Sajjadeh Movahedinia - Academia.edu (original) (raw)
articles by Sajjadeh Movahedinia
Iranian Journal of Medical Microbiology, 2021
Background and Aim: The system of architectural design, space and installation of facilities and ... more Background and Aim: The system of architectural design, space and installation of facilities and equipment in the medical laboratory is based on a multifaceted structure. Considering these conditions increases the productivity and profitability to all the involved groups. The present study sought to understand and design of this structure. Materials and Methods: This descriptive-analytical research was carried out studying the literature. Results: According to the results, the adequate architectural design for a medical laboratory includes the following points: observing the separation of physical spaces, proximity of the spaces in the laboratory, the principle of flexibility in designing physical space and the ability to develop and expand the physical space, the space design and requirements to meet the mobility needs of the people with disabilities, desk designing for the disabled and the elderlies, observing the minimum standards of general space and total spaces, and the number of staff considering their safety. Conclusion: The design of medical laboratories, considering the cases mentioned in this report, will lead to the construction of a place that will not only meet the needs of clients but also provide comfort and safety for the staff. Such a laboratory will be more profitable by increasing the productivity, which will ultimately lead to a comprehensive profit. The errors and mistakes in the design and execution of any of these cases can cause minor and major damages.
Papers by Sajjadeh Movahedinia
Current Respiratory Medicine Reviews, Nov 12, 2023
iranian journal of pathology, Jun 30, 2023
Iranian Red Crescent Medical Journal, Dec 5, 2013
Background: Breast cancer is one of the most common cancers in the world and is the first cause o... more Background: Breast cancer is one of the most common cancers in the world and is the first cause of death due to cancer among women. Mammography is the best screening method and mammographic density, which determines the percentage of fibro glandular tissue of breast, is one of the strongest risk factors of breast cancer. Because benign and malignant lesions may present as dense lesions in mammography so it is necessary to take a core biopsy of any suspicious lesions to evaluate pathologic findings. Objectives: The aim of this study was to assess the association between mammographic density and histopathological findings in Iranian population. Moreover, we assessed the correlation between mammographic density and protein expression profile. We indeed, determined the accuracy and positive predictive value and negative predictive value of mammographic reports in our center. Patients and Method: This study is a cross-sectional study carried out among 131 eligible women who had referred to imaging center for mammographic examination and had been advised to take biopsy of breast tissue. All participants of the study had filled out the informed consent. Pathologic review was performed blinded to the density status. Patients were divided into low density breast tissue group (ACR density group 1-2) and high density breast tissue group (ACR 3, 4) and data was compared between these two groups. Statistical analysis performed using SPSS for windows, version 11.5. We used chi-square, t-test, and logistic regression test for analysis and Odds Ratio calculated where indicated. Results: In patients with high breast densities, malignant cases (61.2%) were significantly more in comparison to patients with low breast densities (37.3%) (P= 0.007, OR=2.66 95% CI=1.29-5.49). After adjusting for age, density was associated with malignancy in age groups <46 years (P=0.007), and 46-60 years (P=0.024) but not in age group >60yrs (P=0.559). Adjusting for menopausal status, density showed association with malignancy in both pre-menopause (P=0.041) and menopause (P=0.010) patients. Using logistic regression test, only age and density showed independent association with risk of breast cancer. No association was found between density and protein profile expression. Mammographic method has a false negative percent of 10.3% for negative BI-RADS group and a Positive Predictive Value (PPV) of 69.6% for positive BI-RADS group. PPVs for BI-RADS 4a, 4b, 4c and 5 were 16%, 87.5%, 84.6%, and 91.5% respectively. NPVs for BI-RADS 1, 2 and 3 were 66.7%, 95.8% and 90.0% respectively. Conclusions: In this study we found that increasing in mammographic density is associated with an increase in malignant pathology reports. Expression of ER, PR and HER-2 receptors didn't show association with density. Our mammographic reports had a sensitivity of 94.1% and a specificity of 55.6%, which shows that our mammography is an acceptable method for screening breast cancer in this center.
Reproductive Biomedicine Online, Nov 1, 2020
Highlights EGF and PDGF expression is increased in PFMCs of patients with endometriosis. Vita... more Highlights EGF and PDGF expression is increased in PFMCs of patients with endometriosis. Vitamin D3 markedly decreases EGF and MDGF expression in endometriosis. Vitamin D3 has an in-vitro inhibitory effect on PDGF expression at 6 hours following treatment, but not at 24 h or 48 h time points. Immunomodulatory effects of vitamin D3 on gene expression of MDGF, EGF, and PDGF in peritoneal fluid mononuclear cells of patients with endometriosis
Iranian Journal of Pathology
Scan to discover online Background: To gain insight into the pathogenesis and clinical course of ... more Scan to discover online Background: To gain insight into the pathogenesis and clinical course of COVID-19 from a historical perspective, we reviewed paraclinical diagnostic tools of this disease and prioritized the patients with a more severe form of disease admitted to intensive care units (ICUs). The objective was to better predict the course and severity of the disease by collecting more paraclinical data, specifically by examining the relationship between hematological findings and cytological variation of blood neutrophils and monocytes. Methods: This retrospective study was conducted on 112 patients with confirmed COVID-19 admitted to Imam Hossein Hospital (Tehran, Iran) from August to September 2020. Peripheral blood smears of these patients were differentiated according to several cytological variations of neutrophils and monocytes, and the correlation to the severity of the disease was specified. Results: The mean percentages of degenerated monocytes, degenerated granulocytes, and spiky biky neutrophils were significantly different among critical and non-critical patients (P<0.05). Degenerated monocytes and granulocytes were higher in critical patients as opposed to spiky biky neutrophils, which were higher among non-critical ones. Comparing the peripheral blood smears of COVID-19 patients (regarding pulmonary involvement in chest computed tomography [CT] scans [subtle, mild, moderate, and severe groups]), the twisted form of neutrophils was significantly higher in the subtle group than in the mild and moderate groups (P=0.003). Conclusion: Different cytological morphologies of neutrophils and monocytes, including degenerated monocytes, degenerated granulocytes, and spiky biky and twisted neutrophils, could help to predict the course and severity of the disease.
BMC Complementary Medicine and Therapies
Background Aging is associated with impaired renal function and structural alterations. Oxidative... more Background Aging is associated with impaired renal function and structural alterations. Oxidative stress plays a vital role in renal senescence and damage. Sirtuin 1 (SIRT1) is thought to protect cells from oxidative stress through nuclear factor erythroid 2-related factor 2 (NRF2). Ellagic acid (EA), a natural antioxidant, has been demonstrated to have renoprotective roles in vitro and in vivo. This study investigated if SIRT1 and NRF2 mediate the protective effects of EA in aged kidneys. Methods Male Wistar rats were divided into three groups including young (4 months), old, and old + EA (25 months). Young and old groups received EA solvent, while the old + EA group was treated with EA (30 mg/kg) by gavage for 30 days. Then, the level of renal oxidative stress, SIRT1 and NRF2 expression, kidney function parameters, and histopathological indices were measured. Results Treatment with EA significantly increased the level of antioxidant enzymes and reduced malondialdehyde concentratio...
Journal of Experimental Orthopaedics
Purpose Studies have suggested some predictors for hamstring tendon (HT) autograft diameter based... more Purpose Studies have suggested some predictors for hamstring tendon (HT) autograft diameter based on anthropometric factors and preoperative magnetic resonance imaging (MRI) with variable results. Some authors have attributed the variability to gender differences. This prospective cohort reports the sensitivity and specificity of anthropometric and MRI predictors in males and females separately to determine the difference. Methods Forty-two eligible patients who underwent anterior cruciate ligament reconstruction (ACLR) and MRI in our center were included. ACLR was performed by the senior surgeon using a 4-stranded HT autograft for all patients. A blinded musculoskeletal radiologist measured the cross-sectional area (CSA) of gracilis and semitendinosus tendons using the free-hand region of interest tool for all patients. An orthopaedic resident (PGY4) collected anthropometric factors and measured intraoperative autograft diameter. Results Mean intraoperative autograft diameter was 8...
Current Respiratory Medicine Reviews
Background: COVID-19 is an infectious disease caused by SARS-CoV-2 and can lead to acute respirat... more Background: COVID-19 is an infectious disease caused by SARS-CoV-2 and can lead to acute respiratory distress. Objective: We aimed to investigate the association between COVID-19 severity and serum apelin-17 and inflammatory mediator levels. Method: This cross-sectional study was conducted on patients with COVID-19. COVID-19 infec-tion was confirmed by the RT-PCR test. The patients' data were extracted from their records. Ve-nous blood samples were obtained from the patients to investigate the serum levels of apelin-17 and inflammatory mediators. Results: Eighty-six COVID-19 patients were studied. The mean age of the participants was 55.56±14.88, and 43 (50 %) were male. Clinical symptoms were dyspnea 77.6 %, fever 52.3 %, cough 48.8 %, gastrointestinal symptoms 15.1 %, and chest pain 7 %. The overall mortality rate was 7 %. No significant relationship was found between serum apelin-17 levels and COVID-19 severity (P= 0.48). However, there was a significant and direct relationsh...
Human-Machine Communication for Educational Systems Design, 1994
Pathology - Research and Practice, 2016
Atypical cartilaginous tumor and enchondroma are similar in histopathologic aspects. Although the... more Atypical cartilaginous tumor and enchondroma are similar in histopathologic aspects. Although the clinical course, radiologic and pathologic examinations enable distinction in most cases, difficulties are still encountered by the pathologists. There is no known biomarker to help make a distinction between benign and malignant cartilaginous tumors. Insulin-like growth factor II mRNA binding protein (IMP3) is a member of an oncofetal family of proteins that is expressed in different human malignancies and rapidly emerging as a prognostic and diagnostic marker in surgical pathology. In this study, IMP3 expression was examined by immunohistochemistry in 36 enchondromas and 42 chondrosarcomas of different histologic grades. The results showed that all 36 cases of enchondroma were negative for IMP3, while it was overexpressed in 15 of 42 chondrosarcomas (36%) (P < 0.01). Significant higher levels of IMP3 were detected in grade III chondrosarcomas (6 of 7; 85.7%) when compared to low-grade tumors (6 of 19; 31.5% in grade II and 3 of 16; 18.7% in Atypical Cartilaginous Tumor). We proved statistically significant difference in IMP3 expression between enchondromas and ACTs (P = 0.025). Our study clearly demonstrated differentiation-dependent expression of IMP3 in chondrosarcoma, and suggests IMP3 as a novel marker for differentiating problematic cases of enchondroma from well-differentiated chondrosarcomas. To our knowledge, this study is the first study to clarify expression of IMP-3 in chondromas and chondrosarcomas.
مجله دانشکده پزشکی اصفهان, 2019
Background: Cartilage grafts are used in plastic surgery in restorations that require strength. D... more Background: Cartilage grafts are used in plastic surgery in restorations that require strength. Due to varying degrees of strength in these regenerations, cartilage grafts from different sources are used in block, crushed, and diced forms. The aim of this study was to compare the survival rate of in crushed, diced, and block autograft cartilage forms of rabbit ear. Methods: This study was performed on 36 New Zealand white male rabbits weighing 2000 to 2500 grams and aged 12 to 16 weeks. The cartilage of the right ear of each rabbit was harvested, and three graft samples of crushed, diced, and block forms were obtained. The grafts were put in three separate subcutaneous envelopes adjacent to the rabbit's backbone. After 3 months, the specimens were removed, stained with hematoxylin and eosinophil (H & E), and histologically examined. Findings: The mean graft weight increased in all groups using crushed, diced, and block cartilage forms, but it was not statistically significant. T...
Iranian Journal of Medical Microbiology, 2021
Background and Aim: The system of architectural design, space and installation of facilities and ... more Background and Aim: The system of architectural design, space and installation of facilities and equipment in the medical laboratory is based on a multifaceted structure. Considering these conditions increases the productivity and profitability to all the involved groups. The present study sought to understand and design of this structure. Materials and Methods: This descriptive-analytical research was carried out studying the literature. Results: According to the results, the adequate architectural design for a medical laboratory includes the following points: observing the separation of physical spaces, proximity of the spaces in the laboratory, the principle of flexibility in designing physical space and the ability to develop and expand the physical space, the space design and requirements to meet the mobility needs of the people with disabilities, desk designing for the disabled and the elderlies, observing the minimum standards of general space and total spaces, and the number of staff considering their safety. Conclusion: The design of medical laboratories, considering the cases mentioned in this report, will lead to the construction of a place that will not only meet the needs of clients but also provide comfort and safety for the staff. Such a laboratory will be more profitable by increasing the productivity, which will ultimately lead to a comprehensive profit. The errors and mistakes in the design and execution of any of these cases can cause minor and major damages.
Fundamental & Clinical Pharmacology
The Archives of Bone & Joint Surgery, 2016
Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla ... more Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla of long bones. ABC rarely arises within the cortex or in the subperiosteal region, radiographically mimicking other conditions, in particular surface osteosarcomathat is low-grade in nature and may go secondary ABC changes, and telangiectatic osteosarcoma. Both of these are sometimes mistaken microscopically for primary ABC. We review the characteristics of ABC cases in our center and report four unusualsurface ABCs arising in the subperiosteal or cortical region of long bones, identified among 38 histologically proven ABCs during a four-year period in our center. The surface ABCs occurred at an older agewith a predilection for diaphysis of femur, tibia, and humerus.
Basic and Clinical Neuroscience, 2020
Introduction: Primary Diffuse Large B Cell Lymphoma of CNS (PCNSL) is a rare variant of Diffuse L... more Introduction: Primary Diffuse Large B Cell Lymphoma of CNS (PCNSL) is a rare variant of Diffuse Large B Cell Lymphoma (DLBCL) and presents with an aggressive clinical course and usually resistant to commonly used therapy regimens. Recently, role of immune checkpoint molecules including PD-1 and PD-L1 confirmed in some solid tumors and lymphoma resulting tumor cells escape the immune system and help to survive and to spread. Inhibitors of PD-1 and PD-L1 have shown lasting responses in several solid and some hematological tumors, while limited studies evaluate checkpoint molecules on PCNSL. Method: In this study, we investigated PD-1 and PD-L1 expression by immunostaining on 71 patients with PCNSL and correlation with demographic data, location of the tumor, proliferation rate, cell of origin, and CD8 positive T cell infiltration in tumor microenvironment. Results: 16 from71 showed PD-1 expression, while PD-L1 expression were 42/71. No association was determined between PD-1/PD-L1 exp...
1. Department of Pathology, Hematology Research Center, School of Medicine, Shiraz University of ... more 1. Department of Pathology, Hematology Research Center, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran. 2. Department of Pathology, Cancer Prevention Research Center, Isfahan University of Medical Science, Isfahan, Iran. 3. Department of Pathology, Molecular Pathology and Cytogenetics Division, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran. 4. Department of Pathology, Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran. 5. Department of Pathology, Faculty of Medicine, Kerman University of Medical Science, Kerman, Iran. 6. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
The archives of bone and joint surgery, 2016
Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla ... more Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla of long bones. ABC rarely arises within the cortex or in the subperiosteal region, radiographically mimicking other conditions, in particular surface osteosarcomathat is low-grade in nature and may go secondary ABC changes, and telangiectatic osteosarcoma. Both of these are sometimes mistaken microscopically for primary ABC. We review the characteristics of ABC cases in our center and report four unusualsurface ABCs arising in the subperiosteal or cortical region of long bones, identified among 38 histologically proven ABCs during a four-year period in our center. The surface ABCs occurred at an older agewith a predilection for diaphysis of femur, tibia, and humerus.
Archives of Iranian medicine, 2021
BACKGROUND The pathogenesis of the COVID19 pandemic, that has killed one million nine hundred peo... more BACKGROUND The pathogenesis of the COVID19 pandemic, that has killed one million nine hundred people and infected more the 90 million until end of 2020, has been studied by many researchers. Here, we try to explain its biological behavior based on our recent autopsy information and review of literature. METHODS In this study, patients with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) result were considered eligible for enrollment. Histopathological examinations were done on 13 people who were hospitalized in Afzalipour hospital, Kerman, Iran. Clinical and laboratory data were reviewed. Tissue examination was done by light microscopy, immunohistochemistry and electron microscopy. RESULTS The most frequent co-morbidity in the patients was cardiovascular disease. The common initial symptoms of COVID-19 infection were dyspnea and cough. In all cases, the number of white blood cells was higher than the normal range. Common histopathological findings were variab...
RESEARCH QUESTION Endometriosis, an inflammatory disease, is assumed to be associated with an inc... more RESEARCH QUESTION Endometriosis, an inflammatory disease, is assumed to be associated with an increased production of growth-related cytokines. Based on the emerging immunomodulatory role of vitamin D3 in different inflammatory conditions, this study aimed to examine its modulatory effect on the expression levels of the genes for platelet-derived growth factor-B (PDGFB), monocyte/macrophage-derived growth factor (MDGF, also known as PPBP) and epidermal growth factor (EGF) in peritoneal fluid mononuclear cells (PFMC) in women with and without endometriosis. DESIGN PFMC from 10 women with endometriosis and 10 control participants were treated with vitamin D3.The gene expression levels of PDGFB, MDGF and EGF were measured 6, 24 and 48 h following vitamin D3 administration using real-time PCR. RESULTS Gene expression levels of EGF and PDGFB were higher in the PFMC of women with endometriosis than the control group (P = 0.006, P < 0.001, respectively). Although MDGF expression showed ...
Iranian Journal of Medical Microbiology, 2021
Background and Aim: The system of architectural design, space and installation of facilities and ... more Background and Aim: The system of architectural design, space and installation of facilities and equipment in the medical laboratory is based on a multifaceted structure. Considering these conditions increases the productivity and profitability to all the involved groups. The present study sought to understand and design of this structure. Materials and Methods: This descriptive-analytical research was carried out studying the literature. Results: According to the results, the adequate architectural design for a medical laboratory includes the following points: observing the separation of physical spaces, proximity of the spaces in the laboratory, the principle of flexibility in designing physical space and the ability to develop and expand the physical space, the space design and requirements to meet the mobility needs of the people with disabilities, desk designing for the disabled and the elderlies, observing the minimum standards of general space and total spaces, and the number of staff considering their safety. Conclusion: The design of medical laboratories, considering the cases mentioned in this report, will lead to the construction of a place that will not only meet the needs of clients but also provide comfort and safety for the staff. Such a laboratory will be more profitable by increasing the productivity, which will ultimately lead to a comprehensive profit. The errors and mistakes in the design and execution of any of these cases can cause minor and major damages.
Current Respiratory Medicine Reviews, Nov 12, 2023
iranian journal of pathology, Jun 30, 2023
Iranian Red Crescent Medical Journal, Dec 5, 2013
Background: Breast cancer is one of the most common cancers in the world and is the first cause o... more Background: Breast cancer is one of the most common cancers in the world and is the first cause of death due to cancer among women. Mammography is the best screening method and mammographic density, which determines the percentage of fibro glandular tissue of breast, is one of the strongest risk factors of breast cancer. Because benign and malignant lesions may present as dense lesions in mammography so it is necessary to take a core biopsy of any suspicious lesions to evaluate pathologic findings. Objectives: The aim of this study was to assess the association between mammographic density and histopathological findings in Iranian population. Moreover, we assessed the correlation between mammographic density and protein expression profile. We indeed, determined the accuracy and positive predictive value and negative predictive value of mammographic reports in our center. Patients and Method: This study is a cross-sectional study carried out among 131 eligible women who had referred to imaging center for mammographic examination and had been advised to take biopsy of breast tissue. All participants of the study had filled out the informed consent. Pathologic review was performed blinded to the density status. Patients were divided into low density breast tissue group (ACR density group 1-2) and high density breast tissue group (ACR 3, 4) and data was compared between these two groups. Statistical analysis performed using SPSS for windows, version 11.5. We used chi-square, t-test, and logistic regression test for analysis and Odds Ratio calculated where indicated. Results: In patients with high breast densities, malignant cases (61.2%) were significantly more in comparison to patients with low breast densities (37.3%) (P= 0.007, OR=2.66 95% CI=1.29-5.49). After adjusting for age, density was associated with malignancy in age groups <46 years (P=0.007), and 46-60 years (P=0.024) but not in age group >60yrs (P=0.559). Adjusting for menopausal status, density showed association with malignancy in both pre-menopause (P=0.041) and menopause (P=0.010) patients. Using logistic regression test, only age and density showed independent association with risk of breast cancer. No association was found between density and protein profile expression. Mammographic method has a false negative percent of 10.3% for negative BI-RADS group and a Positive Predictive Value (PPV) of 69.6% for positive BI-RADS group. PPVs for BI-RADS 4a, 4b, 4c and 5 were 16%, 87.5%, 84.6%, and 91.5% respectively. NPVs for BI-RADS 1, 2 and 3 were 66.7%, 95.8% and 90.0% respectively. Conclusions: In this study we found that increasing in mammographic density is associated with an increase in malignant pathology reports. Expression of ER, PR and HER-2 receptors didn't show association with density. Our mammographic reports had a sensitivity of 94.1% and a specificity of 55.6%, which shows that our mammography is an acceptable method for screening breast cancer in this center.
Reproductive Biomedicine Online, Nov 1, 2020
Highlights EGF and PDGF expression is increased in PFMCs of patients with endometriosis. Vita... more Highlights EGF and PDGF expression is increased in PFMCs of patients with endometriosis. Vitamin D3 markedly decreases EGF and MDGF expression in endometriosis. Vitamin D3 has an in-vitro inhibitory effect on PDGF expression at 6 hours following treatment, but not at 24 h or 48 h time points. Immunomodulatory effects of vitamin D3 on gene expression of MDGF, EGF, and PDGF in peritoneal fluid mononuclear cells of patients with endometriosis
Iranian Journal of Pathology
Scan to discover online Background: To gain insight into the pathogenesis and clinical course of ... more Scan to discover online Background: To gain insight into the pathogenesis and clinical course of COVID-19 from a historical perspective, we reviewed paraclinical diagnostic tools of this disease and prioritized the patients with a more severe form of disease admitted to intensive care units (ICUs). The objective was to better predict the course and severity of the disease by collecting more paraclinical data, specifically by examining the relationship between hematological findings and cytological variation of blood neutrophils and monocytes. Methods: This retrospective study was conducted on 112 patients with confirmed COVID-19 admitted to Imam Hossein Hospital (Tehran, Iran) from August to September 2020. Peripheral blood smears of these patients were differentiated according to several cytological variations of neutrophils and monocytes, and the correlation to the severity of the disease was specified. Results: The mean percentages of degenerated monocytes, degenerated granulocytes, and spiky biky neutrophils were significantly different among critical and non-critical patients (P<0.05). Degenerated monocytes and granulocytes were higher in critical patients as opposed to spiky biky neutrophils, which were higher among non-critical ones. Comparing the peripheral blood smears of COVID-19 patients (regarding pulmonary involvement in chest computed tomography [CT] scans [subtle, mild, moderate, and severe groups]), the twisted form of neutrophils was significantly higher in the subtle group than in the mild and moderate groups (P=0.003). Conclusion: Different cytological morphologies of neutrophils and monocytes, including degenerated monocytes, degenerated granulocytes, and spiky biky and twisted neutrophils, could help to predict the course and severity of the disease.
BMC Complementary Medicine and Therapies
Background Aging is associated with impaired renal function and structural alterations. Oxidative... more Background Aging is associated with impaired renal function and structural alterations. Oxidative stress plays a vital role in renal senescence and damage. Sirtuin 1 (SIRT1) is thought to protect cells from oxidative stress through nuclear factor erythroid 2-related factor 2 (NRF2). Ellagic acid (EA), a natural antioxidant, has been demonstrated to have renoprotective roles in vitro and in vivo. This study investigated if SIRT1 and NRF2 mediate the protective effects of EA in aged kidneys. Methods Male Wistar rats were divided into three groups including young (4 months), old, and old + EA (25 months). Young and old groups received EA solvent, while the old + EA group was treated with EA (30 mg/kg) by gavage for 30 days. Then, the level of renal oxidative stress, SIRT1 and NRF2 expression, kidney function parameters, and histopathological indices were measured. Results Treatment with EA significantly increased the level of antioxidant enzymes and reduced malondialdehyde concentratio...
Journal of Experimental Orthopaedics
Purpose Studies have suggested some predictors for hamstring tendon (HT) autograft diameter based... more Purpose Studies have suggested some predictors for hamstring tendon (HT) autograft diameter based on anthropometric factors and preoperative magnetic resonance imaging (MRI) with variable results. Some authors have attributed the variability to gender differences. This prospective cohort reports the sensitivity and specificity of anthropometric and MRI predictors in males and females separately to determine the difference. Methods Forty-two eligible patients who underwent anterior cruciate ligament reconstruction (ACLR) and MRI in our center were included. ACLR was performed by the senior surgeon using a 4-stranded HT autograft for all patients. A blinded musculoskeletal radiologist measured the cross-sectional area (CSA) of gracilis and semitendinosus tendons using the free-hand region of interest tool for all patients. An orthopaedic resident (PGY4) collected anthropometric factors and measured intraoperative autograft diameter. Results Mean intraoperative autograft diameter was 8...
Current Respiratory Medicine Reviews
Background: COVID-19 is an infectious disease caused by SARS-CoV-2 and can lead to acute respirat... more Background: COVID-19 is an infectious disease caused by SARS-CoV-2 and can lead to acute respiratory distress. Objective: We aimed to investigate the association between COVID-19 severity and serum apelin-17 and inflammatory mediator levels. Method: This cross-sectional study was conducted on patients with COVID-19. COVID-19 infec-tion was confirmed by the RT-PCR test. The patients' data were extracted from their records. Ve-nous blood samples were obtained from the patients to investigate the serum levels of apelin-17 and inflammatory mediators. Results: Eighty-six COVID-19 patients were studied. The mean age of the participants was 55.56±14.88, and 43 (50 %) were male. Clinical symptoms were dyspnea 77.6 %, fever 52.3 %, cough 48.8 %, gastrointestinal symptoms 15.1 %, and chest pain 7 %. The overall mortality rate was 7 %. No significant relationship was found between serum apelin-17 levels and COVID-19 severity (P= 0.48). However, there was a significant and direct relationsh...
Human-Machine Communication for Educational Systems Design, 1994
Pathology - Research and Practice, 2016
Atypical cartilaginous tumor and enchondroma are similar in histopathologic aspects. Although the... more Atypical cartilaginous tumor and enchondroma are similar in histopathologic aspects. Although the clinical course, radiologic and pathologic examinations enable distinction in most cases, difficulties are still encountered by the pathologists. There is no known biomarker to help make a distinction between benign and malignant cartilaginous tumors. Insulin-like growth factor II mRNA binding protein (IMP3) is a member of an oncofetal family of proteins that is expressed in different human malignancies and rapidly emerging as a prognostic and diagnostic marker in surgical pathology. In this study, IMP3 expression was examined by immunohistochemistry in 36 enchondromas and 42 chondrosarcomas of different histologic grades. The results showed that all 36 cases of enchondroma were negative for IMP3, while it was overexpressed in 15 of 42 chondrosarcomas (36%) (P < 0.01). Significant higher levels of IMP3 were detected in grade III chondrosarcomas (6 of 7; 85.7%) when compared to low-grade tumors (6 of 19; 31.5% in grade II and 3 of 16; 18.7% in Atypical Cartilaginous Tumor). We proved statistically significant difference in IMP3 expression between enchondromas and ACTs (P = 0.025). Our study clearly demonstrated differentiation-dependent expression of IMP3 in chondrosarcoma, and suggests IMP3 as a novel marker for differentiating problematic cases of enchondroma from well-differentiated chondrosarcomas. To our knowledge, this study is the first study to clarify expression of IMP-3 in chondromas and chondrosarcomas.
مجله دانشکده پزشکی اصفهان, 2019
Background: Cartilage grafts are used in plastic surgery in restorations that require strength. D... more Background: Cartilage grafts are used in plastic surgery in restorations that require strength. Due to varying degrees of strength in these regenerations, cartilage grafts from different sources are used in block, crushed, and diced forms. The aim of this study was to compare the survival rate of in crushed, diced, and block autograft cartilage forms of rabbit ear. Methods: This study was performed on 36 New Zealand white male rabbits weighing 2000 to 2500 grams and aged 12 to 16 weeks. The cartilage of the right ear of each rabbit was harvested, and three graft samples of crushed, diced, and block forms were obtained. The grafts were put in three separate subcutaneous envelopes adjacent to the rabbit's backbone. After 3 months, the specimens were removed, stained with hematoxylin and eosinophil (H & E), and histologically examined. Findings: The mean graft weight increased in all groups using crushed, diced, and block cartilage forms, but it was not statistically significant. T...
Iranian Journal of Medical Microbiology, 2021
Background and Aim: The system of architectural design, space and installation of facilities and ... more Background and Aim: The system of architectural design, space and installation of facilities and equipment in the medical laboratory is based on a multifaceted structure. Considering these conditions increases the productivity and profitability to all the involved groups. The present study sought to understand and design of this structure. Materials and Methods: This descriptive-analytical research was carried out studying the literature. Results: According to the results, the adequate architectural design for a medical laboratory includes the following points: observing the separation of physical spaces, proximity of the spaces in the laboratory, the principle of flexibility in designing physical space and the ability to develop and expand the physical space, the space design and requirements to meet the mobility needs of the people with disabilities, desk designing for the disabled and the elderlies, observing the minimum standards of general space and total spaces, and the number of staff considering their safety. Conclusion: The design of medical laboratories, considering the cases mentioned in this report, will lead to the construction of a place that will not only meet the needs of clients but also provide comfort and safety for the staff. Such a laboratory will be more profitable by increasing the productivity, which will ultimately lead to a comprehensive profit. The errors and mistakes in the design and execution of any of these cases can cause minor and major damages.
Fundamental & Clinical Pharmacology
The Archives of Bone & Joint Surgery, 2016
Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla ... more Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla of long bones. ABC rarely arises within the cortex or in the subperiosteal region, radiographically mimicking other conditions, in particular surface osteosarcomathat is low-grade in nature and may go secondary ABC changes, and telangiectatic osteosarcoma. Both of these are sometimes mistaken microscopically for primary ABC. We review the characteristics of ABC cases in our center and report four unusualsurface ABCs arising in the subperiosteal or cortical region of long bones, identified among 38 histologically proven ABCs during a four-year period in our center. The surface ABCs occurred at an older agewith a predilection for diaphysis of femur, tibia, and humerus.
Basic and Clinical Neuroscience, 2020
Introduction: Primary Diffuse Large B Cell Lymphoma of CNS (PCNSL) is a rare variant of Diffuse L... more Introduction: Primary Diffuse Large B Cell Lymphoma of CNS (PCNSL) is a rare variant of Diffuse Large B Cell Lymphoma (DLBCL) and presents with an aggressive clinical course and usually resistant to commonly used therapy regimens. Recently, role of immune checkpoint molecules including PD-1 and PD-L1 confirmed in some solid tumors and lymphoma resulting tumor cells escape the immune system and help to survive and to spread. Inhibitors of PD-1 and PD-L1 have shown lasting responses in several solid and some hematological tumors, while limited studies evaluate checkpoint molecules on PCNSL. Method: In this study, we investigated PD-1 and PD-L1 expression by immunostaining on 71 patients with PCNSL and correlation with demographic data, location of the tumor, proliferation rate, cell of origin, and CD8 positive T cell infiltration in tumor microenvironment. Results: 16 from71 showed PD-1 expression, while PD-L1 expression were 42/71. No association was determined between PD-1/PD-L1 exp...
1. Department of Pathology, Hematology Research Center, School of Medicine, Shiraz University of ... more 1. Department of Pathology, Hematology Research Center, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran. 2. Department of Pathology, Cancer Prevention Research Center, Isfahan University of Medical Science, Isfahan, Iran. 3. Department of Pathology, Molecular Pathology and Cytogenetics Division, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran. 4. Department of Pathology, Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran. 5. Department of Pathology, Faculty of Medicine, Kerman University of Medical Science, Kerman, Iran. 6. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
The archives of bone and joint surgery, 2016
Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla ... more Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla of long bones. ABC rarely arises within the cortex or in the subperiosteal region, radiographically mimicking other conditions, in particular surface osteosarcomathat is low-grade in nature and may go secondary ABC changes, and telangiectatic osteosarcoma. Both of these are sometimes mistaken microscopically for primary ABC. We review the characteristics of ABC cases in our center and report four unusualsurface ABCs arising in the subperiosteal or cortical region of long bones, identified among 38 histologically proven ABCs during a four-year period in our center. The surface ABCs occurred at an older agewith a predilection for diaphysis of femur, tibia, and humerus.
Archives of Iranian medicine, 2021
BACKGROUND The pathogenesis of the COVID19 pandemic, that has killed one million nine hundred peo... more BACKGROUND The pathogenesis of the COVID19 pandemic, that has killed one million nine hundred people and infected more the 90 million until end of 2020, has been studied by many researchers. Here, we try to explain its biological behavior based on our recent autopsy information and review of literature. METHODS In this study, patients with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) result were considered eligible for enrollment. Histopathological examinations were done on 13 people who were hospitalized in Afzalipour hospital, Kerman, Iran. Clinical and laboratory data were reviewed. Tissue examination was done by light microscopy, immunohistochemistry and electron microscopy. RESULTS The most frequent co-morbidity in the patients was cardiovascular disease. The common initial symptoms of COVID-19 infection were dyspnea and cough. In all cases, the number of white blood cells was higher than the normal range. Common histopathological findings were variab...
RESEARCH QUESTION Endometriosis, an inflammatory disease, is assumed to be associated with an inc... more RESEARCH QUESTION Endometriosis, an inflammatory disease, is assumed to be associated with an increased production of growth-related cytokines. Based on the emerging immunomodulatory role of vitamin D3 in different inflammatory conditions, this study aimed to examine its modulatory effect on the expression levels of the genes for platelet-derived growth factor-B (PDGFB), monocyte/macrophage-derived growth factor (MDGF, also known as PPBP) and epidermal growth factor (EGF) in peritoneal fluid mononuclear cells (PFMC) in women with and without endometriosis. DESIGN PFMC from 10 women with endometriosis and 10 control participants were treated with vitamin D3.The gene expression levels of PDGFB, MDGF and EGF were measured 6, 24 and 48 h following vitamin D3 administration using real-time PCR. RESULTS Gene expression levels of EGF and PDGFB were higher in the PFMC of women with endometriosis than the control group (P = 0.006, P < 0.001, respectively). Although MDGF expression showed ...
Journal of Food Biochemistry
The aging process leads to progressive loss of kidney function. Sirtuin1 (SIRT1) exerts renoprote... more The aging process leads to progressive loss of kidney function. Sirtuin1 (SIRT1) exerts renoprotective effects by conferring resistance to cellular stresses. Trehalose potentially displayed various beneficial effects to promote health span. In this study, we investigated the effects of trehalose on renal SIRT1 and kidney function in senescent rats. Trehalose (2% w/v) was administrated in drinking water for 1 month to male aged rats (24 months). Then, the level of SIRT1 mRNA and protein, malondialdehyde, total antioxidant capacity, tumor necrosis factor α as well as parameters related to the function and histology of the kidneys were evaluated. Trehalose supplementation increased the level of SIRT1, whereas alleviated the level of oxidative stress, inflammation, and histopathology scores in senescent tissues. However, trehalose administration did not alter kidney function indices in old rats. Collectively, these findings suggested that trehalose was an effective intervention to ameliorate some aspects of age-associated injury in the old kidneys. PRACTICAL APPLICATIONS: Aging is associated with impairment in renal structure and function. Trehalose is a natural disaccharide, which is widely distributed in many organisms. The consumption of trehalose as a dietary supplement is increasing worldwide. This study showed that trehalose administration to aged rats had renoprotective effects through reducing oxidative stress and inflammation, which was mediated by SIRT1. Our results provide useful information for individuals using this sugar as a supplement.