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Research paper thumbnail of Volatiles composition and antioxidant activity Inula oculus-christi L. from Serbia

Natural Product Research, 2019

The chemical composition of the essential oil and the volatiles obtained by static headspace (HS)... more The chemical composition of the essential oil and the volatiles obtained by static headspace (HS) of Inula oculus-christi L. is presented. The GC-MS analysis of the hydrodistilled oil resulted in the identification of 90 components, representing 92.7% of the oil. The most abundant compounds were: caryophyllene oxide (9.8%), trans-longipinocarveol (9.2%), eucalyptol (7.3%) and intermedeol (6.2%). The major constituent of I. oculus-christi L. HS volatiles was eucalyptol (87.4%). The antioxidant activity was evaluated by four different methods: 2,2-diphenyl-1-picryl-hydrazylhydrate free radical assay (DPPH), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method, total reducing power (TRP), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC). Total phenolic content in (TPC) examined oil was 177.95 mg GAE/mg oil. Radical scavenging potential of the oil was promising RSC-DPPH was 57.4% and RSC-ABTS was 82.7%.

Research paper thumbnail of Antimicrobial activity of Hypericum annulatum moris and Hypericum elegans stephan ex willd. essential oils from Serbia

Chemical Industry and Chemical Engineering Quarterly, 2013

The in vitro antimicrobial activity of Hypericum annulatum and Hypericum elegans essential oils w... more The in vitro antimicrobial activity of Hypericum annulatum and Hypericum elegans essential oils was evaluated against a panel of standardized bacteria and fungi using broth microdilution assay. Both essential oils showed antimicrobial activity against all the tested microorganisms. Hypericum annulatum essential oil showed better antibacterial than antifungal activity, being more effective against Pseudomonas aeruginosa and Escherichia coli while H. elegans essential oil showed no significant difference between antibacterial and antifungal activity. Antimicrobial testing of ?-pinene, ?-pinene and ?-myrcene compounds was also performed. All the compounds were active against all the tested microorganisms, however, based on the MIC, MBC and MFC values, none of these compounds could be thought of as the main bearer of the oils? antimicrobial activity. This is the first report regarding the antimicrobial activity of the essential oils of the two Hypericum species.

Research paper thumbnail of Chemical Composition, Antimicrobial Activity and Chemotaxonomy of Essential Oil of Aerial Parts of <i>Hypericum rumeliacum</i> Boiss. Species

Journal of Essential Oil Bearing Plants, Mar 3, 2020

In this study, the chemical composition, antimicrobial and antioxidant activities of Litsea cubeb... more In this study, the chemical composition, antimicrobial and antioxidant activities of Litsea cubeba essential oils extracted in different months were analysed. Results showed that the essential oil contents of fruits collected in June, July and August were 3.47%, 5.02% and 5.64%, respectively, and contained 13, 17 and 17 components, respectively. Neral and geranial were the main components and accounted for 54.76%. The essential oil extracted from fruits collected in July had the highest antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Salmonella typhimurium, and it was the most effective based on the OHÁ scavenging activity test. The essential oil extracted from fruits collected in August was the most effective based on the test for DPPHÁ scavenging activity and ferric reducing antioxidant power. Considering the contents, chemical compositions and antimicrobial and antioxidant activities, the appropriate harvest time for L. cubeba essential oils is from July to August.

Research paper thumbnail of Recent Advances in Analysis of Essential Oils

Current Analytical Chemistry, 2013

This review provides an overview of the emerging trends in analysis of essential oils and indicat... more This review provides an overview of the emerging trends in analysis of essential oils and indicates future trends. Since early human history the essential oils have been used in folk medicine, food and cosmetic industries in various parts of the world. GC-FID is the traditional method for essential oils quantification while GC-MS is the most common analytical method for qualitative analysis. Chiral GC allowed the identification of a great number of chiral essential oil constituents. An alternative to GC analysis is HPLC chromatography. The use of hyphenated techniques, such as LC-MS-MS provides important information about the structure of essential oils constituents. However, only a comparatively small number of reports on essential oil analyses by HPLC can be found in the literature. Multidimensional chromatography is an approach capable of providing greater resolution. 13 C-NMR spectroscopy is a complementary tool for analysis of essential oils. Advantage of this method compared to mass spectrometry is identification of stereoisomers and thermally unstable compounds while its disadvantage is inability to identify the minor oils constituents. 1 H-NMR as an online tool for GC analysis showed promising results but requires further research to be applied on the analysis of essential oils. The range of information obtained from essential oils analysis enables the application of chemometrics.

Research paper thumbnail of Dittrichia graveolens(L.)GreuterEssential Oil: Chemical Composition, Multivariate Analysis, and Antimicrobial Activity

Chemistry & Biodiversity, 2016

Thechemical compositionand in vitro antimicrobial activities of Dittrichia graveolens (L.) Greute... more Thechemical compositionand in vitro antimicrobial activities of Dittrichia graveolens (L.) Greuter essential oil was studied. Moreover, using agglomerative hierarchical cluster (AHC)a nd principal component analyses (PCA), the interrelationships of the D. graveolens essential-oil profiles characterized so far (including the samplefrom this study)were investigated. To evaluate the chemical compositiono ft he essentialo il, GC-FID and GC/MSa nalyses were performed. Altogether, 54 compounds were identified, accounting for 92.9% of the total oil composition.The D. graveolens oil belongs to the monoterpenoid chemotype,with monoterpenoids comprising 87.4% of the totally identified compounds.The major componentswere borneol (43.6%) and bornyl acetate(38.3%). Multivariate analysis showedthat the compounds borneol and bornyl acetate exerted the greatest influence on the spatiald ifferencesi nt he compositiono ft he reported oils.T he antimicrobial activity against five bacterial and one fungal strain was determined using ad isk-diffusion assay.T he studied essential oil was active only against Gram-positive bacteria.

Research paper thumbnail of Volatiles composition and antioxidant activity Inula oculus-christi L. from Serbia

Natural Product Research, 2019

The chemical composition of the essential oil and the volatiles obtained by static headspace (HS)... more The chemical composition of the essential oil and the volatiles obtained by static headspace (HS) of Inula oculus-christi L. is presented. The GC-MS analysis of the hydrodistilled oil resulted in the identification of 90 components, representing 92.7% of the oil. The most abundant compounds were: caryophyllene oxide (9.8%), trans-longipinocarveol (9.2%), eucalyptol (7.3%) and intermedeol (6.2%). The major constituent of I. oculus-christi L. HS volatiles was eucalyptol (87.4%). The antioxidant activity was evaluated by four different methods: 2,2-diphenyl-1-picryl-hydrazylhydrate free radical assay (DPPH), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method, total reducing power (TRP), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC). Total phenolic content in (TPC) examined oil was 177.95 mg GAE/mg oil. Radical scavenging potential of the oil was promising RSC-DPPH was 57.4% and RSC-ABTS was 82.7%.

Research paper thumbnail of Antimicrobial activity of Hypericum annulatum moris and Hypericum elegans stephan ex willd. essential oils from Serbia

Chemical Industry and Chemical Engineering Quarterly, 2013

The in vitro antimicrobial activity of Hypericum annulatum and Hypericum elegans essential oils w... more The in vitro antimicrobial activity of Hypericum annulatum and Hypericum elegans essential oils was evaluated against a panel of standardized bacteria and fungi using broth microdilution assay. Both essential oils showed antimicrobial activity against all the tested microorganisms. Hypericum annulatum essential oil showed better antibacterial than antifungal activity, being more effective against Pseudomonas aeruginosa and Escherichia coli while H. elegans essential oil showed no significant difference between antibacterial and antifungal activity. Antimicrobial testing of ?-pinene, ?-pinene and ?-myrcene compounds was also performed. All the compounds were active against all the tested microorganisms, however, based on the MIC, MBC and MFC values, none of these compounds could be thought of as the main bearer of the oils? antimicrobial activity. This is the first report regarding the antimicrobial activity of the essential oils of the two Hypericum species.

Research paper thumbnail of Chemical Composition, Antimicrobial Activity and Chemotaxonomy of Essential Oil of Aerial Parts of <i>Hypericum rumeliacum</i> Boiss. Species

Journal of Essential Oil Bearing Plants, Mar 3, 2020

In this study, the chemical composition, antimicrobial and antioxidant activities of Litsea cubeb... more In this study, the chemical composition, antimicrobial and antioxidant activities of Litsea cubeba essential oils extracted in different months were analysed. Results showed that the essential oil contents of fruits collected in June, July and August were 3.47%, 5.02% and 5.64%, respectively, and contained 13, 17 and 17 components, respectively. Neral and geranial were the main components and accounted for 54.76%. The essential oil extracted from fruits collected in July had the highest antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Salmonella typhimurium, and it was the most effective based on the OHÁ scavenging activity test. The essential oil extracted from fruits collected in August was the most effective based on the test for DPPHÁ scavenging activity and ferric reducing antioxidant power. Considering the contents, chemical compositions and antimicrobial and antioxidant activities, the appropriate harvest time for L. cubeba essential oils is from July to August.

Research paper thumbnail of Recent Advances in Analysis of Essential Oils

Current Analytical Chemistry, 2013

This review provides an overview of the emerging trends in analysis of essential oils and indicat... more This review provides an overview of the emerging trends in analysis of essential oils and indicates future trends. Since early human history the essential oils have been used in folk medicine, food and cosmetic industries in various parts of the world. GC-FID is the traditional method for essential oils quantification while GC-MS is the most common analytical method for qualitative analysis. Chiral GC allowed the identification of a great number of chiral essential oil constituents. An alternative to GC analysis is HPLC chromatography. The use of hyphenated techniques, such as LC-MS-MS provides important information about the structure of essential oils constituents. However, only a comparatively small number of reports on essential oil analyses by HPLC can be found in the literature. Multidimensional chromatography is an approach capable of providing greater resolution. 13 C-NMR spectroscopy is a complementary tool for analysis of essential oils. Advantage of this method compared to mass spectrometry is identification of stereoisomers and thermally unstable compounds while its disadvantage is inability to identify the minor oils constituents. 1 H-NMR as an online tool for GC analysis showed promising results but requires further research to be applied on the analysis of essential oils. The range of information obtained from essential oils analysis enables the application of chemometrics.

Research paper thumbnail of Dittrichia graveolens(L.)GreuterEssential Oil: Chemical Composition, Multivariate Analysis, and Antimicrobial Activity

Chemistry & Biodiversity, 2016

Thechemical compositionand in vitro antimicrobial activities of Dittrichia graveolens (L.) Greute... more Thechemical compositionand in vitro antimicrobial activities of Dittrichia graveolens (L.) Greuter essential oil was studied. Moreover, using agglomerative hierarchical cluster (AHC)a nd principal component analyses (PCA), the interrelationships of the D. graveolens essential-oil profiles characterized so far (including the samplefrom this study)were investigated. To evaluate the chemical compositiono ft he essentialo il, GC-FID and GC/MSa nalyses were performed. Altogether, 54 compounds were identified, accounting for 92.9% of the total oil composition.The D. graveolens oil belongs to the monoterpenoid chemotype,with monoterpenoids comprising 87.4% of the totally identified compounds.The major componentswere borneol (43.6%) and bornyl acetate(38.3%). Multivariate analysis showedthat the compounds borneol and bornyl acetate exerted the greatest influence on the spatiald ifferencesi nt he compositiono ft he reported oils.T he antimicrobial activity against five bacterial and one fungal strain was determined using ad isk-diffusion assay.T he studied essential oil was active only against Gram-positive bacteria.