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Papers by RENATA MARIA SANTOS

Arquivos de Ciências da Saúde da UNIPAR, 2018

O Rugby em cadeira de rodas (RCR) é um esporte paralímpico praticado por homens e mulheres com te... more O Rugby em cadeira de rodas (RCR) é um esporte paralímpico praticado por homens e mulheres com tetraplegia decorrente de lesão na medula espinhal (LME). Nos esportes de alto rendimento o desempenho do atleta depende de preparo físico, aspectos tático e técnico. Dentre as variáveis fisiológicas importantes no controle do treinamento e na resposta aos treinos encontra-se a frequência cardíaca (FC). O presente estudo teve como objetivo verificar a intensidade da FC durante jogos de RCR. Para isso, utilizou-se do frequencímetro FIRTSBEAT modelo SPORTS Team 4.6®, para o monitoramento da FC dos atletas de RCR durante os jogos. A amostra foi composta por nove atletas homens de RCR com LME com nível de lesão acima da vértebra T6. Os resultados obtidos demonstraram que a média das FC máximas foi de 138,55 ± 17,5 bpm. A intensidade variou cerca de 77% do tempo entre Zona aeróbia 1, Zona aeróbia 2 e Zona de limiar anaeróbio, indicando uma grande oscilação, o que é esperado por se tratar de um ...

Studies have consistently reported a decreased level of brain derived neurotrophic factor (BDNF) ... more Studies have consistently reported a decreased level of brain derived neurotrophic factor (BDNF) in individuals with Parkinson's disease (PD). The benefits of exercise on BDNF levels are well-documented in humans, however, the effects of acute exercise are inconclusive in neurological disorders. In addition, there are no studies investigating a precursor molecule - proBDNF - and its comparison to patients with vs. without depression or fatigue. Thirty patients with PD were instructed to walk on a treadmill at light to moderate intensity for 30 minutes. Generalized Estimating Equation (GEE) showed a significant effect of time (pre- vs. post-exercise) when compared individuals with vs. without depression [Wald Chi Square (4.392), p = 0.036)] and with vs. without fatigue [Wald Chi Square (7.123), p = 0.008)] for mature BDNF (mBDNF) level. There was no effect of group, time, and group x time interaction for proBDNF level when compared individuals with vs. without depression or fatig...

Arquivos de Neuro-Psiquiatria, 2020

Although fatigue is an expressive symptom of Parkinson’s disease (PD), few studies have investiga... more Although fatigue is an expressive symptom of Parkinson’s disease (PD), few studies have investigated the association between fatigue, mobility and walking capacity of these patients. Objective: To investigate whether fatigue is an independent factor associated with mobility and the walking capacity in patients with PD. Methods: Forty-eight patients with PD (22 with fatigue) were tested for mobility and their walking capacity: Timed Up and Go (TUG), 10-Meter Walk Test (10MWT) at usual and fastest speed, and 6-Minute Walk Test (6MWT). Fatigue was measured with Parkinson’s Fatigue Scale (PFS-16). Linear regression analysis was used to investigate if fatigue is an independent factor contributing to variance in mobility and walking capacity. Results: There was a positive correlation between PFS-16 and TUG (rs=0.385; p=0.007). There was a negative correlation between PFS-16 and 10MWT at comfortable (r=-0.385; p=0.007) and fast speeds (r=-0.396; p=0.005), and 6MWT (r=-0.472; p=0.001). Line...

Journal of Neurological Disorders, 2017

Background: Many studies show the beneficial effects of overground gait training in stroke patien... more Background: Many studies show the beneficial effects of overground gait training in stroke patients. However, it is not know whether it is able to induce changes in brain-derived neurotrophic factor (BDNF) levels, which could positively influence neurophysiological mechanisms. Objective: To evaluate the effect of a single session of light-to-moderate intensity walk on BDNF serum levels and its precursors (proBDNF) in chronic ischemic stroke patients. Methods: Patients were asked to walk for 30 minutes in the target heart rate training zone (30-60% of maximal heart rate). Blood samples were collected immediately before and after a single session. Results: Fifteen individuals with 60.8 (7.7) years old participated of this study. There was no significant difference in proBDNF (p=0.573) and BDNF (p=0.563) serum levels between pre-and post-session. Conclusion: This study used light-to-moderate intensity because the goal is to approach the gait training in clinical setting. The lack of increase in BDNF levels can be explained by two reasons: the intensity zone of the heart rate selected during the session and not having a gradual increase in this intensity.

Journal of the Neurological Sciences, 2016

To investigate the influence of interleukin-6 (IL-6) and soluble tumor necrosis factor receptors ... more To investigate the influence of interleukin-6 (IL-6) and soluble tumor necrosis factor receptors (sTNFR) in fatigued Parkinson's disease (PD) patients. Forty-four PD patients were evaluated, and fatigue was assessed with the Parkinson Fatigue Scale. Logistic regression analysis was used to evaluate the contribution of disease severity scores and cytokine levels on fatigue scores. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic values of IL-6 in fatigue. Fatigued PD patients had worse cognitive function and depressive symptoms. These patients had worse PD signs and symptoms, displayed more advanced stages of PD, and had greater functional dependence. There was a significant difference in IL-6 serum levels (p = 0.026), but there was no difference in sTNFR levels. Total scores on the Unified Parkinson Disease Rating Scale (β = 1.108; p = 0.004) and IL-6 levels (β = 12.843; p = 0.020) were found to be significant predictors of fatigue scores. A ROC curve revealed that IL-6 concentrations of 1.18 pg/ml represented the best cutoff value for detecting fatigue (sensitivity of 0.941 and specificity of 0.704). Fatigued PD patients have poor clinical outcomes and elevated IL-6 serum levels when compared with non-fatigued patients. These results suggest that IL-6 may play a role in the pathophysiology of fatigue in PD.

Anais do Congresso de Iniciação Científica da Unicamp, 2015

Resumo O Rugby de cadeira de rodas (RCR) é um esporte desenvolvido para pessoas com tetraplegia. ... more Resumo O Rugby de cadeira de rodas (RCR) é um esporte desenvolvido para pessoas com tetraplegia. A frequência cardíaca (FC) é um importante parâmetro utilizado para o controle de treinos, e será utilizada, levando em consideração as modificações fisiológicas e metabólicas. O objetivo deste estudo é analisar a intensidade de esforço através do comportamento da FC dos atletas durante partidas de RCR. A amostra trata de 6 atletas de RCR com lesão cervical, do sexo masculino, durante 9 jogos, monitorados por sua FC.

Este texto tem como fundamento apresentar a importância para a formacao docente, do aprendizado e... more Este texto tem como fundamento apresentar a importância para a formacao docente, do aprendizado e conhecimento sobre as fontes de pesquisas digitais, mais, particularmente, as bibliotecas digitais, bem como as transformacoes que as Tecnologias da Comunicacao e Informacao vem acarretando na forma da pesquisa e da divulgacao cientifica e a decorrente necessidade do futuro professor estar apto a compreender os novos desafios e mecanismos que as TIC trouxeram para o ensino. Palavras-chaves : Pesquisa; Formacao docente; Era da Informacao; TIC.

Arquivos de Ciências da Saúde da UNIPAR, 2018

O Rugby em cadeira de rodas (RCR) é um esporte paralímpico praticado por homens e mulheres com te... more O Rugby em cadeira de rodas (RCR) é um esporte paralímpico praticado por homens e mulheres com tetraplegia decorrente de lesão na medula espinhal (LME). Nos esportes de alto rendimento o desempenho do atleta depende de preparo físico, aspectos tático e técnico. Dentre as variáveis fisiológicas importantes no controle do treinamento e na resposta aos treinos encontra-se a frequência cardíaca (FC). O presente estudo teve como objetivo verificar a intensidade da FC durante jogos de RCR. Para isso, utilizou-se do frequencímetro FIRTSBEAT modelo SPORTS Team 4.6®, para o monitoramento da FC dos atletas de RCR durante os jogos. A amostra foi composta por nove atletas homens de RCR com LME com nível de lesão acima da vértebra T6. Os resultados obtidos demonstraram que a média das FC máximas foi de 138,55 ± 17,5 bpm. A intensidade variou cerca de 77% do tempo entre Zona aeróbia 1, Zona aeróbia 2 e Zona de limiar anaeróbio, indicando uma grande oscilação, o que é esperado por se tratar de um ...

Studies have consistently reported a decreased level of brain derived neurotrophic factor (BDNF) ... more Studies have consistently reported a decreased level of brain derived neurotrophic factor (BDNF) in individuals with Parkinson's disease (PD). The benefits of exercise on BDNF levels are well-documented in humans, however, the effects of acute exercise are inconclusive in neurological disorders. In addition, there are no studies investigating a precursor molecule - proBDNF - and its comparison to patients with vs. without depression or fatigue. Thirty patients with PD were instructed to walk on a treadmill at light to moderate intensity for 30 minutes. Generalized Estimating Equation (GEE) showed a significant effect of time (pre- vs. post-exercise) when compared individuals with vs. without depression [Wald Chi Square (4.392), p = 0.036)] and with vs. without fatigue [Wald Chi Square (7.123), p = 0.008)] for mature BDNF (mBDNF) level. There was no effect of group, time, and group x time interaction for proBDNF level when compared individuals with vs. without depression or fatig...

Arquivos de Neuro-Psiquiatria, 2020

Although fatigue is an expressive symptom of Parkinson’s disease (PD), few studies have investiga... more Although fatigue is an expressive symptom of Parkinson’s disease (PD), few studies have investigated the association between fatigue, mobility and walking capacity of these patients. Objective: To investigate whether fatigue is an independent factor associated with mobility and the walking capacity in patients with PD. Methods: Forty-eight patients with PD (22 with fatigue) were tested for mobility and their walking capacity: Timed Up and Go (TUG), 10-Meter Walk Test (10MWT) at usual and fastest speed, and 6-Minute Walk Test (6MWT). Fatigue was measured with Parkinson’s Fatigue Scale (PFS-16). Linear regression analysis was used to investigate if fatigue is an independent factor contributing to variance in mobility and walking capacity. Results: There was a positive correlation between PFS-16 and TUG (rs=0.385; p=0.007). There was a negative correlation between PFS-16 and 10MWT at comfortable (r=-0.385; p=0.007) and fast speeds (r=-0.396; p=0.005), and 6MWT (r=-0.472; p=0.001). Line...

Journal of Neurological Disorders, 2017

Background: Many studies show the beneficial effects of overground gait training in stroke patien... more Background: Many studies show the beneficial effects of overground gait training in stroke patients. However, it is not know whether it is able to induce changes in brain-derived neurotrophic factor (BDNF) levels, which could positively influence neurophysiological mechanisms. Objective: To evaluate the effect of a single session of light-to-moderate intensity walk on BDNF serum levels and its precursors (proBDNF) in chronic ischemic stroke patients. Methods: Patients were asked to walk for 30 minutes in the target heart rate training zone (30-60% of maximal heart rate). Blood samples were collected immediately before and after a single session. Results: Fifteen individuals with 60.8 (7.7) years old participated of this study. There was no significant difference in proBDNF (p=0.573) and BDNF (p=0.563) serum levels between pre-and post-session. Conclusion: This study used light-to-moderate intensity because the goal is to approach the gait training in clinical setting. The lack of increase in BDNF levels can be explained by two reasons: the intensity zone of the heart rate selected during the session and not having a gradual increase in this intensity.

Journal of the Neurological Sciences, 2016

To investigate the influence of interleukin-6 (IL-6) and soluble tumor necrosis factor receptors ... more To investigate the influence of interleukin-6 (IL-6) and soluble tumor necrosis factor receptors (sTNFR) in fatigued Parkinson's disease (PD) patients. Forty-four PD patients were evaluated, and fatigue was assessed with the Parkinson Fatigue Scale. Logistic regression analysis was used to evaluate the contribution of disease severity scores and cytokine levels on fatigue scores. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic values of IL-6 in fatigue. Fatigued PD patients had worse cognitive function and depressive symptoms. These patients had worse PD signs and symptoms, displayed more advanced stages of PD, and had greater functional dependence. There was a significant difference in IL-6 serum levels (p = 0.026), but there was no difference in sTNFR levels. Total scores on the Unified Parkinson Disease Rating Scale (β = 1.108; p = 0.004) and IL-6 levels (β = 12.843; p = 0.020) were found to be significant predictors of fatigue scores. A ROC curve revealed that IL-6 concentrations of 1.18 pg/ml represented the best cutoff value for detecting fatigue (sensitivity of 0.941 and specificity of 0.704). Fatigued PD patients have poor clinical outcomes and elevated IL-6 serum levels when compared with non-fatigued patients. These results suggest that IL-6 may play a role in the pathophysiology of fatigue in PD.

Anais do Congresso de Iniciação Científica da Unicamp, 2015

Resumo O Rugby de cadeira de rodas (RCR) é um esporte desenvolvido para pessoas com tetraplegia. ... more Resumo O Rugby de cadeira de rodas (RCR) é um esporte desenvolvido para pessoas com tetraplegia. A frequência cardíaca (FC) é um importante parâmetro utilizado para o controle de treinos, e será utilizada, levando em consideração as modificações fisiológicas e metabólicas. O objetivo deste estudo é analisar a intensidade de esforço através do comportamento da FC dos atletas durante partidas de RCR. A amostra trata de 6 atletas de RCR com lesão cervical, do sexo masculino, durante 9 jogos, monitorados por sua FC.

Este texto tem como fundamento apresentar a importância para a formacao docente, do aprendizado e... more Este texto tem como fundamento apresentar a importância para a formacao docente, do aprendizado e conhecimento sobre as fontes de pesquisas digitais, mais, particularmente, as bibliotecas digitais, bem como as transformacoes que as Tecnologias da Comunicacao e Informacao vem acarretando na forma da pesquisa e da divulgacao cientifica e a decorrente necessidade do futuro professor estar apto a compreender os novos desafios e mecanismos que as TIC trouxeram para o ensino. Palavras-chaves : Pesquisa; Formacao docente; Era da Informacao; TIC.