Prof.dr.filiz Karagöz - Academia.edu (original) (raw)

Papers by Prof.dr.filiz Karagöz

Indian Journal of Pathology & Microbiology, 2011

Duodenal nodularity is an uncommon endoscopic appearance of numerous visible mucosal nodules in t... more Duodenal nodularity is an uncommon endoscopic appearance of numerous visible mucosal nodules in the proximal duodenum. In this retrospective study we aimed to determine the clinical significance and histopathologic features of duodenal nodularity in children. The medical records of the patients who were defined to have duodenal nodularity by endoscopy were reviewed. The data were expressed as mean ± SD and percentages (%). Seventeen patients with endoscopically defined duodenal nodularity were chosen. The mean age at diagnosis was 12.1 years (range: 6-17 years), 9 males. Abdominal pain (47%) was the most common clinical symptom and antral nodularity (41%) was the most common endoscopic finding in children with duodenal nodularity. Histopathologic evaluation of duodenal nodules revealed chronic inflammation in all patients, increased intercryptal and intraepithelial numbers of eosinophils in 70.5%, and villous atrophy in 47% of patients. Giardia infestation was demonstrated in 6 patients by histologic examination and/or Giardia lamblia-specific antigen positivity in stools. The clinical diagnoses of the patients have shown variations, such as celiac disease, giardiasis, secretory IgA deficiency, and Helicobacter pylori gastritis, and some of them were associated with the others. Although the endoscopic appearance is similar, clinical spectrum and pathologic features are not so similar and there are no specific histomorphologic findings for nodularity. The most demonstrative findings we observed in children were increased lymphocyte and/or eosinophil infiltration in the duodenal mucosa. We suggested that care should be taken in the evaluation of microbiological and immunologic etiologies causing this prominent inflammatory reaction.

Journal of Experimental & Clinical Medicine, 1989

SOLITARY SPINAL NEUROFIBROMA WITH UNUSUAL HISTOLOGICAL STRUCTURE In this paper, a case of neurofi... more SOLITARY SPINAL NEUROFIBROMA WITH UNUSUAL HISTOLOGICAL STRUCTURE In this paper, a case of neurofibroma with excessive vascular proliferation which is accepted an unusual histopathological characteristic was presented. OZET Bu makalede, olagan disi histopatolojik bulgu olarak kabul edi¬len asiri vaskuler proliferasyonla karakterize bir norofibroma olgusu sunulmustur.

DergiPark (Istanbul University), Mar 1, 2004

PubMed, 2003

This study was designed to examine the immunohistochemical expression of proliferating cell nucle... more This study was designed to examine the immunohistochemical expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 45 cases with advanced laryngeal squamous cell carcinoma who had undergone total laryngectomy with unilateral modified radical neck dissection, and the relation of this expression to some prognostic factors such as tumor front grading and neck lymph node metastases. Sections were reevaluated for routine histologic grade, tumor front grading and neck lymph node metastases, and were stained with monoclonal antibodies against PCNA and bcl-2. Significant correlation was present between the severity of PCNA expression and incidence of lymph node metastasis (p<0.05). No correlation was found between the severity of PCNA expression and tumor front grading. Bcl-2 expression did not associate with either parameters. In conclusion, PCNA is important in predicting prognosis and no association is present between the bcl-2 protein expression and prognostic factors.

Saudi Medical Journal, Dec 1, 2004

Brown tumors are focal bone lesions caused by increased osteoclastic activity and fibroblastic pr... more Brown tumors are focal bone lesions caused by increased osteoclastic activity and fibroblastic proliferation encountered in primary or more rarely secondary hyperparathyroidism. Ninety-two percent of the patients undergoing dialysis develop secondary hyperparathyroidism. Of these, approximately 1.5% develops brown tumors. Brown tumors of hyperparathyroidism may appear in any bone but are frequently found in the facial bones and jaws, particularly in long-standing cases of the disease. As it becomes common for hyperparathyroidism to be detected earlier during the disease, the bony manifestations of the disease are rarely seen. The following report describes a case of brown tumor of the maxilla and mandible in a patient with renal insufficiency. This patient presented multiple skeletal lesions, which are uncommonly seen nowadays.

European Archives of Oto-rhino-laryngology, Jun 21, 2005

Das pleomorphe Adenom (PA) ist der häufigste gutartige Tumor der großen Speicheldrüsen. Er kann a... more Das pleomorphe Adenom (PA) ist der häufigste gutartige Tumor der großen Speicheldrüsen. Er kann auch von kleineren Speicheldrüsen des oberen Aerodigestivtraktes ausgehen. PA des Gehörgangs ist dagegen eine Rarität. Die frühere Hypothese, dass PA des Gehörgangs von ektopen Speicheldrüsengewebe abstammt, konnte bisher nicht belegt werden. Aktuell geht man davon aus, dass PA des äußeren Gehörgangs seinen Ausgang von den Myoepithelien der ortsständigen Zeruminaldrüsen nimmt. Der Tumor wird von der WHO dementsprechend als Zeruminaladenom klassifiziert. Die von PA der Speicheldrüsen bekannte Rezidivneigung sowie maligne Transformation wurde auch für PA des Gehörgangs beschrieben.

Hernia, Sep 1, 2000

Summary Most of mesh materials used in the repair of ventral hernias lead to considerable adhesio... more Summary Most of mesh materials used in the repair of ventral hernias lead to considerable adhesion formation. In this study we evaluated the effects of a bioabsorbable membrane composed of carboxymethylcellulose and hyaluronic acid (HA membrane) on adhesion formation in the presence of a polypropylene mesh used to repair an incisional hernia model in rats. We repaired the defects either

Research Square (Research Square), Sep 21, 2022

Background: Although it is not a good prognostic marker for all breast cancers, pathological comp... more Background: Although it is not a good prognostic marker for all breast cancers, pathological complete response (pCR) is an endpoint in evaluating neoadjuvant chemotherapy (NAC) e cacy. Ki67, a proliferation marker, has a complex role as a predictive marker in determining the NAC response. This study aimed to investigate the relationship between pretreatment and posttreatment Ki67 levels, posttreatment Ki67 change and treatment response using the Miller-Payne (MP) and Residual Cancer Burden (RCB) response assessment systems. Methods: A total of 178 invasive breast carcinoma patients who underwent NAC were included in the study. Ki67 levels were evaluated by immunohistochemical method in trucut biopsy and surgical excision specimens. Treatment response in the surgical excision specimen was classi ed according to both MP and RCB classi cations. We investigated the relationships between pretreatment Ki67 level, posttreatment Ki67 level and posttreatment change in Ki67 with NAC response and survival. Additionally, the cutoff value of the pretreatment Ki67 level for pCR and nonpathological response (pNR) was investigated. Results. The pretreatment Ki67 level was signi cantly higher in the pCR group than in the partial response (pPR) and pNR groups (p<0.001) in both the MP and RCB systems. The posttreatment Ki67 level was signi cantly higher in the pNR group than in the pPR group (p<0.001) in both systems. There was a negative correlation between pretreatment Ki67 and disease-free survival (DFS) in the luminal B HER2negative subtype (r=-0.377, p=0.036) and a signi cant negative correlation between posttreatment Ki67 and overall survival (OS) in the HER2-positive subtype (r=-0.544, p= 0.0209). A signi cant correlation was found between the posttreatment Ki67 change and the degree of response in the luminal B HER2-positive and HER2-positive subtypes (p<0.05). The Ki67 cutoff value was 37.5 for pCR in both the MP and RCB classi cation systems (95% CI 0.673-0.833 and 95% CI0.66-0.827) (p<0.001). There was a signi cant moderate agreement between the MP and RCB systems (p<0.001). Conclusions: Pre-and posttreatment Ki67 levels may be used to assess treatment response in various molecular subtypes of breast cancer. In this study, the cutoff value of Ki67 for pCR was 37%. More aggressive treatments may be considered in luminal B HER2-negative tumours with high pretreatment Ki67 levels and tumours that do not show a Ki67 decrease.

DergiPark (Istanbul University), Dec 23, 2009

Journal of Surgery and Medicine

Background/Aim: Expression of extracellular matrix proteins and metalloproteases (MMPs) has been ... more Background/Aim: Expression of extracellular matrix proteins and metalloproteases (MMPs) has been implicated in neoplasm recurrence. Some recent studies have suggested a correlation between matrix modifier proteins and recurrence or invasion of meningiomas. Based on previous data, the aim of this study was to find a correlation between the immunohistochemical (IHC) expression patterns of a group of matrix modifier proteins, including CD147, Matrix Metalloprotease 2 and 9 (MMP2 and 9, respectively), Epithelial Cadherin (ECAD), and Galectin-3 (GAL3) with World Health Organization (WHO)-defined grade, brain invasion, recurrence, and other clinicopathological features. Methods: This study was a cohort study. All patients with meningioma who underwent resection over a 10-year period were identified from the electronic pathology archives. Tissue microarrays (TMAs) were created for IHC studies, and IHC staining was performed using standard methodology. Results: A total of 231 cases fulfille...

The anticonvulsant hypersensitivity syndrome is defined as an idiosyncratic reaction cau¬sed by d... more The anticonvulsant hypersensitivity syndrome is defined as an idiosyncratic reaction cau¬sed by disturbed drug metabolism. Rash, hepatitis, eosinophilia, fever and lymphadenopathy are the main characteristics of this syndrome. Prognosis is poor in the severe cases with fulminant hepatic failure, where as it is good in mild cases with skin rash. The cases should be treated with prednisone and antihistamines. In this paper, 12-year-old girl with hypersensitivity syndrome induced by carbamazepine four weeks after therapy was presented.

Journal of Experimental & Clinical Medicine, 2001

Gastric Cancer in a Young Patient: A Case Report of Twenty Year-Old Patient, and Review of The Li... more Gastric Cancer in a Young Patient: A Case Report of Twenty Year-Old Patient, and Review of The Literature In general, gastric cancer is seen in patients at 50-70 years of age. Its incidence in those younger than 35 years of age is approximately 2-5%. In recent years some genetic deficiencies and family history have been primarily accused in the etiopathogenesis of gastric cancer seen in the younger group of patients. We, herewith, reported a 22 year-old male patient with gastric cancer, whose two family members have had gastric cancer and breast cancer. In review with the recent data, we think that genetic deficiencies rather than environmental factors play a major role in the etiology of gastric cancer in young patients. Mide kanseri genellikle 50-70 yaslarda ortaya cikar. Otuzbes ve daha genc yaslarda mide kanseri gorulme sikligi %2-5'tir. Bu yas grubunda gorulen mide kanserinin eti-yopatogenezi ile ilgili olarak son yillarda bazi genetik farkliliklar ve aile hikayesi suclanma...

Saudi medical journal, 2004

Diagnostic Pathology, 2010

Rheumatology International, 2004

Journal of Plastic, Reconstructive & Aesthetic Surgery, 2011

Fibrolipomas are characterised by fat lobules embedded in perivascular oval fibrocytes and thick ... more Fibrolipomas are characterised by fat lobules embedded in perivascular oval fibrocytes and thick bundles of collagen. Actively growing superficial fibrolipomas rarely display a pedunculated protrusion and, thus, cosmetic and functional problems are uncommon. We present an exceptional case. While trauma and ischaemia can lead to fibrosis and dystrophic calcification in fibrolipomas as late sequelae, osseous and cartilaginous metaplasia can infrequently manifest after a long, chronic persistence. Further, depending on the chronic irritation, ulcerated wounds may develop on the surface, and these can be clinically confused with malignancy. In this article, we present a case of a pedunculated giant fibrolipoma manifesting metaplasic changes in its structure.

Indian Journal of Pathology and Microbiology, 2011