Simon Leigh - Academia.edu (original) (raw)

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Papers by Simon Leigh

Research paper thumbnail of A Tale of Two Thresholds: A Framework for Prioritization within the Cancer Drugs Fund

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

The Cancer Drugs Fund (CDF) has been the subject of controversy since its inception, with critics... more The Cancer Drugs Fund (CDF) has been the subject of controversy since its inception, with critics arguing that it creates a "backdoor" to the National Health Service (NHS), circumventing the National Institute for Health and Care Excellence and its health technology assessment program. Nonetheless, with its creation comes a new decision problem, how to best allocate resources among cancer drugs. Our objective was to estimate CDF's willingness and ability to pay for cancer drugs, providing guidance regarding where CDF funds are best spent, and determining the number of NHS quality-adjusted life-years (QALYs) displaced through the existence of the fund. Using CDF utilization figures, cost-per-QALY, and treatment episode costs from National Institute for Health and Care Excellence health technology assessment reports, the league-table approach was applied to determine appropriate cost-effectiveness thresholds to inform the CDF's decision making. The CDF exhibits a wil...

Research paper thumbnail of The incidence and implications of cerebral palsy following potentially avoidable obstetric complications: a preliminary burden of disease study

BJOG : an international journal of obstetrics and gynaecology, 2014

To determine the extent of cerebral palsy attributable to adverse obstetric events, and estimate ... more To determine the extent of cerebral palsy attributable to adverse obstetric events, and estimate the lifetime mortality and morbidity expectations of these individuals relative to age-matched members of the UK general population. Simulation model. All projected live births during 2014. Using published data regarding the incidence and aetiology of cerebral palsy, we simulated the outcomes of a hypothetical cohort of UK live births. Survival and quality of life (QoL) for those with cerebral palsy were compared with age-matched individuals representative of the UK general population, in order to estimate the number of quality-adjusted life years (QALYs) lost following asphyxia-related cerebral palsy. Incidence of asphyxia-related cerebral palsy, QALYS, QoL, and survival. A total of 207 (95% CI 169-245) cases of asphyxia-related cerebral palsy were projected amongst UK children born during the year 2014, with approximately 15.2 QALYs lost per case. If these results held true in a real b...

Research paper thumbnail of App-based psychological interventions: friend or foe?: Table 1

Evidence Based Mental Health, 2015

Research paper thumbnail of A Tale of Two Thresholds: A Framework for Prioritization within the Cancer Drugs Fund

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

The Cancer Drugs Fund (CDF) has been the subject of controversy since its inception, with critics... more The Cancer Drugs Fund (CDF) has been the subject of controversy since its inception, with critics arguing that it creates a "backdoor" to the National Health Service (NHS), circumventing the National Institute for Health and Care Excellence and its health technology assessment program. Nonetheless, with its creation comes a new decision problem, how to best allocate resources among cancer drugs. Our objective was to estimate CDF's willingness and ability to pay for cancer drugs, providing guidance regarding where CDF funds are best spent, and determining the number of NHS quality-adjusted life-years (QALYs) displaced through the existence of the fund. Using CDF utilization figures, cost-per-QALY, and treatment episode costs from National Institute for Health and Care Excellence health technology assessment reports, the league-table approach was applied to determine appropriate cost-effectiveness thresholds to inform the CDF's decision making. The CDF exhibits a wil...

Research paper thumbnail of The incidence and implications of cerebral palsy following potentially avoidable obstetric complications: a preliminary burden of disease study

BJOG : an international journal of obstetrics and gynaecology, 2014

To determine the extent of cerebral palsy attributable to adverse obstetric events, and estimate ... more To determine the extent of cerebral palsy attributable to adverse obstetric events, and estimate the lifetime mortality and morbidity expectations of these individuals relative to age-matched members of the UK general population. Simulation model. All projected live births during 2014. Using published data regarding the incidence and aetiology of cerebral palsy, we simulated the outcomes of a hypothetical cohort of UK live births. Survival and quality of life (QoL) for those with cerebral palsy were compared with age-matched individuals representative of the UK general population, in order to estimate the number of quality-adjusted life years (QALYs) lost following asphyxia-related cerebral palsy. Incidence of asphyxia-related cerebral palsy, QALYS, QoL, and survival. A total of 207 (95% CI 169-245) cases of asphyxia-related cerebral palsy were projected amongst UK children born during the year 2014, with approximately 15.2 QALYs lost per case. If these results held true in a real b...

Research paper thumbnail of App-based psychological interventions: friend or foe?: Table 1

Evidence Based Mental Health, 2015

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