Ryosuke MITSUI - Academia.edu (original) (raw)
Papers by Ryosuke MITSUI
Acta Crystallographica Section E-structure Reports Online, 2008
diffractometer Absorption correction: numerical
Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C 25 H 16 Cl 2 O 4 ÁC 2 H 6 O, the two 4chlorobenzoyl groups are in syn or... more In the title compound, C 25 H 16 Cl 2 O 4 ÁC 2 H 6 O, the two 4chlorobenzoyl groups are in syn orientations with respect to the naphthalene ring system and are approximately parallel to each other: the dihedral angle between the benzene rings is 11.43 (16). The conformation around each of the carbonyl C-(C O)-C groups forms a larger angle to the plane of the naphthalene ring system than that to the benzene ring; the angles of the C O bond vector with the naphthalene ring system and the benzene ring are 55.4 (3) versus 13.5 (3) and 52.2 (3) versus 17.9 (3). An intramolecular O-HÁ Á ÁO C hydrogen bond generates a six-membered ring. In the crystal structure, intermolecular O-HÁ Á ÁO hydrogen bonds including the ethanol solvent molecule are observed. A C-HÁ Á ÁO interaction also occurs. The ethyl group of the ethanol molecule is disordered over two positions with site occupancies of 0.63 and 0.37. The crystal studied was an inversion twin.
Acta Crystallographica Section E Structure Reports Online, 2008
Acta Crystallographica Section E Structure Reports Online, 2010
Cell-derived nanoparticles (CDNPs) containing cytosolic proteins and RNAs/DNAs can be isolated fr... more Cell-derived nanoparticles (CDNPs) containing cytosolic proteins and RNAs/DNAs can be isolated from stressed eukaryotic cells. Previously, CDNPs isolated from cultured cells, exerted immunomodulatory activities in different infections. Here, we sought to elucidate the role of CDNPs using a murine model of cecal ligation and puncture (CLP). We hypothesized that CDNPs influence the immune response at the site of infection, where severe cellular stress occurs. We observed early CDNP accumulation in the peritoneum after 4 hours and continued CDNP presence 24 hours after CLP. To determine whether CDNPs influence the host response to sepsis, we isolated CDNPs from a murine fibroblast cell line stressed by nutrient-deprivation, and injected them into septic mice. CDNP-treated mice demonstrated decreased peritoneal IL6-levels and an approximately 2-log lower bacterial load compared to control mice 24 hours after CLP. Additionally, a 20% CFU reduction was observed when incubating CDNPs with Pseudomona aeroginosa, indicating that CDNPs are bactericidal. To identify CDNP-responsive cells, CFSElabeled CDNPs were injected into mice at the time of CLP. We observed that CDNPs were preferentially ingested by F4/80 + macrophages, and to a lesser degree, associated with inflammatory monocytes and neutrophils. Strikingly, CDNP-ingesting cells demonstrated elevated CD11b and MHCII expression compared to control cells. Altogether, our data indicate that CDNPs enhance the immune response at the site of infection and promote bacterial clearance, by 1) direct bacterial killing and 2) increasing phagocyte activation. Thus, CDNPs represent a novel, unexplored endogenous sepsis modulator with therapeutic potential.
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](Acta Crystallographica Section E Structure Reports Online, 2010
Acta Crystallographica Section E Structure Reports Online, 2009
Electronics, 2015
With the escalating demands for downsizing and functionalizing mobile electronics, flexible elect... more With the escalating demands for downsizing and functionalizing mobile electronics, flexible electronics have become an important aspect of future technologies. To address limitations concerning junction deformation, we developed a new connection method using a film-type connector that is less than 0.1 mm thick. The film-type connector is composed of an organic film substrate, a UV-curable adhesive that deforms elastically under pressure, and electrodes that are arranged on the adhesive. The film-type connection relies on a plate-to-plate contact, which ensures a sufficient contact area. The electrical reliability of the film-type connection was investigated based on changes in the resistance during bending at curvature radii of 70, 50, 25, 10, 5, and 2.5 mm. The connection was bent 1000 times to investigate the reproducibility of the connector's bending properties. The tests showed that no disconnections occurred due to bending in the vertical direction of the electrode, but disconnections were observed due to bending in the parallel direction at curvature radii of 10, 5, and 2.5 mm. In addition, the maximum average change in resistance was less than 70 milliohms unless a disconnection was generated. These results support the application of the new film-type connection in future flexible devices.
Scientific Reports, 2016
We describe a flexible capacitance-type sensor that can detect an approaching human without conta... more We describe a flexible capacitance-type sensor that can detect an approaching human without contact, fabricated by developing and applying duplex conductive-ink printing to a film substrate. The results of our calculations show that the difference in size between the top and bottom electrodes of the sensor allows for the spatial extension of the electric field distribution over the electrodes. Hence, such a component functions as a proximity sensor. This thin and light device with a large form factor can be arranged at various places, including curved surfaces and the back of objects such that it is unnoticeable. In our experiment, we attached it to the back of a bed, and found that our device successfully detected the breathing of a subject on the bed without contacting his body. This should contribute to reducing the physical and psychological discomfort among patients during medical checks, or when their condition is being monitored.
Japanese Journal of Applied Physics, 2016
International Journal of Organic Chemistry, 2012
AlCl 3-mediated cleavage of ethereal methyl-oxygen bond in aroylated 2,7-dimethoxynaphthalene com... more AlCl 3-mediated cleavage of ethereal methyl-oxygen bond in aroylated 2,7-dimethoxynaphthalene compounds proceeds chemospecifically and regioselectively. The ethereal bond at the β(2)-position of 1-monoaroylated 2,7-dimeth-oxynaphthalene is cleaved readily and predominantly against the β(7)-position, whereas scission of β-ethereal bonds of 1,8-diaroylated 2,7-dimethoxynaphthalene hardly undergoes like the non-aroylated mother frame compound of 2,7dimethoxynaphthalene.
ChemInform, 2012
Lewis Acid-Mediated ArS E Aroylation of Naphthalene Derivative: Distinct Second Aroylation Behavi... more Lewis Acid-Mediated ArS E Aroylation of Naphthalene Derivative: Distinct Second Aroylation Behavior of α-Naphthyl Ketone.-In the presented title reaction the formation of the products strongly depends on the Lewis acid and the specific conditions.-(OKAMOTO, A.;
Journal of Micromechanics and Microengineering, 2014
ABSTRACT Screen-offset printing combines screen-printing on a silicone blanket with transference ... more ABSTRACT Screen-offset printing combines screen-printing on a silicone blanket with transference of the print from the blanket to a substrate. The blanket absorbs organic solvents in the ink, and therefore, the ink does not disperse through the material. This prevents blurring and allows fine patterns with widths of a few tens of micrometres to be produced. However, continuous printing deteriorates the pattern's shape, which may be a result of decay in the absorption abilities of the blanket. Thus, we have developed a new technique for refreshing the blanket by substituting high-boiling-point solvents present on the blanket surface with low-boiling-point solvents. We analyse the efficacy of this technique, and demonstrate continuous fine pattern formation for 100 screen-offset printing processes.
2014 International Conference on Electronics Packaging (ICEP), 2014
ABSTRACT A reliability of a new film-type connection is investigated and compared to a convention... more ABSTRACT A reliability of a new film-type connection is investigated and compared to a conventional anisotropic conducting adhesive technology, e.g., an anisotropic conductive film (ACF) joint by measuring the contact resistance through environmental tests and flexibility tests. A film-type connector which thickness less than 0.1 mm is composed of a base material such as polyimide, an adhesive layer which deforms elastically against pressure, and electrodes arranged on the adhesive layer. Results of the test show that the film-type connection has some advantages compared to the ACF joint in mildness of the connecting condition and the contact resistance stability.
2014 International Conference on Electronics Packaging (ICEP), 2014
ABSTRACT We developed a new printing method called “screen-offset printing.” This method is the c... more ABSTRACT We developed a new printing method called “screen-offset printing.” This method is the combination of screen printing and transfer printing techniques; ink is first screen-printed on a silicone blanket, and the ink is then transferred from the blanket onto a substrate. Such a procedure allows the formation of patterns with highly rectangular cross sections and finer patterns than can be achieved by conventional screen printing. In the present paper, we explain the details of this process and analyze its efficacy by comparing the experimental results of screen-offset printing with those of conventional screen printing. Further, we introduce a currently developing automated screen-offset printing machine and demonstrate the formation of fine patterns 20 μm in width.
2014 IEEE 3rd Global Conference on Consumer Electronics (GCCE), 2014
Microelectronic Engineering, 2014
Screen printing is a useful method for fabricating electrodes or signal wires of electronic devic... more Screen printing is a useful method for fabricating electrodes or signal wires of electronic devices. However, finer patterns, e.g., 50-lm-wide, are difficult to form. Herein, we introduce a newly developed printing technique called ''screen-offset printing,'' as a candidate method for solving this problem. In this process, first, ink patterns are screen-printed on a silicone-resin blanket; they are then transferred from the blanket to an object. In the present study, we analyze the features of screen-offset printing by observing printed conductive patterns, and elucidate the impact of this method by comparing the experimental results of screen-offset printing and conventional screen printing. In addition, we demonstrate the fabrication of fine patterns with a line and space (L/S) of 50/50 and 30/30 lm.
Acta Crystallographica Section E-structure Reports Online, 2008
diffractometer Absorption correction: numerical
Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C 25 H 16 Cl 2 O 4 ÁC 2 H 6 O, the two 4chlorobenzoyl groups are in syn or... more In the title compound, C 25 H 16 Cl 2 O 4 ÁC 2 H 6 O, the two 4chlorobenzoyl groups are in syn orientations with respect to the naphthalene ring system and are approximately parallel to each other: the dihedral angle between the benzene rings is 11.43 (16). The conformation around each of the carbonyl C-(C O)-C groups forms a larger angle to the plane of the naphthalene ring system than that to the benzene ring; the angles of the C O bond vector with the naphthalene ring system and the benzene ring are 55.4 (3) versus 13.5 (3) and 52.2 (3) versus 17.9 (3). An intramolecular O-HÁ Á ÁO C hydrogen bond generates a six-membered ring. In the crystal structure, intermolecular O-HÁ Á ÁO hydrogen bonds including the ethanol solvent molecule are observed. A C-HÁ Á ÁO interaction also occurs. The ethyl group of the ethanol molecule is disordered over two positions with site occupancies of 0.63 and 0.37. The crystal studied was an inversion twin.
Acta Crystallographica Section E Structure Reports Online, 2008
Acta Crystallographica Section E Structure Reports Online, 2010
Cell-derived nanoparticles (CDNPs) containing cytosolic proteins and RNAs/DNAs can be isolated fr... more Cell-derived nanoparticles (CDNPs) containing cytosolic proteins and RNAs/DNAs can be isolated from stressed eukaryotic cells. Previously, CDNPs isolated from cultured cells, exerted immunomodulatory activities in different infections. Here, we sought to elucidate the role of CDNPs using a murine model of cecal ligation and puncture (CLP). We hypothesized that CDNPs influence the immune response at the site of infection, where severe cellular stress occurs. We observed early CDNP accumulation in the peritoneum after 4 hours and continued CDNP presence 24 hours after CLP. To determine whether CDNPs influence the host response to sepsis, we isolated CDNPs from a murine fibroblast cell line stressed by nutrient-deprivation, and injected them into septic mice. CDNP-treated mice demonstrated decreased peritoneal IL6-levels and an approximately 2-log lower bacterial load compared to control mice 24 hours after CLP. Additionally, a 20% CFU reduction was observed when incubating CDNPs with Pseudomona aeroginosa, indicating that CDNPs are bactericidal. To identify CDNP-responsive cells, CFSElabeled CDNPs were injected into mice at the time of CLP. We observed that CDNPs were preferentially ingested by F4/80 + macrophages, and to a lesser degree, associated with inflammatory monocytes and neutrophils. Strikingly, CDNP-ingesting cells demonstrated elevated CD11b and MHCII expression compared to control cells. Altogether, our data indicate that CDNPs enhance the immune response at the site of infection and promote bacterial clearance, by 1) direct bacterial killing and 2) increasing phagocyte activation. Thus, CDNPs represent a novel, unexplored endogenous sepsis modulator with therapeutic potential.
Acta Crystallographica Section E Structure Reports Online, 2010
Acta Crystallographica Section E Structure Reports Online, 2009
Electronics, 2015
With the escalating demands for downsizing and functionalizing mobile electronics, flexible elect... more With the escalating demands for downsizing and functionalizing mobile electronics, flexible electronics have become an important aspect of future technologies. To address limitations concerning junction deformation, we developed a new connection method using a film-type connector that is less than 0.1 mm thick. The film-type connector is composed of an organic film substrate, a UV-curable adhesive that deforms elastically under pressure, and electrodes that are arranged on the adhesive. The film-type connection relies on a plate-to-plate contact, which ensures a sufficient contact area. The electrical reliability of the film-type connection was investigated based on changes in the resistance during bending at curvature radii of 70, 50, 25, 10, 5, and 2.5 mm. The connection was bent 1000 times to investigate the reproducibility of the connector's bending properties. The tests showed that no disconnections occurred due to bending in the vertical direction of the electrode, but disconnections were observed due to bending in the parallel direction at curvature radii of 10, 5, and 2.5 mm. In addition, the maximum average change in resistance was less than 70 milliohms unless a disconnection was generated. These results support the application of the new film-type connection in future flexible devices.
Scientific Reports, 2016
We describe a flexible capacitance-type sensor that can detect an approaching human without conta... more We describe a flexible capacitance-type sensor that can detect an approaching human without contact, fabricated by developing and applying duplex conductive-ink printing to a film substrate. The results of our calculations show that the difference in size between the top and bottom electrodes of the sensor allows for the spatial extension of the electric field distribution over the electrodes. Hence, such a component functions as a proximity sensor. This thin and light device with a large form factor can be arranged at various places, including curved surfaces and the back of objects such that it is unnoticeable. In our experiment, we attached it to the back of a bed, and found that our device successfully detected the breathing of a subject on the bed without contacting his body. This should contribute to reducing the physical and psychological discomfort among patients during medical checks, or when their condition is being monitored.
Japanese Journal of Applied Physics, 2016
International Journal of Organic Chemistry, 2012
AlCl 3-mediated cleavage of ethereal methyl-oxygen bond in aroylated 2,7-dimethoxynaphthalene com... more AlCl 3-mediated cleavage of ethereal methyl-oxygen bond in aroylated 2,7-dimethoxynaphthalene compounds proceeds chemospecifically and regioselectively. The ethereal bond at the β(2)-position of 1-monoaroylated 2,7-dimeth-oxynaphthalene is cleaved readily and predominantly against the β(7)-position, whereas scission of β-ethereal bonds of 1,8-diaroylated 2,7-dimethoxynaphthalene hardly undergoes like the non-aroylated mother frame compound of 2,7dimethoxynaphthalene.
ChemInform, 2012
Lewis Acid-Mediated ArS E Aroylation of Naphthalene Derivative: Distinct Second Aroylation Behavi... more Lewis Acid-Mediated ArS E Aroylation of Naphthalene Derivative: Distinct Second Aroylation Behavior of α-Naphthyl Ketone.-In the presented title reaction the formation of the products strongly depends on the Lewis acid and the specific conditions.-(OKAMOTO, A.;
Journal of Micromechanics and Microengineering, 2014
ABSTRACT Screen-offset printing combines screen-printing on a silicone blanket with transference ... more ABSTRACT Screen-offset printing combines screen-printing on a silicone blanket with transference of the print from the blanket to a substrate. The blanket absorbs organic solvents in the ink, and therefore, the ink does not disperse through the material. This prevents blurring and allows fine patterns with widths of a few tens of micrometres to be produced. However, continuous printing deteriorates the pattern's shape, which may be a result of decay in the absorption abilities of the blanket. Thus, we have developed a new technique for refreshing the blanket by substituting high-boiling-point solvents present on the blanket surface with low-boiling-point solvents. We analyse the efficacy of this technique, and demonstrate continuous fine pattern formation for 100 screen-offset printing processes.
2014 International Conference on Electronics Packaging (ICEP), 2014
ABSTRACT A reliability of a new film-type connection is investigated and compared to a convention... more ABSTRACT A reliability of a new film-type connection is investigated and compared to a conventional anisotropic conducting adhesive technology, e.g., an anisotropic conductive film (ACF) joint by measuring the contact resistance through environmental tests and flexibility tests. A film-type connector which thickness less than 0.1 mm is composed of a base material such as polyimide, an adhesive layer which deforms elastically against pressure, and electrodes arranged on the adhesive layer. Results of the test show that the film-type connection has some advantages compared to the ACF joint in mildness of the connecting condition and the contact resistance stability.
2014 International Conference on Electronics Packaging (ICEP), 2014
ABSTRACT We developed a new printing method called “screen-offset printing.” This method is the c... more ABSTRACT We developed a new printing method called “screen-offset printing.” This method is the combination of screen printing and transfer printing techniques; ink is first screen-printed on a silicone blanket, and the ink is then transferred from the blanket onto a substrate. Such a procedure allows the formation of patterns with highly rectangular cross sections and finer patterns than can be achieved by conventional screen printing. In the present paper, we explain the details of this process and analyze its efficacy by comparing the experimental results of screen-offset printing with those of conventional screen printing. Further, we introduce a currently developing automated screen-offset printing machine and demonstrate the formation of fine patterns 20 μm in width.
2014 IEEE 3rd Global Conference on Consumer Electronics (GCCE), 2014
Microelectronic Engineering, 2014
Screen printing is a useful method for fabricating electrodes or signal wires of electronic devic... more Screen printing is a useful method for fabricating electrodes or signal wires of electronic devices. However, finer patterns, e.g., 50-lm-wide, are difficult to form. Herein, we introduce a newly developed printing technique called ''screen-offset printing,'' as a candidate method for solving this problem. In this process, first, ink patterns are screen-printed on a silicone-resin blanket; they are then transferred from the blanket to an object. In the present study, we analyze the features of screen-offset printing by observing printed conductive patterns, and elucidate the impact of this method by comparing the experimental results of screen-offset printing and conventional screen printing. In addition, we demonstrate the fabrication of fine patterns with a line and space (L/S) of 50/50 and 30/30 lm.