Piyali Khamkat - Academia.edu (original) (raw)
Papers by Piyali Khamkat
Research journal of pharmacy and technology, Jun 28, 2022
One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical... more One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical practice because they do not have sufficient compliance and bioavailability for patients. So, nowadays transdermal route is a greater area of interest of pharmaceutical research for delivering drug. But skin is the most challenging area to cross in transdermal delivery of drug as the stratum corneum & the outer layer of the skin have tight intracellular junctions. Researchers have developed various approaches like micro needle, sonophoresis, electrophoresis, and iontophoresis etc to overcome those complications for the transdermal delivery of drugs. Chemical permeation enhancers are needed in vesicular drug delivery system such as niosomes, liposomes, elastic liposomes (transfersomes and ethosomes) to improve their penetration property. Transferosomes can be prepared by a number of methods like vortexing, sonication method, freeze–thaw method, ethanol injection method, Reverse-phase evaporation method, etc. Transfersomes can carry wide ranges of drugs having a wide range of solubility within it as they are constructed of hydrophobic as well as hydrophilic moieties. The main property of transferosome is deformability. This flexible nature of the vesicle membrane helps transfersome to go across the narrow pores with a maximum amount of drugs present within it. They have high deformable capacity which exhibits advanced penetration capability of intact vesicles. Both high and low molecular weight drugs like albumin, insulin, corticosteroids, sex hormones, anesthetic, anticancer, analgesic can be fused within transfersome.
Research Journal of Pharmacy and Technology
Traditional phytomedicines owing to their affordable price and fewer side effects over synthetic ... more Traditional phytomedicines owing to their affordable price and fewer side effects over synthetic preparations may have a wide range of applications in primary health care system. However, there was no scientific report documented so far on the excision wound healing activity of Parthenium hysterophorus-Turmeric ethanolic extract on rabbits. The present study deals with the formulation and evaluation of Parthenium hysterophorus-Turmeric ointment in definite ratio. The four batches were examined for hemocompatibility study and characterised for physical appearance, pH, rheological behaviour, in-vitro drug diffusion pattern, skin irritation excision wound healing and stability study. All the hemocompatible herbal formulations were found to possess satisfactory organoleptic properties and applicability parameters. An inverse relationship was observed between viscosity and % spreadability of ointments. Non-Fickian diffusion based controlled drug release was observed for all these topical...
Research Journal of Pharmacy and Technology
Numerous attempts were improved to access the bioavailability and clinical output of oral dosage ... more Numerous attempts were improved to access the bioavailability and clinical output of oral dosage forms. Different types of gastro retentive drug delivery systems (GRDDS) was developed to enhance the therapeutic efficacy of medications which are unstable at alkaline pH, results a narrow absorption window with active locally in the stomach, and gets easily solubilized in acidic conditions. So the physiological condition of the stomach and the different elements that influence GRDDS will be discussed. In general, this review will illuminate and direct detailing researchers in planning, formulation, and designing the GRDDS.
Research Journal of Pharmacy and Technology
One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical... more One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical practice because they do not have sufficient compliance and bioavailability for patients. So, nowadays transdermal route is a greater area of interest of pharmaceutical research for delivering drug. But skin is the most challenging area to cross in transdermal delivery of drug as the stratum corneum & the outer layer of the skin have tight intracellular junctions. Researchers have developed various approaches like micro needle, sonophoresis, electrophoresis, and iontophoresis etc to overcome those complications for the transdermal delivery of drugs. Chemical permeation enhancers are needed in vesicular drug delivery system such as niosomes, liposomes, elastic liposomes (transfersomes and ethosomes) to improve their penetration property. Transferosomes can be prepared by a number of methods like vortexing, sonication method, freeze–thaw method, ethanol injection method, Reverse-phase eva...
Biomarkers provide a dynamic and powerful approach to understand the spectrum of various diseases... more Biomarkers provide a dynamic and powerful approach to understand the spectrum of various diseases including neurological diseases with application in observational and analytic epidemiology, randomized clinical trials, screening, and diagnosis. Successful implementation of biomarkers in drug development can decrease development timelines by allowing earlier go/no go decisions and increase the success of drugs in clinical trials by rationally guiding dose and indication selection. Biomarkers has gathered immense scientific as well as clinical value and is most favored and incorporated in practice of medicine. Its ability to reflect the entire spectrum of disease from the earliest manifestations to the terminal stages guides in proper treatment of the individual reduces the chances of casualties and even economic losses. This substances and their ability for the discovery of new drugs opens the door for treatment of diseases like Alzheimer‟s and various type of rare and deadly cancer....
International Journal of Pharmaceutical Investigation
In this work, the photo components were investigated utilising GC-MS analysis and in vitro antiox... more In this work, the photo components were investigated utilising GC-MS analysis and in vitro antioxidant activity, and the anthelmintic potential of methanolic extract of aerial parts of the Lagenaria siceraria (MEALS). By using the soxhlation method. Materials and Methods: MEALS were made from aerial components, and phytochemical analysis was carried out for a qualitative evaluation. The in vitro antioxidant activity was measured using the ABTS technique, and the current extract was utilised to analyse phytocomponents by GC-MS and study anthelmintic activity on Pheretima posthuma. The extract of Lagenaria siceraria included 59 components, according to the GC-MS study's phytochemical analysis. Results: Results from anthelmintic research reveal that MEALS had paralysis times between 4.76 and 2.17 min and death times between 6.18 and 2.34 min when compared to the medicine Albendazole, which is the gold standard (paralysis time 4.76 min to 2.17 min and death time 5.87 min to 1.96 min on Peritima posthuma in increasing order of concentration). The percentage of scavenging ranged from 33.31% to 82.33% (IC 50 143) and by standard medicine (ascorbic acid) from 49.47% to 94.73% (IC 50 103) using the ABTS technique in the evaluation of an antioxidant activity. Conclusion: Due to the presence of physiologically active phytocomponents, aerial sections of the Lagenaria siceraria (MEALS) were shown to be potent anthelmintic and antioxidant agents.
Asian Journal of Pharmaceutical and Clinical Research
Personalized medication (PM) is a wide and progressed field of medical science with more accuracy... more Personalized medication (PM) is a wide and progressed field of medical science with more accuracy of medication to educate every individual’s clinical data. This model categorizes individuals within discrete subject groups with medical accountability, utility, or products being customized to each group based on their expected response. It is an emergent and rapidly developing method of clinical practice which utilizes advanced technologies that give a conclusion concerning to the prognosis, prevention, recognition, and treatment of diseases. The advantages is to improve the usefulness of PM over traditionally approved drugs due to less toxicity and side effect with therapeutic efficacy, which leads to patient stratification, proactive treatment regimens resulting in reduced health-care costs, and ultimately enhanced the quality of life. This review focused to an extensive understanding of personalized medicines as a major therapeutic approach to overpass the health-care problems and...
Innovare Journal of Social Sciences
The COVID-19 pandemic has wreaked havoc on education systems around the world, affecting approxim... more The COVID-19 pandemic has wreaked havoc on education systems around the world, affecting approximately 1.7 billion students in over 200 nations. More than 95% of the world’s student population has been touched by school, institution, and other learning facility closures. This has resulted in significant changes in every part of our life. Traditional educational techniques have been considerably disrupted by social alienation and limited movement policies. The reopening of schools once the restrictions have been lifted is another challenge, as many new standard operating procedures have been implemented. Many scholars have shared their work on teaching and learning in various ways in the aftermath of the COVID-19 outbreak. Face-to-face instruction has been phased out at a number of schools, colleges, and universities. There is concern that the 2020 academic year, or maybe more in the future, would be lost. Innovation and implementation of alternative educational systems and assessmen...
Multifunctional Theranostic Nanomedicines in Cancer, 2021
This book and the individual contributions contained in it are protected under copyright by the P... more This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
Research journal of pharmacy and technology, Jun 28, 2022
One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical... more One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical practice because they do not have sufficient compliance and bioavailability for patients. So, nowadays transdermal route is a greater area of interest of pharmaceutical research for delivering drug. But skin is the most challenging area to cross in transdermal delivery of drug as the stratum corneum & the outer layer of the skin have tight intracellular junctions. Researchers have developed various approaches like micro needle, sonophoresis, electrophoresis, and iontophoresis etc to overcome those complications for the transdermal delivery of drugs. Chemical permeation enhancers are needed in vesicular drug delivery system such as niosomes, liposomes, elastic liposomes (transfersomes and ethosomes) to improve their penetration property. Transferosomes can be prepared by a number of methods like vortexing, sonication method, freeze–thaw method, ethanol injection method, Reverse-phase evaporation method, etc. Transfersomes can carry wide ranges of drugs having a wide range of solubility within it as they are constructed of hydrophobic as well as hydrophilic moieties. The main property of transferosome is deformability. This flexible nature of the vesicle membrane helps transfersome to go across the narrow pores with a maximum amount of drugs present within it. They have high deformable capacity which exhibits advanced penetration capability of intact vesicles. Both high and low molecular weight drugs like albumin, insulin, corticosteroids, sex hormones, anesthetic, anticancer, analgesic can be fused within transfersome.
Research Journal of Pharmacy and Technology
Traditional phytomedicines owing to their affordable price and fewer side effects over synthetic ... more Traditional phytomedicines owing to their affordable price and fewer side effects over synthetic preparations may have a wide range of applications in primary health care system. However, there was no scientific report documented so far on the excision wound healing activity of Parthenium hysterophorus-Turmeric ethanolic extract on rabbits. The present study deals with the formulation and evaluation of Parthenium hysterophorus-Turmeric ointment in definite ratio. The four batches were examined for hemocompatibility study and characterised for physical appearance, pH, rheological behaviour, in-vitro drug diffusion pattern, skin irritation excision wound healing and stability study. All the hemocompatible herbal formulations were found to possess satisfactory organoleptic properties and applicability parameters. An inverse relationship was observed between viscosity and % spreadability of ointments. Non-Fickian diffusion based controlled drug release was observed for all these topical...
Research Journal of Pharmacy and Technology
Numerous attempts were improved to access the bioavailability and clinical output of oral dosage ... more Numerous attempts were improved to access the bioavailability and clinical output of oral dosage forms. Different types of gastro retentive drug delivery systems (GRDDS) was developed to enhance the therapeutic efficacy of medications which are unstable at alkaline pH, results a narrow absorption window with active locally in the stomach, and gets easily solubilized in acidic conditions. So the physiological condition of the stomach and the different elements that influence GRDDS will be discussed. In general, this review will illuminate and direct detailing researchers in planning, formulation, and designing the GRDDS.
Research Journal of Pharmacy and Technology
One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical... more One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical practice because they do not have sufficient compliance and bioavailability for patients. So, nowadays transdermal route is a greater area of interest of pharmaceutical research for delivering drug. But skin is the most challenging area to cross in transdermal delivery of drug as the stratum corneum & the outer layer of the skin have tight intracellular junctions. Researchers have developed various approaches like micro needle, sonophoresis, electrophoresis, and iontophoresis etc to overcome those complications for the transdermal delivery of drugs. Chemical permeation enhancers are needed in vesicular drug delivery system such as niosomes, liposomes, elastic liposomes (transfersomes and ethosomes) to improve their penetration property. Transferosomes can be prepared by a number of methods like vortexing, sonication method, freeze–thaw method, ethanol injection method, Reverse-phase eva...
Biomarkers provide a dynamic and powerful approach to understand the spectrum of various diseases... more Biomarkers provide a dynamic and powerful approach to understand the spectrum of various diseases including neurological diseases with application in observational and analytic epidemiology, randomized clinical trials, screening, and diagnosis. Successful implementation of biomarkers in drug development can decrease development timelines by allowing earlier go/no go decisions and increase the success of drugs in clinical trials by rationally guiding dose and indication selection. Biomarkers has gathered immense scientific as well as clinical value and is most favored and incorporated in practice of medicine. Its ability to reflect the entire spectrum of disease from the earliest manifestations to the terminal stages guides in proper treatment of the individual reduces the chances of casualties and even economic losses. This substances and their ability for the discovery of new drugs opens the door for treatment of diseases like Alzheimer‟s and various type of rare and deadly cancer....
International Journal of Pharmaceutical Investigation
In this work, the photo components were investigated utilising GC-MS analysis and in vitro antiox... more In this work, the photo components were investigated utilising GC-MS analysis and in vitro antioxidant activity, and the anthelmintic potential of methanolic extract of aerial parts of the Lagenaria siceraria (MEALS). By using the soxhlation method. Materials and Methods: MEALS were made from aerial components, and phytochemical analysis was carried out for a qualitative evaluation. The in vitro antioxidant activity was measured using the ABTS technique, and the current extract was utilised to analyse phytocomponents by GC-MS and study anthelmintic activity on Pheretima posthuma. The extract of Lagenaria siceraria included 59 components, according to the GC-MS study's phytochemical analysis. Results: Results from anthelmintic research reveal that MEALS had paralysis times between 4.76 and 2.17 min and death times between 6.18 and 2.34 min when compared to the medicine Albendazole, which is the gold standard (paralysis time 4.76 min to 2.17 min and death time 5.87 min to 1.96 min on Peritima posthuma in increasing order of concentration). The percentage of scavenging ranged from 33.31% to 82.33% (IC 50 143) and by standard medicine (ascorbic acid) from 49.47% to 94.73% (IC 50 103) using the ABTS technique in the evaluation of an antioxidant activity. Conclusion: Due to the presence of physiologically active phytocomponents, aerial sections of the Lagenaria siceraria (MEALS) were shown to be potent anthelmintic and antioxidant agents.
Asian Journal of Pharmaceutical and Clinical Research
Personalized medication (PM) is a wide and progressed field of medical science with more accuracy... more Personalized medication (PM) is a wide and progressed field of medical science with more accuracy of medication to educate every individual’s clinical data. This model categorizes individuals within discrete subject groups with medical accountability, utility, or products being customized to each group based on their expected response. It is an emergent and rapidly developing method of clinical practice which utilizes advanced technologies that give a conclusion concerning to the prognosis, prevention, recognition, and treatment of diseases. The advantages is to improve the usefulness of PM over traditionally approved drugs due to less toxicity and side effect with therapeutic efficacy, which leads to patient stratification, proactive treatment regimens resulting in reduced health-care costs, and ultimately enhanced the quality of life. This review focused to an extensive understanding of personalized medicines as a major therapeutic approach to overpass the health-care problems and...
Innovare Journal of Social Sciences
The COVID-19 pandemic has wreaked havoc on education systems around the world, affecting approxim... more The COVID-19 pandemic has wreaked havoc on education systems around the world, affecting approximately 1.7 billion students in over 200 nations. More than 95% of the world’s student population has been touched by school, institution, and other learning facility closures. This has resulted in significant changes in every part of our life. Traditional educational techniques have been considerably disrupted by social alienation and limited movement policies. The reopening of schools once the restrictions have been lifted is another challenge, as many new standard operating procedures have been implemented. Many scholars have shared their work on teaching and learning in various ways in the aftermath of the COVID-19 outbreak. Face-to-face instruction has been phased out at a number of schools, colleges, and universities. There is concern that the 2020 academic year, or maybe more in the future, would be lost. Innovation and implementation of alternative educational systems and assessmen...
Multifunctional Theranostic Nanomedicines in Cancer, 2021
This book and the individual contributions contained in it are protected under copyright by the P... more This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.