrospective analysis) conducted in Rajendra Institute of Medical Sciences, a tertiary care teaching hospital in Ranchi, Jharkhand over a period of 2 years from 1st January 2017 to 31st December 2018.Results: A total of 162 cases of GTD were identified during the study period. Disease spectrum comprised of complete molar pregnancy in 146 (90.12%) and partial molar pregnancy in 7 (4.3%), GTN in 9 out of 162 cases (5.5%). Bleeding per vaginum preceded by amenorrhea was the most common symptom, observed in 95.4% of the cases. Uterine size was more than period of amenorrhea in almost 50% of the cases. Theca lutein cysts were found in 39.8%...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2020

Background: The objective of the present study was to compare the two most commonly used agents f... more Background: The objective of the present study was to compare the two most commonly used agents for induction of labor-vaginal misoprostol and intracervical dinoprostone gel in terms of the incidence of cardiotocography (CTG) abnormalities and its correlation with fetal distress and fetomaternal outcome.Methods: This is prospective case-control study conducted in department of obstetrics and gynecology, RIMS, Ranchi over a period of 15 months. 112 women requiring induction were randomly assigned to two groups of 56 each, Group M received vaginal misoprostol and Group D received intracervical dinoprostone E2 gel. 56 women with spontaneous labor served as control group. Groups were compared in terms of the incidence of suspicious or pathological CTG tracings, fetal distress, induction to vaginal delivery time, vaginal delivery rates, dose requirements, rate of emergency cesarean.Results: Misoprostol was associated with shorter induction to delivery time (9.54 hours) than dinoprostone ...

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Jan 13, 2017

Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). W... more Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular disease in the presence of chronic kidney disease due to an accumulation of reactive oxygen species and decreased microvascular perfusion of the myocardium. To isolate the exclusive effect of GPx3 deficiency in kidney disease-induced cardiac disease, we studied the GPx3 knockout mouse strain (GPx3-/-) in the setting of surgery-induced CKD. Ribonucleic acid (RNA) microarray screening of non-stimulated GPx3-/- heart tissue show increased expression of genes associated with cardiomyopathy including myh7, plac9, serpine1 and cd74 compared with wild-type (WT) controls. GPx3-/- mice underwent surgically induced renal mass reduction to generate a model of CKD. GPx3-/- + CKD mice underwent echocardiography 4 weeks after injury. Fractional shortening (FS) was decreased to 32.9 ± 5.8% in GPx3-/- + CKD compared to 62.0% ± 10.3 in WT + C...

Kidney International, 2017

Vascular progenitor cells show promise for the treatment of microvasculature endothelial injury. ... more Vascular progenitor cells show promise for the treatment of microvasculature endothelial injury. We investigated the function of renal artery progenitor cells derived from radical nephrectomy patients, in animal models of acute ischemic and hyperperfusion injuries. Present in human adventitia, CD34positive/CD105negative cells were clonal and expressed transcription factors Sox2/Oct4 as well as surface markers CXCR4 (CD184)/KDR(CD309) consistent with endothelial progenitor cells. Termed renal artery-derived vascular progenitor cells (RAPC), injected cells were associated with decreased serum creatinine after ischemia/reperfusion, reduced albuminuria after hyperperfusion, and improved blood flow in both models. A small population of RAPC integrated with the renal microvasculature following either experimental injury. At a cellular level, RAPC promoted local endothelial migration in co-culture. Profiling of RAPC microRNA identified high levels of miRNA 218; also found at high levels in exosomes isolated from RAPC conditioned media after cell contact for 24 hours. After hydrogen peroxide-induced endothelial injury, RAPC exosomes harbored Robo-1 transcript; a gene known to be regulated by mir218. Such exosomes enhanced endothelial cell migration in culture in the absence of RAPC. Thus, our work shows the

Kidney International, 2015

Vascular inflammation is a major contributor to the severity of acute kidney injury. In the conte... more Vascular inflammation is a major contributor to the severity of acute kidney injury. In the context of vasospasm-independent reperfusion injury we studied the potential anti-inflammatory role of the Gα-related RGS protein, RGS4. Transgenic RGS4 mice were resistant to 25 minute injury, although post-ischemic renal arteriolar diameter was equal to the wild type early after injury. A 10 minute unilateral injury was performed to study reperfusion without vasospasm. Eighteen hours after injury blood flow was decreased in the inner cortex of wild type mice with preservation of tubular architecture. Angiotensin II levels in the kidneys of wild type and transgenic mice were elevated in a sub-vasoconstrictive range 12 and 18 hours after injury. Angiotensin II stimulated pre-glomerular vascular smooth muscle cells (VSMC) to secrete the macrophage chemoattractant, RANTES; a process decreased by angiotensin II R2 (AT2) inhibition. However, RANTES increased when RGS4 expression was suppressed implicating Gα protein activation in an AT2-RGS4-dependent pathway. RGS4 function, specific to VSMC, was tested in a conditional VSMCspecific RGS4 knockout showing high macrophage density by T2 MRI compared to transgenic and non-transgenic mice after the 10 minute injury. Arteriolar diameter of this knockout was unchanged at successive time points after injury. Thus, RGS4 expression, specific to renal VSMC,

Identification of the unknown (material) is the need of the hour in the world of insecurities. Ra... more Identification of the unknown (material) is the need of the hour in the world of insecurities. Raman spectroscopy is an important technique for assigning molecular signature for detection and identification of unknown sample. Raman Spectroscopy is based on the inelastic scattering of the incident light by the vibrational test molecule. Raman spectrum is unique for particular molecule or compound and this property is employed for identification. This paper proposes a simpler, cheaper and less complex technique for capturing and analyzing the Raman spectra. A dedicated program has been developed, using Labview software, for analyzing the Raman spectrum and identifying the same. The program has been tested and has proved to detect and identify the element successfully and effectively.

International Conference on Computing, Communication & Automation, 2015

With the broadening followers of wireless communication technology current technology for radio o... more With the broadening followers of wireless communication technology current technology for radio or wireless network is required to be enhanced in terms of managing the present provided resources. There is a committing encouraging technology that can enhance the usage of wireless spectrum. The basic approach for this is to combine hardware as well as software framework to built a architecture that meets the requirements of the spectrum and comply with the enforcements of spectrum policy rule. In this paper, we propose a rational supervisory technique for cognitive radio called as cognitive spectrum management framework. This framework is able to deal with various environmental circumstances. It assigns channels, rearranges radio distribution parameters, assures fidelity of three main layers : Interface layer, decision layer and enforcement layer. Cognitive spectrum management technique is implemented on a USRP N210 that is connected to MATLAB. Spectrum Sensing and physical parameters are collected with the help of network sniffer and later optimization procedure handles the behavior of transmission.

International Journal of Advanced Research, Apr 30, 2018

Background:Uterine rupture is a rare obstetrical complication associated with disastrous outcome.... more Background:Uterine rupture is a rare obstetrical complication associated with disastrous outcome. Since the rate of caesarean deliveries has increased in the past decades, the risk of scar rupture is also expected to increase. The incidence of uterine rupture is inversely proportional to quality of obstetric care being provided. In the developing world, uterine rupture can have devastating maternal and/or fetal outcomes due to delayed recognition and/or intervention Materials and Methods:This is a retrospective study of patients with uterine rupture from January 2017 to December 2017, admitted in Rajendra Institute of Medical Sciences, Ranchi in the Department of Obstetrics and Gynecology. All the cases of uterine rupture were included and detailed study of their case history, obstetric history, surgical history was done. Details of their referral, duration & augmentation of labor, diagnosis on admission, site of rupture, surgical intervention requiring hysterectomy or repair and fe...

Introduction: Obstructed labor continues to plague thousands of women each year, accounting for a... more Introduction: Obstructed labor continues to plague thousands of women each year, accounting for about 8% of all maternal deaths in developing countries like India. It is the leading cause of hospitalization, comprising up to 39% of all obstetric patients in developing countries. Obstructed labor is the single most important cause of maternal death and is one of the three leading causes of perinatal mortality with the case fatality rate of 87%100%. Materials and Methods: This Retrospective study of obstructed labour was conducted from January 2019 to December 2020 in the Department of obstetrics and Gynaecology of Hazaribagh Medical College, Hazaribagh, Jharkhand. All patients admitted with obstructed labour were included in the study. Detailed history regarding age, socioeconomic status, parity, previous obstetric history, past history, antenatal care, duration of labour, details of referral and management were recorded. During admission, the general condition of mother was assessed...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2020

Background: Gestational Trophoblastic Diseases (GTD) encompass a wide spectrum of proliferative d... more Background: Gestational Trophoblastic Diseases (GTD) encompass a wide spectrum of proliferative disorders of trophoblast tissue, which hold a good prognosis if diagnosed and treated on time. A close understanding of the disease spectrum is therefore needed to reduce morbidity and mortality.Methods: This is an observational study (both prospective and retrospective analysis) conducted in Rajendra Institute of Medical Sciences, a tertiary care teaching hospital in Ranchi, Jharkhand over a period of 2 years from 1st January 2017 to 31st December 2018.Results: A total of 162 cases of GTD were identified during the study period. Disease spectrum comprised of complete molar pregnancy in 146 (90.12%) and partial molar pregnancy in 7 (4.3%), GTN in 9 out of 162 cases (5.5%). Bleeding per vaginum preceded by amenorrhea was the most common symptom, observed in 95.4% of the cases. Uterine size was more than period of amenorrhea in almost 50% of the cases. Theca lutein cysts were found in 39.8%...

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2020

Background: The objective of the present study was to compare the two most commonly used agents f... more Background: The objective of the present study was to compare the two most commonly used agents for induction of labor-vaginal misoprostol and intracervical dinoprostone gel in terms of the incidence of cardiotocography (CTG) abnormalities and its correlation with fetal distress and fetomaternal outcome.Methods: This is prospective case-control study conducted in department of obstetrics and gynecology, RIMS, Ranchi over a period of 15 months. 112 women requiring induction were randomly assigned to two groups of 56 each, Group M received vaginal misoprostol and Group D received intracervical dinoprostone E2 gel. 56 women with spontaneous labor served as control group. Groups were compared in terms of the incidence of suspicious or pathological CTG tracings, fetal distress, induction to vaginal delivery time, vaginal delivery rates, dose requirements, rate of emergency cesarean.Results: Misoprostol was associated with shorter induction to delivery time (9.54 hours) than dinoprostone ...

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Jan 13, 2017

Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). W... more Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular disease in the presence of chronic kidney disease due to an accumulation of reactive oxygen species and decreased microvascular perfusion of the myocardium. To isolate the exclusive effect of GPx3 deficiency in kidney disease-induced cardiac disease, we studied the GPx3 knockout mouse strain (GPx3-/-) in the setting of surgery-induced CKD. Ribonucleic acid (RNA) microarray screening of non-stimulated GPx3-/- heart tissue show increased expression of genes associated with cardiomyopathy including myh7, plac9, serpine1 and cd74 compared with wild-type (WT) controls. GPx3-/- mice underwent surgically induced renal mass reduction to generate a model of CKD. GPx3-/- + CKD mice underwent echocardiography 4 weeks after injury. Fractional shortening (FS) was decreased to 32.9 ± 5.8% in GPx3-/- + CKD compared to 62.0% ± 10.3 in WT + C...

Kidney International, 2017

Vascular progenitor cells show promise for the treatment of microvasculature endothelial injury. ... more Vascular progenitor cells show promise for the treatment of microvasculature endothelial injury. We investigated the function of renal artery progenitor cells derived from radical nephrectomy patients, in animal models of acute ischemic and hyperperfusion injuries. Present in human adventitia, CD34positive/CD105negative cells were clonal and expressed transcription factors Sox2/Oct4 as well as surface markers CXCR4 (CD184)/KDR(CD309) consistent with endothelial progenitor cells. Termed renal artery-derived vascular progenitor cells (RAPC), injected cells were associated with decreased serum creatinine after ischemia/reperfusion, reduced albuminuria after hyperperfusion, and improved blood flow in both models. A small population of RAPC integrated with the renal microvasculature following either experimental injury. At a cellular level, RAPC promoted local endothelial migration in co-culture. Profiling of RAPC microRNA identified high levels of miRNA 218; also found at high levels in exosomes isolated from RAPC conditioned media after cell contact for 24 hours. After hydrogen peroxide-induced endothelial injury, RAPC exosomes harbored Robo-1 transcript; a gene known to be regulated by mir218. Such exosomes enhanced endothelial cell migration in culture in the absence of RAPC. Thus, our work shows the

Kidney International, 2015

Vascular inflammation is a major contributor to the severity of acute kidney injury. In the conte... more Vascular inflammation is a major contributor to the severity of acute kidney injury. In the context of vasospasm-independent reperfusion injury we studied the potential anti-inflammatory role of the Gα-related RGS protein, RGS4. Transgenic RGS4 mice were resistant to 25 minute injury, although post-ischemic renal arteriolar diameter was equal to the wild type early after injury. A 10 minute unilateral injury was performed to study reperfusion without vasospasm. Eighteen hours after injury blood flow was decreased in the inner cortex of wild type mice with preservation of tubular architecture. Angiotensin II levels in the kidneys of wild type and transgenic mice were elevated in a sub-vasoconstrictive range 12 and 18 hours after injury. Angiotensin II stimulated pre-glomerular vascular smooth muscle cells (VSMC) to secrete the macrophage chemoattractant, RANTES; a process decreased by angiotensin II R2 (AT2) inhibition. However, RANTES increased when RGS4 expression was suppressed implicating Gα protein activation in an AT2-RGS4-dependent pathway. RGS4 function, specific to VSMC, was tested in a conditional VSMCspecific RGS4 knockout showing high macrophage density by T2 MRI compared to transgenic and non-transgenic mice after the 10 minute injury. Arteriolar diameter of this knockout was unchanged at successive time points after injury. Thus, RGS4 expression, specific to renal VSMC,

Identification of the unknown (material) is the need of the hour in the world of insecurities. Ra... more Identification of the unknown (material) is the need of the hour in the world of insecurities. Raman spectroscopy is an important technique for assigning molecular signature for detection and identification of unknown sample. Raman Spectroscopy is based on the inelastic scattering of the incident light by the vibrational test molecule. Raman spectrum is unique for particular molecule or compound and this property is employed for identification. This paper proposes a simpler, cheaper and less complex technique for capturing and analyzing the Raman spectra. A dedicated program has been developed, using Labview software, for analyzing the Raman spectrum and identifying the same. The program has been tested and has proved to detect and identify the element successfully and effectively.