Orçun Barkay - Academia.edu (original) (raw)
Papers by Orçun Barkay
Cureus, Sep 7, 2023
Introduction Chronic hepatitis B (CHB) continues to be a significant global public health problem... more Introduction Chronic hepatitis B (CHB) continues to be a significant global public health problem. Conventional serological markers play a pivotal role in diagnosing and prognosticating CHB, but atypical serological profiles deviating from established norms pose challenges. Methods A cohort of 35 CHB patients who did not receive an antiviral treatment with atypical serological markers was followed for five years (2017-2022). Demographics, serological parameters, and changes were documented. Serological parameters and serum viral loads (hepatitis B virus (HBV)-deoxyribonucleic acid (DNA) levels) were assayed at the central laboratory during their routine follow-ups. Three groups of atypical serological markers are defined: hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) positivity; hepatitis B e antigen (HBeAg) and anti-hepatitis B e-antigen (anti-HBe) positivity; and isolated core (anti-hepatitis B core (anti-HBc) immunoglobulin G (IgG)) positivity. Patients with concomitant HBsAg and anti-HBs were also stratified into seroreversion groups. Changes in serological markers and HBV-DNA levels across the study period were documented and evaluated at the end of the study period. Statistical analysis was conducted using the Kruskal-Wallis test and IBM SPSS Statistics software for Windows, Version 23.0 (IBM Corp., Armonk, NY, USA). Results In a cohort of 35 patients with atypical hepatitis B serology, demographic analysis revealed that 51.4% (n=18) were female and 48.6% (n=17) were male, with a mean age of 45.7 years. Educational distribution showed that 45.7% (n=16) completed primary education, 22.8% (n=8) had a high school education, and 31.5% (n=11) held university degrees. Among these patients, 10 displayed the concurrent presence of HBsAg and anti-HBs, with 60% (n=6) being female. Serum HBV-DNA was detectable in all cases. After five years, 60% (n=6) exhibited seroconversion from HBsAg to anti-HBs, particularly notable in females (66.7%). These patients showed lower HBsAg titers and serum HBV-DNA levels (p = 0.048, p = 0.036). A subset of 15 patients demonstrated simultaneous HBeAg and anti-HBe positivity. The HBeAg seropositivity waned over time, with 40% (n=6) and 26.7% (n=4) females and males, respectively, retaining positivity by the fifth year. During this period, serum HBV-DNA levels decreased. The remaining five patients sustained HBeAg and anti-HBe positivity. Among 10 patients solely positive for anti-HBc IgG, three had concurrent HBV-DNA positivity. Strikingly, three patients with negative HBV-DNA developed anti-HBs positivity after five years. Conclusion The complexity of CHB infection demands a comprehensive understanding. Atypical serological profiles suggest distinct disease stages, immune response variations, and viral mutations. This study enhances comprehension of viral replication, immune responses, and disease progression, potentially guiding tailored therapeutic strategies.
Haydarpasa Numune Training and Research Hospital Medical Journal
Introduction: Tuberculosis (TB) is a prevalent opportunistic infection among individuals afflicte... more Introduction: Tuberculosis (TB) is a prevalent opportunistic infection among individuals afflicted with human immunodeficiency virus (HIV). HIV infection significantly heightens the risk of TB development, whereas TB, in turn, accelerates the progression of HIV. Among individuals living with HIV, TB remains the most frequently observed disease. Our study's aim is the evaluation of TB tests among HIV/ acquired immunodeficiency syndrome (AIDS) cases. Methods: This study encompassed HIV/AIDS patients aged over 18 years. Tuberculin skin test (TST) and interferon-gamma release assay test (IGRA) results of the patients were evaluated retrospectively. Microsoft Excel and Chi-square test were used to analyze the data and the relationship between assessments. Results: 109 patients underwent TST, with twenty of them displaying reactions of ≥5 mm. Ten patients received IGRA testing and two of them tested positive. Two patients who were confirmed to have active TB during the study exhibited negative TST results, with IGRA not being evaluated in these cases. Among the 22 patients found to be TST positive, TB prophylaxis was initiated. The mean CD4+ T lymphocyte count in patients with TST positivity was 500.4/mm3, whereas in patients with IGRA positivity, it was 497/mm 3. Moreover, the mean CD4 + T lymphocyte count in patients with negative TST results was 444.1/mm 3 , and it was 392.2/mm 3 in patients with negative IGRA results. No statistically significant correlation was observed between TST results and patients' CD4 + T lymphocyte counts and serum HIV-RNA levels. Discussion and Conclusion: The evaluation of TST and IGRA data within the context of HIV-infected cases presents a crucial perspective on the management of TB in this population. Our findings, alongside relevant literature, contribute to a deeper understanding of TB diagnostics and co-infection dynamics among individuals living with HIV. TB remains the leading cause of HIV-related morbidity and mortality. Screening for TB is essential in newly diagnosed HIV-infected cases.
Diagnostics
Hemodialysis (HD) patients should be screened for latent tuberculosis (TB) infection. We aimed to... more Hemodialysis (HD) patients should be screened for latent tuberculosis (TB) infection. We aimed to determine the frequency of latent TB infection in HD patients and to compare the effectiveness of the tests used. The files of 56 HD patients followed between 1 January 2021 and 1 October 2022 were retrospectively analyzed. Demographic data, the presence of the Bacillus Calmette-Guerin (BCG) vaccine, whether or not the patients had previously received treatment for TB before, the status of encountering a patient with active TB of patients over 18 years of age, without active tuberculosis and who had a T-SPOT.TB test or a Tuberculin Skin Test (TST) were obtained from the patient files. The presence of previous TB in a posterior–anterior (PA) chest X-ray was obtained by evaluating PA chest X-rays taken routinely. Of the patients, 60.7% (n = 34) were male and their mean age was 60.18 ± 14.85 years. The mean duration of dialysis was 6.43 ± 6.03 years, and 76.8% (n = 43) had 2 BCG scars. The...
Klimik Dergisi/Klimik Journal
Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency vi... more Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected individuals results in increased hepatic complications. HBV and HIV viruses are transmitted by blood and unprotected sexual intercourse. People with HIV and HBV coinfection are at increased risk for liver-related morbidity and mortality. HCV-related liver injury progresses more rapidly among people coinfected with HIV. HCV coinfection may also affect the management of HIV infection. This review aims to go over the management of HIV-HCV and HIV-HBV coinfections.
Klimik Dergisi/Klimik Journal
TSK Koruyucu Hekimlik Bülteni, 2010
... Selda Bülbül, Ayşegül Alpcan, Orçun Barkay Kırıkkale Ünivesitesi Tıp Fak. Çocuk Sağlığı ve Ha... more ... Selda Bülbül, Ayşegül Alpcan, Orçun Barkay Kırıkkale Ünivesitesi Tıp Fak. Çocuk Sağlığı ve Hastalıkları AD, Kırıkkale. Anahtar Kelimeler: Hiperkolesterolemi, Hipokolesterolemi, Kritik Hastalıklar. ... 261 KAYNAKLAR 1. Doğan P. Steroidlerin Biyosentezi. Turkiye Klinikleri. ...
Kocaeli tıp dergisi, May 1, 2021
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017
Tularemia is a zoonotic infection which is caused by gram negative coccobacilli, Francisella tula... more Tularemia is a zoonotic infection which is caused by gram negative coccobacilli, Francisella tularensis. The disease occurs after contact with blood and body fluids of infected animals, bites and ingestion of infected food and water. Although it commonly presents with skin lesions, there may also be serious organ involvements. A55-year woman was consulted for presumptive diagnosis of tuberculosis. Multiple lymphadenopathy in right cervical area was present on physical examination. Pleural effusion on left side was detected with computed tomography. In detailed history, knowledge of a family member with the diagnosis of tularemia was obtained. Both of them had the history of contact with infected animals. Diagnosis of tularemia was confirmed with microagglutination test. With this patient who was initially presumptively diagnosed as tuberculosis, we aim to draw attention to diagnosis of tularemia in the presence of pleuropnemonia and peripheral lymphadenopathy and emphasize importanc...
Infectious Diseases and Clinical Microbiology, 2020
Objective: Serological tests are the most commonly used tests in the diagnosis of brucellosis; ho... more Objective: Serological tests are the most commonly used tests in the diagnosis of brucellosis; however, each serological test has some drawbacks. In this study, we aimed to determine the value of the Brucella Coombs gel test (BCGT) in the serological diagnosis of brucellosis in comparison with Standard tube agglutination (STA) and ELISA tests. Materials and Methods: The study included 42 patients who were considered to have brucellosis as a preliminary diagnosis. BCGT, Brucella-IgM/IgG ELISA, and STA tests were performed from serum samples of the patients. The correlation of the diagnostic tests was analyzed using Cohen’s Kappa Analysis. Results: Twenty-seven (64.2%) of 42 patients were diagnosed with brucellosis according to their medical history and clinical and serological tests. The sensitivity and specificity of BCGT to diagnose brucellosis was 96.2%, and 100%, respectively. The sensitivity and specificity for the diagnosis of brucellosis 62.9% and 100% for STA, respectively; ...
Archives of Basic and Clinical Research, 2019
Archives of Basic and Clinical Research (Arch Basic Clin Res) is the scientific, peer reviewed, o... more Archives of Basic and Clinical Research (Arch Basic Clin Res) is the scientific, peer reviewed, open access journal of the Erzincan Binali Yıldırım University School of Medicine. The journal is a triannual publication, published in January, May, and September. The journal's publication languages are English and Turkish. Archives of Basic and Clinical Research aims to contribute to the literature by publishing original clinical and experimental research articles at the highest scientific quality in all fields of medicine. The journal also publishes rare case reports, reviews, letters to the editor, and images of interest. The target audience of the journal includes physicians, researchers, and healthcare professionals who are interested or working in all fields of medicine.
Archives of Basic and Clinical Research, 2019
Archives of Basic and Clinical Research (Arch Basic Clin Res) is the scientific, peer reviewed, o... more Archives of Basic and Clinical Research (Arch Basic Clin Res) is the scientific, peer reviewed, open access journal of the Erzincan Binali Yıldırım University School of Medicine. The journal is a triannual publication, published in January, May, and September. The journal's publication languages are English and Turkish. Archives of Basic and Clinical Research aims to contribute to the literature by publishing original clinical and experimental research articles at the highest scientific quality in all fields of medicine. The journal also publishes rare case reports, reviews, letters to the editor, and images of interest. The target audience of the journal includes physicians, researchers, and healthcare professionals who are interested or working in all fields of medicine.
Journal of Emergency Medicine Case Reports
Introduction: Brucellosis and Crimean-Congo Hemorrhagic Fever (CCHF) are diseases that can presen... more Introduction: Brucellosis and Crimean-Congo Hemorrhagic Fever (CCHF) are diseases that can present with similar clinical and laboratory findings to those of COVID-19, leading to misdiagnosis or confusion by visiting multiple departments. This can delay diagnosis and increase the risk of nosocomial transmission in the case of CCHF. Although misdiagnosis of Brucellosis and CCHF, and even a case of coinfection have been reported in the literature, no case report mentioning CCHF and Brucellosis coinfection hospitalized with the pre-diagnosis of COVID-19 was found. Case Report: A 35-year-old female patient presented to the emergency service with complaints of fever and fatigue. The patient was evaluated in the emergency triage and was taken to the area where COVID-19 pre-diagnosed patients were being examined. A thorax computed tomography (CT) without intravenous contrast usage was reported as normal, and the patient was discharged after being informed about COVID-19 transmission routes....
Kocaeli Medical Journal
Introduction: With the increase in the number of patients presenting with respiratory tract sympt... more Introduction: With the increase in the number of patients presenting with respiratory tract symptoms during the pandemic, the differentia ldiagnosis of seasonal respiratory diseases and Coronavirus 2019 (COVID 19) has gained importance, and multiplex PCR (polymerase chain reaction) techniques are needed due to insufficient clinical and laboratory data for differentiation. W e planned this study to determine the frequency of other respiratory viral agents accompanying SARS CoV-2, to determine the dominant viral agents and to determine the rate of coinfection. Material method: Patients aged 18-80 years who applied to the COVID 19 out patient clinic in our hospital between 01.01.2021 and 01.04.2021 with respiratory tract infection symptoms were included in the study. Two simultaneous nasopharyngeal swab samples were taken from the patients and examined for SARS CoV-2 and other respiratory viral agents. Demographic data, clinical complaints and laboratory values of the patients were recorded. Conclusion: A total of 80 patients were included in the study. SARS CoV-2 PCR positivity was detected in 14 of the patients (17.5%), and rhinovirus in 4 patients, rhinovirus/enterovirus and SARS COV 2 PCR positivity in 1 patient. Co-infection was seen in 1 (1.25%) patient. Discussion: In our study, the frequency of viral agents other than SARS CoV-2 was found to be less than the incidence in the pre-pandemic period. This situation was thought to be related to the mask, distance and hand hygiene measures taken to protect against COVID 19 infection. Other respiratory viral agents should be kept in mind in cases who present with symptoms of respiratory tract infection and have a negative SARS CoV-2 PCR test and imaging findings do not support COVID 19.
Canadian Journal of Ophthalmology
Objective: To evaluate the effects of SARS-CoV-2 infection on the optic nerve, macula, and retina... more Objective: To evaluate the effects of SARS-CoV-2 infection on the optic nerve, macula, and retinal vascular structures. Methods: This study included 129 participants recovering from COVID-19 and 130 healthy control subjects aged 18 to 55 years. The study was designed as observational and cross-sectional and was conducted between June 2020 and February 2021. The average thicknesses of the retinal nerve fibre layer (RNFL), ganglion cell complex (GCC), and macula also were measured using a spectral domain optical coherence tomography analysis. The vessel densities of the superficial and deep capillary plexuses of the macula, foveal avascular zone, and radial peripapillary capillary plexus of the optic disc were quantified by optical coherence tomography angiography. Results: In all quadrants, the RNFL and GCC were thinner in patients with neurologic symptoms of COVID-19 (p < 0.05). None of the measurements of the Early Treatment Diabetic Retinopathy Study regions significantly differed between patients with and without COVID-19 symptoms (p > 0.05). The foveal avascular zone area, perimeter, circularity index, and vessel densities (%) of the global and inner and outer circles of superficial capillary plexuses and deep capillary plexus and global and superior and inferior halves of the radial peripapillary capillary plexus measurements were found to significantly differ between the symptomatic COVID-19 group and the asymptomatic COVID-19 and control groups (p < 0.05). Conclusion: RNFL and GCC thickness evaluation with optical coherence tomography and vessel density evaluation with optical coherence tomography angiography can be considered remarkable diagnostic methods for retinal neurovascular abnormalities and a biomarker for microvascular abnormalities after infection with SARS-CoV-2.
Cureus, Sep 7, 2023
Introduction Chronic hepatitis B (CHB) continues to be a significant global public health problem... more Introduction Chronic hepatitis B (CHB) continues to be a significant global public health problem. Conventional serological markers play a pivotal role in diagnosing and prognosticating CHB, but atypical serological profiles deviating from established norms pose challenges. Methods A cohort of 35 CHB patients who did not receive an antiviral treatment with atypical serological markers was followed for five years (2017-2022). Demographics, serological parameters, and changes were documented. Serological parameters and serum viral loads (hepatitis B virus (HBV)-deoxyribonucleic acid (DNA) levels) were assayed at the central laboratory during their routine follow-ups. Three groups of atypical serological markers are defined: hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) positivity; hepatitis B e antigen (HBeAg) and anti-hepatitis B e-antigen (anti-HBe) positivity; and isolated core (anti-hepatitis B core (anti-HBc) immunoglobulin G (IgG)) positivity. Patients with concomitant HBsAg and anti-HBs were also stratified into seroreversion groups. Changes in serological markers and HBV-DNA levels across the study period were documented and evaluated at the end of the study period. Statistical analysis was conducted using the Kruskal-Wallis test and IBM SPSS Statistics software for Windows, Version 23.0 (IBM Corp., Armonk, NY, USA). Results In a cohort of 35 patients with atypical hepatitis B serology, demographic analysis revealed that 51.4% (n=18) were female and 48.6% (n=17) were male, with a mean age of 45.7 years. Educational distribution showed that 45.7% (n=16) completed primary education, 22.8% (n=8) had a high school education, and 31.5% (n=11) held university degrees. Among these patients, 10 displayed the concurrent presence of HBsAg and anti-HBs, with 60% (n=6) being female. Serum HBV-DNA was detectable in all cases. After five years, 60% (n=6) exhibited seroconversion from HBsAg to anti-HBs, particularly notable in females (66.7%). These patients showed lower HBsAg titers and serum HBV-DNA levels (p = 0.048, p = 0.036). A subset of 15 patients demonstrated simultaneous HBeAg and anti-HBe positivity. The HBeAg seropositivity waned over time, with 40% (n=6) and 26.7% (n=4) females and males, respectively, retaining positivity by the fifth year. During this period, serum HBV-DNA levels decreased. The remaining five patients sustained HBeAg and anti-HBe positivity. Among 10 patients solely positive for anti-HBc IgG, three had concurrent HBV-DNA positivity. Strikingly, three patients with negative HBV-DNA developed anti-HBs positivity after five years. Conclusion The complexity of CHB infection demands a comprehensive understanding. Atypical serological profiles suggest distinct disease stages, immune response variations, and viral mutations. This study enhances comprehension of viral replication, immune responses, and disease progression, potentially guiding tailored therapeutic strategies.
Haydarpasa Numune Training and Research Hospital Medical Journal
Introduction: Tuberculosis (TB) is a prevalent opportunistic infection among individuals afflicte... more Introduction: Tuberculosis (TB) is a prevalent opportunistic infection among individuals afflicted with human immunodeficiency virus (HIV). HIV infection significantly heightens the risk of TB development, whereas TB, in turn, accelerates the progression of HIV. Among individuals living with HIV, TB remains the most frequently observed disease. Our study's aim is the evaluation of TB tests among HIV/ acquired immunodeficiency syndrome (AIDS) cases. Methods: This study encompassed HIV/AIDS patients aged over 18 years. Tuberculin skin test (TST) and interferon-gamma release assay test (IGRA) results of the patients were evaluated retrospectively. Microsoft Excel and Chi-square test were used to analyze the data and the relationship between assessments. Results: 109 patients underwent TST, with twenty of them displaying reactions of ≥5 mm. Ten patients received IGRA testing and two of them tested positive. Two patients who were confirmed to have active TB during the study exhibited negative TST results, with IGRA not being evaluated in these cases. Among the 22 patients found to be TST positive, TB prophylaxis was initiated. The mean CD4+ T lymphocyte count in patients with TST positivity was 500.4/mm3, whereas in patients with IGRA positivity, it was 497/mm 3. Moreover, the mean CD4 + T lymphocyte count in patients with negative TST results was 444.1/mm 3 , and it was 392.2/mm 3 in patients with negative IGRA results. No statistically significant correlation was observed between TST results and patients' CD4 + T lymphocyte counts and serum HIV-RNA levels. Discussion and Conclusion: The evaluation of TST and IGRA data within the context of HIV-infected cases presents a crucial perspective on the management of TB in this population. Our findings, alongside relevant literature, contribute to a deeper understanding of TB diagnostics and co-infection dynamics among individuals living with HIV. TB remains the leading cause of HIV-related morbidity and mortality. Screening for TB is essential in newly diagnosed HIV-infected cases.
Diagnostics
Hemodialysis (HD) patients should be screened for latent tuberculosis (TB) infection. We aimed to... more Hemodialysis (HD) patients should be screened for latent tuberculosis (TB) infection. We aimed to determine the frequency of latent TB infection in HD patients and to compare the effectiveness of the tests used. The files of 56 HD patients followed between 1 January 2021 and 1 October 2022 were retrospectively analyzed. Demographic data, the presence of the Bacillus Calmette-Guerin (BCG) vaccine, whether or not the patients had previously received treatment for TB before, the status of encountering a patient with active TB of patients over 18 years of age, without active tuberculosis and who had a T-SPOT.TB test or a Tuberculin Skin Test (TST) were obtained from the patient files. The presence of previous TB in a posterior–anterior (PA) chest X-ray was obtained by evaluating PA chest X-rays taken routinely. Of the patients, 60.7% (n = 34) were male and their mean age was 60.18 ± 14.85 years. The mean duration of dialysis was 6.43 ± 6.03 years, and 76.8% (n = 43) had 2 BCG scars. The...
Klimik Dergisi/Klimik Journal
Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency vi... more Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected individuals results in increased hepatic complications. HBV and HIV viruses are transmitted by blood and unprotected sexual intercourse. People with HIV and HBV coinfection are at increased risk for liver-related morbidity and mortality. HCV-related liver injury progresses more rapidly among people coinfected with HIV. HCV coinfection may also affect the management of HIV infection. This review aims to go over the management of HIV-HCV and HIV-HBV coinfections.
Klimik Dergisi/Klimik Journal
TSK Koruyucu Hekimlik Bülteni, 2010
... Selda Bülbül, Ayşegül Alpcan, Orçun Barkay Kırıkkale Ünivesitesi Tıp Fak. Çocuk Sağlığı ve Ha... more ... Selda Bülbül, Ayşegül Alpcan, Orçun Barkay Kırıkkale Ünivesitesi Tıp Fak. Çocuk Sağlığı ve Hastalıkları AD, Kırıkkale. Anahtar Kelimeler: Hiperkolesterolemi, Hipokolesterolemi, Kritik Hastalıklar. ... 261 KAYNAKLAR 1. Doğan P. Steroidlerin Biyosentezi. Turkiye Klinikleri. ...
Kocaeli tıp dergisi, May 1, 2021
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017
Tularemia is a zoonotic infection which is caused by gram negative coccobacilli, Francisella tula... more Tularemia is a zoonotic infection which is caused by gram negative coccobacilli, Francisella tularensis. The disease occurs after contact with blood and body fluids of infected animals, bites and ingestion of infected food and water. Although it commonly presents with skin lesions, there may also be serious organ involvements. A55-year woman was consulted for presumptive diagnosis of tuberculosis. Multiple lymphadenopathy in right cervical area was present on physical examination. Pleural effusion on left side was detected with computed tomography. In detailed history, knowledge of a family member with the diagnosis of tularemia was obtained. Both of them had the history of contact with infected animals. Diagnosis of tularemia was confirmed with microagglutination test. With this patient who was initially presumptively diagnosed as tuberculosis, we aim to draw attention to diagnosis of tularemia in the presence of pleuropnemonia and peripheral lymphadenopathy and emphasize importanc...
Infectious Diseases and Clinical Microbiology, 2020
Objective: Serological tests are the most commonly used tests in the diagnosis of brucellosis; ho... more Objective: Serological tests are the most commonly used tests in the diagnosis of brucellosis; however, each serological test has some drawbacks. In this study, we aimed to determine the value of the Brucella Coombs gel test (BCGT) in the serological diagnosis of brucellosis in comparison with Standard tube agglutination (STA) and ELISA tests. Materials and Methods: The study included 42 patients who were considered to have brucellosis as a preliminary diagnosis. BCGT, Brucella-IgM/IgG ELISA, and STA tests were performed from serum samples of the patients. The correlation of the diagnostic tests was analyzed using Cohen’s Kappa Analysis. Results: Twenty-seven (64.2%) of 42 patients were diagnosed with brucellosis according to their medical history and clinical and serological tests. The sensitivity and specificity of BCGT to diagnose brucellosis was 96.2%, and 100%, respectively. The sensitivity and specificity for the diagnosis of brucellosis 62.9% and 100% for STA, respectively; ...
Archives of Basic and Clinical Research, 2019
Archives of Basic and Clinical Research (Arch Basic Clin Res) is the scientific, peer reviewed, o... more Archives of Basic and Clinical Research (Arch Basic Clin Res) is the scientific, peer reviewed, open access journal of the Erzincan Binali Yıldırım University School of Medicine. The journal is a triannual publication, published in January, May, and September. The journal's publication languages are English and Turkish. Archives of Basic and Clinical Research aims to contribute to the literature by publishing original clinical and experimental research articles at the highest scientific quality in all fields of medicine. The journal also publishes rare case reports, reviews, letters to the editor, and images of interest. The target audience of the journal includes physicians, researchers, and healthcare professionals who are interested or working in all fields of medicine.
Archives of Basic and Clinical Research, 2019
Archives of Basic and Clinical Research (Arch Basic Clin Res) is the scientific, peer reviewed, o... more Archives of Basic and Clinical Research (Arch Basic Clin Res) is the scientific, peer reviewed, open access journal of the Erzincan Binali Yıldırım University School of Medicine. The journal is a triannual publication, published in January, May, and September. The journal's publication languages are English and Turkish. Archives of Basic and Clinical Research aims to contribute to the literature by publishing original clinical and experimental research articles at the highest scientific quality in all fields of medicine. The journal also publishes rare case reports, reviews, letters to the editor, and images of interest. The target audience of the journal includes physicians, researchers, and healthcare professionals who are interested or working in all fields of medicine.
Journal of Emergency Medicine Case Reports
Introduction: Brucellosis and Crimean-Congo Hemorrhagic Fever (CCHF) are diseases that can presen... more Introduction: Brucellosis and Crimean-Congo Hemorrhagic Fever (CCHF) are diseases that can present with similar clinical and laboratory findings to those of COVID-19, leading to misdiagnosis or confusion by visiting multiple departments. This can delay diagnosis and increase the risk of nosocomial transmission in the case of CCHF. Although misdiagnosis of Brucellosis and CCHF, and even a case of coinfection have been reported in the literature, no case report mentioning CCHF and Brucellosis coinfection hospitalized with the pre-diagnosis of COVID-19 was found. Case Report: A 35-year-old female patient presented to the emergency service with complaints of fever and fatigue. The patient was evaluated in the emergency triage and was taken to the area where COVID-19 pre-diagnosed patients were being examined. A thorax computed tomography (CT) without intravenous contrast usage was reported as normal, and the patient was discharged after being informed about COVID-19 transmission routes....
Kocaeli Medical Journal
Introduction: With the increase in the number of patients presenting with respiratory tract sympt... more Introduction: With the increase in the number of patients presenting with respiratory tract symptoms during the pandemic, the differentia ldiagnosis of seasonal respiratory diseases and Coronavirus 2019 (COVID 19) has gained importance, and multiplex PCR (polymerase chain reaction) techniques are needed due to insufficient clinical and laboratory data for differentiation. W e planned this study to determine the frequency of other respiratory viral agents accompanying SARS CoV-2, to determine the dominant viral agents and to determine the rate of coinfection. Material method: Patients aged 18-80 years who applied to the COVID 19 out patient clinic in our hospital between 01.01.2021 and 01.04.2021 with respiratory tract infection symptoms were included in the study. Two simultaneous nasopharyngeal swab samples were taken from the patients and examined for SARS CoV-2 and other respiratory viral agents. Demographic data, clinical complaints and laboratory values of the patients were recorded. Conclusion: A total of 80 patients were included in the study. SARS CoV-2 PCR positivity was detected in 14 of the patients (17.5%), and rhinovirus in 4 patients, rhinovirus/enterovirus and SARS COV 2 PCR positivity in 1 patient. Co-infection was seen in 1 (1.25%) patient. Discussion: In our study, the frequency of viral agents other than SARS CoV-2 was found to be less than the incidence in the pre-pandemic period. This situation was thought to be related to the mask, distance and hand hygiene measures taken to protect against COVID 19 infection. Other respiratory viral agents should be kept in mind in cases who present with symptoms of respiratory tract infection and have a negative SARS CoV-2 PCR test and imaging findings do not support COVID 19.
Canadian Journal of Ophthalmology
Objective: To evaluate the effects of SARS-CoV-2 infection on the optic nerve, macula, and retina... more Objective: To evaluate the effects of SARS-CoV-2 infection on the optic nerve, macula, and retinal vascular structures. Methods: This study included 129 participants recovering from COVID-19 and 130 healthy control subjects aged 18 to 55 years. The study was designed as observational and cross-sectional and was conducted between June 2020 and February 2021. The average thicknesses of the retinal nerve fibre layer (RNFL), ganglion cell complex (GCC), and macula also were measured using a spectral domain optical coherence tomography analysis. The vessel densities of the superficial and deep capillary plexuses of the macula, foveal avascular zone, and radial peripapillary capillary plexus of the optic disc were quantified by optical coherence tomography angiography. Results: In all quadrants, the RNFL and GCC were thinner in patients with neurologic symptoms of COVID-19 (p < 0.05). None of the measurements of the Early Treatment Diabetic Retinopathy Study regions significantly differed between patients with and without COVID-19 symptoms (p > 0.05). The foveal avascular zone area, perimeter, circularity index, and vessel densities (%) of the global and inner and outer circles of superficial capillary plexuses and deep capillary plexus and global and superior and inferior halves of the radial peripapillary capillary plexus measurements were found to significantly differ between the symptomatic COVID-19 group and the asymptomatic COVID-19 and control groups (p < 0.05). Conclusion: RNFL and GCC thickness evaluation with optical coherence tomography and vessel density evaluation with optical coherence tomography angiography can be considered remarkable diagnostic methods for retinal neurovascular abnormalities and a biomarker for microvascular abnormalities after infection with SARS-CoV-2.