Seth Whittaker - Academia.edu (original) (raw)
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Central Research Institute for Dryland Agriculture
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Papers by Seth Whittaker
Clinical and Experimental Dermatology, 1996
We present a ease of malignant carcinoid initially diagnosed as rosacea. This patient was later f... more We present a ease of malignant carcinoid initially diagnosed as rosacea. This patient was later found to have an additional functioning parathyroid tumour. Although a pituitary tumour was nor identified, the association represents a probable case of multiple endocrine neoplasia type 1 (MEN 1). This autosomal dominant syndrome is characterized by tumours of the pancreas, parathyroid and pituitary. Inoperable carcinoid rumour is best treated with a long‐acting somatostatin analogue, octreotide. A diagnosis of MKN I has important connotations for the proband's first‐degree relatives, who should be entered into an appropriate screening programme.
Toxic Epidermal necrolysis (TEN) is a rare, life threatening dermatological disorder that is usua... more Toxic Epidermal necrolysis (TEN) is a rare, life threatening dermatological disorder that is usually induced by medications. Anti-convulsants such as phenytoin, carbamazepine and phenobarbital have been enlisted as high risk drugs for causing TEN. A 25 year old man, a known case of epilepsy, who consumed inadvertently escalated daily dose of 600 mg/day of phenytoin for 10 days, developed TEN which involving more than 30% of body surface area with mucosal involvement. Rigorous treatment of 18 days using systemic and topical antibiotics along with glucocorticoids helped in complete recovery of the patient. Causality analysis of this Adverse Drug Reactions (ADR) showed a probable association on both World Health Organisation (WHO)-Uppsala Monitoring Centre (UMC) scale and Naranjo's probability scale and Severity scale of 5 on Modified Hartwig and Siegel scale. Medication error is an important cause of such life threatening reactions which requires concern of all health care professionals.
Clinical and Experimental Dermatology, 1996
We present a ease of malignant carcinoid initially diagnosed as rosacea. This patient was later f... more We present a ease of malignant carcinoid initially diagnosed as rosacea. This patient was later found to have an additional functioning parathyroid tumour. Although a pituitary tumour was nor identified, the association represents a probable case of multiple endocrine neoplasia type 1 (MEN 1). This autosomal dominant syndrome is characterized by tumours of the pancreas, parathyroid and pituitary. Inoperable carcinoid rumour is best treated with a long‐acting somatostatin analogue, octreotide. A diagnosis of MKN I has important connotations for the proband's first‐degree relatives, who should be entered into an appropriate screening programme.
Toxic Epidermal necrolysis (TEN) is a rare, life threatening dermatological disorder that is usua... more Toxic Epidermal necrolysis (TEN) is a rare, life threatening dermatological disorder that is usually induced by medications. Anti-convulsants such as phenytoin, carbamazepine and phenobarbital have been enlisted as high risk drugs for causing TEN. A 25 year old man, a known case of epilepsy, who consumed inadvertently escalated daily dose of 600 mg/day of phenytoin for 10 days, developed TEN which involving more than 30% of body surface area with mucosal involvement. Rigorous treatment of 18 days using systemic and topical antibiotics along with glucocorticoids helped in complete recovery of the patient. Causality analysis of this Adverse Drug Reactions (ADR) showed a probable association on both World Health Organisation (WHO)-Uppsala Monitoring Centre (UMC) scale and Naranjo's probability scale and Severity scale of 5 on Modified Hartwig and Siegel scale. Medication error is an important cause of such life threatening reactions which requires concern of all health care professionals.