Pelin Sut - Academia.edu (original) (raw)
Papers by Pelin Sut
Oncology, 2005
There is much evidence for the detrimental effect of treatment interruptions on tumor control, pa... more There is much evidence for the detrimental effect of treatment interruptions on tumor control, particularly in head and neck cancer. In order to determine the outcome of the treatment interruptions in postoperative irradiation of breast cancer, 853 female patients treated between 1990 and 1999 inclusive were retrospectively analyzed. Locally advanced breast cancer patients who received neoadjuvant chemotherapy were not included in the study. Five hundred and forty-six patients (64%) treated with mastectomy and 307 patients (36%) with breast-conserving surgery were analyzed. A total dose of 50 Gy (46--54 Gy) was given to the chest wall/breast and regional lymph nodes in 1.8- to 2-Gy daily fractions, 5 times per week. A 14-Gy (10- to 20-Gy) photon or electron boost was given to the tumor bed of the patients with breast-conserving surgery. Unplanned treatment interruptions occurred in 741 (87%) of the patients and the median duration of the gaps was 13 days (1--91 days). A total of 348 patients (41%) had no treatment break or interruptions of 1 week or less, whereas 505 patients (59%) had treatment interruptions of more than 1 week. The locoregional control (LC) and overall survival (OS) rates were estimated with the Kaplan-Meier method. A Cox proportional hazard regression model was used to evaluate the influence of host- and treatment-related factors on LC and OS (age, menopausal status, histological subtype, grade, hormonal receptor status, pT stage, pN stage, type of surgery, adjuvant treatment, number of gaps and duration of gaps). For all patients LC rates for 5 and 10 years were 95 and 87%, respectively, and OS rates were 78% for 5 years and 62% for 10 years. LC rates for the group of patients with no treatment break or interruptions of 1 week or less, for 5 and 10 years were 94 and 90%, whereas the LC rates for 5 and 10 years were 89 and 86%, for the group of patients with interruptions of more than 1 week (p=0.019). Treatment interruptions of more than 1 week and premenopausal status appeared to be independent adverse prognostic factors in multivariate analyses affecting the LC (p=0.043 and p=0.005, respectively). The OS rates for the patients without treatment interruptions or interruptions of 1 week or less were also significantly better than for the patients with treatment interruptions of more than 1 week (p=0.026) in multivariate analyses. Interruptions more than 1 week during postoperative irradiation of breast cancer adversely affect the treatment outcome.
X-ACT (Xeloda in Adjuvant Colon Cancer Therapy) Calismasi’na gore kapesitabin kolon kanserlerinde... more X-ACT (Xeloda in Adjuvant Colon Cancer Therapy) Calismasi’na gore kapesitabin kolon kanserlerinde adjuvan kemoterapide standart bir tedavi haline gelmis bulunmaktadir. Ancak, biz kendi pratigimizde kapesitabinin daha sik yan etkisi bulundugunu gozlemlemekteyiz. Calismamizda karsilastigimiz yan etki profilini sunarak kapesitabin kullaniminin klinik pratikte farkli sonuclarla karsimiza gelebilecegini gostermeyi hedefledik. Calismamizda, kolon kanserli 89 hastamizin kuratif rezeksiyon sonrasi kapesitabin ile postoperatif 8 siklus adjuvan kapesitabin kemoterapisi sirasinda gelisen yan etkileri ve buna bagli tedavi sonlandirilma gereksinimlerini retrospektif olarak inceledik. Calismaya alinan 89 hastanin 82’si tedavi sikluslarini tamamlamis olup 3'u 6 siklus; 2’si ise 3 siklus sonunda tedaviyi birakmislardir. Baslangic dozu her hasta tarafindan tolere edilmis ancak tum hastalarda tedavi suresince doz azaltimina gidilmistir. Calismamizda, kapesitabinin onerilen dozlarini toksisite...
Bezmialem Science
Amaç: Yapılan bazı çalışmalar düşük dozlu radyoterapinin (RT), tümör invazyonu ve metastazları ar... more Amaç: Yapılan bazı çalışmalar düşük dozlu radyoterapinin (RT), tümör invazyonu ve metastazları artırabileceğini göstermiştir. Risk altındaki organların zarar görmesini önlemek için genellikle çoklu RT alanları kullanılır. Çoklu alanlar kullanıldığında düşük doz RT alanları artacağından invazyon veya metastazları artırabileceği endişesi ile klinik bir çalışma gerçekleştirdik. İyonize Radyasyon (IR), tümör mikroçevresini değiştirerek, konakçı mikrokanser hücrelerinin metastatik potansiyelini artırabilir. Yöntemler: Radyoterapi ve/veya kemoterapi uygulanmış, ECOG performansları 1-3, yaşları 45-87 arası, herhangibir metastazı olmayan, evre II-IIIB 50 akciğer kanseri hastası üzerinde klinik retrospektif bir çalışma yapıldı. RT, günlük 180-200 cGy fraksiyonla haftada 5 gün total 54-66 Gy uygulandı. Akciğerin V5, V10, V20, V40, V50, V60 değerlerinin hastalıksız yaşam ve genel yaşam üzerine olan etkileri istatistiksel olarak Mann Witney U ve l par testleri ile analiz edildi. Bulgular: Akciğerin düşük RT doz alanlarını oluşturan V5, V10 ve V20 değerlerinin nükssüz yaşam ve genel yaşamı r korelasyon değerlerine göre minimal düzeyde pozitif olarak etkilediği belirlendi. Sonuç: Yaşam oranlarını daha da artırabilmek için düşük doz radyasyonun etkilerinin de yapılacak çalışmalarla daha net olarak araştılması yoluna gidilebilir.
Bezmialem Science
Objective: Some previous studies have shown that low-dose radiotherapy (RT) can increase tumor in... more Objective: Some previous studies have shown that low-dose radiotherapy (RT) can increase tumor invasion and metastasis. Multiple RT fields are usually used to prevent the damage to the organs at risk. We performed a clinical study with a concern that low-dose RT might increase invasion or metastasis. Ionizing radiation (IR) can enhance the potential tumor micro-environment by modifying the host micro-metastatic cancer cells. Methods: We conducted a retrospective study on 50 patients aged between 45 and 87 years, who were applied RT and/or chemotherapy, had the Eastern Cooperative Oncology Group performance status (ECOG) between 1 and 3 and stage II-III lung cancer, and were without any metastasis. RT was applied at daily fractions of 180-200 cGy (5 days/week) and a 54-66 Gy total dose. V5, V10, V20, V40, V50, and V60 values of the lung in a disease-free life, and general life effects statistically analysed with Mann-Whitney U and L Par testS. Results: A lower RT dose range, which produced V5, V10, and V20 volume values of the lung, was analyzed. It was observed that the V5, V10, and V20 RT volumes of the lung provided a minimal positive effect on relapse-free and general survival according to the Rcorrelation values. Conclusion: Larger studies are necessary according to these results to evaluate the impact of low-dose radiation and to increase the survival rates.
Precision Radiation Oncology
Objective: Several studies have shown that low-dose radiotherapy (RT) might increase tumor invasi... more Objective: Several studies have shown that low-dose radiotherapy (RT) might increase tumor invasion and metastases. Whereas multiple RT fields that increase low-dose RT areas are often used to prevent damage to organs at risk. We carried out a clinical trial with the concern that lowdose RT sites could increase invasions or metastases when multiple sites were used. Methods: A clinical retrospective study was carried out on 50 lung cancer patients with stage II-IIIB cancer, who underwent RT and/or chemotherapy, had Eastern Cooperative Oncology Group performances 1-3, were aged 45-87 years, and without metastases. RT was carried out for 5 days with 180-200 cGy fractions per day with a total dose of 54-66 Gy. The radiation dose volume areas V5, V10, V20, V40, V50, and V60 of lung were calculated and analyzed by Mann-Whitney U-test and L par test on disease-free and overall survival statistically. Results: It was determined that V5, V10, and V20, which constitute the low RT dose areas of the lung, positively affected the recurrence-free and overall survival minimally according to r correlation values. Conclusion: Low-dose RT volumes were positively affected minimally by recurrence-free survival and overall survival in the present study. The effects of low-dose radiation must be evaluated more clearly in studies.
Journal of Clinical Oncology
Dental, Oral and Craniofacial Research
Sarcomatoid (spindle cell) carcinoma is a unique variant of squamous cell carcinoma. So far very ... more Sarcomatoid (spindle cell) carcinoma is a unique variant of squamous cell carcinoma. So far very rare cases of sarcomatoid carcinoma with maxillary origin have been reported in the Pubmed based research. A new case of spindle cell squamous cell carcinoma with ptosis is reporting in a 65-year old Turkish man. The mass lesion was mainly localized in the maxillary sinus, nasal cavity and extending towards the orbital wall. The cells had a large vesicular nucleus and marked macronucleoles. Tumor cells showed strong immunreactivity comprising both sarcomatous and epithelial components. Case was reported as sarcomatoid carcinoma of maxilla based on these characteristics. The patient was at stage 4b in clinical staging and was regarded as non-operable. Intensity modulated radiotherapy technique was used and a regression at a rate of 1/3 was observed in the tumor.
Oncology Letters, 2014
Anaplastic thyroid carcinoma is a significantly fatal endocrine neoplasm, with an average surviva... more Anaplastic thyroid carcinoma is a significantly fatal endocrine neoplasm, with an average survival time of 4-12 months following diagnosis. The present study reports the case of a 57-year-old male patient who presented to the Bağcılar Training and Research Hospital (Istanbul, Turkey) due to swelling in the neck and difficulty swallowing. The jugular mass biopsy results were consistent with a diagnosis of anaplastic thyroid cancer. The patient was regarded to have advanced-stage subcarinal, paratracheal, aortopulmonary, trancheobronchial and mediastinal lymphadenopathies and exhibited a good prognosis following chemotherapy. However, the patient succumbed one month later due to the emergence of diffuse skin lesions. The histopathological and immunohistochemical assessment of the skin biopsy displayed the characteristics of the underlying thyroid carcinoma.
Oncology, 2005
There is much evidence for the detrimental effect of treatment interruptions on tumor control, pa... more There is much evidence for the detrimental effect of treatment interruptions on tumor control, particularly in head and neck cancer. In order to determine the outcome of the treatment interruptions in postoperative irradiation of breast cancer, 853 female patients treated between 1990 and 1999 inclusive were retrospectively analyzed. Locally advanced breast cancer patients who received neoadjuvant chemotherapy were not included in the study. Five hundred and forty-six patients (64%) treated with mastectomy and 307 patients (36%) with breast-conserving surgery were analyzed. A total dose of 50 Gy (46--54 Gy) was given to the chest wall/breast and regional lymph nodes in 1.8- to 2-Gy daily fractions, 5 times per week. A 14-Gy (10- to 20-Gy) photon or electron boost was given to the tumor bed of the patients with breast-conserving surgery. Unplanned treatment interruptions occurred in 741 (87%) of the patients and the median duration of the gaps was 13 days (1--91 days). A total of 348 patients (41%) had no treatment break or interruptions of 1 week or less, whereas 505 patients (59%) had treatment interruptions of more than 1 week. The locoregional control (LC) and overall survival (OS) rates were estimated with the Kaplan-Meier method. A Cox proportional hazard regression model was used to evaluate the influence of host- and treatment-related factors on LC and OS (age, menopausal status, histological subtype, grade, hormonal receptor status, pT stage, pN stage, type of surgery, adjuvant treatment, number of gaps and duration of gaps). For all patients LC rates for 5 and 10 years were 95 and 87%, respectively, and OS rates were 78% for 5 years and 62% for 10 years. LC rates for the group of patients with no treatment break or interruptions of 1 week or less, for 5 and 10 years were 94 and 90%, whereas the LC rates for 5 and 10 years were 89 and 86%, for the group of patients with interruptions of more than 1 week (p=0.019). Treatment interruptions of more than 1 week and premenopausal status appeared to be independent adverse prognostic factors in multivariate analyses affecting the LC (p=0.043 and p=0.005, respectively). The OS rates for the patients without treatment interruptions or interruptions of 1 week or less were also significantly better than for the patients with treatment interruptions of more than 1 week (p=0.026) in multivariate analyses. Interruptions more than 1 week during postoperative irradiation of breast cancer adversely affect the treatment outcome.
Journal of B.U.ON.: official journal of the Balkan Union of Oncology
Patients treated in the years 1990-2003 with breast conserving surgery and postoperative adjuvant... more Patients treated in the years 1990-2003 with breast conserving surgery and postoperative adjuvant radiotherapy were retrospectively analyzed in order to determine the impact of radiotherapy interruptions on the treatment outcome. 470 patients received breast irradiation with (60)Co or with 4MV photon linear accelerator (total dose 50 Gy, range 46-54). Four hundred and sixty-two (98%) patients had boost dose of 10-20 Gy to the tumor bed either with photon or electron irradiation. Irradiation of the lymphatic fields was carried out according to the number of involved nodes. Even one day of treatment break was accepted as treatment interruption. Unplanned treatment interruptions occurred in 423 (90%) patients. A total of 196 (41%) patients had no treatment breaks or had interruptions of 7 days or less and 274 (59%) patients had treatment interruptions longer than 7 days. Locoregional control (LC) and overall survival (OS) rates were estimated by Kaplan-Meier method. The groups were com...
Oncology, 2005
There is much evidence for the detrimental effect of treatment interruptions on tumor control, pa... more There is much evidence for the detrimental effect of treatment interruptions on tumor control, particularly in head and neck cancer. In order to determine the outcome of the treatment interruptions in postoperative irradiation of breast cancer, 853 female patients treated between 1990 and 1999 inclusive were retrospectively analyzed. Locally advanced breast cancer patients who received neoadjuvant chemotherapy were not included in the study. Five hundred and forty-six patients (64%) treated with mastectomy and 307 patients (36%) with breast-conserving surgery were analyzed. A total dose of 50 Gy (46--54 Gy) was given to the chest wall/breast and regional lymph nodes in 1.8- to 2-Gy daily fractions, 5 times per week. A 14-Gy (10- to 20-Gy) photon or electron boost was given to the tumor bed of the patients with breast-conserving surgery. Unplanned treatment interruptions occurred in 741 (87%) of the patients and the median duration of the gaps was 13 days (1--91 days). A total of 348 patients (41%) had no treatment break or interruptions of 1 week or less, whereas 505 patients (59%) had treatment interruptions of more than 1 week. The locoregional control (LC) and overall survival (OS) rates were estimated with the Kaplan-Meier method. A Cox proportional hazard regression model was used to evaluate the influence of host- and treatment-related factors on LC and OS (age, menopausal status, histological subtype, grade, hormonal receptor status, pT stage, pN stage, type of surgery, adjuvant treatment, number of gaps and duration of gaps). For all patients LC rates for 5 and 10 years were 95 and 87%, respectively, and OS rates were 78% for 5 years and 62% for 10 years. LC rates for the group of patients with no treatment break or interruptions of 1 week or less, for 5 and 10 years were 94 and 90%, whereas the LC rates for 5 and 10 years were 89 and 86%, for the group of patients with interruptions of more than 1 week (p=0.019). Treatment interruptions of more than 1 week and premenopausal status appeared to be independent adverse prognostic factors in multivariate analyses affecting the LC (p=0.043 and p=0.005, respectively). The OS rates for the patients without treatment interruptions or interruptions of 1 week or less were also significantly better than for the patients with treatment interruptions of more than 1 week (p=0.026) in multivariate analyses. Interruptions more than 1 week during postoperative irradiation of breast cancer adversely affect the treatment outcome.
X-ACT (Xeloda in Adjuvant Colon Cancer Therapy) Calismasi’na gore kapesitabin kolon kanserlerinde... more X-ACT (Xeloda in Adjuvant Colon Cancer Therapy) Calismasi’na gore kapesitabin kolon kanserlerinde adjuvan kemoterapide standart bir tedavi haline gelmis bulunmaktadir. Ancak, biz kendi pratigimizde kapesitabinin daha sik yan etkisi bulundugunu gozlemlemekteyiz. Calismamizda karsilastigimiz yan etki profilini sunarak kapesitabin kullaniminin klinik pratikte farkli sonuclarla karsimiza gelebilecegini gostermeyi hedefledik. Calismamizda, kolon kanserli 89 hastamizin kuratif rezeksiyon sonrasi kapesitabin ile postoperatif 8 siklus adjuvan kapesitabin kemoterapisi sirasinda gelisen yan etkileri ve buna bagli tedavi sonlandirilma gereksinimlerini retrospektif olarak inceledik. Calismaya alinan 89 hastanin 82’si tedavi sikluslarini tamamlamis olup 3'u 6 siklus; 2’si ise 3 siklus sonunda tedaviyi birakmislardir. Baslangic dozu her hasta tarafindan tolere edilmis ancak tum hastalarda tedavi suresince doz azaltimina gidilmistir. Calismamizda, kapesitabinin onerilen dozlarini toksisite...
Bezmialem Science
Amaç: Yapılan bazı çalışmalar düşük dozlu radyoterapinin (RT), tümör invazyonu ve metastazları ar... more Amaç: Yapılan bazı çalışmalar düşük dozlu radyoterapinin (RT), tümör invazyonu ve metastazları artırabileceğini göstermiştir. Risk altındaki organların zarar görmesini önlemek için genellikle çoklu RT alanları kullanılır. Çoklu alanlar kullanıldığında düşük doz RT alanları artacağından invazyon veya metastazları artırabileceği endişesi ile klinik bir çalışma gerçekleştirdik. İyonize Radyasyon (IR), tümör mikroçevresini değiştirerek, konakçı mikrokanser hücrelerinin metastatik potansiyelini artırabilir. Yöntemler: Radyoterapi ve/veya kemoterapi uygulanmış, ECOG performansları 1-3, yaşları 45-87 arası, herhangibir metastazı olmayan, evre II-IIIB 50 akciğer kanseri hastası üzerinde klinik retrospektif bir çalışma yapıldı. RT, günlük 180-200 cGy fraksiyonla haftada 5 gün total 54-66 Gy uygulandı. Akciğerin V5, V10, V20, V40, V50, V60 değerlerinin hastalıksız yaşam ve genel yaşam üzerine olan etkileri istatistiksel olarak Mann Witney U ve l par testleri ile analiz edildi. Bulgular: Akciğerin düşük RT doz alanlarını oluşturan V5, V10 ve V20 değerlerinin nükssüz yaşam ve genel yaşamı r korelasyon değerlerine göre minimal düzeyde pozitif olarak etkilediği belirlendi. Sonuç: Yaşam oranlarını daha da artırabilmek için düşük doz radyasyonun etkilerinin de yapılacak çalışmalarla daha net olarak araştılması yoluna gidilebilir.
Bezmialem Science
Objective: Some previous studies have shown that low-dose radiotherapy (RT) can increase tumor in... more Objective: Some previous studies have shown that low-dose radiotherapy (RT) can increase tumor invasion and metastasis. Multiple RT fields are usually used to prevent the damage to the organs at risk. We performed a clinical study with a concern that low-dose RT might increase invasion or metastasis. Ionizing radiation (IR) can enhance the potential tumor micro-environment by modifying the host micro-metastatic cancer cells. Methods: We conducted a retrospective study on 50 patients aged between 45 and 87 years, who were applied RT and/or chemotherapy, had the Eastern Cooperative Oncology Group performance status (ECOG) between 1 and 3 and stage II-III lung cancer, and were without any metastasis. RT was applied at daily fractions of 180-200 cGy (5 days/week) and a 54-66 Gy total dose. V5, V10, V20, V40, V50, and V60 values of the lung in a disease-free life, and general life effects statistically analysed with Mann-Whitney U and L Par testS. Results: A lower RT dose range, which produced V5, V10, and V20 volume values of the lung, was analyzed. It was observed that the V5, V10, and V20 RT volumes of the lung provided a minimal positive effect on relapse-free and general survival according to the Rcorrelation values. Conclusion: Larger studies are necessary according to these results to evaluate the impact of low-dose radiation and to increase the survival rates.
Precision Radiation Oncology
Objective: Several studies have shown that low-dose radiotherapy (RT) might increase tumor invasi... more Objective: Several studies have shown that low-dose radiotherapy (RT) might increase tumor invasion and metastases. Whereas multiple RT fields that increase low-dose RT areas are often used to prevent damage to organs at risk. We carried out a clinical trial with the concern that lowdose RT sites could increase invasions or metastases when multiple sites were used. Methods: A clinical retrospective study was carried out on 50 lung cancer patients with stage II-IIIB cancer, who underwent RT and/or chemotherapy, had Eastern Cooperative Oncology Group performances 1-3, were aged 45-87 years, and without metastases. RT was carried out for 5 days with 180-200 cGy fractions per day with a total dose of 54-66 Gy. The radiation dose volume areas V5, V10, V20, V40, V50, and V60 of lung were calculated and analyzed by Mann-Whitney U-test and L par test on disease-free and overall survival statistically. Results: It was determined that V5, V10, and V20, which constitute the low RT dose areas of the lung, positively affected the recurrence-free and overall survival minimally according to r correlation values. Conclusion: Low-dose RT volumes were positively affected minimally by recurrence-free survival and overall survival in the present study. The effects of low-dose radiation must be evaluated more clearly in studies.
Journal of Clinical Oncology
Dental, Oral and Craniofacial Research
Sarcomatoid (spindle cell) carcinoma is a unique variant of squamous cell carcinoma. So far very ... more Sarcomatoid (spindle cell) carcinoma is a unique variant of squamous cell carcinoma. So far very rare cases of sarcomatoid carcinoma with maxillary origin have been reported in the Pubmed based research. A new case of spindle cell squamous cell carcinoma with ptosis is reporting in a 65-year old Turkish man. The mass lesion was mainly localized in the maxillary sinus, nasal cavity and extending towards the orbital wall. The cells had a large vesicular nucleus and marked macronucleoles. Tumor cells showed strong immunreactivity comprising both sarcomatous and epithelial components. Case was reported as sarcomatoid carcinoma of maxilla based on these characteristics. The patient was at stage 4b in clinical staging and was regarded as non-operable. Intensity modulated radiotherapy technique was used and a regression at a rate of 1/3 was observed in the tumor.
Oncology Letters, 2014
Anaplastic thyroid carcinoma is a significantly fatal endocrine neoplasm, with an average surviva... more Anaplastic thyroid carcinoma is a significantly fatal endocrine neoplasm, with an average survival time of 4-12 months following diagnosis. The present study reports the case of a 57-year-old male patient who presented to the Bağcılar Training and Research Hospital (Istanbul, Turkey) due to swelling in the neck and difficulty swallowing. The jugular mass biopsy results were consistent with a diagnosis of anaplastic thyroid cancer. The patient was regarded to have advanced-stage subcarinal, paratracheal, aortopulmonary, trancheobronchial and mediastinal lymphadenopathies and exhibited a good prognosis following chemotherapy. However, the patient succumbed one month later due to the emergence of diffuse skin lesions. The histopathological and immunohistochemical assessment of the skin biopsy displayed the characteristics of the underlying thyroid carcinoma.
Oncology, 2005
There is much evidence for the detrimental effect of treatment interruptions on tumor control, pa... more There is much evidence for the detrimental effect of treatment interruptions on tumor control, particularly in head and neck cancer. In order to determine the outcome of the treatment interruptions in postoperative irradiation of breast cancer, 853 female patients treated between 1990 and 1999 inclusive were retrospectively analyzed. Locally advanced breast cancer patients who received neoadjuvant chemotherapy were not included in the study. Five hundred and forty-six patients (64%) treated with mastectomy and 307 patients (36%) with breast-conserving surgery were analyzed. A total dose of 50 Gy (46--54 Gy) was given to the chest wall/breast and regional lymph nodes in 1.8- to 2-Gy daily fractions, 5 times per week. A 14-Gy (10- to 20-Gy) photon or electron boost was given to the tumor bed of the patients with breast-conserving surgery. Unplanned treatment interruptions occurred in 741 (87%) of the patients and the median duration of the gaps was 13 days (1--91 days). A total of 348 patients (41%) had no treatment break or interruptions of 1 week or less, whereas 505 patients (59%) had treatment interruptions of more than 1 week. The locoregional control (LC) and overall survival (OS) rates were estimated with the Kaplan-Meier method. A Cox proportional hazard regression model was used to evaluate the influence of host- and treatment-related factors on LC and OS (age, menopausal status, histological subtype, grade, hormonal receptor status, pT stage, pN stage, type of surgery, adjuvant treatment, number of gaps and duration of gaps). For all patients LC rates for 5 and 10 years were 95 and 87%, respectively, and OS rates were 78% for 5 years and 62% for 10 years. LC rates for the group of patients with no treatment break or interruptions of 1 week or less, for 5 and 10 years were 94 and 90%, whereas the LC rates for 5 and 10 years were 89 and 86%, for the group of patients with interruptions of more than 1 week (p=0.019). Treatment interruptions of more than 1 week and premenopausal status appeared to be independent adverse prognostic factors in multivariate analyses affecting the LC (p=0.043 and p=0.005, respectively). The OS rates for the patients without treatment interruptions or interruptions of 1 week or less were also significantly better than for the patients with treatment interruptions of more than 1 week (p=0.026) in multivariate analyses. Interruptions more than 1 week during postoperative irradiation of breast cancer adversely affect the treatment outcome.
Journal of B.U.ON.: official journal of the Balkan Union of Oncology
Patients treated in the years 1990-2003 with breast conserving surgery and postoperative adjuvant... more Patients treated in the years 1990-2003 with breast conserving surgery and postoperative adjuvant radiotherapy were retrospectively analyzed in order to determine the impact of radiotherapy interruptions on the treatment outcome. 470 patients received breast irradiation with (60)Co or with 4MV photon linear accelerator (total dose 50 Gy, range 46-54). Four hundred and sixty-two (98%) patients had boost dose of 10-20 Gy to the tumor bed either with photon or electron irradiation. Irradiation of the lymphatic fields was carried out according to the number of involved nodes. Even one day of treatment break was accepted as treatment interruption. Unplanned treatment interruptions occurred in 423 (90%) patients. A total of 196 (41%) patients had no treatment breaks or had interruptions of 7 days or less and 274 (59%) patients had treatment interruptions longer than 7 days. Locoregional control (LC) and overall survival (OS) rates were estimated by Kaplan-Meier method. The groups were com...