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Papers by Reva Rubenstein

Research paper thumbnail of Setting Safe Acute Exposure Limits for Halon Replacement Chemicals Using Physiologically Based Pharmacokinetic Modeling

Inhalation Toxicology, 2000

Most proposed replacements for Halon 130 1 as a hre suppressant are halogenated hydrocarbons The ... more Most proposed replacements for Halon 130 1 as a hre suppressant are halogenated hydrocarbons The acute toxic endpoint of concern for there agents is cardiac sensibzalion An approach is described that links the cardiac endpoint ds assc~sed in dogs to a target arterial concentrabon in humans Linkage was made using a physiologically based pharmacokinetic (PBPK) model Monte Carlo simulabons, which account for population vaiiability, were used to establish safe exposure times at drfferent exposure concentrations for Halon 1 KIT lbromotiifluoromethane), CF,l (trifluoroiodomethane), HFC-125 lpentafluoroethane), HFC-227ea (I ,

Research paper thumbnail of Setting Safe Acute Exposure Limits for Halon Replacement Chemicals Using Physiologically Based Pharmacokinetic Modeling

Inhalation Toxicology, 2000

Most proposed replacements for Halon 130 1 as a hre suppressant are halogenated hydrocarbons The ... more Most proposed replacements for Halon 130 1 as a hre suppressant are halogenated hydrocarbons The acute toxic endpoint of concern for there agents is cardiac sensibzalion An approach is described that links the cardiac endpoint ds assc~sed in dogs to a target arterial concentrabon in humans Linkage was made using a physiologically based pharmacokinetic (PBPK) model Monte Carlo simulabons, which account for population vaiiability, were used to establish safe exposure times at drfferent exposure concentrations for Halon 1 KIT lbromotiifluoromethane), CF,l (trifluoroiodomethane), HFC-125 lpentafluoroethane), HFC-227ea (I ,

Research paper thumbnail of Risk Assessment of Metals in Groundwater

Metals in Groundwater, 2020

Research paper thumbnail of Setting the Occupational Exposure Limit for CF 3 I *

Occupational exposure limits are established by a number of organizations. The establishment of a... more Occupational exposure limits are established by a number of organizations. The establishment of an occupational exposure limit involves examining the hazard levels associated with the exposure to a chemical. The hazard profile is determined by performing a battery of toxicity tests, the exact nature of which are dependant on the chemical in question. An example of a test battery would include such tests as acute toxicity tests (limit test, but not necessarily an LCW), genotoxicity battery of tests, subchronic tests, and developmental toxicity tests.

Research paper thumbnail of Chemical Hazards in the Workplace

Research paper thumbnail of The History of the Halon Phaseout and Regulation of Halon Alternatives

ACS Symposium Series, 1997

Research paper thumbnail of Regulatory/Safety Considerations

Handbook for Critical Cleaning, 2000

Research paper thumbnail of Mechanistic Insights Aid the Search for CFC Substitutes: Risk Assessment of HCFC-123 as an Example

Risk Analysis, 1994

Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188),

Research paper thumbnail of Fault Tree Analysis for Exposure to Refrigerants Used for Automotive Air Conditioning in the United States

Research paper thumbnail of The History of the Halon Phaseout and Regulation of Halon Alternatives

ACS Symposium Series, 1997

Research paper thumbnail of Setting Safe Acute Exposure Limits for Halon Replacement Chemicals Using Physiologically Based Pharmacokinetic Modeling

Inhalation Toxicology, 2000

Most proposed replacements for Halon 130 1 as a hre suppressant are halogenated hydrocarbons The ... more Most proposed replacements for Halon 130 1 as a hre suppressant are halogenated hydrocarbons The acute toxic endpoint of concern for there agents is cardiac sensibzalion An approach is described that links the cardiac endpoint ds assc~sed in dogs to a target arterial concentrabon in humans Linkage was made using a physiologically based pharmacokinetic (PBPK) model Monte Carlo simulabons, which account for population vaiiability, were used to establish safe exposure times at drfferent exposure concentrations for Halon 1 KIT lbromotiifluoromethane), CF,l (trifluoroiodomethane), HFC-125 lpentafluoroethane), HFC-227ea (I ,

Research paper thumbnail of Setting Safe Acute Exposure Limits for Halon Replacement Chemicals Using Physiologically Based Pharmacokinetic Modeling

Inhalation Toxicology, 2000

Most proposed replacements for Halon 130 1 as a hre suppressant are halogenated hydrocarbons The ... more Most proposed replacements for Halon 130 1 as a hre suppressant are halogenated hydrocarbons The acute toxic endpoint of concern for there agents is cardiac sensibzalion An approach is described that links the cardiac endpoint ds assc~sed in dogs to a target arterial concentrabon in humans Linkage was made using a physiologically based pharmacokinetic (PBPK) model Monte Carlo simulabons, which account for population vaiiability, were used to establish safe exposure times at drfferent exposure concentrations for Halon 1 KIT lbromotiifluoromethane), CF,l (trifluoroiodomethane), HFC-125 lpentafluoroethane), HFC-227ea (I ,

Research paper thumbnail of Risk Assessment of Metals in Groundwater

Metals in Groundwater, 2020

Research paper thumbnail of Setting the Occupational Exposure Limit for CF 3 I *

Occupational exposure limits are established by a number of organizations. The establishment of a... more Occupational exposure limits are established by a number of organizations. The establishment of an occupational exposure limit involves examining the hazard levels associated with the exposure to a chemical. The hazard profile is determined by performing a battery of toxicity tests, the exact nature of which are dependant on the chemical in question. An example of a test battery would include such tests as acute toxicity tests (limit test, but not necessarily an LCW), genotoxicity battery of tests, subchronic tests, and developmental toxicity tests.

Research paper thumbnail of Chemical Hazards in the Workplace

Research paper thumbnail of The History of the Halon Phaseout and Regulation of Halon Alternatives

ACS Symposium Series, 1997

Research paper thumbnail of Regulatory/Safety Considerations

Handbook for Critical Cleaning, 2000

Research paper thumbnail of Mechanistic Insights Aid the Search for CFC Substitutes: Risk Assessment of HCFC-123 as an Example

Risk Analysis, 1994

Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188),

Research paper thumbnail of Fault Tree Analysis for Exposure to Refrigerants Used for Automotive Air Conditioning in the United States

Research paper thumbnail of The History of the Halon Phaseout and Regulation of Halon Alternatives

ACS Symposium Series, 1997