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Papers by Olga Vasilkova

Research paper thumbnail of КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ УРОВНЕЙ МОЗГОВОГО НАТРИЙУРЕТИЧЕСКОГО ПЕПТИДА И ЕГО N-КОНЦЕВОГО ПРЕДШЕСТВЕННИКА У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 2 ТИПА И ХРОНИЧЕСКОЙ БОЛЕЗНЬЮ ПОЧЕК

Juvenis scientia, Feb 28, 2018

Research paper thumbnail of Clinical experience of gel testosterone in men with diabetes type 2 and late-onset hypogonadism

Research paper thumbnail of The influence of anemia on the quality of life of patients with early stages of diabetic nephropathy

Rossiiskii Gumanitarnyi Zhurnal, 2016

Понятие качества жизни положено в основу новой парадигмы понимания болезни и определения эффектив... more Понятие качества жизни положено в основу новой парадигмы понимания болезни и определения эффективности методов ее лечения. Целью исследования являлась оценка влияния анемии на качество жизни больных с ранними стадиями диабетической нефропатии. Обследовано 127 больных с сахарным диабетом 2 типа, осложненным хронической болезнью почек (ХБП) 1-3 стадий. Изучение качества жизни с использованием методики SF-36 показало, что анемия, вне зависимости от стадии ХБП, ассоциирована со снижением показателей по шкалам ролевого функционирования, обусловленного физическим состоянием, и ролевого функционирования, обусловленного эмоциональным состоянием. У больных с анемией и ХБП 3 стадии наблюдалось также снижение качества жизни по шкалам общего состояния здоровья, физического функционирования, интенсивности боли, жизненной активности и психического здоровья. В работе обсуждаются возможные причины выявленных изменений качества жизни и их значение с медицинских и гуманитарных позиций. Ключевые слова: качество жизни, сахарный диабет, диабетическая нефропатия, хроническая болезнь почек, анемия.

Research paper thumbnail of Dyslipidemia with and without insulin resistance: Similarities and differences

Atherosclerosis, 2016

significantly higher in the MetS subjects (3.05±1.30 vs. 1.89±0.08; p<0.0001; for MetS and non-Me... more significantly higher in the MetS subjects (3.05±1.30 vs. 1.89±0.08; p<0.0001; for MetS and non-MetS subjects, respectively). MetS subjects had significantly higher IMT (0.59±0.10 mm vs. 0.54±0.09 mm, p¼0.0002) and no significantly lower FMD value (7.80±3.23% vs. 8.17±3.71%, p¼0.59). In the regression model HOMA-IR was positively associated with IMT (b¼0.0020, p<0.0001), whereas there was no relationship with FMD (b¼-0.19, p¼0.28). Carotid IMT value positively correlated with a number of CVD risk factors, all MetS components, plasma CRP levels, and inversely correlated with brachial FMD. Conclusions: The HOMA index was shown to be associated with carotid IMT, thus highlighting the role of insulin resistance in the intimal-medial thickening investigated in a cohort of police officers.

Research paper thumbnail of Взаимосвязь цистатина C и структурно- геометрических параметров сердца у пациентов с сахарным диабетом и хронической болезнью почек

Введение. Диабетическая нефропатия занимает одно из ведущих мест в структуре смертности пациентов... more Введение. Диабетическая нефропатия занимает одно из ведущих мест в структуре смертности пациентов с сахарным диабетом, при этом значительная часть таких пациентов не доживает до стадии уремии и умирает от сердечно-сосудистых осложнений. В связи с этим становится актуальным выделение биологических маркеров, которые можно использовать для диагностического и прогностического мониторирования риска развития сердечно-сосудистых заболеваний при нарушении функции почек. Цель. Оценить взаимосвязь цистатина C и структурно-геометрических параметров сердца у пациентов с сахарным диабетом и хронической болезнью почек. Материалы и методы. В исследование были включены 499 пациентов обоих полов с СД 1-го типа и СД 2-го типа в возрасте старше 25 лет. Всем пациентам наряду со стандартным клиническим и лабораторным обследованием проводилась оценка уровня цистатина С, а также эхокардиографическое исследование с оценкой структурно-геометрических показателей сердца. Результаты. Уровни цистатина С у пацие...

Research paper thumbnail of Title Leptin is an independent determinant of bone mineral density in men withtype 2 diabetes mellitus

To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type... more To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (T2DM), we screened 168 Belarussian men aged 45 to 65 years. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, triglyceride concentrations were assessed and low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol (LDL-C) were calculated. Hemoglobin A 1c , immune-reactive insulin (IRI), serum total testosterone and sex hormone-binding globulin were also evaluated. BMD was evaluated using dual-energy X-ray absorptiometry. By univariate linear regression analysis, BMD was significantly correlated with body mass index (r=0.23, p=0.002) and leptin (r=0.21, p=0.006). By multivariate regression analysis adjusting for confounding factors, log leptin was independently correlated with BMD (=0.058, p=0.001). Our study revealed that leptin is an independent determinant of BMD in patients with T2DM. Further research is necessary to confirm this association and to develop ways to correct abnormalities of bone metabolism in patients with T2DM.

Research paper thumbnail of SP411THE Interconnection Between Renal Function Parameters and Markers of Hypercoagulation in Men with Metabolic Syndrome

Nephrology Dialysis Transplantation

parenteral nutritional therapy (IDPN) is one of them. We compared the effects of IDPN on protein ... more parenteral nutritional therapy (IDPN) is one of them. We compared the effects of IDPN on protein metabolism, BMI and phase angle in dialysis patients with DM or tumor disease to patients without DM or malignancy METHODS: We analyzed single-center data from 57 chronic hemodialysis patients with malnutrition (17 with DM, 20 with malignancy) who were treated with IDPE for at least six months between January 2013 and December 2015. An individualized IDPN infusion regime containing a volume of 600 ml-800 ml and 800 kcal-1000 kcal per application was administered three times a week. Assessments of laboratory parameters, phase angle and body mass index were performed every three months. RESULTS: IDPN was well tolerated and successfully prevented further deterioration of patients' nutritional status (serum albumin (34 g/l vs. 35 g/l), total protein (6,3 g/dl vs 6,4 g/dl.), phase angle (3,5 vs. 3,5) and body mass (23,3 kg/m 2 vs. 24,3 kg/m 2) during the study period. The protective effect of IDPN therapy was observed in all analyzed subgroups (DM, malignancy and controls). CONCLUSIONS: IDPN can effectively prevent further deterioration of the dietary status of chronic hemodialysis patients with malnutrition. However, high efforts regarding cost and IDPN composition and application have to be taken into account.

Research paper thumbnail of Assessment of quality of life in anemic and non-anemic patients with early stages of diabetic nephropathy

Endocrine Abstracts, 2016

Research paper thumbnail of Relationship of serum leptin and bone mineral density in patients with type 2 diabetes mellitus

Research paper thumbnail of Experience with a 1% testosterone gel in treatment of aging males with hypogonadism and type 2 diabetes mellitus

Research paper thumbnail of Testosterone is an independent determinant of bone mineral density in men with type 2 diabetes mellitus

Clinical Chemistry and Laboratory Medicine, 2000

List of abbreviations body mass index (BMI); bone mineral density (BMD); C-reactive protein (CRP)... more List of abbreviations body mass index (BMI); bone mineral density (BMD); C-reactive protein (CRP); type 2 diabetes mellitus (DT2); follicle-stimulating hormone (FSH); hemoglobin A 1c (HbA 1c); high-density lipoprotein cholesterol (HDL-C); immunoreactive insulin (IRI); lowdensity lipoprotein cholesterol (LDL-C); luteinizing hormone (LH); sex hormonebinding globulin (SHBG); total cholesterol (TC); triglyceride (TG); very low-density lipoprotein cholesterol (VLDL-C); qualitative ultrasound (QUS)

Research paper thumbnail of The prevalence of subclinical late-onset hypogonadism in men with diabetes type 2

Endocrine …, 2009

... Olga Vasilkova 1, 3 , Tatyana Mokhort 2 , Tamara Sharshakova 1 &amp; Igor Sanec 3. ... Lu... more ... Olga Vasilkova 1, 3 , Tatyana Mokhort 2 , Tamara Sharshakova 1 &amp; Igor Sanec 3. ... Luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), calculated free testosterone (cFT) and bioavailable testosterone (bT), sex hormone binding globulin (SHBG), ...

Research paper thumbnail of Leptin is an independent determinant of bone mineral density in men with type 2 diabetes mellitus

Acta Diabetologica

To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type... more To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (T2DM), we screened 168 Belarusian men aged 45-65 years. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, and triglyceride concentrations were assessed, and low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol (LDL-C) were calculated. Hemoglobin A(1c), immune-reactive insulin (IRI), serum total testosterone, and sex hormone-binding globulin were also evaluated. BMD was evaluated using dual-energy X-ray absorptiometry. By univariate linear regression analysis, BMD was significantly correlated with body mass index (r = 0.23, P = 0.002) and leptin (r = 0.21, P = 0.006). By multivariate regression analysis adjusting for confounding factors, log leptin was independently correlated with BMD (β = 0.058, P = 0.001). Our study revealed that leptin is an independent determinant of BMD in patients with T2DM. Further research is ne...

Research paper thumbnail of КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ УРОВНЕЙ МОЗГОВОГО НАТРИЙУРЕТИЧЕСКОГО ПЕПТИДА И ЕГО N-КОНЦЕВОГО ПРЕДШЕСТВЕННИКА У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 2 ТИПА И ХРОНИЧЕСКОЙ БОЛЕЗНЬЮ ПОЧЕК

Juvenis scientia, Feb 28, 2018

Research paper thumbnail of Clinical experience of gel testosterone in men with diabetes type 2 and late-onset hypogonadism

Research paper thumbnail of The influence of anemia on the quality of life of patients with early stages of diabetic nephropathy

Rossiiskii Gumanitarnyi Zhurnal, 2016

Понятие качества жизни положено в основу новой парадигмы понимания болезни и определения эффектив... more Понятие качества жизни положено в основу новой парадигмы понимания болезни и определения эффективности методов ее лечения. Целью исследования являлась оценка влияния анемии на качество жизни больных с ранними стадиями диабетической нефропатии. Обследовано 127 больных с сахарным диабетом 2 типа, осложненным хронической болезнью почек (ХБП) 1-3 стадий. Изучение качества жизни с использованием методики SF-36 показало, что анемия, вне зависимости от стадии ХБП, ассоциирована со снижением показателей по шкалам ролевого функционирования, обусловленного физическим состоянием, и ролевого функционирования, обусловленного эмоциональным состоянием. У больных с анемией и ХБП 3 стадии наблюдалось также снижение качества жизни по шкалам общего состояния здоровья, физического функционирования, интенсивности боли, жизненной активности и психического здоровья. В работе обсуждаются возможные причины выявленных изменений качества жизни и их значение с медицинских и гуманитарных позиций. Ключевые слова: качество жизни, сахарный диабет, диабетическая нефропатия, хроническая болезнь почек, анемия.

Research paper thumbnail of Dyslipidemia with and without insulin resistance: Similarities and differences

Atherosclerosis, 2016

significantly higher in the MetS subjects (3.05±1.30 vs. 1.89±0.08; p<0.0001; for MetS and non-Me... more significantly higher in the MetS subjects (3.05±1.30 vs. 1.89±0.08; p<0.0001; for MetS and non-MetS subjects, respectively). MetS subjects had significantly higher IMT (0.59±0.10 mm vs. 0.54±0.09 mm, p¼0.0002) and no significantly lower FMD value (7.80±3.23% vs. 8.17±3.71%, p¼0.59). In the regression model HOMA-IR was positively associated with IMT (b¼0.0020, p<0.0001), whereas there was no relationship with FMD (b¼-0.19, p¼0.28). Carotid IMT value positively correlated with a number of CVD risk factors, all MetS components, plasma CRP levels, and inversely correlated with brachial FMD. Conclusions: The HOMA index was shown to be associated with carotid IMT, thus highlighting the role of insulin resistance in the intimal-medial thickening investigated in a cohort of police officers.

Research paper thumbnail of Взаимосвязь цистатина C и структурно- геометрических параметров сердца у пациентов с сахарным диабетом и хронической болезнью почек

Введение. Диабетическая нефропатия занимает одно из ведущих мест в структуре смертности пациентов... more Введение. Диабетическая нефропатия занимает одно из ведущих мест в структуре смертности пациентов с сахарным диабетом, при этом значительная часть таких пациентов не доживает до стадии уремии и умирает от сердечно-сосудистых осложнений. В связи с этим становится актуальным выделение биологических маркеров, которые можно использовать для диагностического и прогностического мониторирования риска развития сердечно-сосудистых заболеваний при нарушении функции почек. Цель. Оценить взаимосвязь цистатина C и структурно-геометрических параметров сердца у пациентов с сахарным диабетом и хронической болезнью почек. Материалы и методы. В исследование были включены 499 пациентов обоих полов с СД 1-го типа и СД 2-го типа в возрасте старше 25 лет. Всем пациентам наряду со стандартным клиническим и лабораторным обследованием проводилась оценка уровня цистатина С, а также эхокардиографическое исследование с оценкой структурно-геометрических показателей сердца. Результаты. Уровни цистатина С у пацие...

Research paper thumbnail of Title Leptin is an independent determinant of bone mineral density in men withtype 2 diabetes mellitus

To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type... more To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (T2DM), we screened 168 Belarussian men aged 45 to 65 years. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, triglyceride concentrations were assessed and low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol (LDL-C) were calculated. Hemoglobin A 1c , immune-reactive insulin (IRI), serum total testosterone and sex hormone-binding globulin were also evaluated. BMD was evaluated using dual-energy X-ray absorptiometry. By univariate linear regression analysis, BMD was significantly correlated with body mass index (r=0.23, p=0.002) and leptin (r=0.21, p=0.006). By multivariate regression analysis adjusting for confounding factors, log leptin was independently correlated with BMD (=0.058, p=0.001). Our study revealed that leptin is an independent determinant of BMD in patients with T2DM. Further research is necessary to confirm this association and to develop ways to correct abnormalities of bone metabolism in patients with T2DM.

Research paper thumbnail of SP411THE Interconnection Between Renal Function Parameters and Markers of Hypercoagulation in Men with Metabolic Syndrome

Nephrology Dialysis Transplantation

parenteral nutritional therapy (IDPN) is one of them. We compared the effects of IDPN on protein ... more parenteral nutritional therapy (IDPN) is one of them. We compared the effects of IDPN on protein metabolism, BMI and phase angle in dialysis patients with DM or tumor disease to patients without DM or malignancy METHODS: We analyzed single-center data from 57 chronic hemodialysis patients with malnutrition (17 with DM, 20 with malignancy) who were treated with IDPE for at least six months between January 2013 and December 2015. An individualized IDPN infusion regime containing a volume of 600 ml-800 ml and 800 kcal-1000 kcal per application was administered three times a week. Assessments of laboratory parameters, phase angle and body mass index were performed every three months. RESULTS: IDPN was well tolerated and successfully prevented further deterioration of patients' nutritional status (serum albumin (34 g/l vs. 35 g/l), total protein (6,3 g/dl vs 6,4 g/dl.), phase angle (3,5 vs. 3,5) and body mass (23,3 kg/m 2 vs. 24,3 kg/m 2) during the study period. The protective effect of IDPN therapy was observed in all analyzed subgroups (DM, malignancy and controls). CONCLUSIONS: IDPN can effectively prevent further deterioration of the dietary status of chronic hemodialysis patients with malnutrition. However, high efforts regarding cost and IDPN composition and application have to be taken into account.

Research paper thumbnail of Assessment of quality of life in anemic and non-anemic patients with early stages of diabetic nephropathy

Endocrine Abstracts, 2016

Research paper thumbnail of Relationship of serum leptin and bone mineral density in patients with type 2 diabetes mellitus

Research paper thumbnail of Experience with a 1% testosterone gel in treatment of aging males with hypogonadism and type 2 diabetes mellitus

Research paper thumbnail of Testosterone is an independent determinant of bone mineral density in men with type 2 diabetes mellitus

Clinical Chemistry and Laboratory Medicine, 2000

List of abbreviations body mass index (BMI); bone mineral density (BMD); C-reactive protein (CRP)... more List of abbreviations body mass index (BMI); bone mineral density (BMD); C-reactive protein (CRP); type 2 diabetes mellitus (DT2); follicle-stimulating hormone (FSH); hemoglobin A 1c (HbA 1c); high-density lipoprotein cholesterol (HDL-C); immunoreactive insulin (IRI); lowdensity lipoprotein cholesterol (LDL-C); luteinizing hormone (LH); sex hormonebinding globulin (SHBG); total cholesterol (TC); triglyceride (TG); very low-density lipoprotein cholesterol (VLDL-C); qualitative ultrasound (QUS)

Research paper thumbnail of The prevalence of subclinical late-onset hypogonadism in men with diabetes type 2

Endocrine …, 2009

... Olga Vasilkova 1, 3 , Tatyana Mokhort 2 , Tamara Sharshakova 1 &amp; Igor Sanec 3. ... Lu... more ... Olga Vasilkova 1, 3 , Tatyana Mokhort 2 , Tamara Sharshakova 1 &amp; Igor Sanec 3. ... Luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), calculated free testosterone (cFT) and bioavailable testosterone (bT), sex hormone binding globulin (SHBG), ...

Research paper thumbnail of Leptin is an independent determinant of bone mineral density in men with type 2 diabetes mellitus

Acta Diabetologica

To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type... more To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (T2DM), we screened 168 Belarusian men aged 45-65 years. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, and triglyceride concentrations were assessed, and low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol (LDL-C) were calculated. Hemoglobin A(1c), immune-reactive insulin (IRI), serum total testosterone, and sex hormone-binding globulin were also evaluated. BMD was evaluated using dual-energy X-ray absorptiometry. By univariate linear regression analysis, BMD was significantly correlated with body mass index (r = 0.23, P = 0.002) and leptin (r = 0.21, P = 0.006). By multivariate regression analysis adjusting for confounding factors, log leptin was independently correlated with BMD (β = 0.058, P = 0.001). Our study revealed that leptin is an independent determinant of BMD in patients with T2DM. Further research is ne...