Ralf Radlanski - Academia.edu (original) (raw)
Papers by Ralf Radlanski
Medical Hypotheses, 2004
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Annals of Anatomy - Anatomischer Anzeiger, 2018
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Ann Anatomy, 1999
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Fortschritte der Kieferorthopädie, 1994
Zusammenfassung Elf menschliche Unterkiefer von Embryonen und Feten der Größe zwischen 18 und 66 ... more Zusammenfassung Elf menschliche Unterkiefer von Embryonen und Feten der Größe zwischen 18 und 66 mm Scheitel-Steiß-Länge (SSL) wurden als Schnittserien präpariert und computergraphisch rekonstruiert. Die Ausdehnung des Meckelschen Knorpels und der mandibulären Verknöcherungen wurden in der Horizontalebene morphometrisch untersucht und vor allem Meßwerte zur Beschreibung der Länge, Breite, des dorsalen Öffnungswinkels und der Position des Foramen mentale erfaßt. Außerdem wurden
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Anatomia, Histologia, Embryologia, 2014
Dental hard tissues are formed particularly by odontoblasts (dentin) and ameloblasts (enamel). Wh... more Dental hard tissues are formed particularly by odontoblasts (dentin) and ameloblasts (enamel). Whereas the reparation of dentin is often observed, enamel does not regenerate in most species. However, in mouse incisor, a population of somatic stem cells in the cervical loop is responsible for the incisor regeneration. Understanding of the specificities of these cells is therefore of an interest in basic research as well as regenerative therapies. The Myb transcription factors are involved in essential cellular processes. B-Myb is often linked to the stem cell phenotype, and c-Myb expression marks undifferentiated and proliferating cells such as the stem cells. In the presented study, temporo-spatial expression of B-Myb and c-Myb proteins was correlated with localisation of putative somatic stem cells in the mouse incisor cervical loop by immunohistochemistry. B-Myb expression was localised mostly in the zone of transit-amplifying cells, and c-Myb was found in the inner enamel epithelium, the surrounding mesenchyme and in differentiated cells. Taken together, neither B-Myb nor c-Myb was exclusively present or abundant in the area of the incisor stem cell niche. Their distribution, however, supports recently reported novel functions of c-Myb in differentiation of hard tissue cells.
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Biomaterials, 2005
Establishing and maintaining mature bone at the bone–device interface is critical to the long-ter... more Establishing and maintaining mature bone at the bone–device interface is critical to the long-term success of prosthesis. Poor cell adhesion to orthopaedic and dental implants results in implant failure. Considerable effort has been devoted to alter the surface characteristics of these biomaterials in order to improve the initial interlocking of the device and skeleton. We investigated the effect of surface
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Journal of Oral Pathology & Medicine, 2014
Juvenile idiopathic arthritis (JIA) of the temporomandibular joint (TMJ) can cause severe growth ... more Juvenile idiopathic arthritis (JIA) of the temporomandibular joint (TMJ) can cause severe growth disturbances of the craniomandibular system. Antigen-induced arthritis (AIA) of the rabbit TMJ is simulating the inflammatory process of the TMJ in JIA. The aim of this study was to investigate the effect of a systemic administration of methotrexate (MTX) on AIA in rabbits by means of three different histological staining methods. After sensitization, a bilateral arthritis of the TMJ was induced by an intra-articular administration of ovalbumin in 12 New Zealand white rabbits aged 10 weeks. From the 13th week of age, six of the 12 rabbits received weekly intramuscular injections of MTX, and the other six animals remained without therapy. Another six animals served as controls, receiving no treatment or intra-articular injections at all. After euthanasia at the age of 22 weeks, all TMJs were retrieved en bloc. Sagittal sections were cut and stained with haematoxylin-eosin (H-E), Safranin-O for the evaluation of the Mankin score and tartrate-resistant acid phosphatase (TRAP). In the arthritis group, a chronic inflammation with degeneration of the articular cartilage was visible. In the MTX group, the signs of cartilage degeneration were significantly reduced compared with the arthritis group. In contrast, the joints in the control group were inconspicuous. A correlation between the Mankin score and TRAP-positive cells could be found. Systemic administration of MTX seems to have a positive effect upon the inflammatory process in the rabbit TMJ but fails to eliminate the sign of arthritis completely.
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Archives of Oral Biology, 2005
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Annals of Anatomy-anatomischer Anzeiger, 2001
The development of the muscles in the floor of the mouth is described in 10 human embryos and fet... more The development of the muscles in the floor of the mouth is described in 10 human embryos and fetuses ranging from 6.9 to 76 mm CRL by means of computer-aided graphical 3D-reconstructions. All primordia of the muscles in the floor of the mouth could be identified from the 15.6 mm CRL stage on. The proportions and insertion lines of the early muscles were found to be different from adult anatomy. Each muscle first inserted in the medial surface of Meckels cartilage, but during the developmental period between 19 and 68 mm CRL the insertion lines were gradually transposed to the bony ridges of the mandible which progrediently embraced Meckels cartilage. The fibers of the mylohyoid muscles left the anterior region near the symphysis mentalis free during all stages of this study. The digastric muscle revealed only one belly with a constriction of its continuous fibers where it passed the hyoid bone primordium. There was no attachment of digastric muscle fibers to the hyoid; only geniohyoid and mylohyoid fibers. Geniohyoid and genioglossus muscles basically correspond to their definite arrangement, but they underwent proportional changes. Individual specimens embodied irregularities such as accessory geniohyoid and hyoid portions and muscle fibers separate from the mylohyoide muscle.
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Matrix Biology, 2010
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Journal of Orofacial Orthopedics/Fortschritte der Kieferorthop�die, 2003
During orthodontic treatment with a multiband appliance, enamel decalcifications and periodontal ... more During orthodontic treatment with a multiband appliance, enamel decalcifications and periodontal irritation may occur due to inevitable plaque retention. Besides the band itself, non-cemented gaps between tooth and band constitute a problem that has not yet been investigated from quantitative aspects. In this in vitro study, the cement distribution beneath the orthodontic band was investigated on 48 identical transparent resin replicas of upper molars and lower molars, respectively. The replicas with the cemented orthodontic bands were divided into buccal, distal, oral, and mesial segments so that the inner surfaces of the bands could undergo morphometric analysis for areas not covered with cement. Two different molar bands (Dentaform Snap by Dentaurum, Ispringen, Germany, and "Washbon" by Ormco, Orange, CA, USA), and two glass-ionomer cements (OptiBand by Ormco and Ultra Band-Lok Blue by GAC, Gräfelfing, Germany) were used. In this way, 8 test series with twelve specimens each were performed. Not one cement-band combination was without defects in the cement film, with poorer cement flow properties being observed at the upper than at the lower molars. In general, fewer defects were recorded in the occlusal than in the cervical areas. Overall, the buccal surfaces yielded the best results, and the mesial surfaces the poorest. Since defects in the cement film have so far been unavoidable, the indication for orthodontic treatment with a multiband appliance must continue to be strict. Unless accompanying professional prophylactic care coupled with optimal oral hygiene is ensured, multiband appliances should be used with great caution.
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Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie, 2000
In orthodontics, reduction of tooth-size by grinding interproximal surfaces (stripping) of teeth ... more In orthodontics, reduction of tooth-size by grinding interproximal surfaces (stripping) of teeth is a common procedure. In order to achieve perfectly smooth surfaces, clinicians have carefully tested various methods and progressively improved this therapeutic procedure. In this in-vivo study we used scanning electron microscopy (SEM) to evaluate the morphologic effect of a 3-step technique using an oscillating perforated diamond-coated disc for enamel reduction and 2 Sof-Lex XT discs for polishing. This technique was applied in 32 patients with an average age of 15.5 years. A total of 296 interproximal surfaces was treated and replicas were produced for scanning electron microscopy evaluation. The scanning electron microscopy investigations demonstrated that more than 90% of the reproximated surfaces were very well or well polished, resulting in polished enamel surfaces smoother than untreated enamel. This technique proved to be clinically expedient as it finished each interproximal surface within about 2.2 minutes. At the same time, it was demonstrated to be safe and comfortable for the patient, eliminating the need for lip or cheek protectors and making injuries unlikely.
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Journal of Cranio-Maxillofacial Surgery, 2005
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Journal of Anatomy, 2011
The first mouse molar (M1) is the most common model for odontogenesis, with research particularly... more The first mouse molar (M1) is the most common model for odontogenesis, with research particularly focused on prenatal development. However, the functional dentition forms postnatally, when the histogenesis and morphogenesis of the tooth is completed, the roots form and the tooth physically anchors into the jaw. In this work, M1 was studied from birth to eruption, assessing morphogenesis, proliferation and apoptosis, and correlating these with remodeling of the surrounding bony tissue. The M1 completed crown formation between postnatal (P) days 0-2, and the development of the tooth root was initiated at P4. From P2 until P12, cell proliferation in the dental epithelium reduced and shifted downward to the apical region of the forming root. In contrast, proliferation was maintained or increased in the mesenchymal cells of the dental follicle. At later stages, before tooth eruption (P20), cell proliferation suddenly ceased. This withdrawal from the cell cycle correlated with tooth mineralization and mesenchymal differentiation. Apoptosis was observed during all stages of M1 postnatal morphogenesis, playing a role in the removal of cells such as osteoblasts in the mandibular region and working together with osteoclasts to remodel the bone around the developing tooth. At more advanced developmental stages, apoptotic cells and bodies accumulated in the cell layers above the tooth cusps, in the path of eruption. Three-dimensional reconstruction of the developing postnatal tooth and bone indicates that the alveolar crypts form by resorption underneath the primordia, whereas the ridges form by active bone growth between the teeth and roots to form a functional complex.
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Histochemistry, 1993
In this immunohistochemical study two monoclonal antibodies, ED1 and ED2, which recognize exclusi... more In this immunohistochemical study two monoclonal antibodies, ED1 and ED2, which recognize exclusively cells of the mononuclear phagocyte system (MPS) in the rat, were applied to study the presence of these cells during remodeling of the periodontal tissues following mechanically induced orthodontic tooth movement. The immunohistochemical procedure was carried out successfully on routinely processed, paraffin-embedded histological sections using the avidin-biotin-peroxidase-complex (ABC) technique. Cells of the MPS could be demonstrated on positive control sections of rat spleen and bone marrow. For the study of remodelling of the periodontal tissues only the ED1 antibody proved to be suitable. With this antibody, positive mononuclear and multinuclear cells, i.e. macrophages and osteoclasts, were seen throughout the periodontium even in the control animals. After the induction of orthodontic tooth movement activation of macrophages, osteoclasts and odontoclasts was demonstrable, all of them showing a clear-cut positive reaction to ED1.
Bookmarks Related papers MentionsView impact
European Journal of Oral Sciences, 2004
From a morphogenetic point of view, the mental foramen of the mandible is a highly suitable model... more From a morphogenetic point of view, the mental foramen of the mandible is a highly suitable model to study the interactions of different tissues such as nerves, vessels, mesenchymal cells, cartilage, and bone. In previous work, we provided a three-dimensional description of the mental foramen at different developmental stages, and now we complement those studies with a three-dimensional visualization of different bone remodeling activities around the mental foramen. Histological serial sections of human embryos and fetuses, ranging in size from 25 to 117 mm crown-rump-length (CRL), were used to characterize the bone remodeling activity (apposition, inactivity, and resorption). We quantified and reconstructed this activity in three dimensions, and included information on the spatial relationship of the nerves, vessels, and dental primordia. In general, the mandible showed strong apposition at its outer surfaces. The brim of the mental foramen, however, displayed changing remodeling activity at different stages. In the depth of the bony gutter, which provides space for the nerve and the blood vessels, we found bone resorption beneath the inferior alveolar vein. Bone was also resorbed in proximity to the dental primordia. In future studies, we will relate gene expression data to these morphological findings in order to identify molecular mechanisms that regulate this complex system.
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European Journal of Oral Sciences, 2010
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European Journal of Oral Sciences, 1999
Bookmarks Related papers MentionsView impact
European Journal of Oral Sciences, 2006
Bookmarks Related papers MentionsView impact
European Journal of Oral Sciences, 2001
Bookmarks Related papers MentionsView impact
Medical Hypotheses, 2004
Bookmarks Related papers MentionsView impact
Annals of Anatomy - Anatomischer Anzeiger, 2018
Bookmarks Related papers MentionsView impact
Ann Anatomy, 1999
Bookmarks Related papers MentionsView impact
Fortschritte der Kieferorthopädie, 1994
Zusammenfassung Elf menschliche Unterkiefer von Embryonen und Feten der Größe zwischen 18 und 66 ... more Zusammenfassung Elf menschliche Unterkiefer von Embryonen und Feten der Größe zwischen 18 und 66 mm Scheitel-Steiß-Länge (SSL) wurden als Schnittserien präpariert und computergraphisch rekonstruiert. Die Ausdehnung des Meckelschen Knorpels und der mandibulären Verknöcherungen wurden in der Horizontalebene morphometrisch untersucht und vor allem Meßwerte zur Beschreibung der Länge, Breite, des dorsalen Öffnungswinkels und der Position des Foramen mentale erfaßt. Außerdem wurden
Bookmarks Related papers MentionsView impact
Anatomia, Histologia, Embryologia, 2014
Dental hard tissues are formed particularly by odontoblasts (dentin) and ameloblasts (enamel). Wh... more Dental hard tissues are formed particularly by odontoblasts (dentin) and ameloblasts (enamel). Whereas the reparation of dentin is often observed, enamel does not regenerate in most species. However, in mouse incisor, a population of somatic stem cells in the cervical loop is responsible for the incisor regeneration. Understanding of the specificities of these cells is therefore of an interest in basic research as well as regenerative therapies. The Myb transcription factors are involved in essential cellular processes. B-Myb is often linked to the stem cell phenotype, and c-Myb expression marks undifferentiated and proliferating cells such as the stem cells. In the presented study, temporo-spatial expression of B-Myb and c-Myb proteins was correlated with localisation of putative somatic stem cells in the mouse incisor cervical loop by immunohistochemistry. B-Myb expression was localised mostly in the zone of transit-amplifying cells, and c-Myb was found in the inner enamel epithelium, the surrounding mesenchyme and in differentiated cells. Taken together, neither B-Myb nor c-Myb was exclusively present or abundant in the area of the incisor stem cell niche. Their distribution, however, supports recently reported novel functions of c-Myb in differentiation of hard tissue cells.
Bookmarks Related papers MentionsView impact
Biomaterials, 2005
Establishing and maintaining mature bone at the bone–device interface is critical to the long-ter... more Establishing and maintaining mature bone at the bone–device interface is critical to the long-term success of prosthesis. Poor cell adhesion to orthopaedic and dental implants results in implant failure. Considerable effort has been devoted to alter the surface characteristics of these biomaterials in order to improve the initial interlocking of the device and skeleton. We investigated the effect of surface
Bookmarks Related papers MentionsView impact
Journal of Oral Pathology & Medicine, 2014
Juvenile idiopathic arthritis (JIA) of the temporomandibular joint (TMJ) can cause severe growth ... more Juvenile idiopathic arthritis (JIA) of the temporomandibular joint (TMJ) can cause severe growth disturbances of the craniomandibular system. Antigen-induced arthritis (AIA) of the rabbit TMJ is simulating the inflammatory process of the TMJ in JIA. The aim of this study was to investigate the effect of a systemic administration of methotrexate (MTX) on AIA in rabbits by means of three different histological staining methods. After sensitization, a bilateral arthritis of the TMJ was induced by an intra-articular administration of ovalbumin in 12 New Zealand white rabbits aged 10 weeks. From the 13th week of age, six of the 12 rabbits received weekly intramuscular injections of MTX, and the other six animals remained without therapy. Another six animals served as controls, receiving no treatment or intra-articular injections at all. After euthanasia at the age of 22 weeks, all TMJs were retrieved en bloc. Sagittal sections were cut and stained with haematoxylin-eosin (H-E), Safranin-O for the evaluation of the Mankin score and tartrate-resistant acid phosphatase (TRAP). In the arthritis group, a chronic inflammation with degeneration of the articular cartilage was visible. In the MTX group, the signs of cartilage degeneration were significantly reduced compared with the arthritis group. In contrast, the joints in the control group were inconspicuous. A correlation between the Mankin score and TRAP-positive cells could be found. Systemic administration of MTX seems to have a positive effect upon the inflammatory process in the rabbit TMJ but fails to eliminate the sign of arthritis completely.
Bookmarks Related papers MentionsView impact
Archives of Oral Biology, 2005
Bookmarks Related papers MentionsView impact
Annals of Anatomy-anatomischer Anzeiger, 2001
The development of the muscles in the floor of the mouth is described in 10 human embryos and fet... more The development of the muscles in the floor of the mouth is described in 10 human embryos and fetuses ranging from 6.9 to 76 mm CRL by means of computer-aided graphical 3D-reconstructions. All primordia of the muscles in the floor of the mouth could be identified from the 15.6 mm CRL stage on. The proportions and insertion lines of the early muscles were found to be different from adult anatomy. Each muscle first inserted in the medial surface of Meckels cartilage, but during the developmental period between 19 and 68 mm CRL the insertion lines were gradually transposed to the bony ridges of the mandible which progrediently embraced Meckels cartilage. The fibers of the mylohyoid muscles left the anterior region near the symphysis mentalis free during all stages of this study. The digastric muscle revealed only one belly with a constriction of its continuous fibers where it passed the hyoid bone primordium. There was no attachment of digastric muscle fibers to the hyoid; only geniohyoid and mylohyoid fibers. Geniohyoid and genioglossus muscles basically correspond to their definite arrangement, but they underwent proportional changes. Individual specimens embodied irregularities such as accessory geniohyoid and hyoid portions and muscle fibers separate from the mylohyoide muscle.
Bookmarks Related papers MentionsView impact
Matrix Biology, 2010
Bookmarks Related papers MentionsView impact
Journal of Orofacial Orthopedics/Fortschritte der Kieferorthop�die, 2003
During orthodontic treatment with a multiband appliance, enamel decalcifications and periodontal ... more During orthodontic treatment with a multiband appliance, enamel decalcifications and periodontal irritation may occur due to inevitable plaque retention. Besides the band itself, non-cemented gaps between tooth and band constitute a problem that has not yet been investigated from quantitative aspects. In this in vitro study, the cement distribution beneath the orthodontic band was investigated on 48 identical transparent resin replicas of upper molars and lower molars, respectively. The replicas with the cemented orthodontic bands were divided into buccal, distal, oral, and mesial segments so that the inner surfaces of the bands could undergo morphometric analysis for areas not covered with cement. Two different molar bands (Dentaform Snap by Dentaurum, Ispringen, Germany, and "Washbon" by Ormco, Orange, CA, USA), and two glass-ionomer cements (OptiBand by Ormco and Ultra Band-Lok Blue by GAC, Gräfelfing, Germany) were used. In this way, 8 test series with twelve specimens each were performed. Not one cement-band combination was without defects in the cement film, with poorer cement flow properties being observed at the upper than at the lower molars. In general, fewer defects were recorded in the occlusal than in the cervical areas. Overall, the buccal surfaces yielded the best results, and the mesial surfaces the poorest. Since defects in the cement film have so far been unavoidable, the indication for orthodontic treatment with a multiband appliance must continue to be strict. Unless accompanying professional prophylactic care coupled with optimal oral hygiene is ensured, multiband appliances should be used with great caution.
Bookmarks Related papers MentionsView impact
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie, 2000
In orthodontics, reduction of tooth-size by grinding interproximal surfaces (stripping) of teeth ... more In orthodontics, reduction of tooth-size by grinding interproximal surfaces (stripping) of teeth is a common procedure. In order to achieve perfectly smooth surfaces, clinicians have carefully tested various methods and progressively improved this therapeutic procedure. In this in-vivo study we used scanning electron microscopy (SEM) to evaluate the morphologic effect of a 3-step technique using an oscillating perforated diamond-coated disc for enamel reduction and 2 Sof-Lex XT discs for polishing. This technique was applied in 32 patients with an average age of 15.5 years. A total of 296 interproximal surfaces was treated and replicas were produced for scanning electron microscopy evaluation. The scanning electron microscopy investigations demonstrated that more than 90% of the reproximated surfaces were very well or well polished, resulting in polished enamel surfaces smoother than untreated enamel. This technique proved to be clinically expedient as it finished each interproximal surface within about 2.2 minutes. At the same time, it was demonstrated to be safe and comfortable for the patient, eliminating the need for lip or cheek protectors and making injuries unlikely.
Bookmarks Related papers MentionsView impact
Journal of Cranio-Maxillofacial Surgery, 2005
Bookmarks Related papers MentionsView impact
Journal of Anatomy, 2011
The first mouse molar (M1) is the most common model for odontogenesis, with research particularly... more The first mouse molar (M1) is the most common model for odontogenesis, with research particularly focused on prenatal development. However, the functional dentition forms postnatally, when the histogenesis and morphogenesis of the tooth is completed, the roots form and the tooth physically anchors into the jaw. In this work, M1 was studied from birth to eruption, assessing morphogenesis, proliferation and apoptosis, and correlating these with remodeling of the surrounding bony tissue. The M1 completed crown formation between postnatal (P) days 0-2, and the development of the tooth root was initiated at P4. From P2 until P12, cell proliferation in the dental epithelium reduced and shifted downward to the apical region of the forming root. In contrast, proliferation was maintained or increased in the mesenchymal cells of the dental follicle. At later stages, before tooth eruption (P20), cell proliferation suddenly ceased. This withdrawal from the cell cycle correlated with tooth mineralization and mesenchymal differentiation. Apoptosis was observed during all stages of M1 postnatal morphogenesis, playing a role in the removal of cells such as osteoblasts in the mandibular region and working together with osteoclasts to remodel the bone around the developing tooth. At more advanced developmental stages, apoptotic cells and bodies accumulated in the cell layers above the tooth cusps, in the path of eruption. Three-dimensional reconstruction of the developing postnatal tooth and bone indicates that the alveolar crypts form by resorption underneath the primordia, whereas the ridges form by active bone growth between the teeth and roots to form a functional complex.
Bookmarks Related papers MentionsView impact
Histochemistry, 1993
In this immunohistochemical study two monoclonal antibodies, ED1 and ED2, which recognize exclusi... more In this immunohistochemical study two monoclonal antibodies, ED1 and ED2, which recognize exclusively cells of the mononuclear phagocyte system (MPS) in the rat, were applied to study the presence of these cells during remodeling of the periodontal tissues following mechanically induced orthodontic tooth movement. The immunohistochemical procedure was carried out successfully on routinely processed, paraffin-embedded histological sections using the avidin-biotin-peroxidase-complex (ABC) technique. Cells of the MPS could be demonstrated on positive control sections of rat spleen and bone marrow. For the study of remodelling of the periodontal tissues only the ED1 antibody proved to be suitable. With this antibody, positive mononuclear and multinuclear cells, i.e. macrophages and osteoclasts, were seen throughout the periodontium even in the control animals. After the induction of orthodontic tooth movement activation of macrophages, osteoclasts and odontoclasts was demonstrable, all of them showing a clear-cut positive reaction to ED1.
Bookmarks Related papers MentionsView impact
European Journal of Oral Sciences, 2004
From a morphogenetic point of view, the mental foramen of the mandible is a highly suitable model... more From a morphogenetic point of view, the mental foramen of the mandible is a highly suitable model to study the interactions of different tissues such as nerves, vessels, mesenchymal cells, cartilage, and bone. In previous work, we provided a three-dimensional description of the mental foramen at different developmental stages, and now we complement those studies with a three-dimensional visualization of different bone remodeling activities around the mental foramen. Histological serial sections of human embryos and fetuses, ranging in size from 25 to 117 mm crown-rump-length (CRL), were used to characterize the bone remodeling activity (apposition, inactivity, and resorption). We quantified and reconstructed this activity in three dimensions, and included information on the spatial relationship of the nerves, vessels, and dental primordia. In general, the mandible showed strong apposition at its outer surfaces. The brim of the mental foramen, however, displayed changing remodeling activity at different stages. In the depth of the bony gutter, which provides space for the nerve and the blood vessels, we found bone resorption beneath the inferior alveolar vein. Bone was also resorbed in proximity to the dental primordia. In future studies, we will relate gene expression data to these morphological findings in order to identify molecular mechanisms that regulate this complex system.
Bookmarks Related papers MentionsView impact
European Journal of Oral Sciences, 2010
Bookmarks Related papers MentionsView impact
European Journal of Oral Sciences, 1999
Bookmarks Related papers MentionsView impact
European Journal of Oral Sciences, 2006
Bookmarks Related papers MentionsView impact
European Journal of Oral Sciences, 2001
Bookmarks Related papers MentionsView impact