Paola Casadio - Academia.edu (original) (raw)

Papers by Paola Casadio

Research paper thumbnail of Social Disadvantage: Cause or Consequence of Impending Psychosis?

Schizophrenia Research, Apr 1, 2010

Research paper thumbnail of Adverse childhood experiences, personality disorders and addiction: Which relationship?

European Psychiatry, 2017

IntroductionStressful or traumatic events occurred during childhood do have a role in the genesis... more IntroductionStressful or traumatic events occurred during childhood do have a role in the genesis of personality disorders. Less is known about this remarkable association in people with addictive behaviors.AimsThis study aims to disentangle the relationship between childhood adverse experiences, personality disorders (PDs) and substance use disorders (SUDs).MethodsA cross-sectional naturalistic study of 320 consecutive SUDs outpatients attending an Italian addiction service. Participants were clinically evaluated by a semi-structured interview, the SCID-II (Structured Clinical Interview for DSM-IV Axis II PD), and the CECA-Q (Childhood Experience of Care and Abuse-questionnaire). Multivariate logistic regression analyses were used to estimate odds ratio (OR) and 95% confidence intervals (95% CI)ResultsThe prevalence rate of PDs in our sample of patients is 62.2%. PDs were associated with a history of physical punishment in childhood (OR = 1.82; CI 95%: 1.05–3.16; P = 0.034). Being ...

Research paper thumbnail of 6. Cannabis Use as a Component Cause of Schizophrenia

Research paper thumbnail of Personality Disorders in Addiction Outpatients: Prevalence and Effects on Psychosocial Functioning

Substance Abuse: Research and Treatment, 2014

Aim To evaluate the prevalence of personality disorders (PDs) in the outpatients attending an add... more Aim To evaluate the prevalence of personality disorders (PDs) in the outpatients attending an addiction service, with particular attention to the effects of PDs on social and occupational functioning and on the intensity of treatment required. Design A cross-sectional epidemiological study with the assessment of 320 outpatients, through SCID-II (Structured Clinical Interview for DSM-IV Axis II PDs), SOGS (South Oaks Gambling Screen), and questionnaire extracted from EuropASI. Results The percentage prevalence of PDs was 62.2% (confidence interval at 95% (95% CI): 57–68). PDs were positively associated with placement in an addiction treatment community (odds ratio (OR) = 2.98, CI = 1.77–5.03), having received lifetime treatment at the mental health center (MHC) (OR = 3.67, CI = 1.67–8.07) or having attempted suicide (OR = 2.30, CI = 1.05–5.02). Furthermore, PDs were related to a reduced probability of keeping a job (OR = 0.54, CI = 0.31–0.95) or starting a family (OR = 0.51, CI = 0.3...

Research paper thumbnail of Cognitive impairment after age 60: clinical and social correlates in the Faenza Project

Journal of Alzheimer's Disease, 2010

A total of 7,389 dementia-free elderly (60-102 years old) enrolled in the "Faenza Project&qu... more A total of 7,389 dementia-free elderly (60-102 years old) enrolled in the "Faenza Project" (Northern Italy) were clinically evaluated by nurses and physicians with the aim of detecting the independent and combined association of medical and social factors with cognitive status. Cognitive Impairment No Dementia (CIND) was defined for MMSE scores ≤ 2 standard deviations than the age- and education-corrected mean score obtained by the nondemented persons of the Faenza cohort. Logistic Regression analysis was used to estimate Odds Ratios and 95% Confidence Intervals (OR, 95%CI) for CIND. The diagnostic procedure identified 402 (5.4%) CIND cases. Diabetes (OR, 95%CI = 1.6, 1.2-2.2), stroke (OR, 95%CI = 1.9, 1.4-2.6), and depressive symptoms (OR, 95%CI = 1.9, 1.4-2.7) emerged as the most relevant medical comorbidities of CIND. Low education (OR, 95%CI = 1.8, 1.1-2.9), low Socio Economic Status (SES) (OR, 95%CI = 1.5, 1.1-2.1), and unmarried status (OR, 95%CI = 1.7, 1.2-2.5) were...

Research paper thumbnail of Co-occurence of Substance Use and Personality Disorders

Neuropathology of Drug Addictions and Substance Misuse, 2016

A recent population study has shown that among people manifesting a disorder related to alcohol a... more A recent population study has shown that among people manifesting a disorder related to alcohol and other substances, 28.6% and 47.7% respectively had at least one personality disorder (PD). Numerous sample studies have highlighted the presence of PDs in the drug-addicted population, estimating prevalence rates ranging from 44% to 79%. The most frequent PDs in the clinical sample were antisocial, borderline, avoidant, and paranoid PDs. Various types of relationship between addiction and PDs can be hypothesized: a common etiology (biological or psychic), an etiological relationship (predisposed personality or self-medication hypothesis), or one that is influenced reciprocally. PD comorbidity is associated with a spectrum of substance-correlated disorders, which are more chronic and severe and require many long-term therapeutic programs. Various psychotherapeutic treatments have proven to be efficacious with respect to reducing personality pathology and improving social functioning. This is especially true for cognitive-behaviorally or psychodynamically oriented individual psychotherapies. Considering the models of services organization, dual diagnosis patients can be better treated by using an integrated model with approaches that bridge the gap between the psychiatric and addiction services.

Research paper thumbnail of Cannabis Use as a Component Cause of Schizophrenia

The Origins of Schizophrenia, 2011

Research paper thumbnail of Chapter 8 Does Higher Potency of Cannabis Mean Higher Risk for Psychosis?

Staging Neuropsychiatric Disorders, 2011

Research paper thumbnail of Does Higher Potency of Cannabis Mean Higher Risk for Psychosis?

Staging Neuropsychiatric Disorders, 2013

Research paper thumbnail of Childhood Adverse Experiences and Personality Disorders in Outpatients with Addiction

International Journal of Psychiatry Research

Research paper thumbnail of Cognitive impairment after age 60: clinical and social correlates in the Faenza Project

Journal of Alzheimer's disease : JAD, 2010

A total of 7,389 dementia-free elderly (60-102 years old) enrolled in the "Faenza Project&qu... more A total of 7,389 dementia-free elderly (60-102 years old) enrolled in the "Faenza Project" (Northern Italy) were clinically evaluated by nurses and physicians with the aim of detecting the independent and combined association of medical and social factors with cognitive status. Cognitive Impairment No Dementia (CIND) was defined for MMSE scores ≤ 2 standard deviations than the age- and education-corrected mean score obtained by the nondemented persons of the Faenza cohort. Logistic Regression analysis was used to estimate Odds Ratios and 95% Confidence Intervals (OR, 95%CI) for CIND. The diagnostic procedure identified 402 (5.4%) CIND cases. Diabetes (OR, 95%CI = 1.6, 1.2-2.2), stroke (OR, 95%CI = 1.9, 1.4-2.6), and depressive symptoms (OR, 95%CI = 1.9, 1.4-2.7) emerged as the most relevant medical comorbidities of CIND. Low education (OR, 95%CI = 1.8, 1.1-2.9), low Socio Economic Status (SES) (OR, 95%CI = 1.5, 1.1-2.1), and unmarried status (OR, 95%CI = 1.7, 1.2-2.5) were...

Research paper thumbnail of CANNABIS USE AND PSYCHOTIC EXPERIENCES IN A HEALTHY POPULATION SAMPLE

Schizophrenia Research, 2010

Research paper thumbnail of Social Disadvantage: Cause or Consequence of Impending Psychosis?

Schizophrenia Bulletin, 2013

Research paper thumbnail of Cannabis use in young people: The risk for schizophrenia

Neuroscience & Biobehavioral Reviews, 2011

Research paper thumbnail of Personality disorders in addiction outpatients: prevalence and effects on psychosocial functioning

Substance abuse : research and treatment, 2014

To evaluate the prevalence of personality disorders (PDs) in the outpatients attending an addicti... more To evaluate the prevalence of personality disorders (PDs) in the outpatients attending an addiction service, with particular attention to the effects of PDs on social and occupational functioning and on the intensity of treatment required. A cross-sectional epidemiological study with the assessment of 320 outpatients, through SCID-II (Structured Clinical Interview for DSM-IV Axis II PDs), SOGS (South Oaks Gambling Screen), and questionnaire extracted from EuropASI. The percentage prevalence of PDs was 62.2% (confidence interval at 95% (95% CI): 57-68). PDs were positively associated with placement in an addiction treatment community (odds ratio (OR) = 2.98, CI = 1.77-5.03), having received lifetime treatment at the mental health center (MHC) (OR = 3.67, CI = 1.67-8.07) or having attempted suicide (OR = 2.30, CI = 1.05-5.02). Furthermore, PDs were related to a reduced probability of keeping a job (OR = 0.54, CI = 0.31-0.95) or starting a family (OR = 0.51, CI = 0.30-0.87). Axis II co...

Research paper thumbnail of Social Disadvantage: Cause or Consequence of Impending Psychosis?

Schizophrenia Research, Apr 1, 2010

Research paper thumbnail of Adverse childhood experiences, personality disorders and addiction: Which relationship?

European Psychiatry, 2017

IntroductionStressful or traumatic events occurred during childhood do have a role in the genesis... more IntroductionStressful or traumatic events occurred during childhood do have a role in the genesis of personality disorders. Less is known about this remarkable association in people with addictive behaviors.AimsThis study aims to disentangle the relationship between childhood adverse experiences, personality disorders (PDs) and substance use disorders (SUDs).MethodsA cross-sectional naturalistic study of 320 consecutive SUDs outpatients attending an Italian addiction service. Participants were clinically evaluated by a semi-structured interview, the SCID-II (Structured Clinical Interview for DSM-IV Axis II PD), and the CECA-Q (Childhood Experience of Care and Abuse-questionnaire). Multivariate logistic regression analyses were used to estimate odds ratio (OR) and 95% confidence intervals (95% CI)ResultsThe prevalence rate of PDs in our sample of patients is 62.2%. PDs were associated with a history of physical punishment in childhood (OR = 1.82; CI 95%: 1.05–3.16; P = 0.034). Being ...

Research paper thumbnail of 6. Cannabis Use as a Component Cause of Schizophrenia

Research paper thumbnail of Personality Disorders in Addiction Outpatients: Prevalence and Effects on Psychosocial Functioning

Substance Abuse: Research and Treatment, 2014

Aim To evaluate the prevalence of personality disorders (PDs) in the outpatients attending an add... more Aim To evaluate the prevalence of personality disorders (PDs) in the outpatients attending an addiction service, with particular attention to the effects of PDs on social and occupational functioning and on the intensity of treatment required. Design A cross-sectional epidemiological study with the assessment of 320 outpatients, through SCID-II (Structured Clinical Interview for DSM-IV Axis II PDs), SOGS (South Oaks Gambling Screen), and questionnaire extracted from EuropASI. Results The percentage prevalence of PDs was 62.2% (confidence interval at 95% (95% CI): 57–68). PDs were positively associated with placement in an addiction treatment community (odds ratio (OR) = 2.98, CI = 1.77–5.03), having received lifetime treatment at the mental health center (MHC) (OR = 3.67, CI = 1.67–8.07) or having attempted suicide (OR = 2.30, CI = 1.05–5.02). Furthermore, PDs were related to a reduced probability of keeping a job (OR = 0.54, CI = 0.31–0.95) or starting a family (OR = 0.51, CI = 0.3...

Research paper thumbnail of Cognitive impairment after age 60: clinical and social correlates in the Faenza Project

Journal of Alzheimer's Disease, 2010

A total of 7,389 dementia-free elderly (60-102 years old) enrolled in the "Faenza Project&qu... more A total of 7,389 dementia-free elderly (60-102 years old) enrolled in the "Faenza Project" (Northern Italy) were clinically evaluated by nurses and physicians with the aim of detecting the independent and combined association of medical and social factors with cognitive status. Cognitive Impairment No Dementia (CIND) was defined for MMSE scores ≤ 2 standard deviations than the age- and education-corrected mean score obtained by the nondemented persons of the Faenza cohort. Logistic Regression analysis was used to estimate Odds Ratios and 95% Confidence Intervals (OR, 95%CI) for CIND. The diagnostic procedure identified 402 (5.4%) CIND cases. Diabetes (OR, 95%CI = 1.6, 1.2-2.2), stroke (OR, 95%CI = 1.9, 1.4-2.6), and depressive symptoms (OR, 95%CI = 1.9, 1.4-2.7) emerged as the most relevant medical comorbidities of CIND. Low education (OR, 95%CI = 1.8, 1.1-2.9), low Socio Economic Status (SES) (OR, 95%CI = 1.5, 1.1-2.1), and unmarried status (OR, 95%CI = 1.7, 1.2-2.5) were...

Research paper thumbnail of Co-occurence of Substance Use and Personality Disorders

Neuropathology of Drug Addictions and Substance Misuse, 2016

A recent population study has shown that among people manifesting a disorder related to alcohol a... more A recent population study has shown that among people manifesting a disorder related to alcohol and other substances, 28.6% and 47.7% respectively had at least one personality disorder (PD). Numerous sample studies have highlighted the presence of PDs in the drug-addicted population, estimating prevalence rates ranging from 44% to 79%. The most frequent PDs in the clinical sample were antisocial, borderline, avoidant, and paranoid PDs. Various types of relationship between addiction and PDs can be hypothesized: a common etiology (biological or psychic), an etiological relationship (predisposed personality or self-medication hypothesis), or one that is influenced reciprocally. PD comorbidity is associated with a spectrum of substance-correlated disorders, which are more chronic and severe and require many long-term therapeutic programs. Various psychotherapeutic treatments have proven to be efficacious with respect to reducing personality pathology and improving social functioning. This is especially true for cognitive-behaviorally or psychodynamically oriented individual psychotherapies. Considering the models of services organization, dual diagnosis patients can be better treated by using an integrated model with approaches that bridge the gap between the psychiatric and addiction services.

Research paper thumbnail of Cannabis Use as a Component Cause of Schizophrenia

The Origins of Schizophrenia, 2011

Research paper thumbnail of Chapter 8 Does Higher Potency of Cannabis Mean Higher Risk for Psychosis?

Staging Neuropsychiatric Disorders, 2011

Research paper thumbnail of Does Higher Potency of Cannabis Mean Higher Risk for Psychosis?

Staging Neuropsychiatric Disorders, 2013

Research paper thumbnail of Childhood Adverse Experiences and Personality Disorders in Outpatients with Addiction

International Journal of Psychiatry Research

Research paper thumbnail of Cognitive impairment after age 60: clinical and social correlates in the Faenza Project

Journal of Alzheimer's disease : JAD, 2010

A total of 7,389 dementia-free elderly (60-102 years old) enrolled in the "Faenza Project&qu... more A total of 7,389 dementia-free elderly (60-102 years old) enrolled in the "Faenza Project" (Northern Italy) were clinically evaluated by nurses and physicians with the aim of detecting the independent and combined association of medical and social factors with cognitive status. Cognitive Impairment No Dementia (CIND) was defined for MMSE scores ≤ 2 standard deviations than the age- and education-corrected mean score obtained by the nondemented persons of the Faenza cohort. Logistic Regression analysis was used to estimate Odds Ratios and 95% Confidence Intervals (OR, 95%CI) for CIND. The diagnostic procedure identified 402 (5.4%) CIND cases. Diabetes (OR, 95%CI = 1.6, 1.2-2.2), stroke (OR, 95%CI = 1.9, 1.4-2.6), and depressive symptoms (OR, 95%CI = 1.9, 1.4-2.7) emerged as the most relevant medical comorbidities of CIND. Low education (OR, 95%CI = 1.8, 1.1-2.9), low Socio Economic Status (SES) (OR, 95%CI = 1.5, 1.1-2.1), and unmarried status (OR, 95%CI = 1.7, 1.2-2.5) were...

Research paper thumbnail of CANNABIS USE AND PSYCHOTIC EXPERIENCES IN A HEALTHY POPULATION SAMPLE

Schizophrenia Research, 2010

Research paper thumbnail of Social Disadvantage: Cause or Consequence of Impending Psychosis?

Schizophrenia Bulletin, 2013

Research paper thumbnail of Cannabis use in young people: The risk for schizophrenia

Neuroscience & Biobehavioral Reviews, 2011

Research paper thumbnail of Personality disorders in addiction outpatients: prevalence and effects on psychosocial functioning

Substance abuse : research and treatment, 2014

To evaluate the prevalence of personality disorders (PDs) in the outpatients attending an addicti... more To evaluate the prevalence of personality disorders (PDs) in the outpatients attending an addiction service, with particular attention to the effects of PDs on social and occupational functioning and on the intensity of treatment required. A cross-sectional epidemiological study with the assessment of 320 outpatients, through SCID-II (Structured Clinical Interview for DSM-IV Axis II PDs), SOGS (South Oaks Gambling Screen), and questionnaire extracted from EuropASI. The percentage prevalence of PDs was 62.2% (confidence interval at 95% (95% CI): 57-68). PDs were positively associated with placement in an addiction treatment community (odds ratio (OR) = 2.98, CI = 1.77-5.03), having received lifetime treatment at the mental health center (MHC) (OR = 3.67, CI = 1.67-8.07) or having attempted suicide (OR = 2.30, CI = 1.05-5.02). Furthermore, PDs were related to a reduced probability of keeping a job (OR = 0.54, CI = 0.31-0.95) or starting a family (OR = 0.51, CI = 0.30-0.87). Axis II co...