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Papers by Sajad Arif

Journal of Enam Medical College, 2015

Background: Medically inappropriate, ineffective and economically inefficient use of drugs is ver... more Background: Medically inappropriate, ineffective and economically inefficient use of drugs is very common in our country. About 40% or more drugs expenditure may be wasted through irrational prescribing and dispensing. The need for promoting rational use of drugs is not only because of economic considerations; also it is an essential element for achieving quality of the health and medical care for patients and the community. For this purpose a cross sectional study was carried out among the individuals attending the outpatient departments

Indian Journal of Neurotrauma, 2020

Background Head injury is a major health hazard throughout the world. Overall, the mortality/morb... more Background Head injury is a major health hazard throughout the world. Overall, the mortality/morbidity has not changed much in the last few decades. In developing nations, the situation is worse. Methods The study was conducted for a period of 1 year. The data collected include demographic profile, mode, circumstances and timing of the injury, neurological assessment using Glasgow Coma Scale (GCS) scoring, computed tomography (CT) scan findings, type of management, and outcome. Results Transport-related injuries and falls were the common cause of head injury, with more severe injuries seen in patients without wearing helmets and seat belts. The youth is at high risk of receiving head injuries. The summer season showed a maximum incidence of head injuries. The most common lesions on CT scan were linear fracture of the skull and brain contusion. Mortality rate was 26% and it correlated with the GCS at presentation. Conclusion Head injury mostly affects young people and males outnumber...

Indian Journal of Neurosurgery, 2021

Despite advances in research and improved neurological intensive care in recent years, the clinic... more Despite advances in research and improved neurological intensive care in recent years, the clinical outcome of severely head injured patients is still poor. Primary insult is followed by a complex cascade of molecular and biochemical events that lead to neuroinflammation, brain edema, and delayed neuronal death. No specific pharmacological therapy is currently available which prevents the development of secondary brain injuries, and most therapeutic strategies have failed in translation from bench to bedside. There are limitations of clinical and radiological methods in delineating the exact severity and prognosis of traumatic brain injury (TBI). A myriad complex biochemical markers are under investigation to delineate the extent of brain tissue damage and to independently predict the outcome, but a search for simple biomarker still eludes the research. Progesterone, a gonadal hormone and a neurosteroid, although controversial as a neuroprotective agent, may hold promise as a simple...

The Journal of Spinal Surgery, 2017

Although intramedullary spinal cord tumors are predominantly primary tumors like ependymomas and ... more Although intramedullary spinal cord tumors are predominantly primary tumors like ependymomas and astrocytomas, the intramedullary spinal cord metastatic tumors account for 4 to 9% of all such tumors. With the advent of magnetic resonance imaging (MRI) and improvement in the survival of cancer patients due to effective therapeutic options, the number of patients harboring intramedullary spinal cord metastasis (IMSCM) is increasing. Review of large series of IMSCM has revealed rarity of intramedullary metastasis to conus medullaris (IMCM). We present a short series of two cases of IMCM managed in our hospital and review of literature to describe how it is different from IMSCM at other regions of spinal cord. We also describe various management options available in the light of 25 cases of conus metastasis described in the literature till date.

JMS SKIMS, 2009

A three year old female child presents with a rare combination of three complications, two months... more A three year old female child presents with a rare combination of three complications, two months after closed head injury. The linear fracture grew into a leptomeningeal cyst and a large brain abscess leads to hydrocephalus by causing ventriculitis thereby increasing the size of leptomeningeal cyst. J Med Sci 2009;12(2):56-57.

Asian journal of neurosurgery

We aimed to assess the effect of anti-tyrosine kinase inhibitors (TKIs) (gefitinib) in overall su... more We aimed to assess the effect of anti-tyrosine kinase inhibitors (TKIs) (gefitinib) in overall survival (OS) of the glioblastoma multiforme (GBM) patients in the backdrop of mutational status of epidermal growth factor receptor () and genes. All the patients subjected to resection or biopsies were put on gefitinib, and radiotherapy was delivered as per the hospital protocol. and mutational spectrum was performed by single-strand conformation polymorphism followed by DNA sequencing. In total, 50% GBM tumors had mutation either in or . Median progression-free survival (PFS) and OS observed in patients with +ve/ -ve were significantly favorable ( < 0.05) which aggregated to 9(7, 11) months and 20 (16, 24) months, respectively, than 6 (4, 8) months and 13 (7, 19) months in patients with +ve/ -ve. Patients positive for both / had lower disease-free survival and OS of 6 and 9 months as compared to 6 (5, 7) and 14 (12, 24) months for those negative for both /. We conclude that gene alte...

Journal of pediatric neurosciences

Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldw... more Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldwide. Falls are the most common type of injury, followed by motor vehicle-related accidents and child abuse. The aim and objective of this study was to elucidate the various modes of injury, prognostic factors, complications, incidence of various modes of injury, and outcome in TBI in pediatric population. Patients with TBI, 18 years or less in age, managed in our Department of Neurosurgery, over a period of 2 years, were studied prospectively. Detailed history, general physical examination, systemic examination, and central nervous system examination including assessment of Glasgow Coma Scale score (GCS) and pupillary size and reaction were noted in every patient. Based on GCS, patients were divided into mild head injury (GCS 13-15), moderate head injury (GCS 9-12), and severe head injury (GCS ≤8) categories. All the patients were subjected to plain computed tomography (CT) scan head, an...

Surgical Neurology International, 2017

Background: Injuries to the craniovertebral junction (CVJ) are not uncommon, and are among the fe... more Background: Injuries to the craniovertebral junction (CVJ) are not uncommon, and are among the few skeletal injuries that carry a high mortality rate. Successful management of these injuries depends on familiarity with the normal anatomic relationships of this region, as well as prudent decision making regarding surgical versus conservative management alternatives. Methods: The purpose of this study was to analyze the indications for conservative treatment of CVJ trauma and to analyze the outcomes. Results: Eighty-eight patients admitted with CVJ injuries were managed conservatively. More than half were nearly neurologically intact on admission; 91% improved whereas 80% (excluding deaths/lost to follow) ultimately achieved bony union without surgical intervention. Conclusion: This study documents that conservative management of CVJ injuries in a select population can yield good clinical results.

Surgical Neurology International, 2016

Background: Neural tube defects (NTDs) are the most common congenital malformations affecting the... more Background: Neural tube defects (NTDs) are the most common congenital malformations affecting the brain and spinal cord and have a multifactorial etiology. Genetic and environmental factors have been found to cause these defects, both individually and in combination. Methods: A 2-year hospital-based prospective study was carried out from November 2013 to October 2015 to determine the incidence, types, demographics, risk factors, and other associated anamolies relevant to NTDs in Kashmir Valley. A detailed history of the mother was taken along with detailed clinical examination of neonate including measurement of head circumference and checking the status of fontanella, whether lax/full/bulging/or tense, type of NTD. Investigations that were done included were X-ray skull: Anterior-posterior (AP) and lateral, X-ray spine: AP and lateral, ultrasonography abdomen, magnetic resonance imaging: Spine and brain. Results: The total number of babies with NTD's was 125 with an overall incidence of 0.503. Kupwara district was having the highest incidence (1.047) and Srinagar district the lowest incidence of NTD's (0.197). Majority of NTD's (116 cases, 92.8%) were found in the rural areas. Among the different types of NTD's, spina bifida had an incidence of 0.342 (85 cases, 68%) and anencephaly had an incidence of 0.113 (28 cases, 22.4%). There was a slight preponderance of females over males with NTD's. There were 70 females (56%) and 55 males (44%), respectively, with a male: female ratio of 0.8:1 Conclusions: The incidence rates of NTDs is very high for Kashmir Valley. Geographical distribution of NTDs at this place confirms a relationship between the socioeconomic status, educational status, maternal too young or advanced age, and environmental factors for the development of a NTD. The results of this study point to the importance establishing a health policy to prevent NTD in Kashmir Valley.

Indian Journal of Neurotrauma, 2016

Spinal cord infarction in children is a rare condition that is becoming more widely recognized. T... more Spinal cord infarction in children is a rare condition that is becoming more widely recognized. There are few reports in the pediatric literature characterizing etiology, diagnosis, treatment options, and prognosis of anterior spinal artery infarction following rotatory atlantoaxial subluxation. In many children, the cause of spinal cord ischemia in the absence of vertebral fracture is unknown and is often wrongly diagnosed. Imaging diagnosis of spinal cord ischemia is often difficult due to the small transverse area of the cord, cerebrospinal fluid artifact, and inadequate resolution. The prognosis depends on the level of spinal cord damage, early identification and reversal of ischemia, and follow-up with intensive physical therapy and medical support. In addition to summarizing the literature on spinal cord infarction in children following cervical trauma, this article adds to the literature another case of a child with anterior spinal artery territory infarction due to rotatory atlantoaxial subluxation, leading to kinking and occlusion of vertebral artery, which highlights the difficulties and controversies in the management of this condition.

Indian Journal of Neurotrauma, 2016

Intracranial foreign bodies are usually secondary to penetrating injuries through the orbit, ear,... more Intracranial foreign bodies are usually secondary to penetrating injuries through the orbit, ear, or cranial bones. Nails, knives, screwdrivers, sewing needles, bullets, and shrapnel have been described related to penetrating brain injury (PBI). The majority of deaths from trauma reflect unintentional accidents, but a significant minority follow suicide and even a smaller proportion (less than 10%) reflect homicide. Self-inflicted injuries among psychiatric patients are not uncommon. We report a rare case of a 35-year-old woman who tried to commit suicide by inserting a needle in her brain through cranial defect. Needle was removed and patient recovered uneventfully. Awareness of the psychological condition and suicide precautionary measures should be kept in mind in all cases of self-inflicted PBI patients.

Journal of Carcinogenesis & Mutagenesis, 2015

Glioblastoma multiforme (GBM) is the most aggressive form of glioma. Genetic analysis of GBM tumo... more Glioblastoma multiforme (GBM) is the most aggressive form of glioma. Genetic analysis of GBM tumorigenesis has identified several alterations in particular EGFR and PTEN genes. The purpose of the present study was to analyze the frequency and distribution of EGFR/PTEN mutations in GBM and to determine their relationship with different clinicopathological characteristics. The paired tumor and adjacent normal tissue specimens of 40 consecutive patients with GBM were examined and DNA preparations were evaluated for the occurrence of EGFR/PTEN gene mutations by PCR-SCCP and DNA sequencing. In total, 20 of 40 (50%) GBM tumours had mutation of either an EGFR or PTEN. EGFR gene mutation was present in 13 (32.5%) and PTEN gene mutations in 07 of 40 (17.5%) patients. Both EGFR/PTEN mutations were found in 03 of 40 samples (7.5%). The samples which showed EGFR mutations but were negative for PTEN were detected in 10 of 40 (25%) patients (EGFR+ve/PTEN-ve). The samples with PTEN +ve/EGFR-ve were present in 04 of 40 (10%) patients. Median PFS and Median OS was better in patients with EGFR +ve/PTEN-ve (p>0.05). EGFR and PTEN gene mutations exist in our population with GBM and play a significant role in its development with better survival for patients for EGFR+ve/PTE-ve mutation status.

Saudi Journal of Gastroenterology

Background/Aim: Hydatidosis has a worldwide distribution and the liver is the most common organ i... more Background/Aim: Hydatidosis has a worldwide distribution and the liver is the most common organ involved. Hydatid cysts of the liver can be managed either by nonoperative or operative methods. Nonoperative methods include chemotherapy and percutaneous treatment. The study aimed at understanding the effect of albendazole therapy on the viability of protoscoleces and recurrence rate of hydatid disease of the liver.

International journal of health sciences, 2009

HIV infection has attained extraordinary attention among surgeons and other health care workers a... more HIV infection has attained extraordinary attention among surgeons and other health care workers as a potential source of occupational infection. Disease is usually blood-borne and transmissible, and due to the nature of surgical work, surgical community has become involved and is developing sterile surgical barriers, and improved surgical techniques and procedures.

The Indian Journal of Neurotrauma, 2010

... Abdul Rashid Bhatt, Mohammed Afzal Wani, Altaf Rehman Kirmani, Tariq Raina, Sajad Arif, A Ram... more ... Abdul Rashid Bhatt, Mohammed Afzal Wani, Altaf Rehman Kirmani, Tariq Raina, Sajad Arif, A Ramzan Page 3. Indian Journal of Neurotrauma (IJNT), Vol. 7, No. ... Abdul Rashid Bhatt, Mohammed Afzal Wani, Altaf Rehman Kirmani, Tariq Raina, Sajad Arif, A Ramzan Page 5. ...

The Indian Journal of Neurotrauma, 2010

... 113 Address for correspondence : Dr. Abdul Rashid Bhat (Neurosurgeon) B-4 Faculty Quarters, S... more ... 113 Address for correspondence : Dr. Abdul Rashid Bhat (Neurosurgeon) B-4 Faculty Quarters, Sher-i-Kashmir Institute of Medical Sciences, Srinagar ... Abdul Rashid Bhat M Ch, Muhammed Afzal Wani M Ch, AR Kirmani M Ch, UR Altaf M Ch, TH Raina M Ch, Shafiq Alam M Ch ...

Journal of Neurosurgery: Pediatrics, 2011

Object The aim of this study was to analyze the correlation of hypodensity in extradural hematoma... more Object The aim of this study was to analyze the correlation of hypodensity in extradural hematomas on CT with the clinical profile in pediatric patients. This is the only study available in this age group. Methods This was a prospective study conducted over a period of 3 years in which all children 18 years old or younger with a diagnosis of cranial extradural hematoma were included. The patients were allocated to 2 groups: those with mixed-density clots (17 cases) and those with classically hyperdense clots (52 cases). A comparative analysis between the 2 groups was conducted. Results Patients with mixed-density clots presented earlier to the hospital, had poor Glasgow Coma Scale scores at admission, exhibited large clot volumes, had a high incidence of active bleeding at surgery, and had increased morbidity and mortality as compared with the patients with hyperdense extradural hematomas. Conclusions Early recognition and rapid evacuation of the mixed-density clot with restoration ...

Turkish Neurosurgery, 2010

Epidural hematomas which are located at the vertex are rarely seen and form a small percentage of... more Epidural hematomas which are located at the vertex are rarely seen and form a small percentage of total epidural hematomas. Tearing in the superior sagittal sinus is the usual cause of an epidural hematoma located in the vertex. The clinical features of this entity are non-specific; hence, localization of the lesion is difficult. We report an adult who was hit by a motorcycle and was initially discharged from the hospital as a case of concussional head injury. He returned back with raised intracranial pressure symptoms, so a CT scan was done but was misinterpreted, and he reported one week later with bilateral abducent nerve palsy. Magnetic resonance imaging confirmed vertex EDH for which he was operated.These hematomas are seen rarely and can be interpreted as an artifact. Its recognition is important because it has an excellent prognosis. We concluded that all head injury patients should get high axial cuts on the CT scan, and any degree of suspicion should prompt a neurosurgeon to investigate further with coronal CT scan or MRI.

Journal of Enam Medical College, 2015

Background: Medically inappropriate, ineffective and economically inefficient use of drugs is ver... more Background: Medically inappropriate, ineffective and economically inefficient use of drugs is very common in our country. About 40% or more drugs expenditure may be wasted through irrational prescribing and dispensing. The need for promoting rational use of drugs is not only because of economic considerations; also it is an essential element for achieving quality of the health and medical care for patients and the community. For this purpose a cross sectional study was carried out among the individuals attending the outpatient departments

Indian Journal of Neurotrauma, 2020

Background Head injury is a major health hazard throughout the world. Overall, the mortality/morb... more Background Head injury is a major health hazard throughout the world. Overall, the mortality/morbidity has not changed much in the last few decades. In developing nations, the situation is worse. Methods The study was conducted for a period of 1 year. The data collected include demographic profile, mode, circumstances and timing of the injury, neurological assessment using Glasgow Coma Scale (GCS) scoring, computed tomography (CT) scan findings, type of management, and outcome. Results Transport-related injuries and falls were the common cause of head injury, with more severe injuries seen in patients without wearing helmets and seat belts. The youth is at high risk of receiving head injuries. The summer season showed a maximum incidence of head injuries. The most common lesions on CT scan were linear fracture of the skull and brain contusion. Mortality rate was 26% and it correlated with the GCS at presentation. Conclusion Head injury mostly affects young people and males outnumber...

Indian Journal of Neurosurgery, 2021

Despite advances in research and improved neurological intensive care in recent years, the clinic... more Despite advances in research and improved neurological intensive care in recent years, the clinical outcome of severely head injured patients is still poor. Primary insult is followed by a complex cascade of molecular and biochemical events that lead to neuroinflammation, brain edema, and delayed neuronal death. No specific pharmacological therapy is currently available which prevents the development of secondary brain injuries, and most therapeutic strategies have failed in translation from bench to bedside. There are limitations of clinical and radiological methods in delineating the exact severity and prognosis of traumatic brain injury (TBI). A myriad complex biochemical markers are under investigation to delineate the extent of brain tissue damage and to independently predict the outcome, but a search for simple biomarker still eludes the research. Progesterone, a gonadal hormone and a neurosteroid, although controversial as a neuroprotective agent, may hold promise as a simple...

The Journal of Spinal Surgery, 2017

Although intramedullary spinal cord tumors are predominantly primary tumors like ependymomas and ... more Although intramedullary spinal cord tumors are predominantly primary tumors like ependymomas and astrocytomas, the intramedullary spinal cord metastatic tumors account for 4 to 9% of all such tumors. With the advent of magnetic resonance imaging (MRI) and improvement in the survival of cancer patients due to effective therapeutic options, the number of patients harboring intramedullary spinal cord metastasis (IMSCM) is increasing. Review of large series of IMSCM has revealed rarity of intramedullary metastasis to conus medullaris (IMCM). We present a short series of two cases of IMCM managed in our hospital and review of literature to describe how it is different from IMSCM at other regions of spinal cord. We also describe various management options available in the light of 25 cases of conus metastasis described in the literature till date.

JMS SKIMS, 2009

A three year old female child presents with a rare combination of three complications, two months... more A three year old female child presents with a rare combination of three complications, two months after closed head injury. The linear fracture grew into a leptomeningeal cyst and a large brain abscess leads to hydrocephalus by causing ventriculitis thereby increasing the size of leptomeningeal cyst. J Med Sci 2009;12(2):56-57.

Asian journal of neurosurgery

We aimed to assess the effect of anti-tyrosine kinase inhibitors (TKIs) (gefitinib) in overall su... more We aimed to assess the effect of anti-tyrosine kinase inhibitors (TKIs) (gefitinib) in overall survival (OS) of the glioblastoma multiforme (GBM) patients in the backdrop of mutational status of epidermal growth factor receptor () and genes. All the patients subjected to resection or biopsies were put on gefitinib, and radiotherapy was delivered as per the hospital protocol. and mutational spectrum was performed by single-strand conformation polymorphism followed by DNA sequencing. In total, 50% GBM tumors had mutation either in or . Median progression-free survival (PFS) and OS observed in patients with +ve/ -ve were significantly favorable ( < 0.05) which aggregated to 9(7, 11) months and 20 (16, 24) months, respectively, than 6 (4, 8) months and 13 (7, 19) months in patients with +ve/ -ve. Patients positive for both / had lower disease-free survival and OS of 6 and 9 months as compared to 6 (5, 7) and 14 (12, 24) months for those negative for both /. We conclude that gene alte...

Journal of pediatric neurosciences

Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldw... more Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldwide. Falls are the most common type of injury, followed by motor vehicle-related accidents and child abuse. The aim and objective of this study was to elucidate the various modes of injury, prognostic factors, complications, incidence of various modes of injury, and outcome in TBI in pediatric population. Patients with TBI, 18 years or less in age, managed in our Department of Neurosurgery, over a period of 2 years, were studied prospectively. Detailed history, general physical examination, systemic examination, and central nervous system examination including assessment of Glasgow Coma Scale score (GCS) and pupillary size and reaction were noted in every patient. Based on GCS, patients were divided into mild head injury (GCS 13-15), moderate head injury (GCS 9-12), and severe head injury (GCS ≤8) categories. All the patients were subjected to plain computed tomography (CT) scan head, an...

Surgical Neurology International, 2017

Background: Injuries to the craniovertebral junction (CVJ) are not uncommon, and are among the fe... more Background: Injuries to the craniovertebral junction (CVJ) are not uncommon, and are among the few skeletal injuries that carry a high mortality rate. Successful management of these injuries depends on familiarity with the normal anatomic relationships of this region, as well as prudent decision making regarding surgical versus conservative management alternatives. Methods: The purpose of this study was to analyze the indications for conservative treatment of CVJ trauma and to analyze the outcomes. Results: Eighty-eight patients admitted with CVJ injuries were managed conservatively. More than half were nearly neurologically intact on admission; 91% improved whereas 80% (excluding deaths/lost to follow) ultimately achieved bony union without surgical intervention. Conclusion: This study documents that conservative management of CVJ injuries in a select population can yield good clinical results.

Surgical Neurology International, 2016

Background: Neural tube defects (NTDs) are the most common congenital malformations affecting the... more Background: Neural tube defects (NTDs) are the most common congenital malformations affecting the brain and spinal cord and have a multifactorial etiology. Genetic and environmental factors have been found to cause these defects, both individually and in combination. Methods: A 2-year hospital-based prospective study was carried out from November 2013 to October 2015 to determine the incidence, types, demographics, risk factors, and other associated anamolies relevant to NTDs in Kashmir Valley. A detailed history of the mother was taken along with detailed clinical examination of neonate including measurement of head circumference and checking the status of fontanella, whether lax/full/bulging/or tense, type of NTD. Investigations that were done included were X-ray skull: Anterior-posterior (AP) and lateral, X-ray spine: AP and lateral, ultrasonography abdomen, magnetic resonance imaging: Spine and brain. Results: The total number of babies with NTD's was 125 with an overall incidence of 0.503. Kupwara district was having the highest incidence (1.047) and Srinagar district the lowest incidence of NTD's (0.197). Majority of NTD's (116 cases, 92.8%) were found in the rural areas. Among the different types of NTD's, spina bifida had an incidence of 0.342 (85 cases, 68%) and anencephaly had an incidence of 0.113 (28 cases, 22.4%). There was a slight preponderance of females over males with NTD's. There were 70 females (56%) and 55 males (44%), respectively, with a male: female ratio of 0.8:1 Conclusions: The incidence rates of NTDs is very high for Kashmir Valley. Geographical distribution of NTDs at this place confirms a relationship between the socioeconomic status, educational status, maternal too young or advanced age, and environmental factors for the development of a NTD. The results of this study point to the importance establishing a health policy to prevent NTD in Kashmir Valley.

Indian Journal of Neurotrauma, 2016

Spinal cord infarction in children is a rare condition that is becoming more widely recognized. T... more Spinal cord infarction in children is a rare condition that is becoming more widely recognized. There are few reports in the pediatric literature characterizing etiology, diagnosis, treatment options, and prognosis of anterior spinal artery infarction following rotatory atlantoaxial subluxation. In many children, the cause of spinal cord ischemia in the absence of vertebral fracture is unknown and is often wrongly diagnosed. Imaging diagnosis of spinal cord ischemia is often difficult due to the small transverse area of the cord, cerebrospinal fluid artifact, and inadequate resolution. The prognosis depends on the level of spinal cord damage, early identification and reversal of ischemia, and follow-up with intensive physical therapy and medical support. In addition to summarizing the literature on spinal cord infarction in children following cervical trauma, this article adds to the literature another case of a child with anterior spinal artery territory infarction due to rotatory atlantoaxial subluxation, leading to kinking and occlusion of vertebral artery, which highlights the difficulties and controversies in the management of this condition.

Indian Journal of Neurotrauma, 2016

Intracranial foreign bodies are usually secondary to penetrating injuries through the orbit, ear,... more Intracranial foreign bodies are usually secondary to penetrating injuries through the orbit, ear, or cranial bones. Nails, knives, screwdrivers, sewing needles, bullets, and shrapnel have been described related to penetrating brain injury (PBI). The majority of deaths from trauma reflect unintentional accidents, but a significant minority follow suicide and even a smaller proportion (less than 10%) reflect homicide. Self-inflicted injuries among psychiatric patients are not uncommon. We report a rare case of a 35-year-old woman who tried to commit suicide by inserting a needle in her brain through cranial defect. Needle was removed and patient recovered uneventfully. Awareness of the psychological condition and suicide precautionary measures should be kept in mind in all cases of self-inflicted PBI patients.

Journal of Carcinogenesis & Mutagenesis, 2015

Glioblastoma multiforme (GBM) is the most aggressive form of glioma. Genetic analysis of GBM tumo... more Glioblastoma multiforme (GBM) is the most aggressive form of glioma. Genetic analysis of GBM tumorigenesis has identified several alterations in particular EGFR and PTEN genes. The purpose of the present study was to analyze the frequency and distribution of EGFR/PTEN mutations in GBM and to determine their relationship with different clinicopathological characteristics. The paired tumor and adjacent normal tissue specimens of 40 consecutive patients with GBM were examined and DNA preparations were evaluated for the occurrence of EGFR/PTEN gene mutations by PCR-SCCP and DNA sequencing. In total, 20 of 40 (50%) GBM tumours had mutation of either an EGFR or PTEN. EGFR gene mutation was present in 13 (32.5%) and PTEN gene mutations in 07 of 40 (17.5%) patients. Both EGFR/PTEN mutations were found in 03 of 40 samples (7.5%). The samples which showed EGFR mutations but were negative for PTEN were detected in 10 of 40 (25%) patients (EGFR+ve/PTEN-ve). The samples with PTEN +ve/EGFR-ve were present in 04 of 40 (10%) patients. Median PFS and Median OS was better in patients with EGFR +ve/PTEN-ve (p>0.05). EGFR and PTEN gene mutations exist in our population with GBM and play a significant role in its development with better survival for patients for EGFR+ve/PTE-ve mutation status.

Saudi Journal of Gastroenterology

Background/Aim: Hydatidosis has a worldwide distribution and the liver is the most common organ i... more Background/Aim: Hydatidosis has a worldwide distribution and the liver is the most common organ involved. Hydatid cysts of the liver can be managed either by nonoperative or operative methods. Nonoperative methods include chemotherapy and percutaneous treatment. The study aimed at understanding the effect of albendazole therapy on the viability of protoscoleces and recurrence rate of hydatid disease of the liver.

International journal of health sciences, 2009

HIV infection has attained extraordinary attention among surgeons and other health care workers a... more HIV infection has attained extraordinary attention among surgeons and other health care workers as a potential source of occupational infection. Disease is usually blood-borne and transmissible, and due to the nature of surgical work, surgical community has become involved and is developing sterile surgical barriers, and improved surgical techniques and procedures.

The Indian Journal of Neurotrauma, 2010

... Abdul Rashid Bhatt, Mohammed Afzal Wani, Altaf Rehman Kirmani, Tariq Raina, Sajad Arif, A Ram... more ... Abdul Rashid Bhatt, Mohammed Afzal Wani, Altaf Rehman Kirmani, Tariq Raina, Sajad Arif, A Ramzan Page 3. Indian Journal of Neurotrauma (IJNT), Vol. 7, No. ... Abdul Rashid Bhatt, Mohammed Afzal Wani, Altaf Rehman Kirmani, Tariq Raina, Sajad Arif, A Ramzan Page 5. ...

The Indian Journal of Neurotrauma, 2010

... 113 Address for correspondence : Dr. Abdul Rashid Bhat (Neurosurgeon) B-4 Faculty Quarters, S... more ... 113 Address for correspondence : Dr. Abdul Rashid Bhat (Neurosurgeon) B-4 Faculty Quarters, Sher-i-Kashmir Institute of Medical Sciences, Srinagar ... Abdul Rashid Bhat M Ch, Muhammed Afzal Wani M Ch, AR Kirmani M Ch, UR Altaf M Ch, TH Raina M Ch, Shafiq Alam M Ch ...

Journal of Neurosurgery: Pediatrics, 2011

Object The aim of this study was to analyze the correlation of hypodensity in extradural hematoma... more Object The aim of this study was to analyze the correlation of hypodensity in extradural hematomas on CT with the clinical profile in pediatric patients. This is the only study available in this age group. Methods This was a prospective study conducted over a period of 3 years in which all children 18 years old or younger with a diagnosis of cranial extradural hematoma were included. The patients were allocated to 2 groups: those with mixed-density clots (17 cases) and those with classically hyperdense clots (52 cases). A comparative analysis between the 2 groups was conducted. Results Patients with mixed-density clots presented earlier to the hospital, had poor Glasgow Coma Scale scores at admission, exhibited large clot volumes, had a high incidence of active bleeding at surgery, and had increased morbidity and mortality as compared with the patients with hyperdense extradural hematomas. Conclusions Early recognition and rapid evacuation of the mixed-density clot with restoration ...

Turkish Neurosurgery, 2010

Epidural hematomas which are located at the vertex are rarely seen and form a small percentage of... more Epidural hematomas which are located at the vertex are rarely seen and form a small percentage of total epidural hematomas. Tearing in the superior sagittal sinus is the usual cause of an epidural hematoma located in the vertex. The clinical features of this entity are non-specific; hence, localization of the lesion is difficult. We report an adult who was hit by a motorcycle and was initially discharged from the hospital as a case of concussional head injury. He returned back with raised intracranial pressure symptoms, so a CT scan was done but was misinterpreted, and he reported one week later with bilateral abducent nerve palsy. Magnetic resonance imaging confirmed vertex EDH for which he was operated.These hematomas are seen rarely and can be interpreted as an artifact. Its recognition is important because it has an excellent prognosis. We concluded that all head injury patients should get high axial cuts on the CT scan, and any degree of suspicion should prompt a neurosurgeon to investigate further with coronal CT scan or MRI.