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Research paper thumbnail of 379194 PAMAM Dendrimer As a Platform for Peptide Subunit Vaccine Delivery: Application in the Prevention of Chlamydia Trachomatis Infection

Abstracts: * Ganda & Zhong Vaccine AIChE 05.10.14.docx (17.6KB) - Uploading Abstracts

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Research paper thumbnail of Brazilian red propolis induces apoptosis-like cell death and decreases migration potential in bladder cancer cells

Evidence-based complementary and alternative medicine : eCAM, 2014

Natural products continue to be an invaluable resource of anticancer drug discovery in recent yea... more Natural products continue to be an invaluable resource of anticancer drug discovery in recent years. Propolis is known for its biological activities such as antimicrobial and antitumor effects. This study assessed the effects of Brazilian red propolis (BRP) on apoptosis and migration potential in human bladder cancer cells. The effect of BRP ethanolic extract (25, 50, and 100 μg/mL) on 5637 cells was determined by MTT, LIVE/DEAD, and migration (scratch assay) assays. Apoptosis induction was investigated through flow cytometry and gene expression profile was investigated by qRT-PCR. Results showed cytotoxicity on MTT and LIVE/DEAD assays, with IC50 values of 95 μg/mL in 24 h of treatment. Cellular migration of 5637 cells was significantly inhibited through lower doses of BRP ethanolic extract (25 and 50 μg/mL). Flow cytometry analyses showed that BRP induced cytotoxicity through apoptosis-like mechanisms in 5637 cells and qRT-PCR revealed increased levels of Bax/Bcl-2 ratio, p53, AIF...

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Research paper thumbnail of Starting study of microbial genetics diversity in soils of mangrove preserved in sergipe

BMC Proceedings, 2014

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Research paper thumbnail of Inhibition of DMBA-induced Oral Squamous Cell Carcinomas Growth by Brazilian Red Propolis in Rodent Model

Basic & clinical pharmacology & toxicology, Jan 2, 2015

We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red prop... more We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red propolis (HERP) on DMBA-induced oral squamous cell carcinomas (OSCC) in rodents. The chemical components of the HERP were assessed by Ultra-Fast Liquid Chromatography (UFLC). Carcinogenesis was topically induced in the lower lip of 25 rats using 9,10-dimethyl-1,2-benzanthracene (DMBA); the tumour was treated with saline (TUM1) and Tween 80 (TUM2) as well as HERP at 10, 50 and 100 mg/kg (HERP10, HERP50, and HERP100, respectively) for 20 weeks. Topical application of saline and oral administration of 100 mg/kg HERP was used in five rats as a control group (CTR). After 26 weeks, the histological malignancy grading and immunohistochemical expression of Ki-67 and p16(INK) (4A) were assessed in the tumours/tissue samples. The compounds identified were propyl gallate, daidzein, catechin, epicatechin, formononetin and biochanin A. Formononetin, daidzein and biochanin A showed concentration of 23.29 ...

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Research paper thumbnail of Study of the biological potential of in vitro extracts for Zeyheria tuberculosa (Bignoniaceae)

BMC Proceedings, 2014

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Research paper thumbnail of Evaluation of production of xanthan gum utilizing the corn cob liquor as a carbon source in different strains of Xanthomonas campestres

BMC Proceedings, 2014

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Research paper thumbnail of Study of antimicrobial potential and cytotoxic of Cordia nodosa species

BMC Proceedings, 2014

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Research paper thumbnail of Evaluation of antibacterial and toxicity activity in vitro of extracts from Tournefortia bicolor S.W (Boraginaceae)

BMC Proceedings, 2014

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Research paper thumbnail of Evaluation of antimicrobial potential and cytotoxic of Pouteria venosa species

BMC Proceedings, 2014

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Research paper thumbnail of Evaluation of in vitro biological potential of plant species Sebastiania corniculata (Euphorbiaceae)

BMC Proceedings, 2014

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Research paper thumbnail of Effect of the Maillard reaction on properties of casein and casein films

Journal of Thermal Analysis and Calorimetry, 2011

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Research paper thumbnail of Production and characterization of xantham gum by Xanthomonas campestris using cheese whey as sole carbon source

Journal of Food Engineering, 2009

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Research paper thumbnail of Microorganisms screening for limonene oxidation

Ciência e Tecnologia de Alimentos, 2010

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Research paper thumbnail of Xanthan gum production and rheological behavior using different strains of Xanthomonas sp

Carbohydrate Polymers, 2009

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Research paper thumbnail of Microorganism Screening for Limonene Bioconversion and Correlation With RAPD Markers

Applied Biochemistry and Biotechnology, 2006

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Research paper thumbnail of Proteomic analysis identifies differentially expressed proteins after red propolis treatment in Hep-2 cells

Food and Chemical Toxicology, 2014

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Research paper thumbnail of 379194 PAMAM Dendrimer As a Platform for Peptide Subunit Vaccine Delivery: Application in the Prevention of Chlamydia Trachomatis Infection

Abstracts: * Ganda & Zhong Vaccine AIChE 05.10.14.docx (17.6KB) - Uploading Abstracts

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Brazilian red propolis induces apoptosis-like cell death and decreases migration potential in bladder cancer cells

Evidence-based complementary and alternative medicine : eCAM, 2014

Natural products continue to be an invaluable resource of anticancer drug discovery in recent yea... more Natural products continue to be an invaluable resource of anticancer drug discovery in recent years. Propolis is known for its biological activities such as antimicrobial and antitumor effects. This study assessed the effects of Brazilian red propolis (BRP) on apoptosis and migration potential in human bladder cancer cells. The effect of BRP ethanolic extract (25, 50, and 100 μg/mL) on 5637 cells was determined by MTT, LIVE/DEAD, and migration (scratch assay) assays. Apoptosis induction was investigated through flow cytometry and gene expression profile was investigated by qRT-PCR. Results showed cytotoxicity on MTT and LIVE/DEAD assays, with IC50 values of 95 μg/mL in 24 h of treatment. Cellular migration of 5637 cells was significantly inhibited through lower doses of BRP ethanolic extract (25 and 50 μg/mL). Flow cytometry analyses showed that BRP induced cytotoxicity through apoptosis-like mechanisms in 5637 cells and qRT-PCR revealed increased levels of Bax/Bcl-2 ratio, p53, AIF...

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Research paper thumbnail of Starting study of microbial genetics diversity in soils of mangrove preserved in sergipe

BMC Proceedings, 2014

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Research paper thumbnail of Inhibition of DMBA-induced Oral Squamous Cell Carcinomas Growth by Brazilian Red Propolis in Rodent Model

Basic & clinical pharmacology & toxicology, Jan 2, 2015

We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red prop... more We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red propolis (HERP) on DMBA-induced oral squamous cell carcinomas (OSCC) in rodents. The chemical components of the HERP were assessed by Ultra-Fast Liquid Chromatography (UFLC). Carcinogenesis was topically induced in the lower lip of 25 rats using 9,10-dimethyl-1,2-benzanthracene (DMBA); the tumour was treated with saline (TUM1) and Tween 80 (TUM2) as well as HERP at 10, 50 and 100 mg/kg (HERP10, HERP50, and HERP100, respectively) for 20 weeks. Topical application of saline and oral administration of 100 mg/kg HERP was used in five rats as a control group (CTR). After 26 weeks, the histological malignancy grading and immunohistochemical expression of Ki-67 and p16(INK) (4A) were assessed in the tumours/tissue samples. The compounds identified were propyl gallate, daidzein, catechin, epicatechin, formononetin and biochanin A. Formononetin, daidzein and biochanin A showed concentration of 23.29 ...

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Research paper thumbnail of Study of the biological potential of in vitro extracts for Zeyheria tuberculosa (Bignoniaceae)

BMC Proceedings, 2014

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Research paper thumbnail of Evaluation of production of xanthan gum utilizing the corn cob liquor as a carbon source in different strains of Xanthomonas campestres

BMC Proceedings, 2014

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Research paper thumbnail of Study of antimicrobial potential and cytotoxic of Cordia nodosa species

BMC Proceedings, 2014

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Research paper thumbnail of Evaluation of antibacterial and toxicity activity in vitro of extracts from Tournefortia bicolor S.W (Boraginaceae)

BMC Proceedings, 2014

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Research paper thumbnail of Evaluation of antimicrobial potential and cytotoxic of Pouteria venosa species

BMC Proceedings, 2014

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Research paper thumbnail of Evaluation of in vitro biological potential of plant species Sebastiania corniculata (Euphorbiaceae)

BMC Proceedings, 2014

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Research paper thumbnail of Effect of the Maillard reaction on properties of casein and casein films

Journal of Thermal Analysis and Calorimetry, 2011

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Research paper thumbnail of Production and characterization of xantham gum by Xanthomonas campestris using cheese whey as sole carbon source

Journal of Food Engineering, 2009

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Research paper thumbnail of Microorganisms screening for limonene oxidation

Ciência e Tecnologia de Alimentos, 2010

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Research paper thumbnail of Xanthan gum production and rheological behavior using different strains of Xanthomonas sp

Carbohydrate Polymers, 2009

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Research paper thumbnail of Microorganism Screening for Limonene Bioconversion and Correlation With RAPD Markers

Applied Biochemistry and Biotechnology, 2006

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Research paper thumbnail of Proteomic analysis identifies differentially expressed proteins after red propolis treatment in Hep-2 cells

Food and Chemical Toxicology, 2014

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