Stergios Pispas - Academia.edu (original) (raw)

Papers by Stergios Pispas

Research paper thumbnail of Nano-sized Polymer Structures via Self-assembly and Co-assembly Approaches

The amphiphilic copolymers in selective solvents self-associate into a variety of nano-sized stru... more The amphiphilic copolymers in selective solvents self-associate into a variety of nano-sized structures due to differences in the physicochemical characteristics of the constituent moieties. The properties of the nanoassemblies can be influenced and modified by co-assembly thus forming hybrid nanostructures with tunable morphology and significantly altered aggregate characteristics. The polymerization-induced self-assembly is described as a facile, efficient, and reproducible strategy for preparation of families of polymeric nanoparticles having various morphologies via a one-pot process. In this chapter, the fundamental principles behind those approaches are briefly outlined. Various nanostructures, prepared from stimuli-responsive copolymers, nanoparticles of non-common morphologies, hybrid nanostructures, nanostructures, prepared via electrostatic interactions, hierarchical self-assembly, nanostructures formed on a surface are described by giving examples from the recent literature. The nanoassemblies exhibit tremendous potential for delivery of, e.g., antitumor agents, genetic material, proteins, and other biologically active substances.

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Research paper thumbnail of Induced nanophase ordering in lithium neutralized ionic block copolymers

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Research paper thumbnail of Stimuli-responsive nanocarriers for drug delivery

Elsevier eBooks, 2020

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Research paper thumbnail of Design and evaluation of polymer matrices for the encapsulation of CdSe/ZnS quantum dots in photonic nanocomposite thin films

Journal of Polymer Science Part B, Sep 30, 2015

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Research paper thumbnail of Stimulus-responsive liposomes as smart nanocarriers for drug delivery applications

Elsevier eBooks, 2023

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Research paper thumbnail of Innovative drug nanocarriers by incorporating thermoresponsive polymer in phospholipid bilayers

Global drugs and therapeutics, 2017

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Research paper thumbnail of Drug Delivery Nanosystems

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Research paper thumbnail of Surfactant and Block Copolymer Nanostructures: From Design and Development to Nanomedicine Preclinical Studies

Pharmaceutics, Feb 2, 2023

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Research paper thumbnail of Influence of Lipid’s Main Transition Temperature on the Stability of Chimeric Liposomal Systems

Current nanomedicine, Aug 20, 2019

Background: The incorporation of polymeric components into liposomes promotes structural rearrang... more Background: The incorporation of polymeric components into liposomes promotes structural rearrangement of the lipid bilayers that could affect their properties and their behavior. Therefore, by mixing phospholipids with polymeric compounds the, socalled chimeric liposomal nanosystems are produced and could be advantageous, compared with conventional (e.g. composed of pure phospholipids) liposomal nanostructures. Objective: In this work, we used lipids with different main transition temperature (Tm) i.e 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC, Tm=55°C), L-α-phosphatidylcholine, hydrogenated (Soy) (HSPC, Tm=52 °C) and egg phosphatidylcholine (EggPC, Tm=23 °C) and we studied and compared the physicochemical characteristics and the stability of conventional with that of chimeric liposomes. Methods: Thin-film hydration method (TFH) was used as the preparation protocol for all systems. Dynamic and electrophoretic light scattering (DLS and ELS) were utilized in order to elucidate the physicochemical characteristics of all systems. All liposomal systems exhibited sizes below 100nm while the ζ-potential was around zero, indicating the absence of surface charge. Results: The results revealed that the Tm of each phospholipid influences the biophysical behavior of the lipidic membrane, which contributes to the physicochemical characteristics and affects the physical stability of the liposomal nanosystems. The nature and physicochemical properties of each phospholipid seem to play a key role, regarding the structural characteristics and the formation process of the liposomal nanosystems. Conclusion: : Comparing the physicochemical properties of the conventional liposomes with those of the chimeric liposomal systems, we conclude that the complexity of the latter, due to the incorporation of the polymeric guest into the lipidic bilayer, revealed new properties, which correspond to increased physical stability.

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Research paper thumbnail of Au Nanoparticle-Corona Loaded Polystyrene-b-Quaternized Poly(2-vinylpyridine) Micelles and their Interaction with DNA

Macromolecular Chemistry and Physics, Nov 17, 2016

The incorporation of Au nanoparticles to polystyrene‐b‐quaternized poly(2‐vinylpyridine) (SQVP) m... more The incorporation of Au nanoparticles to polystyrene‐b‐quaternized poly(2‐vinylpyridine) (SQVP) micelles and their interaction with DNA in aqueous solutions is investigated. Micelles of a well‐defined single population in solution keep their size while AuNPs appear to bind near their core, as observed by static and dynamic light scattering. The apparent molecular weight increases as a function of Au concentration, which proves controllable NP loading. Au‐loaded SQVP micelles create complexes with DNA where the micelles still preserve their morphology and size. The fluorescence intensity from SQVP‐Au aggregates drops as Au accumulates on the micelles. The fluorescence spectrum remains practically unaffected by the addition of DNA. SQVP micelles offer a stable and well‐defined template for the formulation of drug and DNA nanocarriers as hierarchically self‐assembled hybrid nanostructured functional materials. image

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Research paper thumbnail of Nickel dithiolene complexes encapsulated in biocompatible amphiphilic diblock copolymer nanoparticles

Journal of Polymer Science Part B, Sep 30, 2016

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Research paper thumbnail of Differential Scanning Calorimetry (DSC): An Invaluable Tool for the Thermal Evaluation of Advanced Chimeric Liposomal Drug Delivery Nanosystems

Series in bioengineering, 2019

Chimeric liposomal systems are classified as advanced drug delivery nanosystems, being composed o... more Chimeric liposomal systems are classified as advanced drug delivery nanosystems, being composed of different kinds of biomaterials, such as phospholipids and polymers. Chimeric liposomes present many advantages, compared to conventional ones, such as great functionality, stimuli-responsiveness and increased targeting to the pathological tissue. Among the analytical techniques established for the liposomal system characterization, Differential Scanning Calorimetry (DSC) is applied to indicate their thermotropic behavior and thermal stability, providing useful information, in order to optimize the quality and therapeutic efficiency of the liposomal formulations. Until very recently, several researches have aimed at explaining the behavior of carrier lipid forms by the DSC method. Therefore, DSC has been quite frequently applied in pharmaceutical research for scanning the thermal behavior of the samples and to record the difference between the heat flows, while it provides quick and accurate information about the physical and energetic parts of a material. In the present chapter, a variety of different chimeric liposomal systems is presented that were analyzed in terms of their thermal behavior, describing the utilized DSC protocols and highlighting the interpretation of the DSC results. The aim of this chapter is to prove, through different literature examples of chimeric liposomal systems, the utility of the DSC technique upon the characterization of their thermotropic behavior which is strictly correlated with the interactions and cooperativity of the different biomaterials, as well as how it predicts the efficacy of the examined liposomal platforms.

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Research paper thumbnail of Design and development of DSPC:DAP:PDMAEMA-b-PLMA nanostructures: from the adumbration of their morphological characteristics to in vitro evaluation

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022

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Research paper thumbnail of Recent Advances on PEO-PCL Block and Graft Copolymers as Nanocarriers for Drug Delivery Applications

Materials

Poly(ethylene oxide)-poly(ε-caprolactone) (PEO-PCL) is a family of block (or graft) copolymers wi... more Poly(ethylene oxide)-poly(ε-caprolactone) (PEO-PCL) is a family of block (or graft) copolymers with several biomedical applications. These types of copolymers are well-known for their good biocompatibility and biodegradability properties, being ideal for biomedical applications and for the formation of a variety of nanosystems intended for controlled drug release. The aim of this review is to present the applications and the properties of different nanocarriers derived from PEO-PCL block and graft copolymers. Micelles, polymeric nanoparticles, drug conjugates, nanocapsules, and hybrid polymer-lipid nanoparticles, such as hybrid liposomes, are the main categories of PEO-PCL based nanocarriers loaded with different active ingredients. The advantages and the limitations in preclinical studies are also discussed in depth. PEO-PCL based nanocarriers could be the next generation of delivery systems with fast clinical translation. Finally, current challenges and future perspectives of the ...

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Research paper thumbnail of Targeting cellular and molecular mechanisms of nanovesicular systems for the treatment of different diseases

Applications of Nanovesicular Drug Delivery

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Research paper thumbnail of Hydrogels as Intelligent Drug Delivery Systems

Drug Delivery Nanosystems, 2019

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Research paper thumbnail of The technology of transdermal delivery nanosystems: from design and development to preclinical studies

International Journal of Pharmaceutics, 2021

Transdermal administration has gained much attention due to their remarkable advantages such as p... more Transdermal administration has gained much attention due to their remarkable advantages such as patient compliance, drug escape from first-pass elimination, favorable pharmacokinetic profile and prolonged release properties. However, the major limitation of these systems is the limited skin penetration of the stratum corneum, the skin's most important barrier, which protects the body from the insertion of substances from the environment. Transdermal drug delivery systems are aiming to the disruption of the stratum corneum in order for the active pharmaceutical ingredients to enter successfully the circulation. Therefore, nanoparticles are holding a great promise because they can act as effective penetration enhancers due to their small size and other physicochemical properties that will be analyzed thoroughly in this report. Apart from the investigation of the physicochemical parameters, a comparison between the different types of nanoparticles will be performed. The complexity of skin anatomy and the unclear mechanisms of penetration should be taken into consideration to reach some realistic conclusions regarding the way that the described parameters affect the skin permeability. To the best of the authors knowledge, this is among the few reports on the literature describing the technology of transdermal delivery systems and how this technology affects the biological activity.

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Research paper thumbnail of Determination of Intimate Composition of Theranostic Polyplexes Based on (Co)Polymers of Poly(vinyl benzyl trimethylammonium chloride)

Macromolecular Chemistry and Physics, 2017

Novel hybrid nanoparticulate systems that exhibit potential to combine therapeutic, diagnostic, a... more Novel hybrid nanoparticulate systems that exhibit potential to combine therapeutic, diagnostic, and sensing modalities in a single nanoparticle are investigated. They are composed of a homopolymer of poly(vinyl benzyl trimethylammonium chloride) (or its copolymer with poly[oligo(ethylene glycol) methacrylate]), DNA, and gold nanoparticles (AuNPs). Using the approach of classic dynamic and static light scattering, parameters such as molar mass, particle size, geometry and density, and intimate composition are determined, trying to establish what the theranostic polyplexes really carry. According to the analysis, the polyplex particles are composed of up to 154 DNA molecules and 1612 (co)polymer molecules at amino‐to‐phosphate groups ratio (N/P) of 0.5 and 1 DNA and up to 252 (co)polymer molecules at higher N/P ratios. The particle morphology is consistent with “hairy surface on a compact sphere” with density that is lower than the density of the familiar copolymer micelles. The intro...

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Research paper thumbnail of Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads

Acta Pharmaceutica, 2020

A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, ... more A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their thermal degradation properties. It has been found that the release of MLT from the beads was reversibly proportional to the extent of their expansion, which depends on the molecular mass/viscosity of the biopolymers present in the beads; the higher the molecular mass/viscosity of the hydrogels the greater the beads swelling and the less the MLT’s release. Thermogravimetric analysis (TGA) data support the presence of the components in the hybrid hydrogel beads and elucidate their effects on the thermal stability of the systems. Thus, the physicochemical properties of the biopolymers used, along with their stereoelectronic features modulate the release of MLT from the beads, providing formul...

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Research paper thumbnail of Physicochemical, morphological and thermal evaluation of lyotropic lipidic liquid crystalline nanoparticles: The effect of stimuli-responsive polymeric stabilizer

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020

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Research paper thumbnail of Nano-sized Polymer Structures via Self-assembly and Co-assembly Approaches

The amphiphilic copolymers in selective solvents self-associate into a variety of nano-sized stru... more The amphiphilic copolymers in selective solvents self-associate into a variety of nano-sized structures due to differences in the physicochemical characteristics of the constituent moieties. The properties of the nanoassemblies can be influenced and modified by co-assembly thus forming hybrid nanostructures with tunable morphology and significantly altered aggregate characteristics. The polymerization-induced self-assembly is described as a facile, efficient, and reproducible strategy for preparation of families of polymeric nanoparticles having various morphologies via a one-pot process. In this chapter, the fundamental principles behind those approaches are briefly outlined. Various nanostructures, prepared from stimuli-responsive copolymers, nanoparticles of non-common morphologies, hybrid nanostructures, nanostructures, prepared via electrostatic interactions, hierarchical self-assembly, nanostructures formed on a surface are described by giving examples from the recent literature. The nanoassemblies exhibit tremendous potential for delivery of, e.g., antitumor agents, genetic material, proteins, and other biologically active substances.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Induced nanophase ordering in lithium neutralized ionic block copolymers

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Stimuli-responsive nanocarriers for drug delivery

Elsevier eBooks, 2020

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Design and evaluation of polymer matrices for the encapsulation of CdSe/ZnS quantum dots in photonic nanocomposite thin films

Journal of Polymer Science Part B, Sep 30, 2015

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Stimulus-responsive liposomes as smart nanocarriers for drug delivery applications

Elsevier eBooks, 2023

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Innovative drug nanocarriers by incorporating thermoresponsive polymer in phospholipid bilayers

Global drugs and therapeutics, 2017

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Drug Delivery Nanosystems

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Surfactant and Block Copolymer Nanostructures: From Design and Development to Nanomedicine Preclinical Studies

Pharmaceutics, Feb 2, 2023

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Research paper thumbnail of Influence of Lipid’s Main Transition Temperature on the Stability of Chimeric Liposomal Systems

Current nanomedicine, Aug 20, 2019

Background: The incorporation of polymeric components into liposomes promotes structural rearrang... more Background: The incorporation of polymeric components into liposomes promotes structural rearrangement of the lipid bilayers that could affect their properties and their behavior. Therefore, by mixing phospholipids with polymeric compounds the, socalled chimeric liposomal nanosystems are produced and could be advantageous, compared with conventional (e.g. composed of pure phospholipids) liposomal nanostructures. Objective: In this work, we used lipids with different main transition temperature (Tm) i.e 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC, Tm=55°C), L-α-phosphatidylcholine, hydrogenated (Soy) (HSPC, Tm=52 °C) and egg phosphatidylcholine (EggPC, Tm=23 °C) and we studied and compared the physicochemical characteristics and the stability of conventional with that of chimeric liposomes. Methods: Thin-film hydration method (TFH) was used as the preparation protocol for all systems. Dynamic and electrophoretic light scattering (DLS and ELS) were utilized in order to elucidate the physicochemical characteristics of all systems. All liposomal systems exhibited sizes below 100nm while the ζ-potential was around zero, indicating the absence of surface charge. Results: The results revealed that the Tm of each phospholipid influences the biophysical behavior of the lipidic membrane, which contributes to the physicochemical characteristics and affects the physical stability of the liposomal nanosystems. The nature and physicochemical properties of each phospholipid seem to play a key role, regarding the structural characteristics and the formation process of the liposomal nanosystems. Conclusion: : Comparing the physicochemical properties of the conventional liposomes with those of the chimeric liposomal systems, we conclude that the complexity of the latter, due to the incorporation of the polymeric guest into the lipidic bilayer, revealed new properties, which correspond to increased physical stability.

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Research paper thumbnail of Au Nanoparticle-Corona Loaded Polystyrene-b-Quaternized Poly(2-vinylpyridine) Micelles and their Interaction with DNA

Macromolecular Chemistry and Physics, Nov 17, 2016

The incorporation of Au nanoparticles to polystyrene‐b‐quaternized poly(2‐vinylpyridine) (SQVP) m... more The incorporation of Au nanoparticles to polystyrene‐b‐quaternized poly(2‐vinylpyridine) (SQVP) micelles and their interaction with DNA in aqueous solutions is investigated. Micelles of a well‐defined single population in solution keep their size while AuNPs appear to bind near their core, as observed by static and dynamic light scattering. The apparent molecular weight increases as a function of Au concentration, which proves controllable NP loading. Au‐loaded SQVP micelles create complexes with DNA where the micelles still preserve their morphology and size. The fluorescence intensity from SQVP‐Au aggregates drops as Au accumulates on the micelles. The fluorescence spectrum remains practically unaffected by the addition of DNA. SQVP micelles offer a stable and well‐defined template for the formulation of drug and DNA nanocarriers as hierarchically self‐assembled hybrid nanostructured functional materials. image

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Research paper thumbnail of Nickel dithiolene complexes encapsulated in biocompatible amphiphilic diblock copolymer nanoparticles

Journal of Polymer Science Part B, Sep 30, 2016

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Research paper thumbnail of Differential Scanning Calorimetry (DSC): An Invaluable Tool for the Thermal Evaluation of Advanced Chimeric Liposomal Drug Delivery Nanosystems

Series in bioengineering, 2019

Chimeric liposomal systems are classified as advanced drug delivery nanosystems, being composed o... more Chimeric liposomal systems are classified as advanced drug delivery nanosystems, being composed of different kinds of biomaterials, such as phospholipids and polymers. Chimeric liposomes present many advantages, compared to conventional ones, such as great functionality, stimuli-responsiveness and increased targeting to the pathological tissue. Among the analytical techniques established for the liposomal system characterization, Differential Scanning Calorimetry (DSC) is applied to indicate their thermotropic behavior and thermal stability, providing useful information, in order to optimize the quality and therapeutic efficiency of the liposomal formulations. Until very recently, several researches have aimed at explaining the behavior of carrier lipid forms by the DSC method. Therefore, DSC has been quite frequently applied in pharmaceutical research for scanning the thermal behavior of the samples and to record the difference between the heat flows, while it provides quick and accurate information about the physical and energetic parts of a material. In the present chapter, a variety of different chimeric liposomal systems is presented that were analyzed in terms of their thermal behavior, describing the utilized DSC protocols and highlighting the interpretation of the DSC results. The aim of this chapter is to prove, through different literature examples of chimeric liposomal systems, the utility of the DSC technique upon the characterization of their thermotropic behavior which is strictly correlated with the interactions and cooperativity of the different biomaterials, as well as how it predicts the efficacy of the examined liposomal platforms.

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Research paper thumbnail of Design and development of DSPC:DAP:PDMAEMA-b-PLMA nanostructures: from the adumbration of their morphological characteristics to in vitro evaluation

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022

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Research paper thumbnail of Recent Advances on PEO-PCL Block and Graft Copolymers as Nanocarriers for Drug Delivery Applications

Materials

Poly(ethylene oxide)-poly(ε-caprolactone) (PEO-PCL) is a family of block (or graft) copolymers wi... more Poly(ethylene oxide)-poly(ε-caprolactone) (PEO-PCL) is a family of block (or graft) copolymers with several biomedical applications. These types of copolymers are well-known for their good biocompatibility and biodegradability properties, being ideal for biomedical applications and for the formation of a variety of nanosystems intended for controlled drug release. The aim of this review is to present the applications and the properties of different nanocarriers derived from PEO-PCL block and graft copolymers. Micelles, polymeric nanoparticles, drug conjugates, nanocapsules, and hybrid polymer-lipid nanoparticles, such as hybrid liposomes, are the main categories of PEO-PCL based nanocarriers loaded with different active ingredients. The advantages and the limitations in preclinical studies are also discussed in depth. PEO-PCL based nanocarriers could be the next generation of delivery systems with fast clinical translation. Finally, current challenges and future perspectives of the ...

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Research paper thumbnail of Targeting cellular and molecular mechanisms of nanovesicular systems for the treatment of different diseases

Applications of Nanovesicular Drug Delivery

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Hydrogels as Intelligent Drug Delivery Systems

Drug Delivery Nanosystems, 2019

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The technology of transdermal delivery nanosystems: from design and development to preclinical studies

International Journal of Pharmaceutics, 2021

Transdermal administration has gained much attention due to their remarkable advantages such as p... more Transdermal administration has gained much attention due to their remarkable advantages such as patient compliance, drug escape from first-pass elimination, favorable pharmacokinetic profile and prolonged release properties. However, the major limitation of these systems is the limited skin penetration of the stratum corneum, the skin's most important barrier, which protects the body from the insertion of substances from the environment. Transdermal drug delivery systems are aiming to the disruption of the stratum corneum in order for the active pharmaceutical ingredients to enter successfully the circulation. Therefore, nanoparticles are holding a great promise because they can act as effective penetration enhancers due to their small size and other physicochemical properties that will be analyzed thoroughly in this report. Apart from the investigation of the physicochemical parameters, a comparison between the different types of nanoparticles will be performed. The complexity of skin anatomy and the unclear mechanisms of penetration should be taken into consideration to reach some realistic conclusions regarding the way that the described parameters affect the skin permeability. To the best of the authors knowledge, this is among the few reports on the literature describing the technology of transdermal delivery systems and how this technology affects the biological activity.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Determination of Intimate Composition of Theranostic Polyplexes Based on (Co)Polymers of Poly(vinyl benzyl trimethylammonium chloride)

Macromolecular Chemistry and Physics, 2017

Novel hybrid nanoparticulate systems that exhibit potential to combine therapeutic, diagnostic, a... more Novel hybrid nanoparticulate systems that exhibit potential to combine therapeutic, diagnostic, and sensing modalities in a single nanoparticle are investigated. They are composed of a homopolymer of poly(vinyl benzyl trimethylammonium chloride) (or its copolymer with poly[oligo(ethylene glycol) methacrylate]), DNA, and gold nanoparticles (AuNPs). Using the approach of classic dynamic and static light scattering, parameters such as molar mass, particle size, geometry and density, and intimate composition are determined, trying to establish what the theranostic polyplexes really carry. According to the analysis, the polyplex particles are composed of up to 154 DNA molecules and 1612 (co)polymer molecules at amino‐to‐phosphate groups ratio (N/P) of 0.5 and 1 DNA and up to 252 (co)polymer molecules at higher N/P ratios. The particle morphology is consistent with “hairy surface on a compact sphere” with density that is lower than the density of the familiar copolymer micelles. The intro...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads

Acta Pharmaceutica, 2020

A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, ... more A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their thermal degradation properties. It has been found that the release of MLT from the beads was reversibly proportional to the extent of their expansion, which depends on the molecular mass/viscosity of the biopolymers present in the beads; the higher the molecular mass/viscosity of the hydrogels the greater the beads swelling and the less the MLT’s release. Thermogravimetric analysis (TGA) data support the presence of the components in the hybrid hydrogel beads and elucidate their effects on the thermal stability of the systems. Thus, the physicochemical properties of the biopolymers used, along with their stereoelectronic features modulate the release of MLT from the beads, providing formul...

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Research paper thumbnail of Physicochemical, morphological and thermal evaluation of lyotropic lipidic liquid crystalline nanoparticles: The effect of stimuli-responsive polymeric stabilizer

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020

Bookmarks Related papers MentionsView impact