Francine Padilha - Academia.edu (original) (raw)
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Papers by Francine Padilha
Abstracts: * Ganda & Zhong Vaccine AIChE 05.10.14.docx (17.6KB) - Uploading Abstracts
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Evidence-based complementary and alternative medicine : eCAM, 2014
Natural products continue to be an invaluable resource of anticancer drug discovery in recent yea... more Natural products continue to be an invaluable resource of anticancer drug discovery in recent years. Propolis is known for its biological activities such as antimicrobial and antitumor effects. This study assessed the effects of Brazilian red propolis (BRP) on apoptosis and migration potential in human bladder cancer cells. The effect of BRP ethanolic extract (25, 50, and 100 μg/mL) on 5637 cells was determined by MTT, LIVE/DEAD, and migration (scratch assay) assays. Apoptosis induction was investigated through flow cytometry and gene expression profile was investigated by qRT-PCR. Results showed cytotoxicity on MTT and LIVE/DEAD assays, with IC50 values of 95 μg/mL in 24 h of treatment. Cellular migration of 5637 cells was significantly inhibited through lower doses of BRP ethanolic extract (25 and 50 μg/mL). Flow cytometry analyses showed that BRP induced cytotoxicity through apoptosis-like mechanisms in 5637 cells and qRT-PCR revealed increased levels of Bax/Bcl-2 ratio, p53, AIF...
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BMC Proceedings, 2014
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Basic & clinical pharmacology & toxicology, Jan 2, 2015
We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red prop... more We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red propolis (HERP) on DMBA-induced oral squamous cell carcinomas (OSCC) in rodents. The chemical components of the HERP were assessed by Ultra-Fast Liquid Chromatography (UFLC). Carcinogenesis was topically induced in the lower lip of 25 rats using 9,10-dimethyl-1,2-benzanthracene (DMBA); the tumour was treated with saline (TUM1) and Tween 80 (TUM2) as well as HERP at 10, 50 and 100 mg/kg (HERP10, HERP50, and HERP100, respectively) for 20 weeks. Topical application of saline and oral administration of 100 mg/kg HERP was used in five rats as a control group (CTR). After 26 weeks, the histological malignancy grading and immunohistochemical expression of Ki-67 and p16(INK) (4A) were assessed in the tumours/tissue samples. The compounds identified were propyl gallate, daidzein, catechin, epicatechin, formononetin and biochanin A. Formononetin, daidzein and biochanin A showed concentration of 23.29 ...
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BMC Proceedings, 2014
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BMC Proceedings, 2014
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BMC Proceedings, 2014
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BMC Proceedings, 2014
Bookmarks Related papers MentionsView impact
BMC Proceedings, 2014
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BMC Proceedings, 2014
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Journal of Thermal Analysis and Calorimetry, 2011
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Journal of Food Engineering, 2009
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Ciência e Tecnologia de Alimentos, 2010
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Carbohydrate Polymers, 2009
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Applied Biochemistry and Biotechnology, 2006
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Food and Chemical Toxicology, 2014
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Abstracts: * Ganda & Zhong Vaccine AIChE 05.10.14.docx (17.6KB) - Uploading Abstracts
Bookmarks Related papers MentionsView impact
Evidence-based complementary and alternative medicine : eCAM, 2014
Natural products continue to be an invaluable resource of anticancer drug discovery in recent yea... more Natural products continue to be an invaluable resource of anticancer drug discovery in recent years. Propolis is known for its biological activities such as antimicrobial and antitumor effects. This study assessed the effects of Brazilian red propolis (BRP) on apoptosis and migration potential in human bladder cancer cells. The effect of BRP ethanolic extract (25, 50, and 100 μg/mL) on 5637 cells was determined by MTT, LIVE/DEAD, and migration (scratch assay) assays. Apoptosis induction was investigated through flow cytometry and gene expression profile was investigated by qRT-PCR. Results showed cytotoxicity on MTT and LIVE/DEAD assays, with IC50 values of 95 μg/mL in 24 h of treatment. Cellular migration of 5637 cells was significantly inhibited through lower doses of BRP ethanolic extract (25 and 50 μg/mL). Flow cytometry analyses showed that BRP induced cytotoxicity through apoptosis-like mechanisms in 5637 cells and qRT-PCR revealed increased levels of Bax/Bcl-2 ratio, p53, AIF...
Bookmarks Related papers MentionsView impact
BMC Proceedings, 2014
Bookmarks Related papers MentionsView impact
Basic & clinical pharmacology & toxicology, Jan 2, 2015
We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red prop... more We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red propolis (HERP) on DMBA-induced oral squamous cell carcinomas (OSCC) in rodents. The chemical components of the HERP were assessed by Ultra-Fast Liquid Chromatography (UFLC). Carcinogenesis was topically induced in the lower lip of 25 rats using 9,10-dimethyl-1,2-benzanthracene (DMBA); the tumour was treated with saline (TUM1) and Tween 80 (TUM2) as well as HERP at 10, 50 and 100 mg/kg (HERP10, HERP50, and HERP100, respectively) for 20 weeks. Topical application of saline and oral administration of 100 mg/kg HERP was used in five rats as a control group (CTR). After 26 weeks, the histological malignancy grading and immunohistochemical expression of Ki-67 and p16(INK) (4A) were assessed in the tumours/tissue samples. The compounds identified were propyl gallate, daidzein, catechin, epicatechin, formononetin and biochanin A. Formononetin, daidzein and biochanin A showed concentration of 23.29 ...
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BMC Proceedings, 2014
Bookmarks Related papers MentionsView impact
BMC Proceedings, 2014
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BMC Proceedings, 2014
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BMC Proceedings, 2014
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BMC Proceedings, 2014
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BMC Proceedings, 2014
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Journal of Thermal Analysis and Calorimetry, 2011
Bookmarks Related papers MentionsView impact
Journal of Food Engineering, 2009
Bookmarks Related papers MentionsView impact
Ciência e Tecnologia de Alimentos, 2010
Bookmarks Related papers MentionsView impact
Carbohydrate Polymers, 2009
Bookmarks Related papers MentionsView impact
Applied Biochemistry and Biotechnology, 2006
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Food and Chemical Toxicology, 2014
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