Salem Said Al Touby - Academia.edu (original) (raw)

Papers by Salem Said Al Touby

Journal of Umm Al-Qura University for Applied Sciences, Apr 13, 2024

Piper nigrum (P. nigrum) is a tropical medicinal plant widely available in Southeast Asian countr... more Piper nigrum (P. nigrum) is a tropical medicinal plant widely available in Southeast Asian countries including Oman. In Asian It has a long history of usage in places such as Oman for treating of rheumatism, colds, and various infections. Based on the medicinal uses, the purpose of this research is to create diverse fractions using increasing solvent polarity from the aerial part of the collected plant species and evaluate their antibacterial and antioxidant activities by using established bioassays. The aerial part was collected from the Southern part of Oman and processed using the standard method. The processed materials were recovered using the maceration method using methanol, and the methanol raw extracts was further fractionated with water extraction, butanol, ethyl acetate (ETA), hexane, and dichloromethane are produced using different liquid polarities. Each of the six plant extracts was tested for antioxidant and antibacterial potential at different concentrations against DPPH (1, 1-diphenyl-2-picrylhydrazyl) and agar diffusion methods. All of the fractions at varied concentrations shown promising antioxidant activity with DPPH against the gallic acid. The maximum activity was observed in hexane extract, while the smallest potential was noticed in butanol extract, in the following order: hexane > chloroform > water > methanol > ethyl acetate > butanol extract. The antibacterial efficacy of six different polarities extracts gives moderate activity against two Gram-positive bacteria strains namely S. saprophyticus and S. aureus and three Gram-negative namely P. vulgaris, K. senegalensis and E. coli. Among the six extracts, hexane extract had the most antibacterial activity, whereas butanol extract had the smallest activity. The remaining four extracts, chloroform, ethyl acetate, methanol, and water, all had comparable activity. In conclusion, the extracts with the greatest activity from the chosen plant types might be employed as natural antioxidants to treat infectious disorders.

Advances in Biomarker Sciences and Technology, Dec 31, 2023

Trends in Medical Research, Dec 1, 2023

Background and Objective: Myrtus communis L. is a plant used in traditional medicine worldwide. S... more Background and Objective: Myrtus communis L. is a plant used in traditional medicine worldwide. Since many ages ago, this herb's berries have all been widely utilized as a traditional medicine to treat conditions like peptic ulcers, diarrhea, haemorrhoids, inflammation and skin diseases. The purpose of the study is to evaluate the antiulcer, antidiabetic enzymatic inhibition, antibacterial and antioxidant actions of different polarity extracts of fruits of Myrtus communis L. Materials and Methods: Methanol (crude extract) and its fractions (n-hexane (MCFH), dichloromethane (MCFD), ethyl acetate (MCFE), butanol (MCFB) and aqueous (MCFA)) from fruits of Myrtus communis L. were produced and assessed for their antimicrobial, antioxidant, α-glucosidase and antiulcer in vitro bioassays. All of the fractions were tested using a brine shrimp lethality assay to determine their cytotoxic effects. Results: The examined samples demonstrated a sizable capacity to fend off the gram-negative and gram-positive bacteria. The MCFB determined the best antibacterial activity of the five extracts, with an average inhibitions zone of 9.3 mm against Staphylococcus aureus and 6.75 mm against Escherichia coli. The MCFA extract displayed the second-highest antibacterial activity against Pseudomonas aeruginosa, with an average inhibition zone of 9.5 mm, while MCFH had the least amount of activity against the bacteria that were tested. In the anti-alpha glucosidase activity, MCFE was the best with IC 50 of 20.04±0.38 µg mLG 1 and the unease inhibition was best seen with the MCFA and MCFB extracts with IC 50 values of 146.87±1.39 and 194.97±1.68 µg mLG 1 , respectively. All extracts showed no significant cytotoxic activity. Conclusion: Therefore, all tested samples, especially MCFE and MCFB extracts, were assumed to have significant capacities for the studied activities.

Accreditation and Quality Assurance, Dec 18, 2023

Arabian Journal of Geosciences, Dec 18, 2023

International Nursing Review, Dec 5, 2023

Food Analytical Methods, Sep 10, 2023

Journal of Umm Al-Qura University for Applied Sciences, Jan 4, 2024

Humans were always in need of new medications to fight the many developing diseases that they fac... more Humans were always in need of new medications to fight the many developing diseases that they face. In recent years, the race to develop new medicines has increased caused for new diseases to occur by bacteria and viruses developed causing accumulation, local damage, and inflammation or irritation. Suaeda maritima (S. maritima) is a plant that was used in the past to treat illness and the plant extracts showed several biological activities especially hepatoprotective, antimicrobial, and antidiabetic activities. The present goal of this work is to prepare plant extracts with varied polarities from the mixture of leaves and stems of S. maritima and examine their bacteriostatic and antidiabetic activities by in vitro methods. The crude extract was prepared from the mixture of leaves and stems powder samples by methanol using the maceration method for 36 h. The methanol was removed from the extract by the usual method and then fractionated methanol extract with different polarities solvents. The bacteriostatic and antidiabetic activities of plant extracts were determined by using disc diffusion and enzyme methods. The prepared varied polarities extract at four different concentrations (2000, 1000, 500, and 250 µg/ mL) were used to evaluate their bacteriostatic activity against the Gram (+ and −) bacterial strains. Among the six plant extracts, ethyl acetate extract showed the highest bacterial activity, and the lowest activity was in DCM extract. However, at low concentrations, almost all plant extracts of the selected plant didn't show any bacteriostatic activity. The antidiabetic activity of plant varied extracts was assessed by using an α-glucosidase bioassay and the highest IC 50 was obtained in methanol extract and the lowest was in hexane extract from this bioassay. The other plant crude extracts also showed promising activity against the α-glucosidase bioassay. The plant extracts with significant activity from the selected plant could be used as natural medication to treat diabetes.

International Journal of Secondary Metabolite, Dec 21, 2022

Diabetes is a chronic metabolic disease that creates high blood sugar level. Therefore, diabetes ... more Diabetes is a chronic metabolic disease that creates high blood sugar level. Therefore, diabetes awareness is necessary to prevent diabetes by reducing sugar intake and using low-calorie alternative sweeteners instead. Stevia rebaudiana is a medicinal plant species belonging to the Compositae family. It is a sweet herb that contains diterpene glycosides, which are directly responsible for the sweet taste, but they have no caloric value. Since ancient times, there have been several reports on the use of S. rebaudiana as an alternative sweetener and extended research has been conducted on its phytochemicals and biological activities. The plant contains a good number of phytochemicals with significant biological activities, namely polyphenolic derivatives, diterpenes glycosides, alkaloids, glycosides, tannins, chlorophylls, carotenoids, etc. For industrial use, those phytochemicals could be extracted from the selected plant and used for the preparation of nutraceuticals and food additives. S. rebaudiana is a natural herb; therefore, it has fewer or minimal adverse effects on human health. The selected plant in various forms is used for the treatment of diabetes, colon cancer, obesity, cavities, and others. However, the literature review shows that the information on this plant and its uses is not systematic. The purpose of the present review is to explore the status of phytochemicals and biological activities of the selected plant for young researchers. Therefore, the updated data will help them to develop new nutraceuticals and food additives that could help in the production of pharmaceuticals to treat different ailments.

Advances in biomarker sciences and technology, 2023

Social Science Research Network, 2022

IOSR Journal of Nursing and Health Science, 2014

International nursing review en español: revista oficial del Consejo Internacional de Enfermeras, 2019

Journal of Epidemiology and Global Health, 2019

Effective use of resources in healthcare research is essential in meeting the United Nation's Sus... more Effective use of resources in healthcare research is essential in meeting the United Nation's Sustainable Development Goal (SDG) 3 to achieve universal health coverage, increase retention of healthcare workers, and strengthen the capacity of all countries to reduce risk and manage global health risks; the World Health Organization (WHO) also identifies nursing research as an important piece of the framework for improving global healthcare. Determining research priorities to reduce redundancy and ensure a solid evidence base for practice is especially critical in resource-limited countries or those facing healthcare crises such as those in the Middle East. To identify regional research priorities for nursing, focus group discussions composed of hospitalbased nurses were conducted in Egypt, Oman, and Saudi Arabia. Forty-eight percent of research priorities were nearly the same as those identified as critical by regional nursing leadership in a previous study, demonstrating consistency between clinicianand administrator-identified research priorities, and suggesting healthcare administrators are well attuned to the research needs of clinicians. Both groups identified critical gaps in population and community health research. Across countries, research priorities identified were related to nursing workforce, health systems research, and quality of care, representing critical issues needing investigation to build a solid evidence base for nursing practice.

International Journal of Nursing Education, 2019

The Clinical placements and clinical learning form a major part of nurse education and have an im... more The Clinical placements and clinical learning form a major part of nurse education and have an important role in students’ perceptions of nursing. This study assessed the perceptions of male nursing students, their views, concerns, challenges in providing care to the children during paediatric clinical placement. A Descriptive, qualitative design with focus group interview was conducted. Analysis of data yielded four themes: 1) Traditionally gendered specialty; 2) Barriers to provision of care; 3) Lack of support; 4) Alternative clinical settings.

Oman Medical Journal, 2014

Arabian Journal of Geosciences

Advances in Biomarker Sciences and Technology

Journal of Umm Al-Qura University for Applied Sciences, Apr 13, 2024

Piper nigrum (P. nigrum) is a tropical medicinal plant widely available in Southeast Asian countr... more Piper nigrum (P. nigrum) is a tropical medicinal plant widely available in Southeast Asian countries including Oman. In Asian It has a long history of usage in places such as Oman for treating of rheumatism, colds, and various infections. Based on the medicinal uses, the purpose of this research is to create diverse fractions using increasing solvent polarity from the aerial part of the collected plant species and evaluate their antibacterial and antioxidant activities by using established bioassays. The aerial part was collected from the Southern part of Oman and processed using the standard method. The processed materials were recovered using the maceration method using methanol, and the methanol raw extracts was further fractionated with water extraction, butanol, ethyl acetate (ETA), hexane, and dichloromethane are produced using different liquid polarities. Each of the six plant extracts was tested for antioxidant and antibacterial potential at different concentrations against DPPH (1, 1-diphenyl-2-picrylhydrazyl) and agar diffusion methods. All of the fractions at varied concentrations shown promising antioxidant activity with DPPH against the gallic acid. The maximum activity was observed in hexane extract, while the smallest potential was noticed in butanol extract, in the following order: hexane > chloroform > water > methanol > ethyl acetate > butanol extract. The antibacterial efficacy of six different polarities extracts gives moderate activity against two Gram-positive bacteria strains namely S. saprophyticus and S. aureus and three Gram-negative namely P. vulgaris, K. senegalensis and E. coli. Among the six extracts, hexane extract had the most antibacterial activity, whereas butanol extract had the smallest activity. The remaining four extracts, chloroform, ethyl acetate, methanol, and water, all had comparable activity. In conclusion, the extracts with the greatest activity from the chosen plant types might be employed as natural antioxidants to treat infectious disorders.

Advances in Biomarker Sciences and Technology, Dec 31, 2023

Trends in Medical Research, Dec 1, 2023

Background and Objective: Myrtus communis L. is a plant used in traditional medicine worldwide. S... more Background and Objective: Myrtus communis L. is a plant used in traditional medicine worldwide. Since many ages ago, this herb's berries have all been widely utilized as a traditional medicine to treat conditions like peptic ulcers, diarrhea, haemorrhoids, inflammation and skin diseases. The purpose of the study is to evaluate the antiulcer, antidiabetic enzymatic inhibition, antibacterial and antioxidant actions of different polarity extracts of fruits of Myrtus communis L. Materials and Methods: Methanol (crude extract) and its fractions (n-hexane (MCFH), dichloromethane (MCFD), ethyl acetate (MCFE), butanol (MCFB) and aqueous (MCFA)) from fruits of Myrtus communis L. were produced and assessed for their antimicrobial, antioxidant, α-glucosidase and antiulcer in vitro bioassays. All of the fractions were tested using a brine shrimp lethality assay to determine their cytotoxic effects. Results: The examined samples demonstrated a sizable capacity to fend off the gram-negative and gram-positive bacteria. The MCFB determined the best antibacterial activity of the five extracts, with an average inhibitions zone of 9.3 mm against Staphylococcus aureus and 6.75 mm against Escherichia coli. The MCFA extract displayed the second-highest antibacterial activity against Pseudomonas aeruginosa, with an average inhibition zone of 9.5 mm, while MCFH had the least amount of activity against the bacteria that were tested. In the anti-alpha glucosidase activity, MCFE was the best with IC 50 of 20.04±0.38 µg mLG 1 and the unease inhibition was best seen with the MCFA and MCFB extracts with IC 50 values of 146.87±1.39 and 194.97±1.68 µg mLG 1 , respectively. All extracts showed no significant cytotoxic activity. Conclusion: Therefore, all tested samples, especially MCFE and MCFB extracts, were assumed to have significant capacities for the studied activities.

Accreditation and Quality Assurance, Dec 18, 2023

Arabian Journal of Geosciences, Dec 18, 2023

International Nursing Review, Dec 5, 2023

Food Analytical Methods, Sep 10, 2023

Journal of Umm Al-Qura University for Applied Sciences, Jan 4, 2024

Humans were always in need of new medications to fight the many developing diseases that they fac... more Humans were always in need of new medications to fight the many developing diseases that they face. In recent years, the race to develop new medicines has increased caused for new diseases to occur by bacteria and viruses developed causing accumulation, local damage, and inflammation or irritation. Suaeda maritima (S. maritima) is a plant that was used in the past to treat illness and the plant extracts showed several biological activities especially hepatoprotective, antimicrobial, and antidiabetic activities. The present goal of this work is to prepare plant extracts with varied polarities from the mixture of leaves and stems of S. maritima and examine their bacteriostatic and antidiabetic activities by in vitro methods. The crude extract was prepared from the mixture of leaves and stems powder samples by methanol using the maceration method for 36 h. The methanol was removed from the extract by the usual method and then fractionated methanol extract with different polarities solvents. The bacteriostatic and antidiabetic activities of plant extracts were determined by using disc diffusion and enzyme methods. The prepared varied polarities extract at four different concentrations (2000, 1000, 500, and 250 µg/ mL) were used to evaluate their bacteriostatic activity against the Gram (+ and −) bacterial strains. Among the six plant extracts, ethyl acetate extract showed the highest bacterial activity, and the lowest activity was in DCM extract. However, at low concentrations, almost all plant extracts of the selected plant didn't show any bacteriostatic activity. The antidiabetic activity of plant varied extracts was assessed by using an α-glucosidase bioassay and the highest IC 50 was obtained in methanol extract and the lowest was in hexane extract from this bioassay. The other plant crude extracts also showed promising activity against the α-glucosidase bioassay. The plant extracts with significant activity from the selected plant could be used as natural medication to treat diabetes.

International Journal of Secondary Metabolite, Dec 21, 2022

Diabetes is a chronic metabolic disease that creates high blood sugar level. Therefore, diabetes ... more Diabetes is a chronic metabolic disease that creates high blood sugar level. Therefore, diabetes awareness is necessary to prevent diabetes by reducing sugar intake and using low-calorie alternative sweeteners instead. Stevia rebaudiana is a medicinal plant species belonging to the Compositae family. It is a sweet herb that contains diterpene glycosides, which are directly responsible for the sweet taste, but they have no caloric value. Since ancient times, there have been several reports on the use of S. rebaudiana as an alternative sweetener and extended research has been conducted on its phytochemicals and biological activities. The plant contains a good number of phytochemicals with significant biological activities, namely polyphenolic derivatives, diterpenes glycosides, alkaloids, glycosides, tannins, chlorophylls, carotenoids, etc. For industrial use, those phytochemicals could be extracted from the selected plant and used for the preparation of nutraceuticals and food additives. S. rebaudiana is a natural herb; therefore, it has fewer or minimal adverse effects on human health. The selected plant in various forms is used for the treatment of diabetes, colon cancer, obesity, cavities, and others. However, the literature review shows that the information on this plant and its uses is not systematic. The purpose of the present review is to explore the status of phytochemicals and biological activities of the selected plant for young researchers. Therefore, the updated data will help them to develop new nutraceuticals and food additives that could help in the production of pharmaceuticals to treat different ailments.

Advances in biomarker sciences and technology, 2023

Social Science Research Network, 2022

IOSR Journal of Nursing and Health Science, 2014

International nursing review en español: revista oficial del Consejo Internacional de Enfermeras, 2019

Journal of Epidemiology and Global Health, 2019

Effective use of resources in healthcare research is essential in meeting the United Nation's Sus... more Effective use of resources in healthcare research is essential in meeting the United Nation's Sustainable Development Goal (SDG) 3 to achieve universal health coverage, increase retention of healthcare workers, and strengthen the capacity of all countries to reduce risk and manage global health risks; the World Health Organization (WHO) also identifies nursing research as an important piece of the framework for improving global healthcare. Determining research priorities to reduce redundancy and ensure a solid evidence base for practice is especially critical in resource-limited countries or those facing healthcare crises such as those in the Middle East. To identify regional research priorities for nursing, focus group discussions composed of hospitalbased nurses were conducted in Egypt, Oman, and Saudi Arabia. Forty-eight percent of research priorities were nearly the same as those identified as critical by regional nursing leadership in a previous study, demonstrating consistency between clinicianand administrator-identified research priorities, and suggesting healthcare administrators are well attuned to the research needs of clinicians. Both groups identified critical gaps in population and community health research. Across countries, research priorities identified were related to nursing workforce, health systems research, and quality of care, representing critical issues needing investigation to build a solid evidence base for nursing practice.

International Journal of Nursing Education, 2019

The Clinical placements and clinical learning form a major part of nurse education and have an im... more The Clinical placements and clinical learning form a major part of nurse education and have an important role in students’ perceptions of nursing. This study assessed the perceptions of male nursing students, their views, concerns, challenges in providing care to the children during paediatric clinical placement. A Descriptive, qualitative design with focus group interview was conducted. Analysis of data yielded four themes: 1) Traditionally gendered specialty; 2) Barriers to provision of care; 3) Lack of support; 4) Alternative clinical settings.

Oman Medical Journal, 2014

Arabian Journal of Geosciences

Advances in Biomarker Sciences and Technology