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Papers by Prasuna Sundari
Asian Journal of Pharmaceutical and Clinical Research
Objective: The present research work aimed to develop herbal mosquito repellents as gels, incense... more Objective: The present research work aimed to develop herbal mosquito repellents as gels, incense sticks, and liquids for plug-in devices and also to assess their performance characteristics. Methods: Herbal materials possessing mosquito-repellent activity were selected from the literature review based on percentage repellency and protection period. In this study, lavender, rosemary, lemongrass, and cedarwood oils were selected as actives. Span 20 and tween 80 were used to emulsify the volatile materials and then incorporated into Carbopol 934 base to form F1 and F2 gels which were evaluated for homogeneity, pH, spread ability, viscosity, and extrudability. Incense sticks were developed using charcoal and jigat as base materials. The prepared incense sticks F3 and F4 were evaluated for burning time, ash weight, and smoke. Solutions F5 and F6 were prepared using surfactants and cosolvents and were evaluated for phase separation. All formulations were screened for their mosquito repel...
The objective of the present study was to develop a super saturable self-emulsifying drug deliver... more The objective of the present study was to develop a super saturable self-emulsifying drug delivery system of Bacopa monnieri to enhance its solubility and its oral bioavailability. The herbal drug Bacopa monnieri (Family-Scrophulariaceae) is a creeping marsh plant used in Ayurveda for neurological rejuvenation, and has implications for memory enhancement and anxiety. Bacopa monnieri is an herbal drug with poor aqueous solubility. Solubility of Bacopa monnieri in various oils was determined to optimize the oil phase of an SSEDDS. Various surfactants and co-surfactants were screened for their emulsification ability with the selected oil. Pseudo ternary phase diagrams were constructed using TRIPLOT V 14 software to identify the selfemulsification region. SEDDS were prepared using Isopropyl myristate as oil, tween 80 as surfactant and Transcutol P as co-surfactant. To overcome the problems with SEDDS they are converted to super saturable SEDDS using HPMC. Formulated S-SEDDS were evaluat...
The aim of the present study was to formulate and evaluate ophthalmic drug delivery system of Bal... more The aim of the present study was to formulate and evaluate ophthalmic drug delivery system of Balofloxacin based on the concept of thermosensitive gelation. Balofloxacin is a fourth generation broad spectrum fluoroquinolone antibiotic indicated for infective ophthalmitis. Insitu gel was formulated by cold method using different concentrations of Poloxamer and Chitosan as thermoreversible polymers. Prepared formulations were evaluated for gelling capacity, drug content, rheological studies, gelation time, gelation temperature, in-vitro diffusion studies and antimicrobial activity. The pH of all the formulations was found to be 7.4. Formulation (G7) was optimized based on drug content and in vitro drug release studies. All the formulations were found to be clear and devoid of particulate matter. With the increase in concentration viscosity of the solution increases which renders sustained release of the drug from the formulation over a period of 10h. Gelling capacity studies revealed ...
is a triazole antifungal drug which is available in different pharmaceutical dosage forms (tablet... more is a triazole antifungal drug which is available in different pharmaceutical dosage forms (tablets, capsules and oral solutions). It is an orally active broad spectrum triazole antifungal agent. This article reviews the analytical methods for identification and quantitative determination of Itraconazole in pharmaceutical and biological samples. The most commonly adopted methods for the determination of Itraconazole are chromatographic (high-pressure liquid chromatography (HPLC, HPTLC), spectrofluorimetric, spectrophotometric and colorimetric methods. Recent preferences in the analysis of Itraconazole proves primacy of HPLC and confirms a general trend of moving towards more sensitive methods having higher resolution potential, consuming small quantities of samples and reagents and requiring less time for analysis.
Woodfordia fruticosa (Family-Lythraceae) is an important traditional medicinal plant. Scientific ... more Woodfordia fruticosa (Family-Lythraceae) is an important traditional medicinal plant. Scientific investigations reported antimicrobial, antiinflammatory, hepatoprotective, analgesic, wound healing and antifertility activity. Phytosome technology has proved to be beneficial in providing better absorption and bioavailability of polar biomolecules over conventional herbal extracts. The aim of the present study was to prepare and evaluate topical phytosomal gel of woodfordia fruticosa extract (WFE). Dried flowers of the plant were subjected to soxhlation using 80% methanol. The extract was complexed with soyalecithin in various drug:lipid ratios of 1:1, 1:2, 1:3, 1:4 and 1:5. Phytosomal complex of WFE was prepared by Ethanol method and Reflux method. All formulations were evaluated for vesicle formation, % yield, Entrapment efficiency and invitro drug release studies. Drug: lipid ratio of 1:3(E3) was suitable as it resulted in greater Entrapment efficiency of 89.15% & invitro drug relea...
Aim: The aim of the present investigation was to formulate and evaluate ion sensitive ocular insi... more Aim: The aim of the present investigation was to formulate and evaluate ion sensitive ocular insitu gels for sustained release of Balofloxacin, a fourth generation broad spectrum antibiotic indicated for infective ophthalmitis. Methods: Insitu ocular gels of Balofloxacin were formulated aseptically by polymer solution method. Sodium alginate, HPMC E50 LV and HPMC K4M in different concentrations were employed. All the formulations were evaluated for pH, clarity, drug content, gelling capacity, viscosity studies, invitro drug release studies, antimicrobial activity. Formulation with good gelling capacity was selected for further studies. Drug-excipient compatibility studies in FK8 were evaluated by FTIR studies. Invitro drug diffusion studies was carried out in modified diffusion apparatus using gelatin sheet as a semipermeable membrane and comparative study of antimicrobial activity of API and formulation was assessed by cup plate technique Results: All the developed formulations had...
Asian Journal of Pharmaceutical and Clinical Research
Objective: The present research work aimed to develop herbal mosquito repellents as gels, incense... more Objective: The present research work aimed to develop herbal mosquito repellents as gels, incense sticks, and liquids for plug-in devices and also to assess their performance characteristics. Methods: Herbal materials possessing mosquito-repellent activity were selected from the literature review based on percentage repellency and protection period. In this study, lavender, rosemary, lemongrass, and cedarwood oils were selected as actives. Span 20 and tween 80 were used to emulsify the volatile materials and then incorporated into Carbopol 934 base to form F1 and F2 gels which were evaluated for homogeneity, pH, spread ability, viscosity, and extrudability. Incense sticks were developed using charcoal and jigat as base materials. The prepared incense sticks F3 and F4 were evaluated for burning time, ash weight, and smoke. Solutions F5 and F6 were prepared using surfactants and cosolvents and were evaluated for phase separation. All formulations were screened for their mosquito repel...
The objective of the present study was to develop a super saturable self-emulsifying drug deliver... more The objective of the present study was to develop a super saturable self-emulsifying drug delivery system of Bacopa monnieri to enhance its solubility and its oral bioavailability. The herbal drug Bacopa monnieri (Family-Scrophulariaceae) is a creeping marsh plant used in Ayurveda for neurological rejuvenation, and has implications for memory enhancement and anxiety. Bacopa monnieri is an herbal drug with poor aqueous solubility. Solubility of Bacopa monnieri in various oils was determined to optimize the oil phase of an SSEDDS. Various surfactants and co-surfactants were screened for their emulsification ability with the selected oil. Pseudo ternary phase diagrams were constructed using TRIPLOT V 14 software to identify the selfemulsification region. SEDDS were prepared using Isopropyl myristate as oil, tween 80 as surfactant and Transcutol P as co-surfactant. To overcome the problems with SEDDS they are converted to super saturable SEDDS using HPMC. Formulated S-SEDDS were evaluat...
The aim of the present study was to formulate and evaluate ophthalmic drug delivery system of Bal... more The aim of the present study was to formulate and evaluate ophthalmic drug delivery system of Balofloxacin based on the concept of thermosensitive gelation. Balofloxacin is a fourth generation broad spectrum fluoroquinolone antibiotic indicated for infective ophthalmitis. Insitu gel was formulated by cold method using different concentrations of Poloxamer and Chitosan as thermoreversible polymers. Prepared formulations were evaluated for gelling capacity, drug content, rheological studies, gelation time, gelation temperature, in-vitro diffusion studies and antimicrobial activity. The pH of all the formulations was found to be 7.4. Formulation (G7) was optimized based on drug content and in vitro drug release studies. All the formulations were found to be clear and devoid of particulate matter. With the increase in concentration viscosity of the solution increases which renders sustained release of the drug from the formulation over a period of 10h. Gelling capacity studies revealed ...
is a triazole antifungal drug which is available in different pharmaceutical dosage forms (tablet... more is a triazole antifungal drug which is available in different pharmaceutical dosage forms (tablets, capsules and oral solutions). It is an orally active broad spectrum triazole antifungal agent. This article reviews the analytical methods for identification and quantitative determination of Itraconazole in pharmaceutical and biological samples. The most commonly adopted methods for the determination of Itraconazole are chromatographic (high-pressure liquid chromatography (HPLC, HPTLC), spectrofluorimetric, spectrophotometric and colorimetric methods. Recent preferences in the analysis of Itraconazole proves primacy of HPLC and confirms a general trend of moving towards more sensitive methods having higher resolution potential, consuming small quantities of samples and reagents and requiring less time for analysis.
Woodfordia fruticosa (Family-Lythraceae) is an important traditional medicinal plant. Scientific ... more Woodfordia fruticosa (Family-Lythraceae) is an important traditional medicinal plant. Scientific investigations reported antimicrobial, antiinflammatory, hepatoprotective, analgesic, wound healing and antifertility activity. Phytosome technology has proved to be beneficial in providing better absorption and bioavailability of polar biomolecules over conventional herbal extracts. The aim of the present study was to prepare and evaluate topical phytosomal gel of woodfordia fruticosa extract (WFE). Dried flowers of the plant were subjected to soxhlation using 80% methanol. The extract was complexed with soyalecithin in various drug:lipid ratios of 1:1, 1:2, 1:3, 1:4 and 1:5. Phytosomal complex of WFE was prepared by Ethanol method and Reflux method. All formulations were evaluated for vesicle formation, % yield, Entrapment efficiency and invitro drug release studies. Drug: lipid ratio of 1:3(E3) was suitable as it resulted in greater Entrapment efficiency of 89.15% & invitro drug relea...
Aim: The aim of the present investigation was to formulate and evaluate ion sensitive ocular insi... more Aim: The aim of the present investigation was to formulate and evaluate ion sensitive ocular insitu gels for sustained release of Balofloxacin, a fourth generation broad spectrum antibiotic indicated for infective ophthalmitis. Methods: Insitu ocular gels of Balofloxacin were formulated aseptically by polymer solution method. Sodium alginate, HPMC E50 LV and HPMC K4M in different concentrations were employed. All the formulations were evaluated for pH, clarity, drug content, gelling capacity, viscosity studies, invitro drug release studies, antimicrobial activity. Formulation with good gelling capacity was selected for further studies. Drug-excipient compatibility studies in FK8 were evaluated by FTIR studies. Invitro drug diffusion studies was carried out in modified diffusion apparatus using gelatin sheet as a semipermeable membrane and comparative study of antimicrobial activity of API and formulation was assessed by cup plate technique Results: All the developed formulations had...