Silvia Ferreira - Academia.edu (original) (raw)

Papers by Silvia Ferreira

Revista brasileira de enfermagem

To identify self-care demands of men with sickle cell disease and priapism and describe self-care... more To identify self-care demands of men with sickle cell disease and priapism and describe self-care measures in light of Orem's Self-Care Theory. This is a descriptive exploratory study with qualitative approach conducted with nine men with a history of sickle cell disease and priapism. Data were analyzed using Orem's Self-Care Theory. Some demands were identified: from universal self-care - difficulty in social interaction and solitude, changes in self-image, self-esteem and sexual activity; from development - the experience with priapism and little knowledge about the pathophysiology of the disease; regarding health deviations - pain crises. Orem's theory allowed to identify self-care demands, which are essential for the nursing care provided for men with priapism. Nursing has an essential role in the measures for the different demands presented.

Revista gaucha de enfermagem, 2018

OBJECTIVE Our purpose was to discuss practices of cervical cancer prevention among Quilombola Wom... more OBJECTIVE Our purpose was to discuss practices of cervical cancer prevention among Quilombola Women. METHOD This study used, in 2014, a qualitative research approach aiming twenty women from a quilombola community (people who live in quilombos, descendants of Afro-Brazilian slaves), which is located in Bahia. A semi-structured interview was developed by researchers in order to collect data. The Ethno-nursing Research method was used to analyze the data. RESULTS The use of cultural care through medicinal plants, and the nursing professional care (Pap Smear exam procedure) were stated by Quilombola women as serving as prevention practices against cervical cancer. However, most women stated that they did not use any prevention practices. CONCLUSION Social, cultural and health access issues are practices that are linked to the cervical cancer prevention among Quilombola Women. Therefore, it is indispensable to create an appropriate care plan for Quilombola women's reality.

Revista Feminismos, 2018

Este artigo analisa a producao do Curso de Doutorado do PPGNEIM. Sao 24 teses alocadas nas quatro... more Este artigo analisa a producao do Curso de Doutorado do PPGNEIM. Sao 24 teses alocadas nas quatro linhas de pesquisa, defendidas desde 2010. A analise leva em conta os temas, as palavras-chave mais utilizadas e as/os autoras/os mais referenciadas/os. A partir dos dados, discutimos como o conhecimento feminista esta sendo desenvolvido, as possibilidades de incorporacao de conceitos e a utilizacao, de maneira intensa, da teoria do standpoint, de modo a anunciar a parcialidade do estudo. A partir destes elementos podemos apontar a necessidade de maior adesao dos projetos as linhas de pesquisa, a necessidade de construcao de prioridades de pesquisa que atendam a realidade nacional e internacional, o fortalecimento de grupos de pesquisa como espacos de reflexao, debate e producao critica engajada.

Pretendeu-se verificar a existência de alterações nos timings de activação dos músculos estabiliz... more Pretendeu-se verificar a existência de alterações nos timings de activação dos músculos estabilizadores da omoplata em indivíduos pós-acidente vascular encefálico e a sua relação com a velocidade. Metodologia: Amostra (n = 17) dividida nos Grupos 1 (n = 10 indivíduos sem patologia) e 2 (n = 7 indivíduos pós-acidente vascular encefálico). Análise electromiográfica e cinemática no alcance de um copo. Resultados: Nas fibras inferiores do trapézio esquerdo (p = 0,043) e grande dentado bilateralmente (p = 0,028), encontraram-se diferenças entre os Grupos. Não se verificou uma relação com a velocidade. Conclusões: Foram encontrados ajustes posturais antecipatórios em alguns dos músculos.

Blood, Jun 27, 2016

Sézary syndrome (SS) is a leukaemic variant of cutaneous T-cell lymphoma (CTCL) and represents an... more Sézary syndrome (SS) is a leukaemic variant of cutaneous T-cell lymphoma (CTCL) and represents an ideal model for study of T-cell transformation. We describe whole exome and SNP array based copy number analyses of CD4+ tumour cells from untreated patients at diagnosis and targeted re-sequencing of 101 SS cases. A total of 824 somatic non-synonymous gene variants were identified including indels, stop gain/loss, splice variants and recurrent gene variants indicative of considerable molecular heterogeneity. Driver genes identified using MutSigCV include POT1, which has not been previously reported in CTCL, TP53 and DNMT3A were also identified consistent with previous reports. Mutations in PLCG1 were detected in 11% of tumours including novel variants not previously described in SS. This study is also the first to show BRCA2 defects in a significant proportion (14%) of SS tumours. Aberrations in PRKCQ were found to occur in 20% of tumours highlighting selection for activation of TCR/NF...

Journal of Investigative Dermatology, 2016

Methylthioadenosine-phosphorylase (MTAP) and the tumour suppressor genes (TSG) CDKN2A-CDKN2B are ... more Methylthioadenosine-phosphorylase (MTAP) and the tumour suppressor genes (TSG) CDKN2A-CDKN2B are frequently deleted in malignancies. The specific role of MTAP in cutaneous T-cell lymphoma (CTCL) subgroups; mycosis fungoides (MF) and Sézary syndrome (SS) is unknown. In 213 skin samples from MF/SS patients, MTAP copy number (CN) loss (34%) was more frequent than CDKN2A (12%) in all CTCL stages using Q-PCR. Importantly, in early stage MF, MTAP loss occurred independently of CDKN2A loss in 37% of samples. In PBMCs from SS patients, co-deletion with CDKN2A occurred in 18% samples but loss of MTAP alone was uncommon. In CD4+ cells from SS, reduced MTAP mRNA expression correlated with MTAP CN loss (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.01) but reduced MTAP expression was also detected in the absence of CN loss. Deep-sequencing of MTAP/CDKN2A-CDKN2B loci in 77 PBMC DNA samples from SS patients did not show any non-synonymous mutations but read-depth analysis suggested focal deletions consistent with MTAP and CDKN2A CN loss detected with Q-PCR. In a CTCL cell line, promoter hypermethylation was shown to down-regulate MTAP expression and may represent a mechanism of MTAP inactivation. In conclusion, our findings suggest that there may be selection in early stages of MF for MTAP deletion within the cutaneous tumor microenvironment.

Revista latino-americana de enfermagem, 2015

to understand the meanings given by women and men with sickle cell disease on the illness experie... more to understand the meanings given by women and men with sickle cell disease on the illness experience. analytical study with a qualitative approach, conducted with 17 adults with sickle cell disease using the Theory Based on Data, or Grounded Theory, as theoretical-methodological referential. Data were collected between the years of 2012 and 2013, in an individual in-depth interview. All the interviews were recorded and analyzed according to the Grounded Theory comparative analysis technique. data show four categories which group the experience of illness, the feelings experienced and the path to living with sickle cell disease. it was possible to understand that the experience was built by a process in which these people redefined the meaning of their lives, applying new directions to life and to care regarding the experience of the illness. In the context of chronic disease, the nurse's care is also seen in this study as a foundation, providing attention, directions, and guidan...

Supplemental digital content 2, Table 1. Cox model exploring independent association between pote... more Supplemental digital content 2, Table 1. Cox model exploring independent association between potential MINS diagnostic criteria of a peak Troponin T ≥0.04 ng/mL with and without an ischemic feature and 30-day mortality Potential diagnostic criteria Adjusted HR (95% CI) p-value Peak TnT ≥0.04 ng/mL with 1 ischemic feature Peak TnT ≥0.04 ng/mL without an ischemic feature TnT ≤0.01 ng/mL 5.06 (3.55-7.21) 3.33 (2.28-4.87) 1.00 <0.001 <0.001 -CI = confidence intervals; HR = hazard ratio; MINS = myocardial injury after noncardiac surgery; % = percentage; TnT = 4 th generation Troponin T Supplemental digital content 2, Table 2. Cox model exploring the independent association between all considered MINS diagnostic criteria and 30-day mortality Potential diagnostic criteria Number of Patients (%) Adjusted HR (95% CI) p-value Peak TnT ≥0.04 ng/mL with 1 ischemic feature Peak TnT ≥0.04 ng/mL without an ischemic feature Peak TnT = 0.03 ng/mL Peak TnT = 0.02 ng/mL TnT ≤0.01 ng/mL 401 (2.7) 540 (3.6) 259 (1.7) 479 (3.2) 13,386 (88.9) 4.82 (3.40-6.84) 3.30 (2.26-4.81) 4.30 (2.68-6.91) 1.61 (0.91-2.86)

Archives of Gynecology and Obstetrics, 2014

To assess sexual function (SF) and quality of life (QOL) in women with polycystic ovary syndrome ... more To assess sexual function (SF) and quality of life (QOL) in women with polycystic ovary syndrome (PCOS). A cross-sectional study was conducted to assess 56 women with PCOS and 102 control women with regular menstrual cycles. To assess SF and QOL in Brazilian women with PCOS with Female Sexual Function Index (FSFI) and the WHOQOL-bref questionnaires. Women with PCOS had a worse evaluation to arousal, lubrication, satisfaction, pain and total FSFI, and there was no difference in sexual desire and orgasm. Besides, they had a worse evaluation concerning health status than controls. The body mass index was inversely correlated to the QOL, especially to the physical, psychological, environment aspects and self-assessment of QOL, but it did not show correlation to the SF. Women with PCOS had a worse sexual function and self-assessment of health condition in comparison to controls. The body weight as isolated symptom was correlated to the worsening in quality of life, but not with the worsening of sexual function.

Social Policy and Society, 2010

Social Policy & Society 9:4, 599–600 C o Cambridge University Press 2010 doi:10.1017/S1474746... more Social Policy & Society 9:4, 599–600 C o Cambridge University Press 2010 doi:10.1017/S147474641000031X ... Ludovica Banfi Jean-Claude Barbier Paul Bayley Xiang Biao Sarah Blandy Graham Bowpitt Mike Brewer Margrit Brückner Claire Callender Mick Carpenter Karen Clarke Jochen Clasen Roger Clough Sharon Collard Rosie Cox Gary Craig Mark Drakeford Sue Edwards Ruth Emond Umet Erel Patricia Evans Brid Featherstone Ann Ferguson Silvia Ferreira John Flint Steve Fotherfill Chris Grover Surinder Guru Sabine Hess Martin Hewitt Claire Hill Donald Hirsch Amanda ...

Journal of Investigative Dermatology, 2012

T-plastin (PLS3) is an actin-bundling protein normally expressed in epithelial cells but absent i... more T-plastin (PLS3) is an actin-bundling protein normally expressed in epithelial cells but absent in cells of hematopoietic origin. Aberrant PLS3 expression has been demonstrated in lymphocytes from Sézary syndrome (SS) patients and has been proposed as a biomarker for SS; however, the mechanism underlying dysregulation of PLS3 has not been determined. In this study, PLS3 mRNA expression was demonstrated in 21/35 (60%) SS patients and in 3/8 (38%) mycosis fungoides patients, all of whom had clonal blood involvement. No evidence for PLS3 mutations within coding or promoter regions was found, but significant hypomethylation of CpG dinucleotides 95-99 within the PLS3 CpG island was observed and this was restricted to the PLS3+ population. A polyclonal antibody specific to PLS3 was raised to examine coexpression of PLS3 with a panel of T-cell differentiation markers. All PLS3+ cells were CD3+CD4+ and CD26-, suggesting that loss of CD26 is consistently associated with gain of PLS3, whereas all other markers were distributed heterogeneously. However, a patient-specific TCR copy number assay also demonstrated heterogeneity in PLS3 expression in tumor cell populations. Importantly, our findings demonstrate PLS3 expression in the majority of SS patients and provide insight into the molecular regulation of PLS3 expression in CTCL.

Journal of Electromyography and Kinesiology, 2014

The study assessed the effect of velocity of arm movement on anticipatory postural adjustments (A... more The study assessed the effect of velocity of arm movement on anticipatory postural adjustments (APAs) generation in the contralateral and ipsilateral muscles of individuals with stroke in seating. Ten healthy and eight post-stroke subjects were studied in sitting. The task consisted in reaching an object placed at scapular plane and mid-sternum height at self-selected and fast velocities. Electromyography was recorded from anterior deltoid (AD), upper (UT) and lower trapezius (LT) and latissimus dorsi (LD). While kinematic analysis was used to assess peak velocity and trunk displacement. Differences were found between the timing of APAs on ipsi and contralateral LD and LT in both movement speeds and in ipsilateral UT during movement of the non-affected arm at a self-selected velocity. A delay on the contralateral LD to reach movement with the non-affected arm at fast velocity was also observed. The trunk displacement was greater in post-stroke subjects. Individuals with stroke demonstrated a delay of APAs in the muscles on both sides of the body compared to healthy subjects. The delay was observed during performance of the reaching task with the fast and self-selected velocity.

Gynecologic Oncology, 2009

To evaluate whether prophylactic chemotherapy (P-chem) with one bolus dose of actinomycin D (Act-... more To evaluate whether prophylactic chemotherapy (P-chem) with one bolus dose of actinomycin D (Act-D) during the uterine evacuation of patients with high-risk hydatidiform mole (Hr-HM) affects reproductive outcomes in subsequent pregnancies. From 1987 to 2006, 1090 patients with gestational trophoblastic disease (GTD) were evaluated at a Trophoblastic Disease Center in southern Brazil; 265 with Hr-HM were selected and retrospectively analyzed. From 1996 to 2006, 163 received one bolus dose of Act-D at the time of uterine evacuation (Hr-HM-chem group); 102 with the same risk factors did not get P-chem (Hr-HM-control group). In March 2009, the number of pregnancies, progression of first pregnancy, and association of low age and low parity with subsequent pregnancy were evaluated. The percentage of patients that became pregnant was similar in both groups (Hr-HM-control: 59.5%; Hr-HM-chem group: 45.7%; p=0.069) and independent of HM progression. Percentages of no pregnancies because of age (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; or =40 years) or hysterectomy were also similar. Type of subsequent pregnancy was not statistically different between groups, and the rate of live births associated with pregnancies for which US showed a live fetus was high. Frequency of repeat GTD was unexpectedly high in both groups (4.2% and 6.3%; p=1.00). P-chem did not affect reproductive outcomes for patients with Hr-HM. Patients allowed to become pregnant again in both groups had high rates of live births associated with normal pregnancies. Chances of a subsequent pregnancy were higher in the low age and low parity subgroups.

European Journal of Endocrinology, 2010

ObjectiveThe currently available data concerning the influence of subclinical thyroid disease (ST... more ObjectiveThe currently available data concerning the influence of subclinical thyroid disease (STD) on morbidity and mortality are conflicting. Our objective was to investigate the relationships between STD and cardiometabolic profile and cardiovascular disease at baseline, as well as with all-cause and cardiovascular mortality in a 7.5-year follow-up.DesignProspective, observational study.MethodsAn overall of 1110 Japanese–Brazilians aged above 30 years, free of thyroid disease, and not taking thyroid medication at baseline were studied. In a cross-sectional analysis, we investigated the prevalence of STD and its relationship with cardiometabolic profile and cardiovascular disease. All-cause and cardiovascular mortality rates were assessed for participants followed for up to 7.5 years. Association between STD and mortality was drawn using multivariate analysis, adjusting for potential confounders.ResultsA total of 913 (82.3%) participants had euthyroidism, 99 (8.7%) had subclinical...

British Journal of Dermatology, 2006

The American Journal of Dermatopathology, 2001