Thierry Sarrazin - Academia.edu (original) (raw)
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Università degli Studi di Firenze (University of Florence)
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Papers by Thierry Sarrazin
Bulletin du Cancer/Radiothérapie, 1996
Oral Oncology, 2014
vous remercie d'accepter de juger cette thèse et d'en présider le jury. Par votre participation a... more vous remercie d'accepter de juger cette thèse et d'en présider le jury. Par votre participation aux comités de suivi de thèse, vous m'avez permis d'orienter ce travail dans une continuité scientifique logique. Par le prêt de certaines lignées cellulaires, nous avons pu poursuivre de façon plus approfondie les travaux sur les souris. Je vous exprime à travers ce travail ma plus profonde reconnaissance pour votre participation et cela malgré la distance.
Cancer/Radiothérapie, 2009
Compass ASIC Synthesizer recognises through an HDL description which operators and variables can ... more Compass ASIC Synthesizer recognises through an HDL description which operators and variables can be mapped onto an X-BLOX element and creates the specification for the Xilinx X-BLOX compiler. This new technique is based upon a powerful recognition mechanism in the HDL code and allows several operators to be implemented into a single element. For example an addition into a memory variable will be implemented into a single accumulator. Such a tool now gives, in most cases, far better results than using classical optimization tools and even specific FPGA optimization tools.
La neurochirurgie et la radiochirurgie stereotaxiques ont pour objet le diagnostic et le traiteme... more La neurochirurgie et la radiochirurgie stereotaxiques ont pour objet le diagnostic et le traitement de petites lesions cerebrales profondes dont l'abord chirurgical classique est delicat. Une methodologie et une informatique specifiques pour le reperage stereotaxique et la planification dosimetrique ont ete developpees. Elles integrent les donnees des differentes modalites d'imagerie medicale (RX, TDM, IRM, ADS). Sur la base de leur experience, les auteurs decrivent les controles de qualite et procedures de securite mis en place
Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)
Physica Medica, 2018
INTRODUCTION This work describes the clinical implementation of a Monte Carlo based platform for ... more INTRODUCTION This work describes the clinical implementation of a Monte Carlo based platform for treatment plan validation for Tomotherapy and Cyberknife, including a semi-automatic plan evaluation module based on dose constraints for organs-at-risk (OAR). METHODS The Monte Carlo-based platform Moderato [1] is based on BEAMnrc/DOSXYZnrc and allows for automated re-calculation of doses planned with Tomotherapy and Cyberknife techniques. The Prescription/Validation module generates a set of dose constraints based on the anatomical region and fractionation scheme considered. Upon achievement of the planning, dose results are displayed with visual warnings in case of constraint violation. The system was tested on 83 patient cases in order to evaluate the influence of difference in calculation algorithms on OAR constraints. RESULTS The first results with the Tomotherapy plans allowed for detecting and correcting a problem with the CT Hounsfield units when using a large reconstruction diameter (a CT artifact that lead to air voxels with an overestimated density). The Cyberknife results also showed some dose differences associated with different energy thresholds between Moderato and the Monte Carlo algorithm used in the Treatment Planning Station. Regarding OAR constraints, re-calculation generated few violations in thoracic, pelvic and abdominal cases. However, in spinal and head cases, significant differences can appear (-11% to +6%) on optic pathways and spinal cord, leading to doses above the limits. CONCLUSIONS The Moderato platform constitutes a promising tool for the validation of plan quality, offering both dose re-calculation and OAR constraints evaluation. First results show the importance of this verification for some specific regions. Further work is ongoing to optimize the quantity and relevance of the information displayed, before fully introducing the system in clinical routine.
Bulletin du Cancer/Radiothérapie, 1996
La Lettre Du Cancerologue, 2009
Acta Metallurgica, 1979
ABSTRACT Compression tests have been performed on single and polycrystals of long period ordered ... more ABSTRACT Compression tests have been performed on single and polycrystals of long period ordered Ni3V. Two different domain sizes have been investigated. The yield stress for small domain specimens is approximately 1.8 times larger than the one for large domain crystals. This can be explained by comparing the different partial dislocations propagating the deformation: 2/3(line type 112) in small domain crystals and 1/6(line type 112) in large domain crystals, as confirmed by electron microscopy. The friction stress acted on these mobile partial dislocations by the 'forest' (attractive junctions) is calculated as a function of their Burgers vector length and accounts for the experimental results.
Bulletin du Cancer/Radiothérapie, 1996
Cancer/Radiothérapie, 2012
Bulletin du Cancer/Radiothérapie, 1996
Oral Oncology, 2014
vous remercie d'accepter de juger cette thèse et d'en présider le jury. Par votre participation a... more vous remercie d'accepter de juger cette thèse et d'en présider le jury. Par votre participation aux comités de suivi de thèse, vous m'avez permis d'orienter ce travail dans une continuité scientifique logique. Par le prêt de certaines lignées cellulaires, nous avons pu poursuivre de façon plus approfondie les travaux sur les souris. Je vous exprime à travers ce travail ma plus profonde reconnaissance pour votre participation et cela malgré la distance.
Cancer/Radiothérapie, 2009
Compass ASIC Synthesizer recognises through an HDL description which operators and variables can ... more Compass ASIC Synthesizer recognises through an HDL description which operators and variables can be mapped onto an X-BLOX element and creates the specification for the Xilinx X-BLOX compiler. This new technique is based upon a powerful recognition mechanism in the HDL code and allows several operators to be implemented into a single element. For example an addition into a memory variable will be implemented into a single accumulator. Such a tool now gives, in most cases, far better results than using classical optimization tools and even specific FPGA optimization tools.
La neurochirurgie et la radiochirurgie stereotaxiques ont pour objet le diagnostic et le traiteme... more La neurochirurgie et la radiochirurgie stereotaxiques ont pour objet le diagnostic et le traitement de petites lesions cerebrales profondes dont l'abord chirurgical classique est delicat. Une methodologie et une informatique specifiques pour le reperage stereotaxique et la planification dosimetrique ont ete developpees. Elles integrent les donnees des differentes modalites d'imagerie medicale (RX, TDM, IRM, ADS). Sur la base de leur experience, les auteurs decrivent les controles de qualite et procedures de securite mis en place
Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)
Physica Medica, 2018
INTRODUCTION This work describes the clinical implementation of a Monte Carlo based platform for ... more INTRODUCTION This work describes the clinical implementation of a Monte Carlo based platform for treatment plan validation for Tomotherapy and Cyberknife, including a semi-automatic plan evaluation module based on dose constraints for organs-at-risk (OAR). METHODS The Monte Carlo-based platform Moderato [1] is based on BEAMnrc/DOSXYZnrc and allows for automated re-calculation of doses planned with Tomotherapy and Cyberknife techniques. The Prescription/Validation module generates a set of dose constraints based on the anatomical region and fractionation scheme considered. Upon achievement of the planning, dose results are displayed with visual warnings in case of constraint violation. The system was tested on 83 patient cases in order to evaluate the influence of difference in calculation algorithms on OAR constraints. RESULTS The first results with the Tomotherapy plans allowed for detecting and correcting a problem with the CT Hounsfield units when using a large reconstruction diameter (a CT artifact that lead to air voxels with an overestimated density). The Cyberknife results also showed some dose differences associated with different energy thresholds between Moderato and the Monte Carlo algorithm used in the Treatment Planning Station. Regarding OAR constraints, re-calculation generated few violations in thoracic, pelvic and abdominal cases. However, in spinal and head cases, significant differences can appear (-11% to +6%) on optic pathways and spinal cord, leading to doses above the limits. CONCLUSIONS The Moderato platform constitutes a promising tool for the validation of plan quality, offering both dose re-calculation and OAR constraints evaluation. First results show the importance of this verification for some specific regions. Further work is ongoing to optimize the quantity and relevance of the information displayed, before fully introducing the system in clinical routine.
Bulletin du Cancer/Radiothérapie, 1996
La Lettre Du Cancerologue, 2009
Acta Metallurgica, 1979
ABSTRACT Compression tests have been performed on single and polycrystals of long period ordered ... more ABSTRACT Compression tests have been performed on single and polycrystals of long period ordered Ni3V. Two different domain sizes have been investigated. The yield stress for small domain specimens is approximately 1.8 times larger than the one for large domain crystals. This can be explained by comparing the different partial dislocations propagating the deformation: 2/3(line type 112) in small domain crystals and 1/6(line type 112) in large domain crystals, as confirmed by electron microscopy. The friction stress acted on these mobile partial dislocations by the 'forest' (attractive junctions) is calculated as a function of their Burgers vector length and accounts for the experimental results.
Bulletin du Cancer/Radiothérapie, 1996
Cancer/Radiothérapie, 2012