Ruben Rodriguez - Academia.edu (original) (raw)

Papers by Ruben Rodriguez

Cefiro is a graduate student organization at Texas Tech University committed to the investigation... more Cefiro is a graduate student organization at Texas Tech University committed to the investigation and diffusion of Latin America's and Iberia's literary and cultural creations. Its journal publishes critical and fictional works on a wide range of themes and authors. Cefiro's journal is intended to be inclusive in its publications while maintaining its professionalism and integrity as an Academic Journal. We invite submissions of creative works, of no more that fifteen double-spaced pages written in Spanish or Portuguese, critical works of no more than twenty double spaced pages written in Spanish, PortUguese and English.

Journal of the American College of Surgeons

American Journal of Physiology-Endocrinology and Metabolism

Inappropriate activation of the renin-angiotensin system decreases glucose uptake in peripheral t... more Inappropriate activation of the renin-angiotensin system decreases glucose uptake in peripheral tissues. Chronic angiotensin receptor type 1 (AT1) blockade increases glucose uptake in skeletal muscle, decreases the abundance of large adipocytes, and macrophage infiltration in adipose. However, the contributions of each tissue to the improvement in hyperglycemia in response to AT1 blockade are not known. Therefore, we determined the static and dynamic responses of soleus muscle, liver, and adipose to an acute glucose challenge following the chronic blockade of AT1. We measured adipocyte morphology along with TNF-α expression, F4/80 and CD11c positive cells in adipose and measured insulin receptor (IR) phosphorylation and AKT phosphorylation in soleus muscle, liver, and retroperitoneal fat before (T0), 60 (T60), and 120 (T120) minutes after an acute glucose challenge in the following groups of male rats: LETO (lean control; n = 5/time point), (2) obese OLETF (n = 7-8/time point) and (...

DYNA

Aerosol-assisted chemical vapor deposition (AACVD) is a technique implicates the atomization of a... more Aerosol-assisted chemical vapor deposition (AACVD) is a technique implicates the atomization of a precursor solution into fine droplets which are dragged by a hot air flow throughout mobile nozzle unto heated reaction zone where occurring chemical reactions. In this work, implementation of the mechanical, electrical and electronic components for AACVD in descriptive way is presented. Equipment and experimental methods implemented are described, together to the automatization criteria of nozzle, temperature control of the heating plate and nebulizing system. The flowchart, the logic sequence of the speed control programming and statistical analysis of the nozzle displacement control were completed and checked, therefore an adequate link between the diverse components via Arduino with the design and automatization criteria was achieved. Finally, we conclude that the criteria and automatization process used permitted successfully to make uniform and reproducible coatings.

Anesthesiology

Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New... more Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the most recent definition. Our primary objective was to describe the natural course and the factors associated with worsening and mortality in this population. Methods This study analyzed patients from the international prospective Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) who had initial mild acute respiratory distress syndrome in the first day of inclusion. This study defined three groups based on the evolution of severity in the first week: “worsening” if moderate or severe acute respiratory distress syndrome cri...

American journal of physiology. Renal physiology, Jan 11, 2018

Pathological activation of the renin-angiotensin system and inflammation are associated with hype... more Pathological activation of the renin-angiotensin system and inflammation are associated with hypertension and the development of metabolic syndrome (MetS). The contributions of angiotensin receptor type 1 (AT1) activation, independent of blood pressure, and inflammation on glucose intolerance and renal damage are not well defined. Using a rat model of MetS, we hypothesized that the onset of glucose intolerance is primarily mediated by AT1 activation and inflammation independent of elevated systolic blood pressure (SBP). In order to address this hypothesis, we measured changes in SBP, adiposity, plasma glucose, triglycerides, and glucose tolerance in six groups of rats: (1) lean, strain-control Long Evans Tokushima Otsuka (LETO; n=5), (2) obese Otsuka Long-Evans Tokushima Fatty (OLETF; n=8), (3) OLETF + angiotensin receptor blocker (ARB; 10 mg olmesartan/kg; n=8), (4) OLETF + tumor necrosis factor-α (TNF-α) inhibitor (ETAN; 1.25mg etanercept/kg; n=6), (5) OLETF + angiotensin receptor...

Cancer Research

Background: Multiple myeloma (MM) is a usually fatal malignancy of plasma cells, with no current ... more Background: Multiple myeloma (MM) is a usually fatal malignancy of plasma cells, with no current therapy considered curative. About 15% of patients diagnosed with MM are stratified as high risk with poor treatment outcomes and short (2-3 years) survival from diagnosis. Standard risk patients tend to live longer but undergo chronic and/or high intensity therapy and likely experience a relapsing and remitting disease pattern. Therefore, there is still a considerable unmet need for innovative therapies that improve outcomes in MM. One such approach is to use adoptive transfer of engineered autologous T cells expressing a chimeric antigen receptor (CAR) directed against malignant cells. The efficacy of CAR T cells directed against hematological malignancies, particularly CD19-expressing B cell leukemia and lymphomas, has been demonstrated in multiple clinical studies. KITE-585 was developed as a CAR T cell immunotherapy product candidate directed against B cell maturation antigen (BCMA). BCMA is nearly ubiquitously expressed on MM cells, plasma cells and subsets of mature B cells, but with limited or absent expression on other tissues. Methods: We generated >50 fully human IgGs directed against BCMA using the BCMA protein as antigen and selection criteria including affinity, cross-reactivity and poly-specificity. Following assessment of the binding of the IgGs to a MM cell line known to express BCMA, >10 IgGs were identified that met the criteria for affinity and selectivity and had a >50-fold binding over background. The 8 IgGs that demonstrated the highest specific binding were then sequence-converted to single-chain variable fragments (scFvs) and incorporated into CARs. Results: In all but one case, human T cells engineered to express these CAR constructs exhibited specific cytolytic activity against MM cell lines (NCI-H929 and MM.1s). These CAR T cells demonstrated killing efficiencies of >95% at effector:target ratios of 1:1 over a 24-hour period. Similarly antigen-specific production of inflammatory cytokines was observed in response to target cell lines in vitro. Assessment of antigen-dependent proliferation over a 5 day period revealed >80% proliferation in the 7 constructs that showed cytolytic activity in vitro. Multiple different anti-BCMA CAR constructs representing distinct epitope binding bins of BCMA were then selected for in vivo evaluation. In two disseminated tumor models of luciferase labeled NCI-H929 or MM.1s cells injected intravenously (i.v.), a single i.v. injection of anti-BCMA CAR T-cells delayed the progression of disease and significantly increased survival when compared to control treatment. Conclusions: The results of these studies highlight the potential of targeting BCMA with adoptive transfer of engineered T cells for the treatment of MM. Given these positive findings, progress towards Phase 1 clinical studies in MM patients with KITE-585 is continuing. Citation Format: Gregor B. Adams, Jun Feng, Atefah Ghogha, Armen Mardiros, Jodi Murakami, Tammy Phung, Ruben Rodriguez, Stuart Sievers, Tassja J. Spindler, Jed Wiltzius, Clare Yarka, Sean C. Yoder, Tony Polverino. Development of KITE-585: A fully human BCMA CAR T-cell therapy for the treatment of multiple myeloma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4979. doi:10.1158/1538-7445.AM2017-4979

Gaceta Medica Espirituana, Oct 4, 2012

In some countries, the conventional Okun’s Law estimates do not show explicative results about th... more In some countries, the conventional Okun’s Law estimates do not show explicative results about the effects of unemployment on output, even if some theoretical extensions on models are included. Barreto and Howland (1993) have pointed out that, under certain conditions, applying the reverse regression on the conventional models could have some advantages. In particular, it allows a more appropriate (

Medicina Clínica, 2007

*Al final del artículo se indican los integrantes del Grupo Barbanza.

Annales de Chirurgie Vasculaire, 2009

L'objectif de cette etude etait de comparer, dans le cadre de l'isch emie critique, le projet th ... more L'objectif de cette etude etait de comparer, dans le cadre de l'isch emie critique, le projet th erapeutique d etermin e sur l' evaluation doppler pr eop eratoire avec le traitement finalement r ealis e, a la lumi ere des r esultats du traitement chirurgical ou endovasculaire. Sur une p eriode de 51 mois, un doppler pr eop eratoire etait r ealis ee chez 335 patients cons ecutifs en une isch emie critique, afin de d eterminer la meilleure strat egie th erapeutique. Les deux projets etaient finalement concordants dans 80%, 82,7% et 59% des cas respectivement, apr es examen des art eres iliaques, f emoro-poplit ees et jambi eres. Le plan op eratoire etait plus fr equemment modifi e dans les proc edures portant sur les vaisseaux distaux (10/44 [22,7%], p<0,01). En conclusion, l' evaluation doppler des patients ayant une maladie art erielle occlusive des membres inf erieurs permet de d eterminer un projet th erapeutique m edical, chirurgical ou endovasculaire avec un niveau elev e de concordance par rapport a ce qui est observ e lors des proc edures de revascularisation.

Journal of Experimental Biology, 2012

SUMMARY The northern elephant seal pup (Mirounga angustirostris) undergoes a 2–3 month post-weani... more SUMMARY The northern elephant seal pup (Mirounga angustirostris) undergoes a 2–3 month post-weaning fast, during which it depends primarily on the oxidation of fatty acids to meet its energetic demands. The concentration of non-esterified fatty acids (NEFAs) increases and is associated with the development of insulin resistance in late-fasted pups. Furthermore, plasma NEFA concentrations respond differentially to an intravenous glucose tolerance test (ivGTT) depending on fasting duration, suggesting that the effects of glucose on lipid metabolism are altered. However, elucidation of the lipolytic mechanisms including lipase activity during prolonged fasting in mammals is scarce. To assess the impact of fasting and glucose on the regulation of lipid metabolism, adipose tissue and plasma samples were collected before and after ivGTTs performed on early (2 weeks, N=5) and late (6–8 weeks; N=8) fasted pups. Glucose administration increased plasma triglycerides and NEFA concentrations in...

Religious Studies and Theology, 2008

(2007) Rodriguez. Religious Studies and Theology. Read by researchers in: 50% Education, 50% Soci... more (2007) Rodriguez. Religious Studies and Theology. Read by researchers in: 50% Education, 50% Social Sciences. This investigation contends that postfoundationalist models of rationality provide a constructive alternative to the positivist models of scientific rationality that once ...

Journal of Laparoendoscopic & Advanced Surgical Techniques, 2011

Thoracoscopic lobectomy for congenital cystic lung lesions is an accepted technique in pediatric ... more Thoracoscopic lobectomy for congenital cystic lung lesions is an accepted technique in pediatric surgery. Since an increasing number of these lesions are detected prenatally, the safety and efficacy of infant resections have been questioned. We reviewed our experience over a 10-year period to evaluate early resection of these lesions. From January 2001 to August 2009, 75 patients under 1 year of age and weighing &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;10 kg underwent thoracoscopic lobectomy at two institutions. Patients carried the following diagnoses: 52 had congenital cystic adenomatoid malformation, 20 had bronchopulmonary sequestration, and 3 had congenital lobar emphysema. All lesions were confirmed after birth by computed tomography scan. Patient age at operation ranged from 4 days to 11 months and patient weight from 3.1 to 10 kg. Seventy-four of 75 lobectomies were thoracoscopically completed. There were 16 upper lobectomies, 1 middle lobectomy, and 55 lower lobectomies. Operative time ranged from 45 to 225 minutes. Hospital length of stay ranged from 1 to 5 days. A subset of 26 patients had surgery younger than 3 months of age and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;5 kg, despite being asymptomatic. Their operative time averaged 90 minutes, and mean length of hospital stay was 1.5 days. Thoracoscopic lobectomy is safe for infants &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;10 kg and avoids the morbidity associated with thoracotomy. Operating early on younger patients may avoid the inflammatory changes associated with both clinically apparent and subclinical infections, even in patients weighing &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;5 kg. This may make the procedures less technically challenging and may result in lower complication and conversion rates.

Free Radical Biology and Medicine, 2011

… European Journal of …, 2004

... Department, University Clinical Hospital, Tv da Choupana s/n, 15706 Santiago de Compostela, S... more ... Department, University Clinical Hospital, Tv da Choupana s/n, 15706 Santiago de Compostela, Spain E-mail: jose.ramon.gonzalez.juatiatey ... 2 Gaede P, Vedel P, Larsen N, Jensen GVH, Parking HH, Pedersen 0. Multifaaorial Intervention and Cardiovascular Disease in Patients ...