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Research paper thumbnail of Effectiveness and feasibility of telerehabilitation in patients with COVID-19: a protocol for a systematic review and meta-analysis

BMJ Open, 2022

IntroductionRespiratory rehabilitation is the use of exercise, education, and behavioural interve... more IntroductionRespiratory rehabilitation is the use of exercise, education, and behavioural interventions to alleviate symptoms and improve quality of life. Recent studies highlight that respiratory rehabilitation is effective and safe for patients with COVID-19. We aim to evaluate the effectiveness and feasibility of respiratory telerehabilitation on patients infected with COVID-19 by conducting a systematic review and meta-analysis.Methods and analysisPubMed, Web of Science, Science Direct, Physiotherapy Evidence Database, Google Scholar and Cochrane Library databases will be searched from inception to the end of November 2021. Randomised controlled trials investigating the effectiveness of telerehabilitation in the management of COVID-19 will be included. The primary outcomes will be functional capacity, cardiopulmonary exercise tests and quality of life. Secondary outcomes will include anxiety/depression level, sleep quality, mortality rate, completion rate, reason for withdrawal,...

Research paper thumbnail of The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019

The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019, 2021

Background In estimating the global burden of cancer, adolescents and young adults with cancer ar... more Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability we...

Research paper thumbnail of Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Nature Medicine

An amendment to this paper has been published and can be accessed via a link at the top of the pa... more An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Research paper thumbnail of Mapping local patterns of childhood overweight and wasting in low-and middle-income countries between 2000 and 2017 LBD Double Burden of Malnutrition Collaborators

Global and local variation in malnutrition trends Globally in 2017, an estimated 38.3 million (5.... more Global and local variation in malnutrition trends Globally in 2017, an estimated 38.3 million (5.6%) children under 5 were overweight and 50.5 million (7.5%) were wasted 15. The majority (91%) of children under 5 affected by wasting and nearly half Mapping local patterns of childhood overweight and wasting in low-and middle-income countries between 2000 and 2017 LBD Double Burden of Malnutrition Collaborators* A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low-and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1-70.8) million) to 6.4% (58.3 (47.6-70.7) million), but is predicted to remain above the World Health Organization's Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8-38.5) million) in 2000 to 6.0% (55.5 (44.8-67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic. Nature MeDiCiNe | www.nature.com/naturemedicine Articles NATurE MEDICINE (48%) of overweight children lived in LMICs, with Africa and Asia accounting for the largest shares of the global burden (25% and 46% of overweight and 27% and 69% of wasted children, respectively) 16. Direct comparisons of population-level trends of childhood overweight and wasting generally provide regional-or country-level estimates 5,16-20 , potentially masking important subnational differences. Previously, we mapped 2000-2017 prevalence and trends in wasting, stunting and underweight among children under 5 across LMICs 21 using Bayesian model-based geostatistical techniques 22. Building from this approach and using data from 420 household surveys representing more than 3 million children, we mapped the relative burdens of overweight and wasting among children under 5 in 105 LMICs from 2000 to 2017. Mapping with a continuous model allows us to incorporate geolocated data and covariates and produce gridded cell-level estimates that can be aggregated to interventionor policy-relevant geographical areas as boundaries change over time. We present estimates at this local grid cell-level and aggregate to first administrative (such as states and provinces), second administrative (such as districts and departments) and national levels. On the basis of 2000 to 2017 weighted annualized rates of change (AROC), which apply more weight to recent data, we predict prevalence of overweight and wasting and estimate their double burden in 2025. The full array of outputs are available at the Global Health Data Exchange (http://ghdx.healthdata.org/record/ihme-data/lmicdouble-burden-of-malnutrition-geospatial-estimates-2000-2017) and can be further explored with our customized visualization tools (https://vizhub.healthdata.org/lbd/dbm). Prevalence and trends in early childhood overweight Across LMICs, the prevalence of early childhood overweight increased from 5.2% (95% uncertainty interval, 4.5-5.4%) to 6.0% (4.8-6.1%) in the modeled study period. Between 2000 and 2017, there were noticeable differences in estimated levels by area (Fig. 1a,b). Although levels varied broadly across LMICs, every modeling region had areas with high estimated prevalence in 2017 (Fig. 1b and Extended Data Fig. 1). These included large contiguous areas across most Central American, Caribbean and South American countries and areas with ≥15% estimated prevalence in central Cuba, southern Panama, western Paraguay, scattered throughout several eastern Brazilian states (for example, in Rio Grande do Sul,

Research paper thumbnail of Determinants of Perinatal Birth Asphyxia Among Preterm Babies in Ethiopia: A Systematic Review and Meta-Analysis of Observational Studies Protocol

Background: Birth asphyxia among preterm babies accounted for nearly fifty percent of neonatal mo... more Background: Birth asphyxia among preterm babies accounted for nearly fifty percent of neonatal mortality in sub-Saharan African countries. This scenario has been worst in Ethiopia where every two out of three deaths attributed to birth asphyxia. Moreover, studies conducted in Ethiopia lack consistency in the prevalence and risk factors of birth asphyxia. Objective: This study aims to analyses collectively and systematically prevalence of birth asphyxia and associated factors among preterm neonates in Ethiopia. Methods: The protocol for this review is registered at PROSPERO with registration number CRD42020158224. A comprehensive search of the following electronic databases were made using: MEDLINE, EMBASE, CINAHL, Scopus, web science, HINARI, Cochrane library, Google Scholar and maternity & infant care databases as well as grey literature uploaded at Ethiopian Health Development Journal will be searched until June 30, 2020. The quality of studies will be assessed using Joanna Briggs...

Research paper thumbnail of Prevalence and factors associated with malaria among under-five children in Ethiopia: A Systematic review and Meta-analysis Protocol

Background: The Sub-Saharan African countries have been carried 80% of the global burden of malar... more Background: The Sub-Saharan African countries have been carried 80% of the global burden of malaria. Consequently, malaria is still the leading cause of under-five mortality in developing nations. In Ethiopia, studies conducted regarding prevalence and associated factors of malaria among under five children are inconsistently reported and highly variable.Objective: to determine the pooled prevalence and associated factors of malaria among under five children in Ethiopia. Methods: The protocol for this review is registered at PROSPERO with registration number: CRD42020157886. A comprehensive search of the following electronic databases were made using: MEDLINE, EMBASE, CINAHL, Scopus, web science, HINARI, Cochrane library, Google Scholar and maternity & infant care databases as well as grey literature uploaded at Ethiopian Health Development Journal were searched until May 2020. The quality of studies will be assessed using Joanna Briggs Institute (JBI) checklist. All identified obse...

Research paper thumbnail of Prevalence and factors associated with malaria among under-five children in Ethiopia: A Systematic review and Meta-analysis Protocol

Background: The Sub-Saharan African countries have been carried 80% of the global burden of malar... more Background: The Sub-Saharan African countries have been carried 80% of the global burden of malaria. Consequently, malaria is still the leading cause of under-five mortality in developing nations. In Ethiopia, studies conducted regarding prevalence and associated factors of malaria among under five children are inconsistently reported and highly variable.Objective: to determine the pooled prevalence and associated factors of malaria among under five children in Ethiopia. Methods: The protocol for this review is registered at PROSPERO with registration number: CRD42020157886. A comprehensive search of the following electronic databases were made using: MEDLINE, EMBASE, CINAHL, Scopus, web science, HINARI, Cochrane library, Google Scholar and maternity & infant care databases as well as grey literature uploaded at Ethiopian Health Development Journal were searched until May 2020. The quality of studies will be assessed using Joanna Briggs Institute (JBI) checklist. All identified obse...

Research paper thumbnail of Effectiveness and feasibility of telerehabilitation in patients with COVID-19: a protocol for a systematic review and meta-analysis

BMJ Open, 2022

IntroductionRespiratory rehabilitation is the use of exercise, education, and behavioural interve... more IntroductionRespiratory rehabilitation is the use of exercise, education, and behavioural interventions to alleviate symptoms and improve quality of life. Recent studies highlight that respiratory rehabilitation is effective and safe for patients with COVID-19. We aim to evaluate the effectiveness and feasibility of respiratory telerehabilitation on patients infected with COVID-19 by conducting a systematic review and meta-analysis.Methods and analysisPubMed, Web of Science, Science Direct, Physiotherapy Evidence Database, Google Scholar and Cochrane Library databases will be searched from inception to the end of November 2021. Randomised controlled trials investigating the effectiveness of telerehabilitation in the management of COVID-19 will be included. The primary outcomes will be functional capacity, cardiopulmonary exercise tests and quality of life. Secondary outcomes will include anxiety/depression level, sleep quality, mortality rate, completion rate, reason for withdrawal,...

Research paper thumbnail of The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019

The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019, 2021

Background In estimating the global burden of cancer, adolescents and young adults with cancer ar... more Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability we...

Research paper thumbnail of Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Nature Medicine

An amendment to this paper has been published and can be accessed via a link at the top of the pa... more An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Research paper thumbnail of Mapping local patterns of childhood overweight and wasting in low-and middle-income countries between 2000 and 2017 LBD Double Burden of Malnutrition Collaborators

Global and local variation in malnutrition trends Globally in 2017, an estimated 38.3 million (5.... more Global and local variation in malnutrition trends Globally in 2017, an estimated 38.3 million (5.6%) children under 5 were overweight and 50.5 million (7.5%) were wasted 15. The majority (91%) of children under 5 affected by wasting and nearly half Mapping local patterns of childhood overweight and wasting in low-and middle-income countries between 2000 and 2017 LBD Double Burden of Malnutrition Collaborators* A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low-and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1-70.8) million) to 6.4% (58.3 (47.6-70.7) million), but is predicted to remain above the World Health Organization's Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8-38.5) million) in 2000 to 6.0% (55.5 (44.8-67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic. Nature MeDiCiNe | www.nature.com/naturemedicine Articles NATurE MEDICINE (48%) of overweight children lived in LMICs, with Africa and Asia accounting for the largest shares of the global burden (25% and 46% of overweight and 27% and 69% of wasted children, respectively) 16. Direct comparisons of population-level trends of childhood overweight and wasting generally provide regional-or country-level estimates 5,16-20 , potentially masking important subnational differences. Previously, we mapped 2000-2017 prevalence and trends in wasting, stunting and underweight among children under 5 across LMICs 21 using Bayesian model-based geostatistical techniques 22. Building from this approach and using data from 420 household surveys representing more than 3 million children, we mapped the relative burdens of overweight and wasting among children under 5 in 105 LMICs from 2000 to 2017. Mapping with a continuous model allows us to incorporate geolocated data and covariates and produce gridded cell-level estimates that can be aggregated to interventionor policy-relevant geographical areas as boundaries change over time. We present estimates at this local grid cell-level and aggregate to first administrative (such as states and provinces), second administrative (such as districts and departments) and national levels. On the basis of 2000 to 2017 weighted annualized rates of change (AROC), which apply more weight to recent data, we predict prevalence of overweight and wasting and estimate their double burden in 2025. The full array of outputs are available at the Global Health Data Exchange (http://ghdx.healthdata.org/record/ihme-data/lmicdouble-burden-of-malnutrition-geospatial-estimates-2000-2017) and can be further explored with our customized visualization tools (https://vizhub.healthdata.org/lbd/dbm). Prevalence and trends in early childhood overweight Across LMICs, the prevalence of early childhood overweight increased from 5.2% (95% uncertainty interval, 4.5-5.4%) to 6.0% (4.8-6.1%) in the modeled study period. Between 2000 and 2017, there were noticeable differences in estimated levels by area (Fig. 1a,b). Although levels varied broadly across LMICs, every modeling region had areas with high estimated prevalence in 2017 (Fig. 1b and Extended Data Fig. 1). These included large contiguous areas across most Central American, Caribbean and South American countries and areas with ≥15% estimated prevalence in central Cuba, southern Panama, western Paraguay, scattered throughout several eastern Brazilian states (for example, in Rio Grande do Sul,

Research paper thumbnail of Determinants of Perinatal Birth Asphyxia Among Preterm Babies in Ethiopia: A Systematic Review and Meta-Analysis of Observational Studies Protocol

Background: Birth asphyxia among preterm babies accounted for nearly fifty percent of neonatal mo... more Background: Birth asphyxia among preterm babies accounted for nearly fifty percent of neonatal mortality in sub-Saharan African countries. This scenario has been worst in Ethiopia where every two out of three deaths attributed to birth asphyxia. Moreover, studies conducted in Ethiopia lack consistency in the prevalence and risk factors of birth asphyxia. Objective: This study aims to analyses collectively and systematically prevalence of birth asphyxia and associated factors among preterm neonates in Ethiopia. Methods: The protocol for this review is registered at PROSPERO with registration number CRD42020158224. A comprehensive search of the following electronic databases were made using: MEDLINE, EMBASE, CINAHL, Scopus, web science, HINARI, Cochrane library, Google Scholar and maternity & infant care databases as well as grey literature uploaded at Ethiopian Health Development Journal will be searched until June 30, 2020. The quality of studies will be assessed using Joanna Briggs...

Research paper thumbnail of Prevalence and factors associated with malaria among under-five children in Ethiopia: A Systematic review and Meta-analysis Protocol

Background: The Sub-Saharan African countries have been carried 80% of the global burden of malar... more Background: The Sub-Saharan African countries have been carried 80% of the global burden of malaria. Consequently, malaria is still the leading cause of under-five mortality in developing nations. In Ethiopia, studies conducted regarding prevalence and associated factors of malaria among under five children are inconsistently reported and highly variable.Objective: to determine the pooled prevalence and associated factors of malaria among under five children in Ethiopia. Methods: The protocol for this review is registered at PROSPERO with registration number: CRD42020157886. A comprehensive search of the following electronic databases were made using: MEDLINE, EMBASE, CINAHL, Scopus, web science, HINARI, Cochrane library, Google Scholar and maternity & infant care databases as well as grey literature uploaded at Ethiopian Health Development Journal were searched until May 2020. The quality of studies will be assessed using Joanna Briggs Institute (JBI) checklist. All identified obse...

Research paper thumbnail of Prevalence and factors associated with malaria among under-five children in Ethiopia: A Systematic review and Meta-analysis Protocol

Background: The Sub-Saharan African countries have been carried 80% of the global burden of malar... more Background: The Sub-Saharan African countries have been carried 80% of the global burden of malaria. Consequently, malaria is still the leading cause of under-five mortality in developing nations. In Ethiopia, studies conducted regarding prevalence and associated factors of malaria among under five children are inconsistently reported and highly variable.Objective: to determine the pooled prevalence and associated factors of malaria among under five children in Ethiopia. Methods: The protocol for this review is registered at PROSPERO with registration number: CRD42020157886. A comprehensive search of the following electronic databases were made using: MEDLINE, EMBASE, CINAHL, Scopus, web science, HINARI, Cochrane library, Google Scholar and maternity & infant care databases as well as grey literature uploaded at Ethiopian Health Development Journal were searched until May 2020. The quality of studies will be assessed using Joanna Briggs Institute (JBI) checklist. All identified obse...