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Papers by Sercan Karabulut

Objective: The increase in the circulatory cytokine levels observed in patients with bipolar diso... more Objective: The increase in the circulatory cytokine levels observed in patients with bipolar disorder (BD) may imply involvement of inflammation in the pathogenesis of mood disorders. However, the association between the inflammatory process and the stage and severity of illness is not well understood. In this study, our aim was to investigate the association between neuroinflammation and disease progression in the clinical course of BD.

Turkish Journal of Psychiatry, 2019

Bipolar bozukluk hastalarında sitokin seviyelerinde gözlenen artış, duygudurum bozukluklarının pa... more Bipolar bozukluk hastalarında sitokin seviyelerinde gözlenen artış, duygudurum bozukluklarının patogenezinde inflamasyonun rolünü gösteriyor olabilir. Bununla birlikte inflamasyon süreci ile hastalığın evresi ve şiddeti arasındaki bağlantı iyi anlaşılamamıştır. Bu çalışmada bipolar bozukluğun seyrinde nöroinflamasyon ve hastalık progresyonu arasındaki ilişkinin araştırılması amaçlanmıştır. Yöntem: IL-6, tümör nekroz faktör-alfa (TNF-α), IL-1 reseptör antagonisti (IL-1RA), nöron spesifik enolaz (NSE) ve S100B seviyeleri, erken evre (n=30), kronik (n=77) ve sağlıklı kontrollerin (n=30) plazma örneklerinde enzim-ilişkili immunosorbent analiz (ELISA) yöntemi kullanılarak ölçüldü. Bulgular: Kronik bipolar bozukluk hastalarında ölçülen tüm nöroinflamasyon belirteçlerinde erken evre ve sağlıklı kontrol grubuna göre anlamlı yükselme gözlendi. IL-6 ve IL-1RA seviyeleri, NSE ve S100B seviyeleri ile koreleydi. TNF-α seviyeleri Montgomery Asberg Depresyon Değerlendirme ölçeği (MADÖ) ve Klinik Global İzlenim ölçeği (KGİÖ) skorlarıyla koreleydi. Sonuç: Sonuçlar bipolar bozukluğun ileri evrelerinde, gliozis ve nöron kaybına eşlik eden bir bulgu olarak, inflamasyonun progresyon gösterdiğini ve bu inflamasyonun kısmi olarak IL-1RA ve IL-6 aktivitesiyle ilişkili olduğunu göstermektedir.

Acta Neuropsychiatrica, 2017

ObjectiveBipolar disorder (BD) patients have recently been shown to exhibit increased proinflamma... more ObjectiveBipolar disorder (BD) patients have recently been shown to exhibit increased proinflammatory cytokine levels indicating the role of inflammation in this disease. As inflammatory responses often include complement level alterations and complement production is influenced by cytokines, we aimed to find out whether complement system is activated in BD in a time-dependent manner and complement factors are involved in BD pathogenesis.MethodsSerum C4, factor B, sC5b-9 and neuron-specific enolase levels were measured by enzyme-linked immunosorbent assay, whereas peripheral blood mononuclear cell messenger RNA (mRNA) expression levels of C1q, C4, factor B and CD55 were measured by real-time polymerase chain reaction in chronic BD patients (n=22), first episode BD patients (n=24) and healthy controls (n=19).ResultsSerum complement levels were significantly reduced in chronic BD patients as compared with first episode BD patients and healthy controls. Serum levels of complement facto...

Anatolian Journal of Psychiatry, 2016

Alopecia involves the loss of some or all of the hair from the head and sometimes other parts of ... more Alopecia involves the loss of some or all of the hair from the head and sometimes other parts of body. The etiology contains a lot of factors including drug use and psychotropic agents at sometimes. New generationl antipsychotics are less frequently accused, compared to the other psychotropic agents. In the literature, olanzapine, risperidone, ziprasidone, loxapine, quetiapine and haloperidol are the reported drugs associated with alopecia. Alopecia which may be seen rarely, was observed in our patient with schizoaffective disorder, thus in this report the patient's followup, treatment process and approach to alopecia cases were described.

CNS drugs, Jan 29, 2016

Earlier commencement of clozapine has been related to a better response in treatment-resistant sc... more Earlier commencement of clozapine has been related to a better response in treatment-resistant schizophrenia. To identify variables that predict clozapine use after a first episode of schizophrenia (FES). Patients with FES and ≤15 days of lifetime antipsychotic treatment were followed up during naturalistic treatment, and the patients who were initiated on clozapine were compared with those receiving non-clozapine antipsychotics for ≥24 months regarding demographic and clinical baseline characteristics, adherence, and relapse patterns during follow-up. Treatment-resistant schizophrenia was defined as two or more antipsychotic trials of adequate dose for ≥6 weeks. Twenty-eight patients who used clozapine and 77 non-clozapine antipsychotic users were included. Clozapine was initiated after a mean of 2.5 ± 1.1 adequate antipsychotic trials. Eight of the 28 clozapine-treated patients (28.6 %) began their clozapine treatment during the first 12 months of follow-up (mean 7.1 ± 3.3 months)...

International Clinical Psychopharmacology, 2015

The aim of this retrospective chart-review study was to investigate the relationship between dela... more The aim of this retrospective chart-review study was to investigate the relationship between delayed commencement of clozapine and the level of response in treatment-resistant schizophrenia (TRS). We included 162 patients with schizophrenia who used clozapine. The mean delay until starting clozapine after fulfillment of the TRS criteria was 29 months. The delay was shorter in those who gained benefit from clozapine (P = 0.04), those who were treated in a specialized psychosis outpatient unit (P = 0.01), and in men (P = 0.009), and it correlated with age (P < 0.001). The delay in starting clozapine and the maximum clozapine dose were independent contributors toward the response to clozapine in the logistic regression analysis. Moreover, of those who gained considerable benefit from clozapine, the patients were younger (P = 0.01), the duration of illness before clozapine treatment was shorter (P = 0.001), and the numbers of adequate antipsychotic trials before the use of clozapine were fewer (P = 0.05). Our findings suggest that efforts aimed at reducing the delay for starting clozapine may increase the effectiveness of clozapine in TRS.

Archives of Neuropsychiatry, 2022

Journal of Trauma & Dissociation, 2014

Dissociative amnesia (DA) among subjects with a dissociative disorder and/or borderline personali... more Dissociative amnesia (DA) among subjects with a dissociative disorder and/or borderline personality disorder (BPD) recruited from a nonclinical population was examined. The Steinberg Dissociative Amnesia Questionnaire (SDAQ), the Childhood Trauma Questionnaire, and the self-report screening tool of the BPD section of the Structured Clinical Interview for DSM-IV(SCID-BPD) were administered to 1,301 college students. A total of 80 participants who were diagnosed with BPD according to the clinician-administered SCID-BPD and 111 nonborderline controls were evaluated using the Structured Clinical Interview for DSM-IV Dissociative Disorders (SCID-D) by a psychiatrist blind to diagnosis and scale scores. Internal consistency analyses and test-retest evaluations suggested that the SDAQ is a reliable instrument for the population studied. Of the participants, 20.6% reported an SDAQ score of 20 or above and impairment by DA. Those who had both dissociative disorder and BPD (n = 78) had the highest SDAQ scores. Both disorders had significant effects on the SCID-D total and amnesia scores in the variance analysis. On SDAQ scores, however, only BPD had this effect. There was a significant interaction between the 2 disorders for the SCID-D total but not for the SDAQ or SCID-D amnesia scores. BPD represented the severity of dissociation and childhood trauma in this study group. However, in contrast to the dissociative disorders, BPD was characterized by better awareness of DA in self-report. The discrepancies between self-report and clinical interview associated with BPD and dissociative disorders are discussed in the context of betrayal theory (J. J. Freyd, 1994) of BPD and perceptual theory (D. B. Beere, 2009) of dissociative disorders.

Anatolian Journal of Psychiatry, 2014

Anatolian Journal of Psychiatry, 2013