Nimetullah BURNAK - Academia.edu (original) (raw)

Papers by Nimetullah BURNAK

Research paper thumbnail of An Economic Approach to the Management of High-Quality Processes

Quality and Reliability Engineering International, May 11, 2012

Modern manufacturing developments have forced researchers to investigate alternative quality cont... more Modern manufacturing developments have forced researchers to investigate alternative quality control techniques for highquality processes. The cumulative count of conforming (CCC) control chart is a powerful alternative approach for monitoring high-quality processes for which traditional control charts are inadequate. This study develops a mathematical model for the economic design of the CCC control chart and presents an application of the proposed model. On the basis of the results of the application, the economic and classical CCC control chart designs of the CCC control chart are compared. The optimal design parameters for different defective fractions are tabulated, and a sensitivity analysis of the model is presented for the CCC control chart user to determine the optimal economic design parameters and minimum hourly costs for one production run according to different defective fractions, cost, time, and process parameters.

Research paper thumbnail of A systematic approach to the solution of the design optimization problem

Total quality management, Feb 1, 1998

... design optimization problem CAFER CËELIÇ K 1 & NIÇ METULLAH BURNAK 2 ... If many perf... more ... design optimization problem CAFER CËELIÇ K 1 & NIÇ METULLAH BURNAK 2 ... If many performance characteristics are optimized simultaneously, more informed analysis can be performed, and less expensive experiments can be run for design improvement. ...

Research paper thumbnail of The determination of mean and/or variance shifts with artificial neural networks

International Journal of Production Research, Jul 1, 1999

ABSTRACT Control charts are tools commonly used in production environments to determine whether a... more ABSTRACT Control charts are tools commonly used in production environments to determine whether a process is in control or not. In this study, in addition to traditional Shewhart control charts, artificial neural networks which attempt to emulate the massively parallel and distributed processing of the brain are being examined for use in statistical process control. It is vital for quality and cost to detect variability (shift in mean and/or variance) in a process. If the time between the occurrence of a variation and its detection and cost are considered, the determination of the variation correctly and quickly is very important for production processes. This study has scope for the determination of mean and/or variance shifts in a process. One model is developed for detection of the shifts in a process. The model includes two neural networks: one determines shifts in process mean and the other determines shifts in variance. The results of these networks are combined to decide which shift has occurred. The performance of the model was compared with that of control charts by evaluating Type II error.

Research paper thumbnail of Optimization of a biosurfactant production from bacteria isolated from soil and characterization of the surfactant

Türk biyokimya dergisi, 2016

Objective: Biosurfactants are surface-active substances produced by microorganisms. The growth of... more Objective: Biosurfactants are surface-active substances produced by microorganisms. The growth of microorganism supports biosurfactant production on hydrocarbon polluted environments. In this study, the capacity of biosurfactant production of Georgenia daeguensis (accession number, KP798810) isolated from hydrocarbon-contaminated soil was studied. Methods: The components of biosurfactant production medium were investigated through Plackett-Burman methodology. By using Placket-Burman based on statistical screening, six of the eleven factors of production medium were found to be critically effective on the biosurfactant production. Results: The significant factors were KCl, ZnSO 4 .7H 2 O, CaCl 2 .2H 2 O, KH 2 PO 4 , MgSO 4 .7H 2 O and glucose. Among of these, KCl had the highest effect contribution with 55.22%. After the optimization by such design, critical micelle concentration value was reached to 2.2 g L-1. When anti-bacterial activity of biosurfactant was screened, it showed antibacterial effect against to Klebsiella pneumoniae. Besides, the biosurfactant was characterized by FT-IR, critic micelle concentration and zeta analysis. Conclusion: This study reported that Georgenia daeguensis is able to produce effective biosurfactant exhibiting antibacterial activity against K. pneumoniae.

Research paper thumbnail of Trametes versicolor ile lakkaz üretimi ve renk giderimi: Taguchi ve Box-Behnken yöntemlerinin uygulaması

Türk biyokimya dergisi, 2014

Research paper thumbnail of Karışım tasarımları: Gıda endüstrisindeki güncel uygulamalar üzerine bir yayın taraması

Design of experiments (DOE) is a systematic approach to applying statistical methods to the exper... more Design of experiments (DOE) is a systematic approach to applying statistical methods to the experimental process. The main purpose of this study is to provide useful insights into mixture design as a special type of DOE and to present a review of current mixture design applications in the food industry. The theoretical principles of mixture design and its application in the food industry, based on an extensive review of the literature, are described. Mixture design types, such as simplex-lattice, simplex-centroid, D-optimal and crossed mixture, are compared in terms of their characteristics and advantages. Multi-response optimization and the application of some heuristics and softwares are discussed. This review focuses on an overview of the more specialized and novel food applications in the recent literature.

Research paper thumbnail of Modeling and analysis of the effects of nano-oil additives on wear properties of AISI 4140 steel material using mixture design

Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 2015

The aim of this study is to investigate the effects of nano-oil additives on the wear properties ... more The aim of this study is to investigate the effects of nano-oil additives on the wear properties of AISI 4140 steel material. This paper also introduces an application of mixture design to the development of a new proportion formulation for nano-oil additives dispersed in engine oil (SAE10W) to enhance lubrication. A mixture design procedure was performed on the basis of design, modeling, optimization, and confirmation steps. Based on a simplex lattice design, a cubic model was established as a function of the nanoparticle fractions. The optimal proportions were obtained by considering the cross-sectional area of the wear profile. A 77.81% decrease compared to the base oil was obtained by using ZnO and carbon nanotubes.

Research paper thumbnail of Laccase production and dye decolorization by Trametes versicolor: Application of Taguchi and Box-Behnken methodologies

Turkish Journal of Biochemistry, 2014

ABSTRACT Objective: The aim of this study was to investigate the laccase production of Trametes v... more ABSTRACT Objective: The aim of this study was to investigate the laccase production of Trametes versicolor under submerged fermentation condition. Then, dye decolorization by laccase was optimized using Box-Behnken methodology. Methods: The optimal culture conditions for producing high amount of laccase were determined using Taguchi methodology. The experiments were designed with five factors (glucose, yeast extract, CuSO4, inoculum size and pH) at three levels with orthogonal array layout of L27 (3(5)). Then, the optimum conditions for high decolorization activity of Reactive Blue 49 by obtained crude laccase were also investigated using Box-Behnken methodology. Results: The optimum culture conditions for production of high amounts of laccase were detected as 2 g L-1 of glucose, 5 g L-1 of yeast extract, 2mM of CuSO4, 4% of inoculum amount and pH 5.5. Yeast extract was the most effective factor, followed by CuSO4, inoculum, glucose and pH. Under these conditions, predicted values were in a good agreement with the actual experimental one. The predicted results showed that the maximum of Reactive Blue 49 decolorization as 98% could be obtained under the optimum conditions of pH 2.95, initial dye concentration 55.6 mg L-1, enzyme amount 0.76 mL and reaction time 46.91 min. The validity and practicability of this statistical optimization strategy was confirmed with the relation between predicted and experimental values. Conclusion: The results suggested that Taguchi method can be used in the optimization of laccase production process. Production of laccase by Trametes versicolor 2008001 can be effectively used for enzymatic decolorization according to the results of decolorization experiments in optimal levels.

Research paper thumbnail of Laccase production and dye decolorization by Trametes versicolor: application of Taguchi and Box-Behnken Methodologies

Objective: The aim of this study was to investigate the laccase production of Trametes versicolor... more Objective: The aim of this study was to investigate the laccase production of Trametes versicolor under submerged fermentation condition. Then, dye decolorization by laccase was optimized using Box-Behnken methodology. Methods: The optimal culture conditions for producing high amount of laccase were determined using Taguchi methodology. The experiments were designed with five factors (glucose, yeast extract, CuSO4, inoculum size and pH) at three levels with orthogonal array layout of L27 (35). Then, the optimum conditions for high decolorization activity of Reactive Blue 49 by obtained crude laccase were also investigated using Box-Behnken methodology. Results: The optimum culture conditions for production of high amounts of laccase were detected as 2 g L-1 of glucose, 5 g L-1 of yeast extract, 2mM of CuSO4, 4% of inoculum amount and pH 5.5. Yeast extract was the most effective factor, followed by CuSO4, inoculum, glucose and pH. Under these conditions, predicted values were in a go...

Research paper thumbnail of Karışım tasarımları: Gıda endüstrisindeki güncel uygulamalar üzerine bir yayın taraması

Design of experiments (DOE) is a systematic approach to applying statistical methods to the exper... more Design of experiments (DOE) is a systematic approach to applying statistical methods to the experimental process. The main purpose of this study is to provide useful insights into mixture design as a special type of DOE and to present a review of current mixture design applications in the food industry. The theoretical principles of mixture design and its application in the food industry, based on an extensive review of the literature, are described. Mixture design types, such as simplex-lattice, simplex-centroid, D-optimal and crossed mixture, are compared in terms of their characteristics and advantages. Multi-response optimization and the application of some heuristics and softwares are discussed. This review focuses on an overview of the more specialized and novel food applications in the recent literature.

Research paper thumbnail of The determination of mean and/or variance shifts with artificial neural networks

International Journal of Production Research, 1999

Control charts are tools commonly used in production environments to determine whether a process ... more Control charts are tools commonly used in production environments to determine whether a process is in control or not. In this study, in addition to traditional Shewhart control charts, artificial neural networks which attempt to emulate the massively parallel and distributed processing of the brain are being examined for use in statistical process control. It is vital for quality and cost to detect variability (shift in mean and/or variance) in a process. If the time between the occurrence of a variation and its detection and cost are considered, the determination of the variation correctly and quickly is very important for production processes. This study has scope for the determination of mean and/or variance shifts in a process. One model is developed for detection of the shifts in a process. The model includes two neural networks: one determines shifts in process mean and the other determines shifts in variance. The results of these networks are combined to decide which shift h...

Research paper thumbnail of A systematic approach to the solution of the design optimization problem

Total Quality Management & Business Excellence, 1998

Design optimization problem is a cost-effective method for improving product/process quality that... more Design optimization problem is a cost-effective method for improving product/process quality that is determined by an optimal set of values for controllable variables, from the point of view of its robustness against various uncontrollable variables. Designing high-quality products/ processes at low cost leads to increased market share and continuous customer loyalty. An efficient way to achieve this is to use Taguchi methods. Although they have a wide application range, Taguchi methods are applied mainly in engineering. In order to apply Taguchi methods to the solution of the problems in various areas, a systematic approach is needed. This paper proposes and discusses the necessary steps for the application of Taguchi methods to the design optimization problem.

Research paper thumbnail of Representing preferences by Choquet integral: Guidelines to specify the capacity type

This study considers representing decision maker preferences by Choquet integral in existence of ... more This study considers representing decision maker preferences by Choquet integral in existence of interactions among criteria. Parameters of the Choquet integral are capacities which assign weights not only to criteria but also to each subset of criteria. This property provides Choquet integral with the ability of modeling some types of interactions. Different capacity types with different degrees of complexity have been defined in the literature. After making a review on the dependence (interaction) and independence concepts used in the multiple criteria decision making literature, we study and represent structures of interactions that can be handled by different capacity types through intuitive graphical demonstrations. Afterwards, we provide guidelines for specifying the appropriate capacity type in practical applications. Such guidance has not been provided in the literature for the practitioners to the best of our knowledge. .

Research paper thumbnail of Modeling and analysis of the effects of nano-oil additives on wear properties of AISI 4140 steel material using mixture design

Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 2015

The aim of this study is to investigate the effects of nano-oil additives on the wear properties ... more The aim of this study is to investigate the effects of nano-oil additives on the wear properties of AISI 4140 steel material. This paper also introduces an application of mixture design to the development of a new proportion formulation for nano-oil additives dispersed in engine oil (SAE10W) to enhance lubrication. A mixture design procedure was performed on the basis of design, modeling, optimization, and confirmation steps. Based on a simplex lattice design, a cubic model was established as a function of the nanoparticle fractions. The optimal proportions were obtained by considering the cross-sectional area of the wear profile. A 77.81% decrease compared to the base oil was obtained by using ZnO and carbon nanotubes.

Research paper thumbnail of PHENOL TOLERANCE AND BIODEGRADATION OPTIMIZATION OF Serratia marcescens NSO9-1 USING PLACKETT-BURMAN AND BOX-BEHNKEN DESIGN

Environmental Engineering and Management Journal

The phenol degradation capacity of Serratia marcescens NSO9-1 isolated from olive mill wastewater... more The phenol degradation capacity of Serratia marcescens NSO9-1 isolated from olive mill wastewater was evaluated and optimized in this study. Plackett-Burman design coupled with Box-Behnken methodology was used to evaluate the effects of medium components and significant parameters on phenol degradation by this relevant strain. According to Plackett-Burmanbased statistical screening, seven of the eleven components of the medium had a significant effect on the metabolism of phenol degradation. The most important factors were MgSO4, NaCl, CaCl2, and molybdenum salt, which had an effective contribution of 90.12%. Additionally, Box-Behnken methodology using a quadratic model was adopted to investigate the mutual interactions between process parameters. The analysis results indicated that interactions between pH and temperature, pH and inoculum amount, and incubation time and inoculum amount critically affected the response variable. The experimental results showed that under the determined conditions, 41.66% of the maximum removal efficiency of phenol was achieved. The optimal conditions were 8.94, 30.22°C, 4.19 days, and 4.68% (v/v) for pH, temperature, incubation time, and inoculum amount, respectively. The validity and practicability of this statistical optimization strategy confirmed the relation between predicted and experimental values. Using a selective isolation method, the performance of this indigenous strain isolated from olive oil mill wastewater, which contained polyphenolic compounds, is comparable to the reported literature at higher phenol concentrations.

Research paper thumbnail of Mixture design: A review of recent applications in the food industry

Öz Design of experiments (DOE) is a systematic approach to applying statistical methods to the ex... more Öz Design of experiments (DOE) is a systematic approach to applying statistical methods to the experimental process. The main purpose of this study is to provide useful insights into mixture design as a special type of DOE and to present a review of current mixture design applications in the food industry. The theoretical principles of mixture design and its application in the food industry, based on an extensive review of the literature, are described. Mixture design types, such as simplex-lattice, simplex-centroid, D-optimal and crossed mixture, are compared in terms of their characteristics and advantages. Multi-response optimization and the application of some heuristics and softwares are discussed. This review focuses on an overview of the more specialized and novel food applications in the recent literature. Deney tasarımı, deneysel süreçlerde istatistiksel teknikleri kullanan sistematik bir yaklaşımdır. Bu çalışmanın temel amacı, deney tasarımının özel bir hali olan karışım tasarımlarının gıda sektöründeki güncel uygulamalarına dönük bir bakış açısı sunmaktır. Karışım tasarımlarına ilişkin teorik bilgiler ve gıda sektöründeki uygulamalar geniş bir literatür temel alınarak açıklanmaya çalışılmıştır. Simpleks Kafes, Merkezlenmiş Simpleks Kafes, D-optimal ve Çapraz tasarımlar gibi bir çok karışım tasarım tipi özellikleri ve avantajları yönüyle karşılaştırılmıştır. Çok yanıtlı eniyileme ve eniyilemede kullanılan bazı algoritmalar ve yazılımlar tartışılmıştır. Özetle, yapılan çalışma gıda endüstrisinde karışım tasarımlarına ilişkin daha özel ve güncel uygulamalara odaklanmıştır.

Research paper thumbnail of An Economic Approach to the Management of High-Quality Processes

Modern manufacturing developments have forced researchers to investigate alternative quality cont... more Modern manufacturing developments have forced researchers to investigate alternative quality control techniques for highquality processes. The cumulative count of conforming (CCC) control chart is a powerful alternative approach for monitoring high-quality processes for which traditional control charts are inadequate. This study develops a mathematical model for the economic design of the CCC control chart and presents an application of the proposed model. On the basis of the results of the application, the economic and classical CCC control chart designs of the CCC control chart are compared. The optimal design parameters for different defective fractions are tabulated, and a sensitivity analysis of the model is presented for the CCC control chart user to determine the optimal economic design parameters and minimum hourly costs for one production run according to different defective fractions, cost, time, and process parameters.

Research paper thumbnail of Lead and nickel biosorption with a dried fungal biomass isolated from lead mine drainage using response surface methodology

New Biotechnology, Sep 26, 2012

Research paper thumbnail of Lead and Nickel Biosorption with a Fungal Biomass Isolated from Metal Mine Drainage: Box-Behnken Experimental Design

International journal of Environmental Science and Technology

The Pb(II) and Ni(II) biosorption of a fungal biomass isolated from mine drainage of metal-proces... more The Pb(II) and Ni(II) biosorption of a fungal biomass isolated from mine drainage of metal-processing industries in Balya (BalA +/- kesir province, Turkey) was optimized using a response surface methodology by altering parameters such as pH, initial metal concentration, contact time and biosorbent dosage. This strain was shown to be highly similar to Penicillium sp. Furthermore, zeta potential measurements and Fourier transform infrared spectroscopy were performed to understand the adsorption mechanism. A Box-Behnken design with 29 experiments was used to evaluate the interactions between independent variables. The results showed that the fungal biomass isolated from the metal mine drainage could have a significant environmental impact through the biosorption of Pb(II) and Ni(II) in waters polluted with heavy metals, particularly in the drainage from metal mines. The maximum removal values were 76 and 47 % at pH 4.5 for both Pb(II) and Ni(II), with 123 and 33 mg/L initial metal conc...

Research paper thumbnail of Laccase production and dye decolorization by Trametes versicolor: application of Taguchi and Box-Behnken Methodologies

Objective: The aim of this study was to investigate the laccase production of Trametes versicolor... more Objective: The aim of this study was to investigate the laccase production of Trametes versicolor under submerged fermentation condition. Then, dye decolorization by laccase was optimized using Box-Behnken methodology. Methods: The optimal culture conditions for producing high amount of laccase were determined using Taguchi methodology. The experiments were designed with five factors (glucose, yeast extract, CuSO4, inoculum size and pH) at three levels with orthogonal array layout of L27 (35). Then, the optimum conditions for high decolorization activity of Reactive Blue 49 by obtained crude laccase were also investigated using Box-Behnken methodology. Results: The optimum culture conditions for production of high amounts of laccase were detected as 2 g L-1 of glucose, 5 g L-1 of yeast extract, 2mM of CuSO4, 4% of inoculum amount and pH 5.5. Yeast extract was the most effective factor, followed by CuSO4, inoculum, glucose and pH. Under these conditions, predicted values were in a go...

Research paper thumbnail of An Economic Approach to the Management of High-Quality Processes

Quality and Reliability Engineering International, May 11, 2012

Modern manufacturing developments have forced researchers to investigate alternative quality cont... more Modern manufacturing developments have forced researchers to investigate alternative quality control techniques for highquality processes. The cumulative count of conforming (CCC) control chart is a powerful alternative approach for monitoring high-quality processes for which traditional control charts are inadequate. This study develops a mathematical model for the economic design of the CCC control chart and presents an application of the proposed model. On the basis of the results of the application, the economic and classical CCC control chart designs of the CCC control chart are compared. The optimal design parameters for different defective fractions are tabulated, and a sensitivity analysis of the model is presented for the CCC control chart user to determine the optimal economic design parameters and minimum hourly costs for one production run according to different defective fractions, cost, time, and process parameters.

Research paper thumbnail of A systematic approach to the solution of the design optimization problem

Total quality management, Feb 1, 1998

... design optimization problem CAFER CËELIÇ K 1 & NIÇ METULLAH BURNAK 2 ... If many perf... more ... design optimization problem CAFER CËELIÇ K 1 & NIÇ METULLAH BURNAK 2 ... If many performance characteristics are optimized simultaneously, more informed analysis can be performed, and less expensive experiments can be run for design improvement. ...

Research paper thumbnail of The determination of mean and/or variance shifts with artificial neural networks

International Journal of Production Research, Jul 1, 1999

ABSTRACT Control charts are tools commonly used in production environments to determine whether a... more ABSTRACT Control charts are tools commonly used in production environments to determine whether a process is in control or not. In this study, in addition to traditional Shewhart control charts, artificial neural networks which attempt to emulate the massively parallel and distributed processing of the brain are being examined for use in statistical process control. It is vital for quality and cost to detect variability (shift in mean and/or variance) in a process. If the time between the occurrence of a variation and its detection and cost are considered, the determination of the variation correctly and quickly is very important for production processes. This study has scope for the determination of mean and/or variance shifts in a process. One model is developed for detection of the shifts in a process. The model includes two neural networks: one determines shifts in process mean and the other determines shifts in variance. The results of these networks are combined to decide which shift has occurred. The performance of the model was compared with that of control charts by evaluating Type II error.

Research paper thumbnail of Optimization of a biosurfactant production from bacteria isolated from soil and characterization of the surfactant

Türk biyokimya dergisi, 2016

Objective: Biosurfactants are surface-active substances produced by microorganisms. The growth of... more Objective: Biosurfactants are surface-active substances produced by microorganisms. The growth of microorganism supports biosurfactant production on hydrocarbon polluted environments. In this study, the capacity of biosurfactant production of Georgenia daeguensis (accession number, KP798810) isolated from hydrocarbon-contaminated soil was studied. Methods: The components of biosurfactant production medium were investigated through Plackett-Burman methodology. By using Placket-Burman based on statistical screening, six of the eleven factors of production medium were found to be critically effective on the biosurfactant production. Results: The significant factors were KCl, ZnSO 4 .7H 2 O, CaCl 2 .2H 2 O, KH 2 PO 4 , MgSO 4 .7H 2 O and glucose. Among of these, KCl had the highest effect contribution with 55.22%. After the optimization by such design, critical micelle concentration value was reached to 2.2 g L-1. When anti-bacterial activity of biosurfactant was screened, it showed antibacterial effect against to Klebsiella pneumoniae. Besides, the biosurfactant was characterized by FT-IR, critic micelle concentration and zeta analysis. Conclusion: This study reported that Georgenia daeguensis is able to produce effective biosurfactant exhibiting antibacterial activity against K. pneumoniae.

Research paper thumbnail of Trametes versicolor ile lakkaz üretimi ve renk giderimi: Taguchi ve Box-Behnken yöntemlerinin uygulaması

Türk biyokimya dergisi, 2014

Research paper thumbnail of Karışım tasarımları: Gıda endüstrisindeki güncel uygulamalar üzerine bir yayın taraması

Design of experiments (DOE) is a systematic approach to applying statistical methods to the exper... more Design of experiments (DOE) is a systematic approach to applying statistical methods to the experimental process. The main purpose of this study is to provide useful insights into mixture design as a special type of DOE and to present a review of current mixture design applications in the food industry. The theoretical principles of mixture design and its application in the food industry, based on an extensive review of the literature, are described. Mixture design types, such as simplex-lattice, simplex-centroid, D-optimal and crossed mixture, are compared in terms of their characteristics and advantages. Multi-response optimization and the application of some heuristics and softwares are discussed. This review focuses on an overview of the more specialized and novel food applications in the recent literature.

Research paper thumbnail of Modeling and analysis of the effects of nano-oil additives on wear properties of AISI 4140 steel material using mixture design

Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 2015

The aim of this study is to investigate the effects of nano-oil additives on the wear properties ... more The aim of this study is to investigate the effects of nano-oil additives on the wear properties of AISI 4140 steel material. This paper also introduces an application of mixture design to the development of a new proportion formulation for nano-oil additives dispersed in engine oil (SAE10W) to enhance lubrication. A mixture design procedure was performed on the basis of design, modeling, optimization, and confirmation steps. Based on a simplex lattice design, a cubic model was established as a function of the nanoparticle fractions. The optimal proportions were obtained by considering the cross-sectional area of the wear profile. A 77.81% decrease compared to the base oil was obtained by using ZnO and carbon nanotubes.

Research paper thumbnail of Laccase production and dye decolorization by Trametes versicolor: Application of Taguchi and Box-Behnken methodologies

Turkish Journal of Biochemistry, 2014

ABSTRACT Objective: The aim of this study was to investigate the laccase production of Trametes v... more ABSTRACT Objective: The aim of this study was to investigate the laccase production of Trametes versicolor under submerged fermentation condition. Then, dye decolorization by laccase was optimized using Box-Behnken methodology. Methods: The optimal culture conditions for producing high amount of laccase were determined using Taguchi methodology. The experiments were designed with five factors (glucose, yeast extract, CuSO4, inoculum size and pH) at three levels with orthogonal array layout of L27 (3(5)). Then, the optimum conditions for high decolorization activity of Reactive Blue 49 by obtained crude laccase were also investigated using Box-Behnken methodology. Results: The optimum culture conditions for production of high amounts of laccase were detected as 2 g L-1 of glucose, 5 g L-1 of yeast extract, 2mM of CuSO4, 4% of inoculum amount and pH 5.5. Yeast extract was the most effective factor, followed by CuSO4, inoculum, glucose and pH. Under these conditions, predicted values were in a good agreement with the actual experimental one. The predicted results showed that the maximum of Reactive Blue 49 decolorization as 98% could be obtained under the optimum conditions of pH 2.95, initial dye concentration 55.6 mg L-1, enzyme amount 0.76 mL and reaction time 46.91 min. The validity and practicability of this statistical optimization strategy was confirmed with the relation between predicted and experimental values. Conclusion: The results suggested that Taguchi method can be used in the optimization of laccase production process. Production of laccase by Trametes versicolor 2008001 can be effectively used for enzymatic decolorization according to the results of decolorization experiments in optimal levels.

Research paper thumbnail of Laccase production and dye decolorization by Trametes versicolor: application of Taguchi and Box-Behnken Methodologies

Objective: The aim of this study was to investigate the laccase production of Trametes versicolor... more Objective: The aim of this study was to investigate the laccase production of Trametes versicolor under submerged fermentation condition. Then, dye decolorization by laccase was optimized using Box-Behnken methodology. Methods: The optimal culture conditions for producing high amount of laccase were determined using Taguchi methodology. The experiments were designed with five factors (glucose, yeast extract, CuSO4, inoculum size and pH) at three levels with orthogonal array layout of L27 (35). Then, the optimum conditions for high decolorization activity of Reactive Blue 49 by obtained crude laccase were also investigated using Box-Behnken methodology. Results: The optimum culture conditions for production of high amounts of laccase were detected as 2 g L-1 of glucose, 5 g L-1 of yeast extract, 2mM of CuSO4, 4% of inoculum amount and pH 5.5. Yeast extract was the most effective factor, followed by CuSO4, inoculum, glucose and pH. Under these conditions, predicted values were in a go...

Research paper thumbnail of Karışım tasarımları: Gıda endüstrisindeki güncel uygulamalar üzerine bir yayın taraması

Design of experiments (DOE) is a systematic approach to applying statistical methods to the exper... more Design of experiments (DOE) is a systematic approach to applying statistical methods to the experimental process. The main purpose of this study is to provide useful insights into mixture design as a special type of DOE and to present a review of current mixture design applications in the food industry. The theoretical principles of mixture design and its application in the food industry, based on an extensive review of the literature, are described. Mixture design types, such as simplex-lattice, simplex-centroid, D-optimal and crossed mixture, are compared in terms of their characteristics and advantages. Multi-response optimization and the application of some heuristics and softwares are discussed. This review focuses on an overview of the more specialized and novel food applications in the recent literature.

Research paper thumbnail of The determination of mean and/or variance shifts with artificial neural networks

International Journal of Production Research, 1999

Control charts are tools commonly used in production environments to determine whether a process ... more Control charts are tools commonly used in production environments to determine whether a process is in control or not. In this study, in addition to traditional Shewhart control charts, artificial neural networks which attempt to emulate the massively parallel and distributed processing of the brain are being examined for use in statistical process control. It is vital for quality and cost to detect variability (shift in mean and/or variance) in a process. If the time between the occurrence of a variation and its detection and cost are considered, the determination of the variation correctly and quickly is very important for production processes. This study has scope for the determination of mean and/or variance shifts in a process. One model is developed for detection of the shifts in a process. The model includes two neural networks: one determines shifts in process mean and the other determines shifts in variance. The results of these networks are combined to decide which shift h...

Research paper thumbnail of A systematic approach to the solution of the design optimization problem

Total Quality Management & Business Excellence, 1998

Design optimization problem is a cost-effective method for improving product/process quality that... more Design optimization problem is a cost-effective method for improving product/process quality that is determined by an optimal set of values for controllable variables, from the point of view of its robustness against various uncontrollable variables. Designing high-quality products/ processes at low cost leads to increased market share and continuous customer loyalty. An efficient way to achieve this is to use Taguchi methods. Although they have a wide application range, Taguchi methods are applied mainly in engineering. In order to apply Taguchi methods to the solution of the problems in various areas, a systematic approach is needed. This paper proposes and discusses the necessary steps for the application of Taguchi methods to the design optimization problem.

Research paper thumbnail of Representing preferences by Choquet integral: Guidelines to specify the capacity type

This study considers representing decision maker preferences by Choquet integral in existence of ... more This study considers representing decision maker preferences by Choquet integral in existence of interactions among criteria. Parameters of the Choquet integral are capacities which assign weights not only to criteria but also to each subset of criteria. This property provides Choquet integral with the ability of modeling some types of interactions. Different capacity types with different degrees of complexity have been defined in the literature. After making a review on the dependence (interaction) and independence concepts used in the multiple criteria decision making literature, we study and represent structures of interactions that can be handled by different capacity types through intuitive graphical demonstrations. Afterwards, we provide guidelines for specifying the appropriate capacity type in practical applications. Such guidance has not been provided in the literature for the practitioners to the best of our knowledge. .

Research paper thumbnail of Modeling and analysis of the effects of nano-oil additives on wear properties of AISI 4140 steel material using mixture design

Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 2015

The aim of this study is to investigate the effects of nano-oil additives on the wear properties ... more The aim of this study is to investigate the effects of nano-oil additives on the wear properties of AISI 4140 steel material. This paper also introduces an application of mixture design to the development of a new proportion formulation for nano-oil additives dispersed in engine oil (SAE10W) to enhance lubrication. A mixture design procedure was performed on the basis of design, modeling, optimization, and confirmation steps. Based on a simplex lattice design, a cubic model was established as a function of the nanoparticle fractions. The optimal proportions were obtained by considering the cross-sectional area of the wear profile. A 77.81% decrease compared to the base oil was obtained by using ZnO and carbon nanotubes.

Research paper thumbnail of PHENOL TOLERANCE AND BIODEGRADATION OPTIMIZATION OF Serratia marcescens NSO9-1 USING PLACKETT-BURMAN AND BOX-BEHNKEN DESIGN

Environmental Engineering and Management Journal

The phenol degradation capacity of Serratia marcescens NSO9-1 isolated from olive mill wastewater... more The phenol degradation capacity of Serratia marcescens NSO9-1 isolated from olive mill wastewater was evaluated and optimized in this study. Plackett-Burman design coupled with Box-Behnken methodology was used to evaluate the effects of medium components and significant parameters on phenol degradation by this relevant strain. According to Plackett-Burmanbased statistical screening, seven of the eleven components of the medium had a significant effect on the metabolism of phenol degradation. The most important factors were MgSO4, NaCl, CaCl2, and molybdenum salt, which had an effective contribution of 90.12%. Additionally, Box-Behnken methodology using a quadratic model was adopted to investigate the mutual interactions between process parameters. The analysis results indicated that interactions between pH and temperature, pH and inoculum amount, and incubation time and inoculum amount critically affected the response variable. The experimental results showed that under the determined conditions, 41.66% of the maximum removal efficiency of phenol was achieved. The optimal conditions were 8.94, 30.22°C, 4.19 days, and 4.68% (v/v) for pH, temperature, incubation time, and inoculum amount, respectively. The validity and practicability of this statistical optimization strategy confirmed the relation between predicted and experimental values. Using a selective isolation method, the performance of this indigenous strain isolated from olive oil mill wastewater, which contained polyphenolic compounds, is comparable to the reported literature at higher phenol concentrations.

Research paper thumbnail of Mixture design: A review of recent applications in the food industry

Öz Design of experiments (DOE) is a systematic approach to applying statistical methods to the ex... more Öz Design of experiments (DOE) is a systematic approach to applying statistical methods to the experimental process. The main purpose of this study is to provide useful insights into mixture design as a special type of DOE and to present a review of current mixture design applications in the food industry. The theoretical principles of mixture design and its application in the food industry, based on an extensive review of the literature, are described. Mixture design types, such as simplex-lattice, simplex-centroid, D-optimal and crossed mixture, are compared in terms of their characteristics and advantages. Multi-response optimization and the application of some heuristics and softwares are discussed. This review focuses on an overview of the more specialized and novel food applications in the recent literature. Deney tasarımı, deneysel süreçlerde istatistiksel teknikleri kullanan sistematik bir yaklaşımdır. Bu çalışmanın temel amacı, deney tasarımının özel bir hali olan karışım tasarımlarının gıda sektöründeki güncel uygulamalarına dönük bir bakış açısı sunmaktır. Karışım tasarımlarına ilişkin teorik bilgiler ve gıda sektöründeki uygulamalar geniş bir literatür temel alınarak açıklanmaya çalışılmıştır. Simpleks Kafes, Merkezlenmiş Simpleks Kafes, D-optimal ve Çapraz tasarımlar gibi bir çok karışım tasarım tipi özellikleri ve avantajları yönüyle karşılaştırılmıştır. Çok yanıtlı eniyileme ve eniyilemede kullanılan bazı algoritmalar ve yazılımlar tartışılmıştır. Özetle, yapılan çalışma gıda endüstrisinde karışım tasarımlarına ilişkin daha özel ve güncel uygulamalara odaklanmıştır.

Research paper thumbnail of An Economic Approach to the Management of High-Quality Processes

Modern manufacturing developments have forced researchers to investigate alternative quality cont... more Modern manufacturing developments have forced researchers to investigate alternative quality control techniques for highquality processes. The cumulative count of conforming (CCC) control chart is a powerful alternative approach for monitoring high-quality processes for which traditional control charts are inadequate. This study develops a mathematical model for the economic design of the CCC control chart and presents an application of the proposed model. On the basis of the results of the application, the economic and classical CCC control chart designs of the CCC control chart are compared. The optimal design parameters for different defective fractions are tabulated, and a sensitivity analysis of the model is presented for the CCC control chart user to determine the optimal economic design parameters and minimum hourly costs for one production run according to different defective fractions, cost, time, and process parameters.

Research paper thumbnail of Lead and nickel biosorption with a dried fungal biomass isolated from lead mine drainage using response surface methodology

New Biotechnology, Sep 26, 2012

Research paper thumbnail of Lead and Nickel Biosorption with a Fungal Biomass Isolated from Metal Mine Drainage: Box-Behnken Experimental Design

International journal of Environmental Science and Technology

The Pb(II) and Ni(II) biosorption of a fungal biomass isolated from mine drainage of metal-proces... more The Pb(II) and Ni(II) biosorption of a fungal biomass isolated from mine drainage of metal-processing industries in Balya (BalA +/- kesir province, Turkey) was optimized using a response surface methodology by altering parameters such as pH, initial metal concentration, contact time and biosorbent dosage. This strain was shown to be highly similar to Penicillium sp. Furthermore, zeta potential measurements and Fourier transform infrared spectroscopy were performed to understand the adsorption mechanism. A Box-Behnken design with 29 experiments was used to evaluate the interactions between independent variables. The results showed that the fungal biomass isolated from the metal mine drainage could have a significant environmental impact through the biosorption of Pb(II) and Ni(II) in waters polluted with heavy metals, particularly in the drainage from metal mines. The maximum removal values were 76 and 47 % at pH 4.5 for both Pb(II) and Ni(II), with 123 and 33 mg/L initial metal conc...

Research paper thumbnail of Laccase production and dye decolorization by Trametes versicolor: application of Taguchi and Box-Behnken Methodologies

Objective: The aim of this study was to investigate the laccase production of Trametes versicolor... more Objective: The aim of this study was to investigate the laccase production of Trametes versicolor under submerged fermentation condition. Then, dye decolorization by laccase was optimized using Box-Behnken methodology. Methods: The optimal culture conditions for producing high amount of laccase were determined using Taguchi methodology. The experiments were designed with five factors (glucose, yeast extract, CuSO4, inoculum size and pH) at three levels with orthogonal array layout of L27 (35). Then, the optimum conditions for high decolorization activity of Reactive Blue 49 by obtained crude laccase were also investigated using Box-Behnken methodology. Results: The optimum culture conditions for production of high amounts of laccase were detected as 2 g L-1 of glucose, 5 g L-1 of yeast extract, 2mM of CuSO4, 4% of inoculum amount and pH 5.5. Yeast extract was the most effective factor, followed by CuSO4, inoculum, glucose and pH. Under these conditions, predicted values were in a go...