Rafidah Hanim Mokhtar - Academia.edu (original) (raw)
Papers by Rafidah Hanim Mokhtar
IIUM Medical Journal Malaysia, 2020
Introduction. Male-to-female transgender individuals are known as mak nyahs in Malaysia. Akin to ... more Introduction. Male-to-female transgender individuals are known as mak nyahs in Malaysia. Akin to many other countries, mak nyahs face discriminations in securing proper employment, thus many end up in sex trade, exposing them to HIV-related high risk behaviours. This paper aims to investigate the knowledge, attitude, and risk behaviours in HIV/AIDS among mak nyahs in Malaysia. Method. Validated questionnaires in local language were used. Knowledge, attitude, and HIV-related risk behaviours were measured. With respondent-driven sampling method, 54 subjects participated in the survey. IBM SPSS was used for data analysis. Results. Majority of the subjects reported to have HIV-related sexual risk, although only a quarter were sex workers. Misconceptions still remained among the subjects. Inconsistent condom use was common. Adequate knowledge did result in better attitude towards HIV/AIDS. However, multiple regression analysis showed that subjects with higher knowledge in HIV/AIDS tend t...
Essential hypertension is a common multifactorial disease which affects 10% to 40% of the populat... more Essential hypertension is a common multifactorial disease which affects 10% to 40% of the population, causing significant cardiovascular morbidity and mortality (P.Trenk et al., 1999). It is believed that hypertension occurs from complex interactions between multiple environmental and genetic factors. Between 30 and 60% of blood pressure variations are determined by genetic factors (Ditto et al., 1993). The molecular mechanisms underlying hypertension are still poorly understood. There are number of genes that have been implicated with hypertension (Richard et al., 2001). ApoE and PON1 genes have been strongly linked with the formation of arthrosclerosis. There were many studies investigating the role of the polymorphisms within these genes with various pathologies including dementia and infectious diseases (M tomasa et al., 2004). Apolipoprotein E (Apo E) is a plasma protein responsible for plasma clearance of triglyceride and cholesterol-rich lipoproteins (Mahley et al., 2000) . T...
Pharmacognosy Journal, 2019
Eurycoma longifolia "EL" (publically known as Tongkat Ali) is a herbal medicinal plant found in S... more Eurycoma longifolia "EL" (publically known as Tongkat Ali) is a herbal medicinal plant found in SouthEast Asia, It is a small rain forest flowering, un-branched, medium-sized slender shrub. The root of the plant has been commonly consumed in traditional medicine for the treatment of many diseases in SouthEast Asia countries. EL has potent antibacterial, antimalarial, antipyretic, antifungal, and antioxidant properties. 11,12 The roots of the EL contain numerous phytochemical bioactive compounds including quassinoids and squalene derivatives and eurycolactones A-C. 13 ABSTRACT Objective: The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether Eurycoma Longifolia (EL) is able to ameliorate these effects. Methods: Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal's testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12 th weeks and the testes samples were processed for histological examination Results: The testosterone level was significantly increased (p < 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. Conclusion: These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet.
IIUM Medical Journal Malaysia, 2014
Introduction: Eurycoma longifolia (E. longifolia) which is better known locally as Tongkat Ali is... more Introduction: Eurycoma longifolia (E. longifolia) which is better known locally as Tongkat Ali is an indigenous plant in Malaysia. It belongs to the family of Simaroubaceae and is popular as a traditional medicine for its aphrodisiac properties. Throughout the years, several studies have been conducted to prove its effect on aphrodisiac action, antimalarial, antibacterial and anxiolytic properties but its effect to the cardiovascular system had not been fully explored. This study was aimed to demonstrate the changes that take place in the isolated heart following the injection of the extract. Methods: Three parameters that were measured included the coronary perfusion pressure (CPP), the left ventricular developed pressure (LVDP) and the heart rate (HR). Eighteen isolated rat hearts were used and were divided equally into three groups. The first group was to observe the effect of Isoprenaline, a β agonist while the second group was to see the effect of sodium nitroprusside (SNP), a ...
Background: Adequate fluid intake is very crucial for mothers during postpartum as any dehydratio... more Background: Adequate fluid intake is very crucial for mothers during postpartum as any dehydration that ensues during this period may predispose them to the risk of developing venous thromboembolism event. Yet, the sociocultural influences may have deterred some of them from adequate fluid intake especially those from Asian region. This study aims to determine hydration status of low risk postpartum women during postpartum period among Malaysian women.Methods: A prospective observationalstudy involving assessment of hydrational status at 3 points; after 24 hours, at the 3rd week and at the 6th week postpartum was conducted. Apart from hydrational status where patients were requested to recordon weekly basis of their input and output fluid intake in a diary, they also underwent a series of biochemical parameters assessment.Results: 56 patients met the inclusion criteria. The sociodemographic data were analysed decriptively whereby all in the patients were in reproductive age group, w...
There is increased prevalence of hypertensives among Malaysians in the last decade. The cost of a... more There is increased prevalence of hypertensives among Malaysians in the last decade. The cost of anti-hypertensive agents is also escalating. There is a dire need for cheaper alternative drugs. In tropical regions, there have been claims that Eurycoma longifolia (EL) a local herbal plant is effective in obliterating headache and reducing blood pressure. Most studies had focused on aphrodisiac property of EL which has been shown to enhance testosterone levels in males. This study exploredthe possible effect of EL as an anti-hypertensive agent and whether the mechanism is related to serum testosterone levels. Twenty four healthy male Sprague-Dawley rats were randomly divided into four groups (n=6): normal diet (ND), normal diet treated with EL (NDEL), high-fat diet (HFD) and HFD treated with EL (HFDEL). EL (15 mg/kg) was administered orally for 12 weeks. The animal's body weight, blood pressure and testosterone level were measured at week 0, 6 and 12.Results showed that the level o...
Jurnal PERADABAN, 2017
Asal usul kewujudan kecitaliwatan sering dibincangkan berasaskan dua teori utama iaitu sarian dan... more Asal usul kewujudan kecitaliwatan sering dibincangkan berasaskan dua teori utama iaitu sarian dan binaan sosial. Konflik dalam wacana kecitaliwatan timbul apabila sarianisme menganggap kecitaliwatan wujud secara semulajadi dalam diri manusia; manakala binaisme sosial menekankan bahawa kecitaliwatan merupakan produk yang terbina hasil daripada interaksi sosial. Oleh itu, makalah ini bertujuan untuk menilai kedua-dua teori menurut pandangan Islam dengan rujukan khas terhadap ayat-ayat al-Qur'an yang berkaitan. Hasil kajian mendapati bahawa kecitaliwatan menurut Islam merupakan suatu yang wujud akibat daripada binaan sosial.
IIUM Medical Journal Malaysia, 2015
European journal of anatomy, 2016
The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on inti... more The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture® 2.0.In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuat...
Hypertension is one of the most important risk factors for cardiovascular events. It has become a... more Hypertension is one of the most important risk factors for cardiovascular events. It has become a sigaificant socioeconomic burden in many countries" Eurycoma longifolia (EL), Simaroubaceae, is a herb that has been used since ancient times to combat many health problems. Its effects are attributed to its bioactive constituents. This study focused on the effects of EL on blood presswe (BP) and body weight (BSD in rats fed high-fat (I{F). Healthy male SD rats wete randomly divided into 4 groups (n:6) and were orally fed the following diets: 1) Normal diet alone (ND); 2) Normal diet plus EL [15 mdke] QID+EL); High-Fat diet (53%) alone (]IFD); High-Fat diet (53%) plus EL [15 mglkg] (I{FD+EL). EL extract was oraliy administered for 12 weeks. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at week 0, 6 and 72 by using CODA@ tail-cuff BP system while the BW was measured weekly. Statistical significance was determined by repeated measure (ANOVA) and one-w...
Atherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in develo... more Atherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in developing countries. Hyperlipidemia is known as a dominant risk factor for the development of atherosclerosis. This study was designed to investigate the effects of Eurycoma Longifolia (EL) also known as Malaysian Ginseng/ Tongkat Ali on the testosterone level, biochemical changes of lipid profile and intima media thickness (IMT) in rats fed on high-fat diet. Twenty young, adult male Sprague-Dawley (SD) rats were housed for 12 weeks. After one week of acclimatization, they were randomly divided into four groups of 5 animals each and treated for 12 weeks as follow: Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15mg/kg) dissolved in distilled water, group HFD was given only high fat diet and group HFDEL was given high fat diet and EL extracts (15mg/kg). Rats which were treated with EL (NDEL and HFDEL) showed a significant increase (p<0.05) in the test...
Mukhannath is not a new group of people which exists in our society. Discussions and debates abou... more Mukhannath is not a new group of people which exists in our society. Discussions and debates about mukhannath have already been going on by former Islamic scholars and medical practitioners. This study aims to clarify the meaning of mukhannath from the perspective of fiqh and medical based on the literature review or previous research. This qualitative study applied document analysis methodology. Classical and modern fiqh books are the main source of reference, alongside books, journals and medical studies that address on the issue of mukhannath. The finding shows that mukhannath was addressed on Al-Quran and Al-Sunnah. Mukhannath was also defined as a male resembling a woman and was divided into two groups namely mukhannath khalqiyy and mukhannath ghayr khalqiyy. The clear meaning of mukhannath can avoid misunderstandings and confusions especially with the other group which is khunsa. In addition, the understanding of the term mukhannath from Islamic and medical perspective can e...
International Islamic University MalaysiaABSTRACT Prolonged exposure to noise can have adverse ef... more International Islamic University MalaysiaABSTRACT Prolonged exposure to noise can have adverse effects on health. Noise has extra auditory effects by activating the sympathetic nervous and hormonal systems. The present study was undertaken to evaluate the effect of acute and chronic high intensity noise on the isolated hearts of rats using the Langendorff apparatus by determining the effect of noise on the coronary perfusion pressure (CPP), heart rate (HR) and left ventricular diastolic pressure (LVDP). The rats were divided into four groups and exposed to noise intensity of 80-100 dBA on duration of 12 hours exposure (acute effect), 8 hours daily for 20 days (chronic effect), 20 days into 3 days exposure and 2 days without 8 hours per day (intermittent effect) and the control group. Noise of 80-100 dBA was found to cause significant increase in CPP, LVDP and HR (p< 0.05) for acute and both chronic groups versus control. On other hand there were no significant differences of the ...
Ramadan 1437H dikejutkan dengan pembunuhan 49 pengunjung kelab homoseksual 'Pulse' di Orl... more Ramadan 1437H dikejutkan dengan pembunuhan 49 pengunjung kelab homoseksual 'Pulse' di Orlando, Florida, oleh Omar Mateen, seorang Muslim.Umat Islam mengutuk sekeraskerasnya pembunuhan berkenaan, tetapi ia cepat digunakan penyokong LGBT di serata dunia dan di Malaysia untuk mendesak agar cara hidup LGBT diterima umat Islam dan menyalahkan institusi agama sebagai menyuburkan homofobia.
Advanced Science Letters, May 1, 2017
Makara Journal of Health Research, 2018
International Journal of Cardiology, 2019
Evidence-Based Complementary and Alternative Medicine, 2012
Testosterone replacement is the choice of treatment in androgen-deficient osteoporosis. However, ... more Testosterone replacement is the choice of treatment in androgen-deficient osteoporosis. However, long-term use of testosterone is potentially carcinogenic.Eurycoma longifolia(EL) has been reported to enhance testosterone level and prevent bone calcium loss but there is a paucity of research regarding its effect on the bone structural parameters. This study was conducted to explore the bone structural changes following EL treatment in normal and androgen-deficient osteoporosis rat model. Thirty-six male Sprague-Dawley rats aged 12 months were divided into normal control, normal rat supplemented with EL, sham-operated, orchidectomised-control, orchidectomised with testosterone replacement, and orchidectomised with EL supplementation groups. Testosterone serum was measured both before and after the completion of the treatment. After 6 weeks of the treatment, the femora were processed for bone histomorphometry. Testosterone replacement was able to raise the testosterone level and restor...
Malaysian Journal of Science Health & Technology
Sleep-wake cycle is the most evident 24 hour rhythms observed in humans. This circadian variation... more Sleep-wake cycle is the most evident 24 hour rhythms observed in humans. This circadian variation is a normal biological clock. The physiological phenomenon, however has been able to explain the onset of cardiac events that also tend to occur during certain time of day. It has been known that there is a tendency for major cardiovascular episodes to occur during the mid-morning hours. With the advent of ambulatory blood pressure monitoring, the fluctuations of blood pressure throughout the day are able to be captured. This is called blood pressure variability (BPV). The factors affecting BPV include age, sex, physical activity, mental activity, behavioural and environmental. Recent studies have shown that high BPV is associated with target organ damage, in particular cardiovascular and coronary artery diseases. In the effort to explain the mechanisms related to these complications out of excessive BPV, several studies explored the role of history of family with hypertension, hyperglycaemia and hyperlipidemia towards developing pre-existing condition that lead to high BPV.
IIUM Medical Journal Malaysia, 2020
Introduction. Male-to-female transgender individuals are known as mak nyahs in Malaysia. Akin to ... more Introduction. Male-to-female transgender individuals are known as mak nyahs in Malaysia. Akin to many other countries, mak nyahs face discriminations in securing proper employment, thus many end up in sex trade, exposing them to HIV-related high risk behaviours. This paper aims to investigate the knowledge, attitude, and risk behaviours in HIV/AIDS among mak nyahs in Malaysia. Method. Validated questionnaires in local language were used. Knowledge, attitude, and HIV-related risk behaviours were measured. With respondent-driven sampling method, 54 subjects participated in the survey. IBM SPSS was used for data analysis. Results. Majority of the subjects reported to have HIV-related sexual risk, although only a quarter were sex workers. Misconceptions still remained among the subjects. Inconsistent condom use was common. Adequate knowledge did result in better attitude towards HIV/AIDS. However, multiple regression analysis showed that subjects with higher knowledge in HIV/AIDS tend t...
Essential hypertension is a common multifactorial disease which affects 10% to 40% of the populat... more Essential hypertension is a common multifactorial disease which affects 10% to 40% of the population, causing significant cardiovascular morbidity and mortality (P.Trenk et al., 1999). It is believed that hypertension occurs from complex interactions between multiple environmental and genetic factors. Between 30 and 60% of blood pressure variations are determined by genetic factors (Ditto et al., 1993). The molecular mechanisms underlying hypertension are still poorly understood. There are number of genes that have been implicated with hypertension (Richard et al., 2001). ApoE and PON1 genes have been strongly linked with the formation of arthrosclerosis. There were many studies investigating the role of the polymorphisms within these genes with various pathologies including dementia and infectious diseases (M tomasa et al., 2004). Apolipoprotein E (Apo E) is a plasma protein responsible for plasma clearance of triglyceride and cholesterol-rich lipoproteins (Mahley et al., 2000) . T...
Pharmacognosy Journal, 2019
Eurycoma longifolia "EL" (publically known as Tongkat Ali) is a herbal medicinal plant found in S... more Eurycoma longifolia "EL" (publically known as Tongkat Ali) is a herbal medicinal plant found in SouthEast Asia, It is a small rain forest flowering, un-branched, medium-sized slender shrub. The root of the plant has been commonly consumed in traditional medicine for the treatment of many diseases in SouthEast Asia countries. EL has potent antibacterial, antimalarial, antipyretic, antifungal, and antioxidant properties. 11,12 The roots of the EL contain numerous phytochemical bioactive compounds including quassinoids and squalene derivatives and eurycolactones A-C. 13 ABSTRACT Objective: The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether Eurycoma Longifolia (EL) is able to ameliorate these effects. Methods: Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal's testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12 th weeks and the testes samples were processed for histological examination Results: The testosterone level was significantly increased (p < 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. Conclusion: These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet.
IIUM Medical Journal Malaysia, 2014
Introduction: Eurycoma longifolia (E. longifolia) which is better known locally as Tongkat Ali is... more Introduction: Eurycoma longifolia (E. longifolia) which is better known locally as Tongkat Ali is an indigenous plant in Malaysia. It belongs to the family of Simaroubaceae and is popular as a traditional medicine for its aphrodisiac properties. Throughout the years, several studies have been conducted to prove its effect on aphrodisiac action, antimalarial, antibacterial and anxiolytic properties but its effect to the cardiovascular system had not been fully explored. This study was aimed to demonstrate the changes that take place in the isolated heart following the injection of the extract. Methods: Three parameters that were measured included the coronary perfusion pressure (CPP), the left ventricular developed pressure (LVDP) and the heart rate (HR). Eighteen isolated rat hearts were used and were divided equally into three groups. The first group was to observe the effect of Isoprenaline, a β agonist while the second group was to see the effect of sodium nitroprusside (SNP), a ...
Background: Adequate fluid intake is very crucial for mothers during postpartum as any dehydratio... more Background: Adequate fluid intake is very crucial for mothers during postpartum as any dehydration that ensues during this period may predispose them to the risk of developing venous thromboembolism event. Yet, the sociocultural influences may have deterred some of them from adequate fluid intake especially those from Asian region. This study aims to determine hydration status of low risk postpartum women during postpartum period among Malaysian women.Methods: A prospective observationalstudy involving assessment of hydrational status at 3 points; after 24 hours, at the 3rd week and at the 6th week postpartum was conducted. Apart from hydrational status where patients were requested to recordon weekly basis of their input and output fluid intake in a diary, they also underwent a series of biochemical parameters assessment.Results: 56 patients met the inclusion criteria. The sociodemographic data were analysed decriptively whereby all in the patients were in reproductive age group, w...
There is increased prevalence of hypertensives among Malaysians in the last decade. The cost of a... more There is increased prevalence of hypertensives among Malaysians in the last decade. The cost of anti-hypertensive agents is also escalating. There is a dire need for cheaper alternative drugs. In tropical regions, there have been claims that Eurycoma longifolia (EL) a local herbal plant is effective in obliterating headache and reducing blood pressure. Most studies had focused on aphrodisiac property of EL which has been shown to enhance testosterone levels in males. This study exploredthe possible effect of EL as an anti-hypertensive agent and whether the mechanism is related to serum testosterone levels. Twenty four healthy male Sprague-Dawley rats were randomly divided into four groups (n=6): normal diet (ND), normal diet treated with EL (NDEL), high-fat diet (HFD) and HFD treated with EL (HFDEL). EL (15 mg/kg) was administered orally for 12 weeks. The animal's body weight, blood pressure and testosterone level were measured at week 0, 6 and 12.Results showed that the level o...
Jurnal PERADABAN, 2017
Asal usul kewujudan kecitaliwatan sering dibincangkan berasaskan dua teori utama iaitu sarian dan... more Asal usul kewujudan kecitaliwatan sering dibincangkan berasaskan dua teori utama iaitu sarian dan binaan sosial. Konflik dalam wacana kecitaliwatan timbul apabila sarianisme menganggap kecitaliwatan wujud secara semulajadi dalam diri manusia; manakala binaisme sosial menekankan bahawa kecitaliwatan merupakan produk yang terbina hasil daripada interaksi sosial. Oleh itu, makalah ini bertujuan untuk menilai kedua-dua teori menurut pandangan Islam dengan rujukan khas terhadap ayat-ayat al-Qur'an yang berkaitan. Hasil kajian mendapati bahawa kecitaliwatan menurut Islam merupakan suatu yang wujud akibat daripada binaan sosial.
IIUM Medical Journal Malaysia, 2015
European journal of anatomy, 2016
The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on inti... more The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture® 2.0.In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuat...
Hypertension is one of the most important risk factors for cardiovascular events. It has become a... more Hypertension is one of the most important risk factors for cardiovascular events. It has become a sigaificant socioeconomic burden in many countries" Eurycoma longifolia (EL), Simaroubaceae, is a herb that has been used since ancient times to combat many health problems. Its effects are attributed to its bioactive constituents. This study focused on the effects of EL on blood presswe (BP) and body weight (BSD in rats fed high-fat (I{F). Healthy male SD rats wete randomly divided into 4 groups (n:6) and were orally fed the following diets: 1) Normal diet alone (ND); 2) Normal diet plus EL [15 mdke] QID+EL); High-Fat diet (53%) alone (]IFD); High-Fat diet (53%) plus EL [15 mglkg] (I{FD+EL). EL extract was oraliy administered for 12 weeks. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at week 0, 6 and 72 by using CODA@ tail-cuff BP system while the BW was measured weekly. Statistical significance was determined by repeated measure (ANOVA) and one-w...
Atherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in develo... more Atherosclerosis in cardiovascular disease (CVD) is a growing health problem, especially in developing countries. Hyperlipidemia is known as a dominant risk factor for the development of atherosclerosis. This study was designed to investigate the effects of Eurycoma Longifolia (EL) also known as Malaysian Ginseng/ Tongkat Ali on the testosterone level, biochemical changes of lipid profile and intima media thickness (IMT) in rats fed on high-fat diet. Twenty young, adult male Sprague-Dawley (SD) rats were housed for 12 weeks. After one week of acclimatization, they were randomly divided into four groups of 5 animals each and treated for 12 weeks as follow: Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15mg/kg) dissolved in distilled water, group HFD was given only high fat diet and group HFDEL was given high fat diet and EL extracts (15mg/kg). Rats which were treated with EL (NDEL and HFDEL) showed a significant increase (p<0.05) in the test...
Mukhannath is not a new group of people which exists in our society. Discussions and debates abou... more Mukhannath is not a new group of people which exists in our society. Discussions and debates about mukhannath have already been going on by former Islamic scholars and medical practitioners. This study aims to clarify the meaning of mukhannath from the perspective of fiqh and medical based on the literature review or previous research. This qualitative study applied document analysis methodology. Classical and modern fiqh books are the main source of reference, alongside books, journals and medical studies that address on the issue of mukhannath. The finding shows that mukhannath was addressed on Al-Quran and Al-Sunnah. Mukhannath was also defined as a male resembling a woman and was divided into two groups namely mukhannath khalqiyy and mukhannath ghayr khalqiyy. The clear meaning of mukhannath can avoid misunderstandings and confusions especially with the other group which is khunsa. In addition, the understanding of the term mukhannath from Islamic and medical perspective can e...
International Islamic University MalaysiaABSTRACT Prolonged exposure to noise can have adverse ef... more International Islamic University MalaysiaABSTRACT Prolonged exposure to noise can have adverse effects on health. Noise has extra auditory effects by activating the sympathetic nervous and hormonal systems. The present study was undertaken to evaluate the effect of acute and chronic high intensity noise on the isolated hearts of rats using the Langendorff apparatus by determining the effect of noise on the coronary perfusion pressure (CPP), heart rate (HR) and left ventricular diastolic pressure (LVDP). The rats were divided into four groups and exposed to noise intensity of 80-100 dBA on duration of 12 hours exposure (acute effect), 8 hours daily for 20 days (chronic effect), 20 days into 3 days exposure and 2 days without 8 hours per day (intermittent effect) and the control group. Noise of 80-100 dBA was found to cause significant increase in CPP, LVDP and HR (p< 0.05) for acute and both chronic groups versus control. On other hand there were no significant differences of the ...
Ramadan 1437H dikejutkan dengan pembunuhan 49 pengunjung kelab homoseksual 'Pulse' di Orl... more Ramadan 1437H dikejutkan dengan pembunuhan 49 pengunjung kelab homoseksual 'Pulse' di Orlando, Florida, oleh Omar Mateen, seorang Muslim.Umat Islam mengutuk sekeraskerasnya pembunuhan berkenaan, tetapi ia cepat digunakan penyokong LGBT di serata dunia dan di Malaysia untuk mendesak agar cara hidup LGBT diterima umat Islam dan menyalahkan institusi agama sebagai menyuburkan homofobia.
Advanced Science Letters, May 1, 2017
Makara Journal of Health Research, 2018
International Journal of Cardiology, 2019
Evidence-Based Complementary and Alternative Medicine, 2012
Testosterone replacement is the choice of treatment in androgen-deficient osteoporosis. However, ... more Testosterone replacement is the choice of treatment in androgen-deficient osteoporosis. However, long-term use of testosterone is potentially carcinogenic.Eurycoma longifolia(EL) has been reported to enhance testosterone level and prevent bone calcium loss but there is a paucity of research regarding its effect on the bone structural parameters. This study was conducted to explore the bone structural changes following EL treatment in normal and androgen-deficient osteoporosis rat model. Thirty-six male Sprague-Dawley rats aged 12 months were divided into normal control, normal rat supplemented with EL, sham-operated, orchidectomised-control, orchidectomised with testosterone replacement, and orchidectomised with EL supplementation groups. Testosterone serum was measured both before and after the completion of the treatment. After 6 weeks of the treatment, the femora were processed for bone histomorphometry. Testosterone replacement was able to raise the testosterone level and restor...
Malaysian Journal of Science Health & Technology
Sleep-wake cycle is the most evident 24 hour rhythms observed in humans. This circadian variation... more Sleep-wake cycle is the most evident 24 hour rhythms observed in humans. This circadian variation is a normal biological clock. The physiological phenomenon, however has been able to explain the onset of cardiac events that also tend to occur during certain time of day. It has been known that there is a tendency for major cardiovascular episodes to occur during the mid-morning hours. With the advent of ambulatory blood pressure monitoring, the fluctuations of blood pressure throughout the day are able to be captured. This is called blood pressure variability (BPV). The factors affecting BPV include age, sex, physical activity, mental activity, behavioural and environmental. Recent studies have shown that high BPV is associated with target organ damage, in particular cardiovascular and coronary artery diseases. In the effort to explain the mechanisms related to these complications out of excessive BPV, several studies explored the role of history of family with hypertension, hyperglycaemia and hyperlipidemia towards developing pre-existing condition that lead to high BPV.