Philip Uzor - Academia.edu (original) (raw)

Papers by Philip Uzor

Research paper thumbnail of Dereplication of Bioactive Markers from the Leaves of Anthocleista nobilis: Searching for new Bioactive Metabolites

Planta medica international open, Oct 1, 2017

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Research paper thumbnail of Green Synthesis of Silver Nanoparticles Using <i>Euphorbia hirta</i> Leaf Extract and the Determination of Their Antimicrobial Activity

Advances in bioscience and bioengineering, 2021

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Research paper thumbnail of Nutritional Status of Adolescent Schoolchildren In South East Nigeria

Pakistan Journal of Nutrition, Aug 15, 2019

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Research paper thumbnail of Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Evidence-based Complementary and Alternative Medicine, Feb 12, 2020

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Research paper thumbnail of Original article: ANTIDIABETIC ACTIVITY OF THE CHEMICAL CONSTITUENTS OF COMBRETUM DOLICHOPETALUM ROOT IN MICE

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Research paper thumbnail of Letter to the editor: RECENT DEVELOPMENTS ON POTENTIAL NEW APPLICATIONS OF EMETINE AS ANTI-CANCER AGENT

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Research paper thumbnail of Prediction of HIV-1 protease cleavage site from octapeptide sequence information using selected classifiers and hybrid descriptors

BMC Bioinformatics, Nov 8, 2022

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Research paper thumbnail of Isolation of the alpha glucosidase inhibitory constituents of Combretum dolichopetalum root

Planta Medica, Nov 25, 2015

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Research paper thumbnail of Antioxidant activity of the root extract of Combretum dolichopetalum and the isolated constituents

Planta Medica, Nov 25, 2015

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Research paper thumbnail of Synergistic hepatoprotective effect of Combretum dolichopetalum root and sylimarin in rats

Planta Medica, Dec 14, 2016

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Research paper thumbnail of Antidiabetic activity and phytochemical screening of Acalypha wilkesiana (Euphorbiaceae) Mull Arg. roots in alloxan-induced diabetic rats

Scientific Research and Essays, Apr 15, 2014

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Research paper thumbnail of Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

Future Journal of Pharmaceutical Sciences

Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to... more Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to treat ulcers and gastrointestinal disorders, including distended spleens and the liver. This study investigated the gastroprotective effects of C. paniculatum leaf extract and its fractions on absolute ethanol-induced gastric ulcers in rats and explored their effects on endogenous antioxidant (SOD, MDA, GSH, and Catalase) levels. Butanol, n-hexane, and ethyl acetate extracts (100 and 200 mg/kg), omeprazole (20 mg/kg), and control (3% Tween 80) were administered orally. Results The methanolic extract and fractions of C. paniculatum exhibited varying degrees of ulcer protection. MECP exhibited significant (P < 0.05) ulcer protection (55.56%) at 200 mg/kg; at 100 and 200 mg/kg, HFCP induced considerable (P < 0.01 & 0.001) ulcer reduction (64.44% and 80.00%), respectively; EAFCP offered substantial (P < 0.05) ulcer reduction (57.78%) at 200 mg/kg, whereas BFCP produced significant ...

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Research paper thumbnail of Study of the Antimalarial Activity of the Leaf Extracts and Fractions of Persea americana and Dacryodes edulis and Their HPLC Analysis

Evidence-Based Complementary and Alternative Medicine

In the present study, the antimalarial activity of the extracts and fractions of the leaves of Pe... more In the present study, the antimalarial activity of the extracts and fractions of the leaves of Persea americana and Dacryodes edulis as well as their phytochemical compositions were examined. Each of the extracts of the plants was successively fractionated to obtain hexane, ethyl acetate, methanol, and water fractions. The extracts and fractions were tested against Plasmodium berghei in both curative and suppressive antimalarial mouse models. Their major phytochemical composition was studied by the standard chemical tests and HPLC analysis. The extracts and fractions of P. americana and D. edulis demonstrated significant ( p < 0.05 ) maximal plasmodial inhibition as 52.16 ± 2.77% and 57.10 ± 1.98%, respectively, and chemosuppression of parasitemia as 64.01 ± 0.08% and 71.99 ± 0.06%, respectively. The major secondary metabolites identified in the plants include alkaloids, flavonoids, and saponins. It was concluded that P. americana and D. edulis possess promising antimalarial acti...

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Research paper thumbnail of Prediction of HIV-1 Protease Cleavage Site from Octapeptide Sequence Information using Selected Classifiers and Hybrid Descriptors

Background: In most parts of the world, especially in underdeveloped countries, Acquired Immunode... more Background: In most parts of the world, especially in underdeveloped countries, Acquired Immunodeficiency Syndrome (AIDS) still remains a major cause of death, disability and unfavorable economic outcomes. This has necessitated intensive research to develop effective therapeutic agents for the treatment of Human Immunodeficiency Virus (HIV) infection, which is responsible for AIDS. Peptide cleavage by HIV-1 protease is an essential step in the replication of HIV-1. Thus, correct and timely prediction of the cleavage site of HIV-1 protease can significantly speed up and optimize the drug discovery process of novel HIV-1 protease inhibitors. In this work, we built and compared the performance of selected machine learning models for the prediction of HIV-1 protease cleavage site utilizing a hybrid of octapeptide sequence information comprising bond composition, amino acid binary profile (AABP), and physicochemical properties as numerical descriptors serving as input variables for some ...

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Research paper thumbnail of Rhamnetin is a Better Inhibitor of SARS-COV-2 2’-O-METHYLTRANSFERASE Than Dolutegravir: A Computational Prediction

African Journal of Infectious Diseases

Background: The 2’-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and cons... more Background: The 2’-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host’s immune system. This study aims at identifying prospective natural inhibitors of the active site of SARS-CoV-2 2’O-methyltransferase (2’-OMT) through an in silico approach. Materials and methods: The target was docked against a library of natural compounds obtained from edible African plants using PyRx - virtual screening software. The antiviral agent, Dolutegravir which has a binding affinity score of -8.5 kcal mol−1 with the SARS-CoV-2 2’-OMT was used as a standard. Compounds were screened for bioavailability through the SWISSADME web server using their molecular descriptors. Screenings for pharmacokinetic properties and bioactivity were performed with PKCSM and Molinspiration web servers respectively. The PLIP and Fpocket webservers were used for the binding site analyses. The Galaxy webserver was used for simulating the time-resolved motions of the a...

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Research paper thumbnail of Computational studies reveal potential dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitors amidst existing drugs

Journal of Biomolecular Structure and Dynamics

Dolichyl-phosphate N-acetylglucosaminephosphotransferase (dpagt1) inhibition is reported to kill ... more Dolichyl-phosphate N-acetylglucosaminephosphotransferase (dpagt1) inhibition is reported to kill tumor cells whose growth progression requires increased branching of N-linked glycans. Available dpagt1 inhibitors are grossly limited and are faced with problems of heamolytic effect and aqueous solubility thereby necessitating the search for new, safe and effective dpagt1 inhibitors. We employed computational methods to screen a dataset of ∼1300 FDA approved drugs in order to obtain theoretical dpagt1 inhibitors which could be repurposed as chemotherapeutic drugs. Top six better performing drugs, binding affinity for dpagt1 at the range of -17.63 to -20.40 kcal/mol, than the reference ligand (tunicamycin; -14.86 kcal/mol) were obtained at the end of structure-based-pharmacophore- and virtual-screening and 'induced fit' docking calculations. Analysis of their binding poses identified essential pharmacophores involved in target-ligand complexation that could be targeted in chemical modification to develop more effective and safe dpagt1 inhibitors.Communicated by Ramaswamy H. Sarma.

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Research paper thumbnail of Limonene

Green Sustainable Process for Chemical and Environmental Engineering and Science

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Research paper thumbnail of GC-MS analysis and evaluation of antimalarial activity of extract and fractions of Icacina trichantha (Icacinaceae) tuber against Plasmodium berghei infected mice

Indian Journal of Traditional Knowledge (IJTK), Mar 11, 2021

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Research paper thumbnail of Acute Toxicity, Phytochemical, and Antimicrobial Properties of Selected Nigeria Medicinal plants on Amoxicillin-resistant Microorganisms

65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA 2017), 2017

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Research paper thumbnail of Effects of methanol leaf extracts of Loranthus micranthus Linn from three host plants on some biochemical indices of diabetic rats

Tropical Journal of Pharmaceutical Research, 2018

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Research paper thumbnail of Dereplication of Bioactive Markers from the Leaves of Anthocleista nobilis: Searching for new Bioactive Metabolites

Planta medica international open, Oct 1, 2017

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Research paper thumbnail of Green Synthesis of Silver Nanoparticles Using &lt;i&gt;Euphorbia hirta&lt;/i&gt; Leaf Extract and the Determination of Their Antimicrobial Activity

Advances in bioscience and bioengineering, 2021

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Research paper thumbnail of Nutritional Status of Adolescent Schoolchildren In South East Nigeria

Pakistan Journal of Nutrition, Aug 15, 2019

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Research paper thumbnail of Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Evidence-based Complementary and Alternative Medicine, Feb 12, 2020

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Research paper thumbnail of Original article: ANTIDIABETIC ACTIVITY OF THE CHEMICAL CONSTITUENTS OF COMBRETUM DOLICHOPETALUM ROOT IN MICE

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Research paper thumbnail of Letter to the editor: RECENT DEVELOPMENTS ON POTENTIAL NEW APPLICATIONS OF EMETINE AS ANTI-CANCER AGENT

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Research paper thumbnail of Prediction of HIV-1 protease cleavage site from octapeptide sequence information using selected classifiers and hybrid descriptors

BMC Bioinformatics, Nov 8, 2022

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Research paper thumbnail of Isolation of the alpha glucosidase inhibitory constituents of Combretum dolichopetalum root

Planta Medica, Nov 25, 2015

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Research paper thumbnail of Antioxidant activity of the root extract of Combretum dolichopetalum and the isolated constituents

Planta Medica, Nov 25, 2015

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Research paper thumbnail of Synergistic hepatoprotective effect of Combretum dolichopetalum root and sylimarin in rats

Planta Medica, Dec 14, 2016

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Research paper thumbnail of Antidiabetic activity and phytochemical screening of Acalypha wilkesiana (Euphorbiaceae) Mull Arg. roots in alloxan-induced diabetic rats

Scientific Research and Essays, Apr 15, 2014

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Research paper thumbnail of Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

Future Journal of Pharmaceutical Sciences

Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to... more Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to treat ulcers and gastrointestinal disorders, including distended spleens and the liver. This study investigated the gastroprotective effects of C. paniculatum leaf extract and its fractions on absolute ethanol-induced gastric ulcers in rats and explored their effects on endogenous antioxidant (SOD, MDA, GSH, and Catalase) levels. Butanol, n-hexane, and ethyl acetate extracts (100 and 200 mg/kg), omeprazole (20 mg/kg), and control (3% Tween 80) were administered orally. Results The methanolic extract and fractions of C. paniculatum exhibited varying degrees of ulcer protection. MECP exhibited significant (P < 0.05) ulcer protection (55.56%) at 200 mg/kg; at 100 and 200 mg/kg, HFCP induced considerable (P < 0.01 & 0.001) ulcer reduction (64.44% and 80.00%), respectively; EAFCP offered substantial (P < 0.05) ulcer reduction (57.78%) at 200 mg/kg, whereas BFCP produced significant ...

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Research paper thumbnail of Study of the Antimalarial Activity of the Leaf Extracts and Fractions of Persea americana and Dacryodes edulis and Their HPLC Analysis

Evidence-Based Complementary and Alternative Medicine

In the present study, the antimalarial activity of the extracts and fractions of the leaves of Pe... more In the present study, the antimalarial activity of the extracts and fractions of the leaves of Persea americana and Dacryodes edulis as well as their phytochemical compositions were examined. Each of the extracts of the plants was successively fractionated to obtain hexane, ethyl acetate, methanol, and water fractions. The extracts and fractions were tested against Plasmodium berghei in both curative and suppressive antimalarial mouse models. Their major phytochemical composition was studied by the standard chemical tests and HPLC analysis. The extracts and fractions of P. americana and D. edulis demonstrated significant ( p < 0.05 ) maximal plasmodial inhibition as 52.16 ± 2.77% and 57.10 ± 1.98%, respectively, and chemosuppression of parasitemia as 64.01 ± 0.08% and 71.99 ± 0.06%, respectively. The major secondary metabolites identified in the plants include alkaloids, flavonoids, and saponins. It was concluded that P. americana and D. edulis possess promising antimalarial acti...

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Research paper thumbnail of Prediction of HIV-1 Protease Cleavage Site from Octapeptide Sequence Information using Selected Classifiers and Hybrid Descriptors

Background: In most parts of the world, especially in underdeveloped countries, Acquired Immunode... more Background: In most parts of the world, especially in underdeveloped countries, Acquired Immunodeficiency Syndrome (AIDS) still remains a major cause of death, disability and unfavorable economic outcomes. This has necessitated intensive research to develop effective therapeutic agents for the treatment of Human Immunodeficiency Virus (HIV) infection, which is responsible for AIDS. Peptide cleavage by HIV-1 protease is an essential step in the replication of HIV-1. Thus, correct and timely prediction of the cleavage site of HIV-1 protease can significantly speed up and optimize the drug discovery process of novel HIV-1 protease inhibitors. In this work, we built and compared the performance of selected machine learning models for the prediction of HIV-1 protease cleavage site utilizing a hybrid of octapeptide sequence information comprising bond composition, amino acid binary profile (AABP), and physicochemical properties as numerical descriptors serving as input variables for some ...

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Research paper thumbnail of Rhamnetin is a Better Inhibitor of SARS-COV-2 2’-O-METHYLTRANSFERASE Than Dolutegravir: A Computational Prediction

African Journal of Infectious Diseases

Background: The 2’-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and cons... more Background: The 2’-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host’s immune system. This study aims at identifying prospective natural inhibitors of the active site of SARS-CoV-2 2’O-methyltransferase (2’-OMT) through an in silico approach. Materials and methods: The target was docked against a library of natural compounds obtained from edible African plants using PyRx - virtual screening software. The antiviral agent, Dolutegravir which has a binding affinity score of -8.5 kcal mol−1 with the SARS-CoV-2 2’-OMT was used as a standard. Compounds were screened for bioavailability through the SWISSADME web server using their molecular descriptors. Screenings for pharmacokinetic properties and bioactivity were performed with PKCSM and Molinspiration web servers respectively. The PLIP and Fpocket webservers were used for the binding site analyses. The Galaxy webserver was used for simulating the time-resolved motions of the a...

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Research paper thumbnail of Computational studies reveal potential dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitors amidst existing drugs

Journal of Biomolecular Structure and Dynamics

Dolichyl-phosphate N-acetylglucosaminephosphotransferase (dpagt1) inhibition is reported to kill ... more Dolichyl-phosphate N-acetylglucosaminephosphotransferase (dpagt1) inhibition is reported to kill tumor cells whose growth progression requires increased branching of N-linked glycans. Available dpagt1 inhibitors are grossly limited and are faced with problems of heamolytic effect and aqueous solubility thereby necessitating the search for new, safe and effective dpagt1 inhibitors. We employed computational methods to screen a dataset of ∼1300 FDA approved drugs in order to obtain theoretical dpagt1 inhibitors which could be repurposed as chemotherapeutic drugs. Top six better performing drugs, binding affinity for dpagt1 at the range of -17.63 to -20.40 kcal/mol, than the reference ligand (tunicamycin; -14.86 kcal/mol) were obtained at the end of structure-based-pharmacophore- and virtual-screening and 'induced fit' docking calculations. Analysis of their binding poses identified essential pharmacophores involved in target-ligand complexation that could be targeted in chemical modification to develop more effective and safe dpagt1 inhibitors.Communicated by Ramaswamy H. Sarma.

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Research paper thumbnail of Limonene

Green Sustainable Process for Chemical and Environmental Engineering and Science

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Research paper thumbnail of GC-MS analysis and evaluation of antimalarial activity of extract and fractions of Icacina trichantha (Icacinaceae) tuber against Plasmodium berghei infected mice

Indian Journal of Traditional Knowledge (IJTK), Mar 11, 2021

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Research paper thumbnail of Acute Toxicity, Phytochemical, and Antimicrobial Properties of Selected Nigeria Medicinal plants on Amoxicillin-resistant Microorganisms

65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA 2017), 2017

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Research paper thumbnail of Effects of methanol leaf extracts of Loranthus micranthus Linn from three host plants on some biochemical indices of diabetic rats

Tropical Journal of Pharmaceutical Research, 2018

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