Sergio Cardoso - Academia.edu (original) (raw)
Papers by Sergio Cardoso
Clinical Oral Investigations, 2015
Amyloidosis is a term used to describe a group of diseases in which there is an extracellular dep... more Amyloidosis is a term used to describe a group of diseases in which there is an extracellular deposition of amorphous fibrillar proteins known as amyloid. The aim of this study was to present clinicopathological data from eight oral amyloidosis-affected patients and a deep review of the literature about the disease. A retrospective study was conducted based on the records of oral amyloidosis-affected patients diagnosed in our institution between 1978 and 2012. The clinicopathological features and immunohistochemical (IHC) staining with anti-kappa and anti-lambda light chain antibodies were carried out and analyzed. Eight patients were diagnosed with the disease; the tongue and women in their sixth decade of life were mostly affected. All lesions demonstrated apple-green birefringence and immunoreactivity for kappa-light chain, and four cases also showed lambda positivity. According to our series, four cases were diagnosed with localized amyloidosis and four with systemic amyloidosis. Prognosis for the systemic ones was gloomy, but good for the localized ones, which was characterized by a slow pattern of deposition without evolution to systemic involvement. This study reinforces our knowledge about predilections, outcomes, and the importance of making a correct and quick diagnosis of oral amyloidosis and shows the necessity of more studies detailing oral amyloidosis predilection on a global scale. The importance and utility of IHC in the typing of the biochemical nature of amyloid deposits are becoming increasingly necessary for proper management of the patient. Correct classification of the type of amyloid is important for treatment consequences. This article highlights the clinicopathological data of patients with amyloidosis affecting oral tissues and compare these new findings with other worldwide descriptions. Because of its rarity, such data are often unfamiliar to most clinicians and pathologists.
The Journal of Pediatrics, 2015
Introdução: O tumor odontogênico queratocístico é raramente encontrado em maxilla. Relato do Caso... more Introdução: O tumor odontogênico queratocístico é raramente encontrado em maxilla. Relato do Caso: Este artigo descreve o relato de um caso de uma paciente de 60 anos de idade, leucoderma, sexo feminino, com um crescimento assintomático na região de maxila posterior diagnosticada como tumor odontogênico queratocístico. Também é discutido o diagnóstico e a propedêutica para este tipo de lesão.
Oral Oncology Supplement, 2007
International Journal of Morphology, 2006
Minerva stomatologica, 2008
Mucoepidermoid carcinomas (MECs) are the most common malignancy of the salivary glands demonstrat... more Mucoepidermoid carcinomas (MECs) are the most common malignancy of the salivary glands demonstrating a wide range of histologic variants and behavior. However, the sclerosing mucoepidermoid carcinoma (SMEC), a morphologic variant of this tumor is extremely rare and has been described almost exclusively in the major glands. The prominent sclerosis observed may obscure its typical morphological feature resulting in a diagnostic challenge. We describe herein a case of SMEC in a 43-year-old-woman, occurring in the minor salivary glands of palate. To our knowledge only 13 cases have been reported until this moment, being only 2 in minor salivary glands. We also performed the immunohistochemical evaluation of c-erbB-2 and Ki-67, searching for an association with the histopathological findings and behavior.
Anticancer research
Both hMSH2 and hMLH1 are integrated in the DNA mismatch repair (MMR) system. Reduced expression o... more Both hMSH2 and hMLH1 are integrated in the DNA mismatch repair (MMR) system. Reduced expression of these proteins has been reported in head and neck carcinoma; however, few studies have examined the normal levels of these proteins in oral tissues or investigated factors which could interfere with this expression. The aim of this study was to detect the expression pattern of hMSH2 and hMLH1 in normal oral mucosa and to correlate this with demographic data, smoking and local inflammation. The expression of hMSH2 and hMLH1 was evaluated in 38 samples of normal mucosa epithelium using immunohistochemistry. No relationship was observed between hMSH2 and hMLH1 and demographic data. The hMLH1 but not hMSH2 expression was altered in smokers and in the presence of inflammation. Both hMSH2 and hMLH1 are highly expressed in the normal epithelium of oral mucosa. In addition, hMLH1 expression is directly influenced by tobacco use and inflammation.
Medicina oral, patología oral y cirugía bucal, 2006
Metallothionein (MT) may play a preventive role in various carcinogenic process. 4NQO is an alkal... more Metallothionein (MT) may play a preventive role in various carcinogenic process. 4NQO is an alkaline compound and potent mutagen that causes the formation of DNA adducts. The purpose of this study was to evaluate the immunoexpression of MT in palatal cells of mice submitted to the carcinogen 4NQO. C57BL/6 mice received applications of 4NQO to palate for periods of 8, 16, 20 and 24 weeks (experimental group). A control group received only applications of propylene glycol for the same periods. Subsequently animals of experimental and control groups were sacrificed and the palate was histologically analysed and MT immunohistochemistry performed. Although morphological atypical features were scant, the expression of MT was higher in the experimental group in comparison to controls. There was an amplified induction of MT expression in oral epithelium of mice treated by 4NQO. These results suggest that MT may act as an endogenous defensive factor against 4NQO in early phases of oral carci...
Oral Oncology Supplement, 2007
International journal of clinical and experimental pathology, 2012
Galectin-3 has been implicated in the tumor development via its mediation of the Wnt signaling pa... more Galectin-3 has been implicated in the tumor development via its mediation of the Wnt signaling pathway. Likewise, glycogen synthase kinase-3beta (GSK3β) also plays a role in the Wnt signaling pathway by controlling the levels of cytoplasmic beta-catenin. Altered GSK3β expression has been described in various tumors, but to date, there are no studies evaluating its expression in models of oral carcinogenesis. Additionally, it is unknown whether the absence of galectin-3 regulates the expression of GSK3β. To this end, Gal3-deficient (Gal3(-/-)) and wild-type (Gal3(+/+)) male mice were treated with 4NQO for 16 weeks and sacrificed at week 16 and 32. The tongues were removed, processed, and stained with H&E to detect dysplasias and carcinomas. An immunohistochemical assay was performed to determine the level of P-GSK3β-Ser9 expression in both groups. Carcinomas were more prevalent in Gal3(+/+) than Gal3(-/-) mice (55.5% vs. 28.5%), but no statistical difference was reached. In the dyspl...
diagnosed. Of these, 63 (30.7%) were malignant epithelial salivary tumors and 142 (69.3%) were be... more diagnosed. Of these, 63 (30.7%) were malignant epithelial salivary tumors and 142 (69.3%) were benign tumors. Mucoepidermoid carcinoma and pleomorphic adenoma were the most common malignant and benign salivary tumors, respectively. The overall agestandardized incidence rate was 12 per million population. Using negative binomial model, the temporal variations in the annual incidence of salivary tumors was not statistically significant. The estimated risk ratio for the linear effect of year was 0.99 (95% CI: 0.91-1.06). It implies that on average the risk of salivary tumors decreased around 1% each year between 1994 and 2005.
Jornal Brasileiro de Patologia e Medicina Laboratorial, 2008
Introdução: A galectina-3 (Gal-3) é uma lectina de mamíferos ligante de resíduos β-galactosídeos.... more Introdução: A galectina-3 (Gal-3) é uma lectina de mamíferos ligante de resíduos β-galactosídeos. Numerosos estudos têm mostrado que a Gal-3 apresenta importantes papéis na biologia tumoral, atuando em fenômenos como apoptose, metástase e transformação maligna. No entanto, em carcinomas de cabeça e pescoço, a real significância da sua expressão ainda é pouco compreendida. Objetivo: O objetivo deste estudo foi avaliar a expressão de Gal-3 em tumores de língua induzidos experimentalmente em camundongos desafiados com o carcinógeno 4-nitroquinolona-1-óxido (4NQO). Material e métodos: Quarenta e dois camundongos C57BL/6, machos, foram desafiados com 4NQO na água de beber por 16 semanas e sacrificados em diferentes períodos depois do tratamento. Após o sacrifício, as línguas foram removidas, processadas, coradas por hematoxilina e eosina (HE) e microscopicamente analisadas quanto à presença de carcinoma. Ensaio imuno-histoquímico para detecção do antígeno Gal-3 e análise descritiva da sua expressão nos tumores induzidos foram realizados. Resultados: Ao final do experimento, foram produzidos 15 tumores. No tecido epitelial não-neoplásico, forte imunorreatividade foi observada apenas na camada parabasal. Nas camadas mais superficiais a intensidade de marcação foi mais fraca, e na camada basal variou de ausente a fraca. Todos os carcinomas bem diferenciados exibiram fraca marcação, exceto nas áreas queratinizantes. No único caso de carcinoma pouco diferenciado, forte imunorreatividade para Gal-3 foi observada. Conclusão: Nossos resultados descritivos mostram que a transformação maligna é acompanhada de redução da intensidade de expressão da Gal-3 e que o aumento da sua expressão com a perda da diferenciação neoplásica sugere a sua vinculação com agressividade tumoral.
Case Reports in Dentistry, 2013
Revista Brasileira em Promoção da Saúde, 2006
Dentre o complexo grupo de tumores odontogênicos, o ameloblastoma se destaca como o tumor odontog... more Dentre o complexo grupo de tumores odontogênicos, o ameloblastoma se destaca como o tumor odontogênico de origem epitelial mais importante e comum. Consiste em um tumor majoritariamente benigno, de curso lento e localmente invasivo, muito embora possa ter altas taxas de recidivas. O ameloblastoma unicístico é uma das variantes do tumor e merece consideração à parte por suas características próprias. Este trabalho teve por finalidade elucidar as peculiaridades desta variante do ameloblastoma, a partir do relato de caso do atendimento de um jovem que teve o acometimento do tumor na mandíbula, abordando os métodos diagnósticos utilizados e o tratamento empregado. Baseando-se nos dados obtidos, conclui-se que o prognóstico para pacientes com ameloblastoma unicístico é bastante favorável, desde que os procedimentos propedêuticos sejam bem conduzidos pelos profissionais em questão.
International Journal of …, 2006
do Carmo SÁ, C. T.; FONSECA, L. M. S.; CARDOSO, S. V.; AGUIAR, M. C. F.& CARMO, M. A. p53 immunoe... more do Carmo SÁ, C. T.; FONSECA, L. M. S.; CARDOSO, S. V.; AGUIAR, M. C. F.& CARMO, M. A. p53 immunoexpression in oral squamous cell carcinomas from different anatomical sites: A comparative study. Int. J. Morphol., 24(2):231-238, 2006.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2008
Myoepithelial carcinoma is a rare and aggressive neoplasm of the salivary glands. One-third of th... more Myoepithelial carcinoma is a rare and aggressive neoplasm of the salivary glands. One-third of the patients may develop regional distant metastases, and lungs and kidneys have been regarded as the most usual sites for implantation. There is, however, little information on the metastatic behavior of this malignancy. We report the first case of patient with multiple cutaneous metastases from a myoepithelial carcinoma of the submandibular gland, which depicted a very aggressive clinical course. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:e26-e29) Uberlândia; and private practice, Uberlândia.
Mycoses, 2011
America. It has been regarded as a multifocal disease, with oral lesions as the prominent feature... more America. It has been regarded as a multifocal disease, with oral lesions as the prominent feature. To provide useful information concerning the diagnosis and management of the disease, this study describes demographic and clinical data from the medical records of a consecutive series of 66 Brazilian patients from an endemic area, evaluated in a referral centre for oral diagnosis. In this sample of patients, there was a predominance of middle-aged male patients, who were primarily rural workers. Chronic multifocal disease was prevalent, with lesions also detected in the lungs, lymph nodes, skin or adrenal glands. Most of the cases presented with lesions at the gingival mucosa followed by the palate and lips; these conditions occurring in the oral cavity were frequently associated with pain. Importantly, most of the patients sought professional care for oral lesions. The diagnosis was obtained through exfoliative cytology and ⁄ or biopsy of the oral lesions. Medical treatment was effective, and there were no mortalities in the sample. The present findings not only confirm the importance of oral lesions in the diagnosis and management of PCM but also illustrate that questions still remain unclear, such as the possibility of direct inoculation of the fungus onto oral tissues.
Journal of Oral Pathology & Medicine, 2008
BACKGROUND: The aim of this study was to describe the human mutS homolog 2 (hMSH2) and human mutL... more BACKGROUND: The aim of this study was to describe the human mutS homolog 2 (hMSH2) and human mutL homolog 1 (hMLH1) immunoexpression in different areas of oral squamous cell carcinoma (OSCC) -central/ superficial (C/S) and invasive tumor front (ITF) -in an attempt to verify if the histological grade of malignancy interferes in this expression. METHODS: Forty-six samples of OSCC were analyzed histologically. Twenty-six cases (56.5%) presented ITF. Histological grades of malignancy were evaluated in all samples, and immunohistochemistry was applied using specific antibodies against hMSH2 and hMLH1 proteins. Immunoexpression was semiquantitatively scored, and results were correlated with their histological grades of malignancy. RESULTS: The hMSH2 immunoexpression in both C/S and ITF was not correlated with histological grades of malignancy, whereas hMLH1 overexpression was correlated (P = 0.043) and associated (P = 0.041) with welldifferentiated tumors. In addition, hMHL1 reduction or negative expression was detected in poorly differentiated tumors. Moreover, negative expression for hMSH2 and hMLH1 proteins was demonstrated in some cases of OSCC. CONCLUSIONS: The findings of the present study indicate that the histological grade of malignancy interferes in hMLH1 immunoexpression. The negativity for both hMSH2 and hMLH1 proteins in some cases suggests a possible association between OSCC and hereditary nonpolyposis colorectal cancer. Further investigation from future studies is needed to elucidate this supposition.
Journal of Cranio-Maxillofacial Surgery, 2009
An exceedingly rare case of an extragnathic odontome is described arising within the brain. A 10-... more An exceedingly rare case of an extragnathic odontome is described arising within the brain. A 10-year-old boy complained of progressive frontal headache for 5 years. Axial computerized tomography the head revealed a solid, calcified lesion with well-defined borders localized in the sellar and suprasellar region composed of multiple calcified structures resembling teeth. The diagnosis was compound odontome. Physical examination and blood analysis revealed hypopituitarism. The patient was submitted for radical tumour resection. He developed persistent diabetes insipidus, hypothyroidism and adrenal insufficiency for which appropriate replacement therapy has been necessary. This case demonstrates that an odontogenic lesion may arise in brain tissues due to the embryological relationship between primordial stomodeum and Rathke's pouch. Its development could be associated with endocrine disturbances.
Journal of Clinical Pathology, 2006
Clinical Oral Investigations, 2015
Amyloidosis is a term used to describe a group of diseases in which there is an extracellular dep... more Amyloidosis is a term used to describe a group of diseases in which there is an extracellular deposition of amorphous fibrillar proteins known as amyloid. The aim of this study was to present clinicopathological data from eight oral amyloidosis-affected patients and a deep review of the literature about the disease. A retrospective study was conducted based on the records of oral amyloidosis-affected patients diagnosed in our institution between 1978 and 2012. The clinicopathological features and immunohistochemical (IHC) staining with anti-kappa and anti-lambda light chain antibodies were carried out and analyzed. Eight patients were diagnosed with the disease; the tongue and women in their sixth decade of life were mostly affected. All lesions demonstrated apple-green birefringence and immunoreactivity for kappa-light chain, and four cases also showed lambda positivity. According to our series, four cases were diagnosed with localized amyloidosis and four with systemic amyloidosis. Prognosis for the systemic ones was gloomy, but good for the localized ones, which was characterized by a slow pattern of deposition without evolution to systemic involvement. This study reinforces our knowledge about predilections, outcomes, and the importance of making a correct and quick diagnosis of oral amyloidosis and shows the necessity of more studies detailing oral amyloidosis predilection on a global scale. The importance and utility of IHC in the typing of the biochemical nature of amyloid deposits are becoming increasingly necessary for proper management of the patient. Correct classification of the type of amyloid is important for treatment consequences. This article highlights the clinicopathological data of patients with amyloidosis affecting oral tissues and compare these new findings with other worldwide descriptions. Because of its rarity, such data are often unfamiliar to most clinicians and pathologists.
The Journal of Pediatrics, 2015
Introdução: O tumor odontogênico queratocístico é raramente encontrado em maxilla. Relato do Caso... more Introdução: O tumor odontogênico queratocístico é raramente encontrado em maxilla. Relato do Caso: Este artigo descreve o relato de um caso de uma paciente de 60 anos de idade, leucoderma, sexo feminino, com um crescimento assintomático na região de maxila posterior diagnosticada como tumor odontogênico queratocístico. Também é discutido o diagnóstico e a propedêutica para este tipo de lesão.
Oral Oncology Supplement, 2007
International Journal of Morphology, 2006
Minerva stomatologica, 2008
Mucoepidermoid carcinomas (MECs) are the most common malignancy of the salivary glands demonstrat... more Mucoepidermoid carcinomas (MECs) are the most common malignancy of the salivary glands demonstrating a wide range of histologic variants and behavior. However, the sclerosing mucoepidermoid carcinoma (SMEC), a morphologic variant of this tumor is extremely rare and has been described almost exclusively in the major glands. The prominent sclerosis observed may obscure its typical morphological feature resulting in a diagnostic challenge. We describe herein a case of SMEC in a 43-year-old-woman, occurring in the minor salivary glands of palate. To our knowledge only 13 cases have been reported until this moment, being only 2 in minor salivary glands. We also performed the immunohistochemical evaluation of c-erbB-2 and Ki-67, searching for an association with the histopathological findings and behavior.
Anticancer research
Both hMSH2 and hMLH1 are integrated in the DNA mismatch repair (MMR) system. Reduced expression o... more Both hMSH2 and hMLH1 are integrated in the DNA mismatch repair (MMR) system. Reduced expression of these proteins has been reported in head and neck carcinoma; however, few studies have examined the normal levels of these proteins in oral tissues or investigated factors which could interfere with this expression. The aim of this study was to detect the expression pattern of hMSH2 and hMLH1 in normal oral mucosa and to correlate this with demographic data, smoking and local inflammation. The expression of hMSH2 and hMLH1 was evaluated in 38 samples of normal mucosa epithelium using immunohistochemistry. No relationship was observed between hMSH2 and hMLH1 and demographic data. The hMLH1 but not hMSH2 expression was altered in smokers and in the presence of inflammation. Both hMSH2 and hMLH1 are highly expressed in the normal epithelium of oral mucosa. In addition, hMLH1 expression is directly influenced by tobacco use and inflammation.
Medicina oral, patología oral y cirugía bucal, 2006
Metallothionein (MT) may play a preventive role in various carcinogenic process. 4NQO is an alkal... more Metallothionein (MT) may play a preventive role in various carcinogenic process. 4NQO is an alkaline compound and potent mutagen that causes the formation of DNA adducts. The purpose of this study was to evaluate the immunoexpression of MT in palatal cells of mice submitted to the carcinogen 4NQO. C57BL/6 mice received applications of 4NQO to palate for periods of 8, 16, 20 and 24 weeks (experimental group). A control group received only applications of propylene glycol for the same periods. Subsequently animals of experimental and control groups were sacrificed and the palate was histologically analysed and MT immunohistochemistry performed. Although morphological atypical features were scant, the expression of MT was higher in the experimental group in comparison to controls. There was an amplified induction of MT expression in oral epithelium of mice treated by 4NQO. These results suggest that MT may act as an endogenous defensive factor against 4NQO in early phases of oral carci...
Oral Oncology Supplement, 2007
International journal of clinical and experimental pathology, 2012
Galectin-3 has been implicated in the tumor development via its mediation of the Wnt signaling pa... more Galectin-3 has been implicated in the tumor development via its mediation of the Wnt signaling pathway. Likewise, glycogen synthase kinase-3beta (GSK3β) also plays a role in the Wnt signaling pathway by controlling the levels of cytoplasmic beta-catenin. Altered GSK3β expression has been described in various tumors, but to date, there are no studies evaluating its expression in models of oral carcinogenesis. Additionally, it is unknown whether the absence of galectin-3 regulates the expression of GSK3β. To this end, Gal3-deficient (Gal3(-/-)) and wild-type (Gal3(+/+)) male mice were treated with 4NQO for 16 weeks and sacrificed at week 16 and 32. The tongues were removed, processed, and stained with H&E to detect dysplasias and carcinomas. An immunohistochemical assay was performed to determine the level of P-GSK3β-Ser9 expression in both groups. Carcinomas were more prevalent in Gal3(+/+) than Gal3(-/-) mice (55.5% vs. 28.5%), but no statistical difference was reached. In the dyspl...
diagnosed. Of these, 63 (30.7%) were malignant epithelial salivary tumors and 142 (69.3%) were be... more diagnosed. Of these, 63 (30.7%) were malignant epithelial salivary tumors and 142 (69.3%) were benign tumors. Mucoepidermoid carcinoma and pleomorphic adenoma were the most common malignant and benign salivary tumors, respectively. The overall agestandardized incidence rate was 12 per million population. Using negative binomial model, the temporal variations in the annual incidence of salivary tumors was not statistically significant. The estimated risk ratio for the linear effect of year was 0.99 (95% CI: 0.91-1.06). It implies that on average the risk of salivary tumors decreased around 1% each year between 1994 and 2005.
Jornal Brasileiro de Patologia e Medicina Laboratorial, 2008
Introdução: A galectina-3 (Gal-3) é uma lectina de mamíferos ligante de resíduos β-galactosídeos.... more Introdução: A galectina-3 (Gal-3) é uma lectina de mamíferos ligante de resíduos β-galactosídeos. Numerosos estudos têm mostrado que a Gal-3 apresenta importantes papéis na biologia tumoral, atuando em fenômenos como apoptose, metástase e transformação maligna. No entanto, em carcinomas de cabeça e pescoço, a real significância da sua expressão ainda é pouco compreendida. Objetivo: O objetivo deste estudo foi avaliar a expressão de Gal-3 em tumores de língua induzidos experimentalmente em camundongos desafiados com o carcinógeno 4-nitroquinolona-1-óxido (4NQO). Material e métodos: Quarenta e dois camundongos C57BL/6, machos, foram desafiados com 4NQO na água de beber por 16 semanas e sacrificados em diferentes períodos depois do tratamento. Após o sacrifício, as línguas foram removidas, processadas, coradas por hematoxilina e eosina (HE) e microscopicamente analisadas quanto à presença de carcinoma. Ensaio imuno-histoquímico para detecção do antígeno Gal-3 e análise descritiva da sua expressão nos tumores induzidos foram realizados. Resultados: Ao final do experimento, foram produzidos 15 tumores. No tecido epitelial não-neoplásico, forte imunorreatividade foi observada apenas na camada parabasal. Nas camadas mais superficiais a intensidade de marcação foi mais fraca, e na camada basal variou de ausente a fraca. Todos os carcinomas bem diferenciados exibiram fraca marcação, exceto nas áreas queratinizantes. No único caso de carcinoma pouco diferenciado, forte imunorreatividade para Gal-3 foi observada. Conclusão: Nossos resultados descritivos mostram que a transformação maligna é acompanhada de redução da intensidade de expressão da Gal-3 e que o aumento da sua expressão com a perda da diferenciação neoplásica sugere a sua vinculação com agressividade tumoral.
Case Reports in Dentistry, 2013
Revista Brasileira em Promoção da Saúde, 2006
Dentre o complexo grupo de tumores odontogênicos, o ameloblastoma se destaca como o tumor odontog... more Dentre o complexo grupo de tumores odontogênicos, o ameloblastoma se destaca como o tumor odontogênico de origem epitelial mais importante e comum. Consiste em um tumor majoritariamente benigno, de curso lento e localmente invasivo, muito embora possa ter altas taxas de recidivas. O ameloblastoma unicístico é uma das variantes do tumor e merece consideração à parte por suas características próprias. Este trabalho teve por finalidade elucidar as peculiaridades desta variante do ameloblastoma, a partir do relato de caso do atendimento de um jovem que teve o acometimento do tumor na mandíbula, abordando os métodos diagnósticos utilizados e o tratamento empregado. Baseando-se nos dados obtidos, conclui-se que o prognóstico para pacientes com ameloblastoma unicístico é bastante favorável, desde que os procedimentos propedêuticos sejam bem conduzidos pelos profissionais em questão.
International Journal of …, 2006
do Carmo SÁ, C. T.; FONSECA, L. M. S.; CARDOSO, S. V.; AGUIAR, M. C. F.& CARMO, M. A. p53 immunoe... more do Carmo SÁ, C. T.; FONSECA, L. M. S.; CARDOSO, S. V.; AGUIAR, M. C. F.& CARMO, M. A. p53 immunoexpression in oral squamous cell carcinomas from different anatomical sites: A comparative study. Int. J. Morphol., 24(2):231-238, 2006.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2008
Myoepithelial carcinoma is a rare and aggressive neoplasm of the salivary glands. One-third of th... more Myoepithelial carcinoma is a rare and aggressive neoplasm of the salivary glands. One-third of the patients may develop regional distant metastases, and lungs and kidneys have been regarded as the most usual sites for implantation. There is, however, little information on the metastatic behavior of this malignancy. We report the first case of patient with multiple cutaneous metastases from a myoepithelial carcinoma of the submandibular gland, which depicted a very aggressive clinical course. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:e26-e29) Uberlândia; and private practice, Uberlândia.
Mycoses, 2011
America. It has been regarded as a multifocal disease, with oral lesions as the prominent feature... more America. It has been regarded as a multifocal disease, with oral lesions as the prominent feature. To provide useful information concerning the diagnosis and management of the disease, this study describes demographic and clinical data from the medical records of a consecutive series of 66 Brazilian patients from an endemic area, evaluated in a referral centre for oral diagnosis. In this sample of patients, there was a predominance of middle-aged male patients, who were primarily rural workers. Chronic multifocal disease was prevalent, with lesions also detected in the lungs, lymph nodes, skin or adrenal glands. Most of the cases presented with lesions at the gingival mucosa followed by the palate and lips; these conditions occurring in the oral cavity were frequently associated with pain. Importantly, most of the patients sought professional care for oral lesions. The diagnosis was obtained through exfoliative cytology and ⁄ or biopsy of the oral lesions. Medical treatment was effective, and there were no mortalities in the sample. The present findings not only confirm the importance of oral lesions in the diagnosis and management of PCM but also illustrate that questions still remain unclear, such as the possibility of direct inoculation of the fungus onto oral tissues.
Journal of Oral Pathology & Medicine, 2008
BACKGROUND: The aim of this study was to describe the human mutS homolog 2 (hMSH2) and human mutL... more BACKGROUND: The aim of this study was to describe the human mutS homolog 2 (hMSH2) and human mutL homolog 1 (hMLH1) immunoexpression in different areas of oral squamous cell carcinoma (OSCC) -central/ superficial (C/S) and invasive tumor front (ITF) -in an attempt to verify if the histological grade of malignancy interferes in this expression. METHODS: Forty-six samples of OSCC were analyzed histologically. Twenty-six cases (56.5%) presented ITF. Histological grades of malignancy were evaluated in all samples, and immunohistochemistry was applied using specific antibodies against hMSH2 and hMLH1 proteins. Immunoexpression was semiquantitatively scored, and results were correlated with their histological grades of malignancy. RESULTS: The hMSH2 immunoexpression in both C/S and ITF was not correlated with histological grades of malignancy, whereas hMLH1 overexpression was correlated (P = 0.043) and associated (P = 0.041) with welldifferentiated tumors. In addition, hMHL1 reduction or negative expression was detected in poorly differentiated tumors. Moreover, negative expression for hMSH2 and hMLH1 proteins was demonstrated in some cases of OSCC. CONCLUSIONS: The findings of the present study indicate that the histological grade of malignancy interferes in hMLH1 immunoexpression. The negativity for both hMSH2 and hMLH1 proteins in some cases suggests a possible association between OSCC and hereditary nonpolyposis colorectal cancer. Further investigation from future studies is needed to elucidate this supposition.
Journal of Cranio-Maxillofacial Surgery, 2009
An exceedingly rare case of an extragnathic odontome is described arising within the brain. A 10-... more An exceedingly rare case of an extragnathic odontome is described arising within the brain. A 10-year-old boy complained of progressive frontal headache for 5 years. Axial computerized tomography the head revealed a solid, calcified lesion with well-defined borders localized in the sellar and suprasellar region composed of multiple calcified structures resembling teeth. The diagnosis was compound odontome. Physical examination and blood analysis revealed hypopituitarism. The patient was submitted for radical tumour resection. He developed persistent diabetes insipidus, hypothyroidism and adrenal insufficiency for which appropriate replacement therapy has been necessary. This case demonstrates that an odontogenic lesion may arise in brain tissues due to the embryological relationship between primordial stomodeum and Rathke's pouch. Its development could be associated with endocrine disturbances.
Journal of Clinical Pathology, 2006