Renata Jastrząb - Academia.edu (original) (raw)

PAPERS by Renata Jastrząb

Metal ions in life sciences, 2017

Ground and especially drinking water could be contaminated by heavy metal ions such as lead and c... more Ground and especially drinking water could be contaminated by heavy metal ions such as lead and chromium, or the metalloid arsenic, discarded from industrial wastewater. These heavy metal ions are regarded as highly toxic pollutants which could cause a wide range of health problems in case of a long-term accumulation in the body. Thus, there have been many efforts to reduce the concentration of lead ions in effluent wastewater. They have included the establishment of stringent permissible discharge levels and management policies, the application of various pollution-control technologies, and the development of adsorbent materials for lead reduction. According to Science [1] encapsulation, developed approximately 65 years ago, has been defined as a major interdisciplinary research technology. Encapsulation has been used to deliver almost everything from advanced drugs to unique consumer sensory experiences. In this chapter we review the art of encapsulation technology as a potential ...

Polyhedron, 2017

Five novel complexes of d-electron metal ions with picolinic and isonicotinic acid amide derivati... more Five novel complexes of d-electron metal ions with picolinic and isonicotinic acid amide derivatives were obtained. All products were characterized in detail with the use of elemental, thermogravimetric, X-ray diffraction, FT-IR and EPR spectra analysis. The chloride, nitrate or acetate salts of Cu(II), Zn(II), Co(II) and Ni(II) were used to the synthesis with carboxamide ligands resulting in five new crystalline compounds. Selected compounds were also used for antifungal activity examination against Fusarium culmorum pathogen. This examination was conducted using two different methods: the inhibition zone measurements and visual observation of retardation influence on fungi spores growth.

Journal of Molecular Structure

Molecules

Binary complexes of α-hydroxy acids (L-Tartaric acid and L-Malic acid) with d-electron metal ions... more Binary complexes of α-hydroxy acids (L-Tartaric acid and L-Malic acid) with d-electron metal ions (copper, cobalt, nickel) were investigated. Potentiometric measurements have been performed in aqueous solution with computer analysis of the data for determination of the stability constants of complexes formed in the studied systems. The coordination mode of the complexes was defined using spectroscopic methods: electron paramagnetic resonance (EPR), ultraviolet-visible (UV-Vis), circular dichroism (CD), and infrared (IR). Results of the equilibrium studies have provided evidence for the formation of dimers with copper(II) ions and monomers with cobalt(II) and nickel(II) ions.

Polyhedron

Abstract This article presents the template condensation reactions of 5-methylsalicylaldehyde wit... more Abstract This article presents the template condensation reactions of 5-methylsalicylaldehyde with 4,5-dimethyl-1,2-phenylenediamine in the presence of copper(II) ion and selected lanthanide(III) ions: Eu(III), Gd(III), and Yb(III). These reactions yielded complexes with a new salen-type Schiff base, namely N,Nʹ-bis(5-methylsalicylidene)-4,5-dimethyl-1,2-phenylenediamine (H2L1). The complexes of different compositions, [Eu3L14(H2O)2](CF3SO3) and [CuL1], were characterized by spectroscopic methods and elemental analysis. The reaction of 5-methylsalicylaldehyde with 4,5-dimethyl-1,2-phenylenediamine in the presence of Yb(NO3)3, Eu(CH3COO)3, and Yb(CF3SO3)3 also produced another ligand, L2 (2-(5,6-dimethyl-1H-benzimidazol-2-yl)-4-methylphenol and its triflate salt. The next template condensation reaction of the same organic reactants in the presence of Eu(NO3)3 and Gd(NO3)3 yielded a new ligand, L3 (2-[1-(2-hydroxy-5-methylbenzyl)-5,6-dimethyl-1H-benzimidazol-2-yl]-4-methylphenol and its nitrate salt. For the complexes [Eu3L14(H2O)2](CF3SO3) and [CuL1], the magnetic susceptibility χ(T) was measured under a magnetic field of µ0H = 0.5 T in the temperature range of 2–300 K.

Coordination Chemistry Reviews

Abstract Despite the rapid development of modern methods of cancer treatments, chemotherapy is st... more Abstract Despite the rapid development of modern methods of cancer treatments, chemotherapy is still one of the most important, and sometimes, the only one method of therapy. The development of cancer treatment methods indicates that search of the new, more effective and safer medicines are necessary. Treatment using common anticancer drugs is associated with their interaction with DNA. Further research on the binding of metal ions and their complexes to DNA resulted from their potential applications as new therapeutic and diagnostic agents. It is well known that mutations in DNA play a significant role in the formation of tumors, however not all of these processes are known. The recognition of binding lanthanide(III) ions or lanthanide(III) complexes to DNA and cleavage DNA via lanthanide(III) complexes are important to understand unknown mutations that lead to cancer and treatment of this disease. The scientists have been undertaking various attempts to interfere the human DNA in order to overcome genetic diseases. Gene therapy could be considered as a kind of scissors that allow to cleavage the DNA in the proper place and insert the corrective gene. Lanthanide(III) ions and their complexes, due to their unique properties, could be widely used as luminescent probes for bioassays and as reagents in optical and magnetic resonance imaging. The luminescence properties of these compounds also have been adopted in medicinal diagnosis. This review will summarize the role of lanthanide(III) ions and their compounds in recent studies on the use of lanthanide(III) complexes to bind, cleavage of DNA also in diagnosis, and monitoring the treatment of cancer disease.

Physical Sciences Reviews, 2016

The first polyamine discovered in a living organism was tetramine, a spermine crystallised out of... more The first polyamine discovered in a living organism was tetramine, a spermine crystallised out of sperm in 1678 by Van Leewenkeuk [9]. Putrescine was discovered in the end of the 19th century in microbes and then triamine: spermidine was discovered in the beginning of the 20th century [2]. Later studies have shown that in animal cells spermidine and spermine occur at elevated levels, while in prokaryotes spermidine and putrescine contents are dominant. Putrescine, spermidine, 1,3-diaminopropan, homospermidine, norspermidine, and norspermine have been found in many gram-negative bacteria and algae [7, 10, 11]. Total concentration of PA in living organisms is on the order of millimols, however, the concentration of free polyamines is much lower. A low level of free amines follows from the fact that they are involved in noncovalent interactions with biomolecules occurring in living organisms such as nucleic acids, proteins, or phospholipids. High concentrations of non-bonded polyamines have been detected first of all in young molecules in the process of growth, in particular in rapidly proliferating cancer cells [6, 12]. Elevated levels of free polyamines have been observed, e.g. in breast, colon, lung, prostate, and skin tumours, accompanied by changed levels of enzymes responsible for biosynthesis and catabolism of polyamines. Because of the increased level of free polyamines and a tendency of their interaction with nucleic acids and other bioligands, these compounds have become objects of intense study [1, 13–19]. There is no doubt that the regulation of biosynthesis of polyamines and catabolism is one of the most important pathways in the search strategy for chemoprevention and chemotherapeutic drugs [14, 15, 20–38]. The present state of knowledge of these processes, their significance in biological systems, and their application in medicine are presented in subsequent sections of this chapter.

Innovative Applications, 2015

Polyhedron, 2015

ABSTRACT Anabasine copper(II) and zinc(II) complexes have been studied using experimental methods... more ABSTRACT Anabasine copper(II) and zinc(II) complexes have been studied using experimental methods and quantum-chemical studies. Preferred coordination centers and possible structures of the complexes have been determined. It has been revealed, that the main coordination center for anabasine complexes with both Cu(II) and Zn(II) ions is the piperidine nitrogen atom, while in zinc complexes also the nitrogen atom from the pyridine residue of anabasine is engaged to some small degree. In both systems investigated preferable formation of hydroxo-complexes was observed.

Journal of Inorganic Biochemistry, 2003

Reactions of metallation and non-covalent interactions have been studied in ternary systems of Cu... more Reactions of metallation and non-covalent interactions have been studied in ternary systems of Cu(II) ions with uridine, uridine 5'-monophosphate and diamines or triamines. It has been found that in metal-free systems the reaction centres of the nucleoside with the polyamine are the donor nitrogen atoms N(3) and protonated -NH(x) groups of the amines. In comparison to systems with adenosine or cytidine, the pH range of complex formation is shifted towards higher values. It is a consequence of significantly higher basicity of uridine and in agreement with the ion-ion, ion-dipole interaction model assumed. Formation of molecular complexes of uridine 5'-monophosphate with polyamines at a low pH is the result of activity of the phosphate group which plays the role of a negatively charged reaction site. Non-covalent interactions interfere in processes of bioligand metallation. Centres of weak interactions are simultaneously binding sites of metal ions. In protonated Cu(Urd)(PA)H(x) complexes, coordination has been found to involve the N(3) atom from the nucleoside and two donor nitrogen atoms from the polyamine (PA). In the heteroligand species Cu(Urd)(PA), despite deprotonation of all amine groups, one of these groups is located outside the inner coordination sphere. In complexes with uridine-5'-monophosphate, the phosphate group is active in metallation. Moreover, in certain coordination compounds this group is engaged in non-covalent interactions with PA molecules, despite binding Cu ions, as has been shown on the basis of equilibrium and spectral studies.

Current Pharmaceutical Design, 2016

Background: This review aims to present the relevant background information and current research ... more Background: This review aims to present the relevant background information and current research status in concentration of polyphenols using membrane technologies. The potential implementation of membrane separation to bioactive compounds like soluble phenolics from aqueous and organic solvent solutions is gaining increasing interest in the recent years. This review does not pretend to cover the abundant published literature on the subject, but to be representative for the observed tendencies in membrane processes applications for concentration of polyphenols derived from natural products. The first part of the article includes general information regarding the polyphenols and the traditional methods for their separation (such as: thin layer chromatography; paper chromatography; gas chromatography; high performance liquid chromatography; capillary electrophoresis), while the second part presents a review of different membrane processes applied for concentration of polyphenols. Thre...

Physical Sciences Reviews, 2016

Acta Chimica Slovenica, 2014

Copper(II)-nicotine complexes with chelating perchlorate, nitrate, acetate and formate ligands ha... more Copper(II)-nicotine complexes with chelating perchlorate, nitrate, acetate and formate ligands have been synthesized and characterized in solid state by elemental analysis and FT-IR spectroscopy. Coordination of Cu(II) by nicotine molecule has been also studied in water solution of various pH by potentiometry and spectroscopic (VIS, EPR and NMR) methods. Furthermore, quantum-mechanical calculations helped elucidate the experimental data as they provided some information on the energetic of the possible interaction modes of Cu(II) with nicotine. The studies showed that nicotine acts as a monodentate ligand utilizing for this purpose the pyridine nitrogen atom. In the Cu(II)/Nicotine system the MHL and ML type complexes were formed in 1:1 metal:ligand ratio.

Acta chimica Slovenica, 2014

Copper(II)-nicotine complexes with chelating perchlorate, nitrate, acetate and formate ligands ha... more Copper(II)-nicotine complexes with chelating perchlorate, nitrate, acetate and formate ligands have been synthesized and characterized in solid state by elemental analysis and FT-IR spectroscopy. Coordination of Cu(II) by nicotine molecule has been also studied in water solution of various pH by potentiometry and spectroscopic (VIS, EPR and NMR) methods. Furthermore, quantum-mechanical calculations helped elucidate the experimental data as they provided some information on the energetic of the possible interaction modes of Cu(II) with nicotine. The studies showed that nicotine acts as a monodentate ligand utilizing for this purpose the pyridine nitrogen atom. In the Cu(II)/Nicotine system the MHL and ML type complexes were formed in 1:1 metal:ligand ratio.

Journal of Inorganic Biochemistry, 2014

For the first time the NMR spectra of quinolizidine alkaloid with Cu(II) are studied. Structures ... more For the first time the NMR spectra of quinolizidine alkaloid with Cu(II) are studied. Structures of new complexes of (-)-cytisine with Cu(+2) and Zn(+2) cations are visualized, discussed in detail and characterized by spectroscopic methods: ESI-MS, NMR, UV-vis, EPR and crystallographic methods. In solution metal coordinates through the protonated nitrogen atoms of secondary amino groups (in piperidine ring) of cytisine molecule. While in solid state the most stable structures of the complexes are those in which the coordination of Cu(II) and Zn(II) salts is realized solely through the lactam carbonyl oxygen atom.

Inorganica Chimica Acta, 2015

ABSTRACT The new gadolinium(III) nitrate complex [Gd(H2L)2(NO3)3(EtOH)]MeOH where H2L is N,N′-bis... more ABSTRACT The new gadolinium(III) nitrate complex [Gd(H2L)2(NO3)3(EtOH)]MeOH where H2L is N,N′-bis(5-methylsalicylidene)-4-methyl-1,3-phenylenediamine was obtained in template condensation reaction of 5-methylsalicylaldehyde with 4-methyl-1,3-phenylenediamine in presence of gadolinium(III) nitrate hexahydrate. The structure of the complex was determined by single-crystal X-ray diffraction analysis and by physicochemical methods. The central cation is nine-coordinated, and the coordination resembles distorted tricapped trigonal prism and only oxygen atoms are involved in coordination. In the crystal structure there is uncoordinated solvent – methanol molecule. The methanol molecule plays an important role in the crystal packing by hydrogen bonding and it connects the complex molecules into infinite chains. Electron paramagnetic resonance studies confirmed complex formation of gadolinium ion because internal coordination sphere of gadolinium was changed. The absorption and fluorescence properties of [Gd(H2L)2(NO3)3(EtOH)]MeOH were studied in different solvents: ethyl acetate, 1-propanol, methanol, ethanol and acetonitrile. Fluorescence quantum yields (ΦF) were calculated for the complex in all solvents and the values, of ΦF are rather low, the exact values depend on solvent, being between 0.0005 (in acetonitrile and ethyl acetate) and 0.0014 (in 1-propanol).

Metal ions in life sciences, 2017

Ground and especially drinking water could be contaminated by heavy metal ions such as lead and c... more Ground and especially drinking water could be contaminated by heavy metal ions such as lead and chromium, or the metalloid arsenic, discarded from industrial wastewater. These heavy metal ions are regarded as highly toxic pollutants which could cause a wide range of health problems in case of a long-term accumulation in the body. Thus, there have been many efforts to reduce the concentration of lead ions in effluent wastewater. They have included the establishment of stringent permissible discharge levels and management policies, the application of various pollution-control technologies, and the development of adsorbent materials for lead reduction. According to Science [1] encapsulation, developed approximately 65 years ago, has been defined as a major interdisciplinary research technology. Encapsulation has been used to deliver almost everything from advanced drugs to unique consumer sensory experiences. In this chapter we review the art of encapsulation technology as a potential ...

Polyhedron, 2017

Five novel complexes of d-electron metal ions with picolinic and isonicotinic acid amide derivati... more Five novel complexes of d-electron metal ions with picolinic and isonicotinic acid amide derivatives were obtained. All products were characterized in detail with the use of elemental, thermogravimetric, X-ray diffraction, FT-IR and EPR spectra analysis. The chloride, nitrate or acetate salts of Cu(II), Zn(II), Co(II) and Ni(II) were used to the synthesis with carboxamide ligands resulting in five new crystalline compounds. Selected compounds were also used for antifungal activity examination against Fusarium culmorum pathogen. This examination was conducted using two different methods: the inhibition zone measurements and visual observation of retardation influence on fungi spores growth.

Journal of Molecular Structure

Molecules

Binary complexes of α-hydroxy acids (L-Tartaric acid and L-Malic acid) with d-electron metal ions... more Binary complexes of α-hydroxy acids (L-Tartaric acid and L-Malic acid) with d-electron metal ions (copper, cobalt, nickel) were investigated. Potentiometric measurements have been performed in aqueous solution with computer analysis of the data for determination of the stability constants of complexes formed in the studied systems. The coordination mode of the complexes was defined using spectroscopic methods: electron paramagnetic resonance (EPR), ultraviolet-visible (UV-Vis), circular dichroism (CD), and infrared (IR). Results of the equilibrium studies have provided evidence for the formation of dimers with copper(II) ions and monomers with cobalt(II) and nickel(II) ions.

Polyhedron

Abstract This article presents the template condensation reactions of 5-methylsalicylaldehyde wit... more Abstract This article presents the template condensation reactions of 5-methylsalicylaldehyde with 4,5-dimethyl-1,2-phenylenediamine in the presence of copper(II) ion and selected lanthanide(III) ions: Eu(III), Gd(III), and Yb(III). These reactions yielded complexes with a new salen-type Schiff base, namely N,Nʹ-bis(5-methylsalicylidene)-4,5-dimethyl-1,2-phenylenediamine (H2L1). The complexes of different compositions, [Eu3L14(H2O)2](CF3SO3) and [CuL1], were characterized by spectroscopic methods and elemental analysis. The reaction of 5-methylsalicylaldehyde with 4,5-dimethyl-1,2-phenylenediamine in the presence of Yb(NO3)3, Eu(CH3COO)3, and Yb(CF3SO3)3 also produced another ligand, L2 (2-(5,6-dimethyl-1H-benzimidazol-2-yl)-4-methylphenol and its triflate salt. The next template condensation reaction of the same organic reactants in the presence of Eu(NO3)3 and Gd(NO3)3 yielded a new ligand, L3 (2-[1-(2-hydroxy-5-methylbenzyl)-5,6-dimethyl-1H-benzimidazol-2-yl]-4-methylphenol and its nitrate salt. For the complexes [Eu3L14(H2O)2](CF3SO3) and [CuL1], the magnetic susceptibility χ(T) was measured under a magnetic field of µ0H = 0.5 T in the temperature range of 2–300 K.

Coordination Chemistry Reviews

Abstract Despite the rapid development of modern methods of cancer treatments, chemotherapy is st... more Abstract Despite the rapid development of modern methods of cancer treatments, chemotherapy is still one of the most important, and sometimes, the only one method of therapy. The development of cancer treatment methods indicates that search of the new, more effective and safer medicines are necessary. Treatment using common anticancer drugs is associated with their interaction with DNA. Further research on the binding of metal ions and their complexes to DNA resulted from their potential applications as new therapeutic and diagnostic agents. It is well known that mutations in DNA play a significant role in the formation of tumors, however not all of these processes are known. The recognition of binding lanthanide(III) ions or lanthanide(III) complexes to DNA and cleavage DNA via lanthanide(III) complexes are important to understand unknown mutations that lead to cancer and treatment of this disease. The scientists have been undertaking various attempts to interfere the human DNA in order to overcome genetic diseases. Gene therapy could be considered as a kind of scissors that allow to cleavage the DNA in the proper place and insert the corrective gene. Lanthanide(III) ions and their complexes, due to their unique properties, could be widely used as luminescent probes for bioassays and as reagents in optical and magnetic resonance imaging. The luminescence properties of these compounds also have been adopted in medicinal diagnosis. This review will summarize the role of lanthanide(III) ions and their compounds in recent studies on the use of lanthanide(III) complexes to bind, cleavage of DNA also in diagnosis, and monitoring the treatment of cancer disease.

Physical Sciences Reviews, 2016

The first polyamine discovered in a living organism was tetramine, a spermine crystallised out of... more The first polyamine discovered in a living organism was tetramine, a spermine crystallised out of sperm in 1678 by Van Leewenkeuk [9]. Putrescine was discovered in the end of the 19th century in microbes and then triamine: spermidine was discovered in the beginning of the 20th century [2]. Later studies have shown that in animal cells spermidine and spermine occur at elevated levels, while in prokaryotes spermidine and putrescine contents are dominant. Putrescine, spermidine, 1,3-diaminopropan, homospermidine, norspermidine, and norspermine have been found in many gram-negative bacteria and algae [7, 10, 11]. Total concentration of PA in living organisms is on the order of millimols, however, the concentration of free polyamines is much lower. A low level of free amines follows from the fact that they are involved in noncovalent interactions with biomolecules occurring in living organisms such as nucleic acids, proteins, or phospholipids. High concentrations of non-bonded polyamines have been detected first of all in young molecules in the process of growth, in particular in rapidly proliferating cancer cells [6, 12]. Elevated levels of free polyamines have been observed, e.g. in breast, colon, lung, prostate, and skin tumours, accompanied by changed levels of enzymes responsible for biosynthesis and catabolism of polyamines. Because of the increased level of free polyamines and a tendency of their interaction with nucleic acids and other bioligands, these compounds have become objects of intense study [1, 13–19]. There is no doubt that the regulation of biosynthesis of polyamines and catabolism is one of the most important pathways in the search strategy for chemoprevention and chemotherapeutic drugs [14, 15, 20–38]. The present state of knowledge of these processes, their significance in biological systems, and their application in medicine are presented in subsequent sections of this chapter.

Innovative Applications, 2015

Polyhedron, 2015

ABSTRACT Anabasine copper(II) and zinc(II) complexes have been studied using experimental methods... more ABSTRACT Anabasine copper(II) and zinc(II) complexes have been studied using experimental methods and quantum-chemical studies. Preferred coordination centers and possible structures of the complexes have been determined. It has been revealed, that the main coordination center for anabasine complexes with both Cu(II) and Zn(II) ions is the piperidine nitrogen atom, while in zinc complexes also the nitrogen atom from the pyridine residue of anabasine is engaged to some small degree. In both systems investigated preferable formation of hydroxo-complexes was observed.

Journal of Inorganic Biochemistry, 2003

Reactions of metallation and non-covalent interactions have been studied in ternary systems of Cu... more Reactions of metallation and non-covalent interactions have been studied in ternary systems of Cu(II) ions with uridine, uridine 5'-monophosphate and diamines or triamines. It has been found that in metal-free systems the reaction centres of the nucleoside with the polyamine are the donor nitrogen atoms N(3) and protonated -NH(x) groups of the amines. In comparison to systems with adenosine or cytidine, the pH range of complex formation is shifted towards higher values. It is a consequence of significantly higher basicity of uridine and in agreement with the ion-ion, ion-dipole interaction model assumed. Formation of molecular complexes of uridine 5'-monophosphate with polyamines at a low pH is the result of activity of the phosphate group which plays the role of a negatively charged reaction site. Non-covalent interactions interfere in processes of bioligand metallation. Centres of weak interactions are simultaneously binding sites of metal ions. In protonated Cu(Urd)(PA)H(x) complexes, coordination has been found to involve the N(3) atom from the nucleoside and two donor nitrogen atoms from the polyamine (PA). In the heteroligand species Cu(Urd)(PA), despite deprotonation of all amine groups, one of these groups is located outside the inner coordination sphere. In complexes with uridine-5'-monophosphate, the phosphate group is active in metallation. Moreover, in certain coordination compounds this group is engaged in non-covalent interactions with PA molecules, despite binding Cu ions, as has been shown on the basis of equilibrium and spectral studies.

Current Pharmaceutical Design, 2016

Background: This review aims to present the relevant background information and current research ... more Background: This review aims to present the relevant background information and current research status in concentration of polyphenols using membrane technologies. The potential implementation of membrane separation to bioactive compounds like soluble phenolics from aqueous and organic solvent solutions is gaining increasing interest in the recent years. This review does not pretend to cover the abundant published literature on the subject, but to be representative for the observed tendencies in membrane processes applications for concentration of polyphenols derived from natural products. The first part of the article includes general information regarding the polyphenols and the traditional methods for their separation (such as: thin layer chromatography; paper chromatography; gas chromatography; high performance liquid chromatography; capillary electrophoresis), while the second part presents a review of different membrane processes applied for concentration of polyphenols. Thre...

Physical Sciences Reviews, 2016

Acta Chimica Slovenica, 2014

Copper(II)-nicotine complexes with chelating perchlorate, nitrate, acetate and formate ligands ha... more Copper(II)-nicotine complexes with chelating perchlorate, nitrate, acetate and formate ligands have been synthesized and characterized in solid state by elemental analysis and FT-IR spectroscopy. Coordination of Cu(II) by nicotine molecule has been also studied in water solution of various pH by potentiometry and spectroscopic (VIS, EPR and NMR) methods. Furthermore, quantum-mechanical calculations helped elucidate the experimental data as they provided some information on the energetic of the possible interaction modes of Cu(II) with nicotine. The studies showed that nicotine acts as a monodentate ligand utilizing for this purpose the pyridine nitrogen atom. In the Cu(II)/Nicotine system the MHL and ML type complexes were formed in 1:1 metal:ligand ratio.

Acta chimica Slovenica, 2014

Copper(II)-nicotine complexes with chelating perchlorate, nitrate, acetate and formate ligands ha... more Copper(II)-nicotine complexes with chelating perchlorate, nitrate, acetate and formate ligands have been synthesized and characterized in solid state by elemental analysis and FT-IR spectroscopy. Coordination of Cu(II) by nicotine molecule has been also studied in water solution of various pH by potentiometry and spectroscopic (VIS, EPR and NMR) methods. Furthermore, quantum-mechanical calculations helped elucidate the experimental data as they provided some information on the energetic of the possible interaction modes of Cu(II) with nicotine. The studies showed that nicotine acts as a monodentate ligand utilizing for this purpose the pyridine nitrogen atom. In the Cu(II)/Nicotine system the MHL and ML type complexes were formed in 1:1 metal:ligand ratio.

Journal of Inorganic Biochemistry, 2014

For the first time the NMR spectra of quinolizidine alkaloid with Cu(II) are studied. Structures ... more For the first time the NMR spectra of quinolizidine alkaloid with Cu(II) are studied. Structures of new complexes of (-)-cytisine with Cu(+2) and Zn(+2) cations are visualized, discussed in detail and characterized by spectroscopic methods: ESI-MS, NMR, UV-vis, EPR and crystallographic methods. In solution metal coordinates through the protonated nitrogen atoms of secondary amino groups (in piperidine ring) of cytisine molecule. While in solid state the most stable structures of the complexes are those in which the coordination of Cu(II) and Zn(II) salts is realized solely through the lactam carbonyl oxygen atom.

Inorganica Chimica Acta, 2015

ABSTRACT The new gadolinium(III) nitrate complex [Gd(H2L)2(NO3)3(EtOH)]MeOH where H2L is N,N′-bis... more ABSTRACT The new gadolinium(III) nitrate complex [Gd(H2L)2(NO3)3(EtOH)]MeOH where H2L is N,N′-bis(5-methylsalicylidene)-4-methyl-1,3-phenylenediamine was obtained in template condensation reaction of 5-methylsalicylaldehyde with 4-methyl-1,3-phenylenediamine in presence of gadolinium(III) nitrate hexahydrate. The structure of the complex was determined by single-crystal X-ray diffraction analysis and by physicochemical methods. The central cation is nine-coordinated, and the coordination resembles distorted tricapped trigonal prism and only oxygen atoms are involved in coordination. In the crystal structure there is uncoordinated solvent – methanol molecule. The methanol molecule plays an important role in the crystal packing by hydrogen bonding and it connects the complex molecules into infinite chains. Electron paramagnetic resonance studies confirmed complex formation of gadolinium ion because internal coordination sphere of gadolinium was changed. The absorption and fluorescence properties of [Gd(H2L)2(NO3)3(EtOH)]MeOH were studied in different solvents: ethyl acetate, 1-propanol, methanol, ethanol and acetonitrile. Fluorescence quantum yields (ΦF) were calculated for the complex in all solvents and the values, of ΦF are rather low, the exact values depend on solvent, being between 0.0005 (in acetonitrile and ethyl acetate) and 0.0014 (in 1-propanol).

Hasła do zapamiętania: kwas D-glukuronowy, N-acetylo-D-glukozamina, kwas hialuronowy, związki kom... more Hasła do zapamiętania: kwas D-glukuronowy, N-acetylo-D-glukozamina, kwas hialuronowy, związki kompleksowe Wykaz skrótów: GluA -kwas D-glukuronowy NAG -N-acetylo-D-glukozamina NAM -kwas N-acetylomuraminowy AHA -kwasy α-hydroksylowe HA -kwas hialuronowy

ĆWICZENIA LABORATORYJNE Z CHEMII BIONIEORGANICZNEJ 9 W celu zaliczenia ćwiczeń laboratoryjnych st... more ĆWICZENIA LABORATORYJNE Z CHEMII BIONIEORGANICZNEJ 9 W celu zaliczenia ćwiczeń laboratoryjnych student zobowiązany jest do: