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Papers by Omaya Dudin
Open biology, 2013
Many cells are able to orient themselves in a non-uniform environment by responding to localized ... more Many cells are able to orient themselves in a non-uniform environment by responding to localized cues. This leads to a polarized cellular response, where the cell can either grow or move towards the cue source. Fungal haploid cells secrete pheromones to signal mating, and respond by growing a mating projection towards a potential mate. Upon contact of the two partner cells, these fuse to form a diploid zygote. In this review, we present our current knowledge on the processes of mating signalling, pheromone-dependent polarized growth and cell fusion in Saccharomyces cerevisiae and Schizosaccharomyces pombe, two highly divergent ascomycete yeast models. While the global architecture of the mating response is very similar between these two species, they differ significantly both in their mating physiologies and in the molecular connections between pheromone perception and downstream responses. The use of both yeast models helps enlighten both conserved solutions and species-specific ad...
Research in Microbiology, 2013
Tel: 0033 476 63 74 84 16 Fax: 0033 476 63 74 97 17 18 hans.geiselmann@ujf-grenoble.fr 19 omaya.d... more Tel: 0033 476 63 74 84 16 Fax: 0033 476 63 74 97 17 18 hans.geiselmann@ujf-grenoble.fr 19 omaya.dudin@unil.ch 20 21 Running title: Crl modulates the induction of a subset of RpoS dependent genes 22
Journal of Bacteriology, 2014
The Journal of cell biology, Jan 30, 2015
Cell-cell fusion is essential for fertilization. For fusion of walled cells, the cell wall must b... more Cell-cell fusion is essential for fertilization. For fusion of walled cells, the cell wall must be degraded at a precise location but maintained in surrounding regions to protect against lysis. In fission yeast cells, the formin Fus1, which nucleates linear actin filaments, is essential for this process. In this paper, we show that this formin organizes a specific actin structure-the actin fusion focus. Structured illumination microscopy and live-cell imaging of Fus1, actin, and type V myosins revealed an aster of actin filaments whose barbed ends are focalized near the plasma membrane. Focalization requires Fus1 and type V myosins and happens asynchronously always in the M cell first. Type V myosins are essential for fusion and concentrate cell wall hydrolases, but not cell wall synthases, at the fusion focus. Thus, the fusion focus focalizes cell wall dissolution within a broader cell wall synthesis zone to shift from cell growth to cell fusion.
Open biology, 2013
Many cells are able to orient themselves in a non-uniform environment by responding to localized ... more Many cells are able to orient themselves in a non-uniform environment by responding to localized cues. This leads to a polarized cellular response, where the cell can either grow or move towards the cue source. Fungal haploid cells secrete pheromones to signal mating, and respond by growing a mating projection towards a potential mate. Upon contact of the two partner cells, these fuse to form a diploid zygote. In this review, we present our current knowledge on the processes of mating signalling, pheromone-dependent polarized growth and cell fusion in Saccharomyces cerevisiae and Schizosaccharomyces pombe, two highly divergent ascomycete yeast models. While the global architecture of the mating response is very similar between these two species, they differ significantly both in their mating physiologies and in the molecular connections between pheromone perception and downstream responses. The use of both yeast models helps enlighten both conserved solutions and species-specific ad...
Research in Microbiology, 2013
Tel: 0033 476 63 74 84 16 Fax: 0033 476 63 74 97 17 18 hans.geiselmann@ujf-grenoble.fr 19 omaya.d... more Tel: 0033 476 63 74 84 16 Fax: 0033 476 63 74 97 17 18 hans.geiselmann@ujf-grenoble.fr 19 omaya.dudin@unil.ch 20 21 Running title: Crl modulates the induction of a subset of RpoS dependent genes 22
Journal of Bacteriology, 2014
The Journal of cell biology, Jan 30, 2015
Cell-cell fusion is essential for fertilization. For fusion of walled cells, the cell wall must b... more Cell-cell fusion is essential for fertilization. For fusion of walled cells, the cell wall must be degraded at a precise location but maintained in surrounding regions to protect against lysis. In fission yeast cells, the formin Fus1, which nucleates linear actin filaments, is essential for this process. In this paper, we show that this formin organizes a specific actin structure-the actin fusion focus. Structured illumination microscopy and live-cell imaging of Fus1, actin, and type V myosins revealed an aster of actin filaments whose barbed ends are focalized near the plasma membrane. Focalization requires Fus1 and type V myosins and happens asynchronously always in the M cell first. Type V myosins are essential for fusion and concentrate cell wall hydrolases, but not cell wall synthases, at the fusion focus. Thus, the fusion focus focalizes cell wall dissolution within a broader cell wall synthesis zone to shift from cell growth to cell fusion.