Sonja Cekić - Academia.edu (original) (raw)

Papers by Sonja Cekić

Acta medica Medianae, Jun 15, 2019

Nigerian Journal of Clinical Practice, 2022

facta.junis.ni.ac.rs

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder involving the cardiovas... more Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder involving the cardiovascular, skeletal and ocular systems. In 90-93 % of cases, MFS is caused by a mutation in fibrillin-1 (FBN1) on chromosome 15. The prevalence of MFS is at least 1/ 5000. The disease has no ethnic or gender predilection and shows an extremely high penetrance but marked inter-and intra-familial variability. The diagnosis of Marfan syndrome requires a multidisciplinary team approach, in view of its multisystem effects and phenotypic variability. The paper presents two twelve-year-old girls who, owing to the problem of poorsightedness, were sent to a consultational examination to the Orthoptic and Pleoptic Cabinet of our clinic. Both of them are typically high, gracious, with long limbs, and with a deformity of the spinal column and chests. They are quiet, reserved and shortsighted with a myopic refraction of the eye, the temporal and upper-bilateral subluxation of the lens, as well as with the enlarged axial diameter of the eye. Suspected to suffer from Marfan syndrome, they were sent to a pediatrician and neuropsychiatrist for further examinations. Marfan syndrome requires early integral and update management by a multidisciplinary group, to obtain the best quality of life and survival.

Journal of Clinical & Experimental Ophthalmology, Oct 26, 2017

Medicinski casopis

Optic nerve head drusen are congenital anomalies of the optic nerve, a form of calcium degenerati... more Optic nerve head drusen are congenital anomalies of the optic nerve, a form of calcium degeneration of axons of the optic nerve head. Initially asymptomatic, drusen may be one of the causes of progressive optic neuropathy. They are clinically presented as acellular, hyaline deposits of globular appearance in prelaminar segment of the optic nerve head. They occure due to: altered axonal transport, small diameter of scleral channel, compression and ischemia. Frequent complications include progressive visual field defects, ischemic optic neuropathy, central retinal artery or vein occlusion, or peripapillar neovascularization. Diagnostic tools: ophthalmoscopy, angiography, computerized perimetry, B-scan ultrasonography, CT, OCT, HRT, GDx, electrophysiological testing. The treatment is medicamentous, laser, or surgery. Most of the pilot studies confirms the benefit of topical hypotensive drugs even when the drusen are not associated with glaucoma. The decrease of intraocular pressure red...

Acta medica …, 2005

The study consists of 100 patients who underwent surgery and were treated at the Surgical Clinic ... more The study consists of 100 patients who underwent surgery and were treated at the Surgical Clinic of Nis Clinical Centre. The patients were divided into two groups: the first one included 50 patients subjected to surgery with the use of the Shouldice operative technique (control group) ...

< e aim of our study was to compeer levels of antioxidative agent –total SH groups and the... more < e aim of our study was to compeer levels of antioxidative agent –total SH groups and the fi-nale product of lipid peroxidation- malondialdehyde (MDA) in serum, and glutathione (GSH) and MDA in nucleocortical parts of lens after extracapsular extraction of cataract. Patient were ( with cataract and controls) matched by sex and years of life. Diagnosis of cataract was established by complete ocular examination. All results are expressed as mean ± S.D. A Student’s t-test was used to estimate diff erences between the groups. < e level of signifi cance was p<,. Total sulfhydryl groups were determined in serum by the method of Ellman as well as GSH content in nucleocortical parts of lenses using the method of Sedlak and Lind-say. Lipid peroxidation, evidenced by formation of thiobarbituric acid reactive substances (TBARS), was determined in nucleocortical parts of the lens and in serum. Our results show a statistical signifi cance in concentration of total SH groups (,±,µmol/L, controls ,±,µmol/L p<,) and MDA (,±,, and controls ,±,µmol/L, p<,) in serum among patients with age related cataract and controls. < ere was no statistical signif-icance in concentration of total SH groups and MDA in serum among patients with diff erent

Srpski arhiv za celokupno lekarstvo, 2019

Introduction/Objective. Intensive oxidative stress is proven in patients with diabetes mellitus a... more Introduction/Objective. Intensive oxidative stress is proven in patients with diabetes mellitus and important in the development of a microvascular complication of type 2 diabetes mellitus. The aim of the study was to investigate the relationship between morphometric parameters of retinal blood vessels in patients with diabetic retinopathy (DR) and the levels of parameters of oxidative stress: advanced oxidation protein product (AOPP), thiobarbituric acid reactive substances (TBARS), and total sulfhydryl (SH) groups in blood samples. Methods. The patients (the group with DR and controls) were sex- and age-matched. Glycaemia, hemoglobin A1C HbA1C, total cholesterol and its fractions, and triglycerides were measured in blood samples. AOPP and total SH groups were determined in the plasma by specific methods. Modification of the thiobarbituric acid method was used for the determination of TBARS. The number and diameter of retinal blood vessels, as morphometric parameters on digital ret...

Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences, 2010

Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with a number of extra-ar... more Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with a number of extra-articular organ manifestations. Ocular manifestations involved with RA are keratoconjunctivitis sicca, episcleritis, scleritis , corneal changes, and retinal vasculitus. The etiopathogenesis of this autoimmune disorder is still unknown. Aim of our study was to present different ocular manifestations of RA and their frequency. We have examined 691 patient with the diagnoses of RA. All examined patients were in I or II stage of the disease according to criteria of The American College of Rheumatology. Ophthalmological exam obtained: visual acuity by Snellen sings, biomicroscopy of anterior segment, Schirmer test, tear break-up time (BUT), applanation tonometry and indirect ophthalmoscopy. In all patients with retinal vasculitis fotofundus and in indicated cases fluorescein angiography was preformed. The most common manifestation of ocular involvement was keratoconjunctivitis sicca. Episcleri...

Vojnosanitetski pregled, 2012

Background/Aim. Transforming growth factor-b1 (TGF-b1), oxidative stress and imbalance between ma... more Background/Aim. Transforming growth factor-b1 (TGF-b1), oxidative stress and imbalance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) may play an important role in pathogenesis of pseudoexfoliation syndrome/glaucoma (PEX Sy/Gl). The aim of the study was to measure concentrations of TGF- b1, MMP-2, TIMP-2 in the aqueous humor in the examined group, as well as to compare the biochemical findings with the following clinical parameters: degree of chamber angle pigmantation, presence of pseudoexfoliation and the value of intraocular pressure (IOP). Methods. Aqueous samples from 30 patients with cataract, 30 patients with PEX Sy, 36 patients with PEX Gl, and 42 patients with primary open-angle glaucoma (POAG) were collected during phacoemulsification cataract surgery. TGF b1, MMP-2, TIMP-2 Fluotokine Multi Analyze Profiling kits and Luminex technology were used to simultaneously measure TGF b1, MMP-2 and TIMP-2. Results. TGF- ?1, MMP-2, TIMP-2 were detected i...

Medical Archives, 2014

Introduction: Age-related macular degeneration (AMD) is a leading cause of irreversible serious v... more Introduction: Age-related macular degeneration (AMD) is a leading cause of irreversible serious vision damage in persons over 50 years of age. In treating AMD many medicaments are applied such as inhibitors of vascular endothelial growth factor (VEGF), have been very carefully included over the last few years after a series of study research. Aims: To analyze the past methods of treatment, discuss emerging therapies which could advance the treatment of exudative AMD. The past anti-VEGF therapies require frequent repetitions of administration, with uncertain visual acuity recovery, as not all patients react to anti-VEGF therapy. Consequently, there is a need to find out additional therapies which could improve the treatment of exudative AMD. The real aim in the treating of AMD is to prevent CNV development. Methods: A survey of the current clinical research and results in the field of the present and future treatments of exudative AMD. Results: There are many areas of research into new methods of the exudative AMD treatment. Conclusion: The future therapies for exudative AMD treatment have a potential not only to reduce the frequency of administration and follow-up visits, but also to improve effects of treatment by targeting additional ways of CNV development, increasing the aptitude of target binding and extending durability of treatment.

Central European Journal of Medicine, 2012

We present three different cases of patients with papilledema: one case with a primary tumour of ... more We present three different cases of patients with papilledema: one case with a primary tumour of the optic nerve, and two cases with secondary involvement of the optic nerve (breast carcinoma and non-Hodgkin lymphoma). The visual acuity varies from sudden, painless, decrease of vision, to blurred vision and proptosis on the affected eye. A characteristic ophthalmoscopic examination shows a swollen optic disc and promonence with tortuosity of blood vessels. A fluorescein angiography shows dilated capillaries of the optic disc with leakage in the early phase and diffuse hyperfluorescence during the late phase. A ultrasonography B-scan of the affected eye shows prominent optic nerves with widened optic nerve sheath. An exhaustive history and complete ophthalmological examination are essential for the diagnosis, to which fluorescein angiography, B-scan ultrasonography, ocular coherent tomography, computerized tomography, and magnetic resonance can be used as useful additional tests. Tre...

Medicinski pregled, 2011

Introduction. Multifocal choroidopathy syndromes are a group of rare disorders, which involve a p... more Introduction. Multifocal choroidopathy syndromes are a group of rare disorders, which involve a primary pathologic process occurring at or near the level of the retinal pigment epithelium, with or without choriocapillaris involvement. The aetiology of multifocal choroidopathy syndrome is still unknown. A case report. We present a case of multifocal choroidopathy syndrome. A 54-year-old woman was referred to our department with blurred vision on both eyes, mild ocular pain, accompanied by metamorphopsia, floaters, scotomas and photopsia. The anterior segment examination showed small to medium size keratic precipitates, posterior synechiae, and iris atrophy. Mild to moderate aqueous inflammation with cells and flair was present in the anterior chamber. The fundus examination showed multiple small yellow-white spots, round-shaped changes located at the level of the retinal pigment epithelium and choriocapillaris. According to the fluorescein angiography the active lesions exhibited blo...

Acta medica medianae, 2013

International Ophthalmology, 2008

Optic nerve aplasia (ONA) is a rare congenital malformation characterized by absence of optic dis... more Optic nerve aplasia (ONA) is a rare congenital malformation characterized by absence of optic disk, optic nerve, retinal ganglion cells, and central retina vessels. It is frequently associated with other ocular and central nervous system anomalies. In this paper, we describe a case of ONA associated with microphthalmos and a rudimental retinal vasculature in an otherwise healthy infant.

Acta Medica Medianae

Pseudoexfoliation syndrome (PEX Sy) is a common age–related disorder of the extracellular matrix ... more Pseudoexfoliation syndrome (PEX Sy) is a common age–related disorder of the extracellular matrix that is frequently associated with severe secondary chronic open-angle glaucoma and cataract. Pseudoexfoliation glaucoma (PEX gl) is one of the most common causes of optic disc damage, low visual accuracy, damage of visual field and blidness. Deposits of white material on the anterior lens surface are the most consistent and important diagnostic feature of PEX syndrome/glaucoma. It is thought that PEX represents aberrant extracellular matrix synthesis. The aim of this paper was to evaluate the gender-related difference in the level of matrix metalloproetinases MMP-2 and tissue inhibitor of matrix metalloproetinases (TIMP-1, TIMP-2, TIMP-3, TIMP-4) in aqueous humor in patients with pseudoexfoliation syndrome/glaucoma.Aqueous humor was aspirated during surgery from 15 patients with PEX syndrome without glaucoma, 42 patients with PEX glaucoma, 36 patients with POAG and 14 age-matched control patients with cataract during cataract surgery or trabeculectomy. Data about medical history, medications, and demographic information were obtained from case notes. In all patients we determined Intra Ocular Pressure (IOP) by (measurement by Goldman aplanation tonometry), PEX appereance (determined with slet lamp examination). Fluorokine MultiAnalite Profiling kits (R&D Systems, Minneapolis, MN) and Luminex technology (Luminex Corporation, Austin, TX) were used to simultaneously measure MMP-2, and TIMP-1, TIMP-2, TIMP-3 and TIMP-4 in aqueous humor samples.Patients with PEX glaucoma are older and of male sex compared to the patients with POAG. Male patients with PEX glaucoma and POAG were significantly older than female patients. Patients with PEX Sy have bilateral ocular changes more often compared to other groups. There were no significant gender differences in aqueous humour MMP-2, TIMP-2, TIMP-3, TIMP-4 levels among examined groups. In the group with PEX syndrome a significantly higher level of TIMP-1 was registred in male patie [...]

American Journal of Ophthalmology, 2000