Rukhsana Rub - Academia.edu (original) (raw)
Papers by Rukhsana Rub
International research journal of pharmacy, Dec 28, 2010
Cichorium intybus a member of Asteraceae family, is a perennial herb cultivated throughout India.... more Cichorium intybus a member of Asteraceae family, is a perennial herb cultivated throughout India. It is commonly known as Chicory. It has been reported to have antifungal, antitibacterial, hypoglycemic and hepatoprotective activity in various traditional systems of medicine. It is also found to have antineoplstic, antioxidant, analgesic and sedative activity. As the Pharmacognostic and Phytochemical data on the seeds of Cichorium intybus have not been reported previously, various pharmacognostic parameters like, examination of macroscopical, microscopical characters, ash values, extractive values, foreign organic matter and LOD were studied with the aim of establishing monograph for this species. Phytochemical screening included qualitative chemical examination and Thin layer chromatography of the detected phytoconstituents. Microscopical characters showed the presence of parenchyma, single layered tangentially elongated epidermis, well defined endosperm and papus. Powder characteristic also showed the presence of epidermal cells, papus and endosperm. The total ash, water soluble ash and acid insoluble ash were found to be 9.2%w/w, 1.1%w/w, 1.4%w/w respectively. The moisture content was found to be 7 w/w. Water, Alcohol and Chloroform soluble extractive values were found to be 12.2%w/w,13.4%w/w, 1.2%w/w respectively. Preliminary phytochemical investigation of aqueous and methanolic extract of seeds of cichorium intybus revealed the presence of Carbohydrates, Alkaloids, Tannins and Flovonoids which were further confirmed by thin layer chromatography with the Rf values as 0.94,0.75 and 0.78 for carbohydrates, alkaloids, flavonoids and 0.81 and 0.90 for tannins and flavonoids respectively.
International Journal of Applied Research in Natural Products, Jan 16, 2012
Research Journal of Pharmacognosy and Phytochemistry, 2010
Cichorium intybus a member of Asteraceae family, is a perennial herb cultivated throughout India.... more Cichorium intybus a member of Asteraceae family, is a perennial herb cultivated throughout India. It is commonly known as Chicory. It has been reported to have antifungal, antitibacterial, hypoglycemic and hepatoprotective activity in various traditional systems of medicine. It is also found to have antineoplstic, antioxidant, analgesic and sedative activity. As the Pharmacognostic and Phytochemical data on the seeds of Cichorium intybus have not been reported previously, various pharmacognostic parameters like, examination of macroscopical, microscopical characters, ash values, extractive values, foreign organic matter and LOD were studied with the aim of establishing monograph for this species. Phytochemical screening included qualitative chemical examination and Thin layer chromatography of the detected phytoconstituents. Microscopical characters showed the presence of parenchyma, single layered tangentially elongated epidermis, well defined endosperm and papus. Powder characteristic also showed the presence of epidermal cells, papus and endosperm. The total ash, water soluble ash and acid insoluble ash were found to be 9.2%w/w, 1.1%w/w, 1.4%w/w respectively. The moisture content was found to be 7 w/w. Water, Alcohol and Chloroform soluble extractive values were found to be 12.2%w/w,13.4%w/w, 1.2%w/w respectively. Preliminary phytochemical investigation of aqueous and methanolic extract of seeds of cichorium intybus revealed the presence of Carbohydrates, Alkaloids, Tannins and Flovonoids which were further confirmed by thin layer chromatography with the Rf values as 0.94,0.75 and 0.78 for carbohydrates, alkaloids, flavonoids and 0.81 and 0.90 for tannins and flavonoids respectively.
international journal of chemical sciences, 2009
International Journal of Pharmaceutical Sciences and Research, 2010
The plant Tephrosia purpurea L. is commonly known as Unhali. T. purpurea (Leguminosae) is a copio... more The plant Tephrosia purpurea L. is commonly known as Unhali. T. purpurea (Leguminosae) is a copiously branched perennial herb. Present work was undertaken to study antioxidant potential of the plant. Dried ethanol and aqueous extracts plant were screened for in-vitro antioxidant activity by DPPH assay and nitric oxide screening methods. Results showed that IC50 value of aqueous extract in DPPH assay and nitric oxide scavenging assay are 78 ug/ml and 89 ug/ml respectively. Phytochemical screening revealed that flavonoids, alkaloids, saponins, tannins and phenolic compound are present in aqueous extract and may be responsible for the activity. It can be concluded that the aqueous extract of T. purpurea L. root can be used as antioxidant and it can be recommended for the treatment of various disease.
Pharmaceutical Biology, 2011
European Journal of Surgical Oncology (EJSO), 2001
J. Pharm. Science and Res, 2010
The present study was undertaken with an objective to find out the antibacterial activity of Ficu... more The present study was undertaken with an objective to find out the antibacterial activity of Ficus Recemosa Linn. Leaves against Actinomycets viscosus .The hydro alcoholic extract of Ficus Recemosa Linn. Was found effective against Actinomyces vicosus (MTCC 7345). The minimum inhibitory concentration (MIC) was determined using Broth dilution technique and found to be 0.08mg/ml. The zone of inhibition was measured using Cup plate diffusion technique.
Aerial parts of Celosia argentea Linn. (Amaranthaceae) were extracted with 70 % ethanol and water... more Aerial parts of Celosia argentea Linn. (Amaranthaceae) were extracted with 70 % ethanol and water to produce respective extracts. These extracts were screened for delayed type hypersensitivity (DTH), neutrophil adhesion test and cyclophosphamide-induced myelosuppression to assess the effect on immunity in Swiss albino mice at the dose of 50 and 100 mg/kg, i.p. Results showed significant immunomodulating activity of aqueous extract.
Latin American Journal of Pharmacy, 2011
Current Aspects in Pharmaceutical Research and Development Vol. 6, 2021
Pharmacognosy Journal, 2012
Chicory, Cichorium intybus, (Asteraceae), is a biennial or perennial herb and is a native of Euro... more Chicory, Cichorium intybus, (Asteraceae), is a biennial or perennial herb and is a native of Europe and Asia. Chicory is an important foodstuff appreciated for its bitter taste. Ground roasted powder of the roots is mixed with coffee to impart rich flavor and to decrease caffeine content of the coffee formulation. The plant is a good tonic, cooling and is useful in headache, throat inflammation and enlargement of spleen. The extensive research work claims hypoglycemic, antiallergic, antineoplstic, fecal bulking property for the roots of Chicory. Immunostimulation, mutagenic, probiotic, hepatoprotective,antitibacterial activity etc are the other pharmacological actions attributed to a wide range of phytoconstituents like sesquiterpene lactones, responsible for bitter taste of the plant, eg: lactucin, lactupicrin; coumarines like cichoriin; flavonoids like quercetin 3 galactoside. It also contains, inulin (upto 60%), phlobaphenes, phenolic acids like cichoric acid. The present review ...
Randia dumetorum Lamk., a plant widely used in the traditional medicinal systems of India, has be... more Randia dumetorum Lamk., a plant widely used in the traditional medicinal systems of India, has been reported to possess antiviral, antibacterial and anti-inflammatory activities. In present study, the attempt was made to screen immunomodulatory activity of methanol extract and its petroleum ether, chloroform, ethyl acetate and methanol fraction of fruits of R. dumetorum. The effects of R. dumetorum on cell mediated and humoral components of the immune system in mice were observed. Administration of chloroform fraction at dose 100 mg/kg produced statistically significant results as evidenced by increase in humoral antibody (HA) titre (p < 0.05), delayed type hypersensitivity (DTH) response (p < 0.001).This fraction also enhanced the total WBC level in cyclophosphamide induced mylosuppression model (p < 0.001) at dose 100 mg/kg. Petroleum ether fraction and methanol fraction affected only cell mediated immunity. Present study, therefore reveals that drug holds promise as immu...
Journal of Pharmaceutical Research International, 2021
Aim: Silymarin, a complex polyphenolic component mixture with anti-oxidant, anti-inflammatory, an... more Aim: Silymarin, a complex polyphenolic component mixture with anti-oxidant, anti-inflammatory, and membrane-stabilizing property is being investigated in several dermatological conditions. Present research aims to evaluate potential of silymarin loaded nanocochleates and liposomal topical application for treating chronic skin diseases. Study Design: Silymarin loaded liposomes and nanocochleates were formulated and optimized using Design Expert software. Different invitro and exvivo tests were performed to compare their performance. Place and Duration of Study: The study was conducted in Smt. Kashibai Navale College of Pharmacy, Pune, India, between January 2019 till February 2020. Methodology: Liposomes were prepared using ethanol injection method and further treated with calcium chloride to form nanocochleates by trapping method. Design of experiments (32 Factorial Design) was used for optimization of nanocochleates. Cell line studies (HaCaT cell lines) and short term stability st...
Asian Journal of Research in Chemistry, 2009
Quirivelia frutescens (Apocynaceae) also known as kalidudhi or shymlata is much branched twining ... more Quirivelia frutescens (Apocynaceae) also known as kalidudhi or shymlata is much branched twining shrub of West Bengal. It is used by natives as wound healing, digestive.etc. However the plant is not much explored pharmacognostically and phytochemically, therefore the aim of this study was to evaluate pharmacognostic and phytochemical characteristics of plant Quirivelia fructescens. Microscopy of leaves showed distinct bicollateral vascular bundle,single layer of palisade, and well defined anomocytic stomata. Presence of calcium oxalate crystal in the form of thin pointed needle and xylem vessels with circular bordered pits were observed in the stem.
Research Journal of Pharmacognosy and Phytochemistry, 2010
Salvadora persica linn. (Salvadoraceae), a desert plant, also known as toothbrush tree or Miswak ... more Salvadora persica linn. (Salvadoraceae), a desert plant, also known as toothbrush tree or Miswak is used as tooth cleaning stick in many third world countries. The aqueous and alcoholic extracts of roots, leaves, bark and pulp of Salvadora persica linn have been found to have antimicrobial, anti-plaque, analgesic, antipyretic, antioxidant and antiulcer activity. Since the plant is not much explored pharmacognistically and phytochemically, the present work is planned to study the pharmacognostic, phytochemical and chromatographic behavior and to establish the monograph of the plant.
Asian Journal of Research in Chemistry, 2009
The aim of this study was to increase the aqueous solubility of Ezetimibe (EZE) by solid dispersi... more The aim of this study was to increase the aqueous solubility of Ezetimibe (EZE) by solid dispersions with polyethylene glycol 6000 (PEG 6000) and polyvinylpyrrolidone K-30 (PVP K30). Amorphous solid dispersions were prepared by freeze drying technique. The interaction of EZE with the hydrophilic polymers was evaluated by differential scanning calorimetry (DSC), powder x-ray diffractometry (PXRD) Fourier transformation-infrared spectroscopy (FTIR), Scanning electron microscopy (SEM). PXRD and DSC analysis confirmed the amorphous state of freeze dried formulations with respect to the plain drug. The influence of type of polymer, the ratio of drug to polymer on the solubility and dissolution rate of the drug were also evaluated. The solubility and dissolution rates of EZE were significantly increased by solid dispersions as well as their physical mixtures. The improvement of solubility using polymers was in the following order: PVP K30 > PEG 6000.
Research Journal of Pharmacognosy and Phytochemistry, 2010
Recent acceptance of natural herbal medicines as an alternative form of health care and developme... more Recent acceptance of natural herbal medicines as an alternative form of health care and development of microbial resistance has led to investigate the antimicrobial action of medicinal plants. Present investigation is focused on antimicrobial potential of nine commonly used Indian medicinal herbs. The antimicrobial screening of hydroalcoholic extract of all the nine plants was carried out by agar welldiffusion method and broth dilution method. The efficacy of extracts has been evaluated in terms of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against pathogenic strains of Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 9027) and Candida albicance (ATCC 10231). MIC values of individual extracts ranged between 0.4–0.9 mg/ml. MIC values of the combined crude extracts were recorded as 0.3 mg/ml (C. albicance), 0.5 mg/ml (Staph. aureus), and 0.6 mg/ml (P. aeruginosa). The MIC values obtained in each test organisms were inhibitory as ...
International research journal of pharmacy, Dec 28, 2010
Cichorium intybus a member of Asteraceae family, is a perennial herb cultivated throughout India.... more Cichorium intybus a member of Asteraceae family, is a perennial herb cultivated throughout India. It is commonly known as Chicory. It has been reported to have antifungal, antitibacterial, hypoglycemic and hepatoprotective activity in various traditional systems of medicine. It is also found to have antineoplstic, antioxidant, analgesic and sedative activity. As the Pharmacognostic and Phytochemical data on the seeds of Cichorium intybus have not been reported previously, various pharmacognostic parameters like, examination of macroscopical, microscopical characters, ash values, extractive values, foreign organic matter and LOD were studied with the aim of establishing monograph for this species. Phytochemical screening included qualitative chemical examination and Thin layer chromatography of the detected phytoconstituents. Microscopical characters showed the presence of parenchyma, single layered tangentially elongated epidermis, well defined endosperm and papus. Powder characteristic also showed the presence of epidermal cells, papus and endosperm. The total ash, water soluble ash and acid insoluble ash were found to be 9.2%w/w, 1.1%w/w, 1.4%w/w respectively. The moisture content was found to be 7 w/w. Water, Alcohol and Chloroform soluble extractive values were found to be 12.2%w/w,13.4%w/w, 1.2%w/w respectively. Preliminary phytochemical investigation of aqueous and methanolic extract of seeds of cichorium intybus revealed the presence of Carbohydrates, Alkaloids, Tannins and Flovonoids which were further confirmed by thin layer chromatography with the Rf values as 0.94,0.75 and 0.78 for carbohydrates, alkaloids, flavonoids and 0.81 and 0.90 for tannins and flavonoids respectively.
International Journal of Applied Research in Natural Products, Jan 16, 2012
Research Journal of Pharmacognosy and Phytochemistry, 2010
Cichorium intybus a member of Asteraceae family, is a perennial herb cultivated throughout India.... more Cichorium intybus a member of Asteraceae family, is a perennial herb cultivated throughout India. It is commonly known as Chicory. It has been reported to have antifungal, antitibacterial, hypoglycemic and hepatoprotective activity in various traditional systems of medicine. It is also found to have antineoplstic, antioxidant, analgesic and sedative activity. As the Pharmacognostic and Phytochemical data on the seeds of Cichorium intybus have not been reported previously, various pharmacognostic parameters like, examination of macroscopical, microscopical characters, ash values, extractive values, foreign organic matter and LOD were studied with the aim of establishing monograph for this species. Phytochemical screening included qualitative chemical examination and Thin layer chromatography of the detected phytoconstituents. Microscopical characters showed the presence of parenchyma, single layered tangentially elongated epidermis, well defined endosperm and papus. Powder characteristic also showed the presence of epidermal cells, papus and endosperm. The total ash, water soluble ash and acid insoluble ash were found to be 9.2%w/w, 1.1%w/w, 1.4%w/w respectively. The moisture content was found to be 7 w/w. Water, Alcohol and Chloroform soluble extractive values were found to be 12.2%w/w,13.4%w/w, 1.2%w/w respectively. Preliminary phytochemical investigation of aqueous and methanolic extract of seeds of cichorium intybus revealed the presence of Carbohydrates, Alkaloids, Tannins and Flovonoids which were further confirmed by thin layer chromatography with the Rf values as 0.94,0.75 and 0.78 for carbohydrates, alkaloids, flavonoids and 0.81 and 0.90 for tannins and flavonoids respectively.
international journal of chemical sciences, 2009
International Journal of Pharmaceutical Sciences and Research, 2010
The plant Tephrosia purpurea L. is commonly known as Unhali. T. purpurea (Leguminosae) is a copio... more The plant Tephrosia purpurea L. is commonly known as Unhali. T. purpurea (Leguminosae) is a copiously branched perennial herb. Present work was undertaken to study antioxidant potential of the plant. Dried ethanol and aqueous extracts plant were screened for in-vitro antioxidant activity by DPPH assay and nitric oxide screening methods. Results showed that IC50 value of aqueous extract in DPPH assay and nitric oxide scavenging assay are 78 ug/ml and 89 ug/ml respectively. Phytochemical screening revealed that flavonoids, alkaloids, saponins, tannins and phenolic compound are present in aqueous extract and may be responsible for the activity. It can be concluded that the aqueous extract of T. purpurea L. root can be used as antioxidant and it can be recommended for the treatment of various disease.
Pharmaceutical Biology, 2011
European Journal of Surgical Oncology (EJSO), 2001
J. Pharm. Science and Res, 2010
The present study was undertaken with an objective to find out the antibacterial activity of Ficu... more The present study was undertaken with an objective to find out the antibacterial activity of Ficus Recemosa Linn. Leaves against Actinomycets viscosus .The hydro alcoholic extract of Ficus Recemosa Linn. Was found effective against Actinomyces vicosus (MTCC 7345). The minimum inhibitory concentration (MIC) was determined using Broth dilution technique and found to be 0.08mg/ml. The zone of inhibition was measured using Cup plate diffusion technique.
Aerial parts of Celosia argentea Linn. (Amaranthaceae) were extracted with 70 % ethanol and water... more Aerial parts of Celosia argentea Linn. (Amaranthaceae) were extracted with 70 % ethanol and water to produce respective extracts. These extracts were screened for delayed type hypersensitivity (DTH), neutrophil adhesion test and cyclophosphamide-induced myelosuppression to assess the effect on immunity in Swiss albino mice at the dose of 50 and 100 mg/kg, i.p. Results showed significant immunomodulating activity of aqueous extract.
Latin American Journal of Pharmacy, 2011
Current Aspects in Pharmaceutical Research and Development Vol. 6, 2021
Pharmacognosy Journal, 2012
Chicory, Cichorium intybus, (Asteraceae), is a biennial or perennial herb and is a native of Euro... more Chicory, Cichorium intybus, (Asteraceae), is a biennial or perennial herb and is a native of Europe and Asia. Chicory is an important foodstuff appreciated for its bitter taste. Ground roasted powder of the roots is mixed with coffee to impart rich flavor and to decrease caffeine content of the coffee formulation. The plant is a good tonic, cooling and is useful in headache, throat inflammation and enlargement of spleen. The extensive research work claims hypoglycemic, antiallergic, antineoplstic, fecal bulking property for the roots of Chicory. Immunostimulation, mutagenic, probiotic, hepatoprotective,antitibacterial activity etc are the other pharmacological actions attributed to a wide range of phytoconstituents like sesquiterpene lactones, responsible for bitter taste of the plant, eg: lactucin, lactupicrin; coumarines like cichoriin; flavonoids like quercetin 3 galactoside. It also contains, inulin (upto 60%), phlobaphenes, phenolic acids like cichoric acid. The present review ...
Randia dumetorum Lamk., a plant widely used in the traditional medicinal systems of India, has be... more Randia dumetorum Lamk., a plant widely used in the traditional medicinal systems of India, has been reported to possess antiviral, antibacterial and anti-inflammatory activities. In present study, the attempt was made to screen immunomodulatory activity of methanol extract and its petroleum ether, chloroform, ethyl acetate and methanol fraction of fruits of R. dumetorum. The effects of R. dumetorum on cell mediated and humoral components of the immune system in mice were observed. Administration of chloroform fraction at dose 100 mg/kg produced statistically significant results as evidenced by increase in humoral antibody (HA) titre (p < 0.05), delayed type hypersensitivity (DTH) response (p < 0.001).This fraction also enhanced the total WBC level in cyclophosphamide induced mylosuppression model (p < 0.001) at dose 100 mg/kg. Petroleum ether fraction and methanol fraction affected only cell mediated immunity. Present study, therefore reveals that drug holds promise as immu...
Journal of Pharmaceutical Research International, 2021
Aim: Silymarin, a complex polyphenolic component mixture with anti-oxidant, anti-inflammatory, an... more Aim: Silymarin, a complex polyphenolic component mixture with anti-oxidant, anti-inflammatory, and membrane-stabilizing property is being investigated in several dermatological conditions. Present research aims to evaluate potential of silymarin loaded nanocochleates and liposomal topical application for treating chronic skin diseases. Study Design: Silymarin loaded liposomes and nanocochleates were formulated and optimized using Design Expert software. Different invitro and exvivo tests were performed to compare their performance. Place and Duration of Study: The study was conducted in Smt. Kashibai Navale College of Pharmacy, Pune, India, between January 2019 till February 2020. Methodology: Liposomes were prepared using ethanol injection method and further treated with calcium chloride to form nanocochleates by trapping method. Design of experiments (32 Factorial Design) was used for optimization of nanocochleates. Cell line studies (HaCaT cell lines) and short term stability st...
Asian Journal of Research in Chemistry, 2009
Quirivelia frutescens (Apocynaceae) also known as kalidudhi or shymlata is much branched twining ... more Quirivelia frutescens (Apocynaceae) also known as kalidudhi or shymlata is much branched twining shrub of West Bengal. It is used by natives as wound healing, digestive.etc. However the plant is not much explored pharmacognostically and phytochemically, therefore the aim of this study was to evaluate pharmacognostic and phytochemical characteristics of plant Quirivelia fructescens. Microscopy of leaves showed distinct bicollateral vascular bundle,single layer of palisade, and well defined anomocytic stomata. Presence of calcium oxalate crystal in the form of thin pointed needle and xylem vessels with circular bordered pits were observed in the stem.
Research Journal of Pharmacognosy and Phytochemistry, 2010
Salvadora persica linn. (Salvadoraceae), a desert plant, also known as toothbrush tree or Miswak ... more Salvadora persica linn. (Salvadoraceae), a desert plant, also known as toothbrush tree or Miswak is used as tooth cleaning stick in many third world countries. The aqueous and alcoholic extracts of roots, leaves, bark and pulp of Salvadora persica linn have been found to have antimicrobial, anti-plaque, analgesic, antipyretic, antioxidant and antiulcer activity. Since the plant is not much explored pharmacognistically and phytochemically, the present work is planned to study the pharmacognostic, phytochemical and chromatographic behavior and to establish the monograph of the plant.
Asian Journal of Research in Chemistry, 2009
The aim of this study was to increase the aqueous solubility of Ezetimibe (EZE) by solid dispersi... more The aim of this study was to increase the aqueous solubility of Ezetimibe (EZE) by solid dispersions with polyethylene glycol 6000 (PEG 6000) and polyvinylpyrrolidone K-30 (PVP K30). Amorphous solid dispersions were prepared by freeze drying technique. The interaction of EZE with the hydrophilic polymers was evaluated by differential scanning calorimetry (DSC), powder x-ray diffractometry (PXRD) Fourier transformation-infrared spectroscopy (FTIR), Scanning electron microscopy (SEM). PXRD and DSC analysis confirmed the amorphous state of freeze dried formulations with respect to the plain drug. The influence of type of polymer, the ratio of drug to polymer on the solubility and dissolution rate of the drug were also evaluated. The solubility and dissolution rates of EZE were significantly increased by solid dispersions as well as their physical mixtures. The improvement of solubility using polymers was in the following order: PVP K30 > PEG 6000.
Research Journal of Pharmacognosy and Phytochemistry, 2010
Recent acceptance of natural herbal medicines as an alternative form of health care and developme... more Recent acceptance of natural herbal medicines as an alternative form of health care and development of microbial resistance has led to investigate the antimicrobial action of medicinal plants. Present investigation is focused on antimicrobial potential of nine commonly used Indian medicinal herbs. The antimicrobial screening of hydroalcoholic extract of all the nine plants was carried out by agar welldiffusion method and broth dilution method. The efficacy of extracts has been evaluated in terms of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against pathogenic strains of Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 9027) and Candida albicance (ATCC 10231). MIC values of individual extracts ranged between 0.4–0.9 mg/ml. MIC values of the combined crude extracts were recorded as 0.3 mg/ml (C. albicance), 0.5 mg/ml (Staph. aureus), and 0.6 mg/ml (P. aeruginosa). The MIC values obtained in each test organisms were inhibitory as ...