Suliman Khan - Academia.edu (original) (raw)

Papers by Suliman Khan

Current Medical Research and Opinion, 2020

The ongoing highly infectious Coronavirus Disease 2019 (COVID-19) pandemic caused by the Severe A... more The ongoing highly infectious Coronavirus Disease 2019 (COVID-19) pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) started at the end of December 2019 in Wuhan, C...

Cancer has many types, in which one of the most common types of cancer is lung cancer, it is the ... more Cancer has many types, in which one of the most common types of cancer is lung cancer, it is the most common type which is diagnosed worldwide. Within five years of diagnosis, 90% of lung cancer patients die. The mortality rate can be reduced by the early detection of this disease [1]. Different types of strategies are used for the analysis of biomarkers in the blood such as changes in the expression of the gene, protein, and micro RNA [2]. The discovery of micro-RNA found in serum has introduced new methods for the diagnosis of the tumor. The micro-RNA can be analyzed through different techniques such as quantitative RT-PCR based on Taqman probe to check the expression level of micro-RNA in the serum [3]. MicroRNAs are noncoding small sequences of RNA that control the expression of mRNA at post transcription level which has a role in cell proliferation, apoptosis, metabolism, and differentiation as well as has a role in oncogenic and anti-oncogenic signals. The abnormal level of mi...

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The present study explores the effect of lemon and ginger extract on carrot and kinnow mixed jam ... more The present study explores the effect of lemon and ginger extract on carrot and kinnow mixed jam during 90 days of storage. The treatments were KCG0, KCG1, KCG2, KCG3, KCG4 and KCG5 having carrot pulp and kinnow juice at ratio of (7:3), 750g sugar, 10ml lemon juice with variations in ginger extract in different levels. All the mixed carrot and kinnow jam samples were eximned physico-chemically (pH, total soluble solids, titratable acidy, Vitamin-C, reducing and non-reducing sugar) and sensory attribute (colour, flavor, texture and overall acceptability). Statistical analysis revealed that treatment as well as storage had significant (p

The Indus River dolphin (IRD; Platanista gangetica minor) is an endangered and blind freshwater c... more The Indus River dolphin (IRD; Platanista gangetica minor) is an endangered and blind freshwater cetacean, endemic to the Indus River system of Pakistan and India. This review article provides detailed information about the major challenges IRDs are facing, and their possible consequences on the population dynamics of the IRD. Furthermore, we have suggested future conservation strategies for the IRD based on the lesson learned from the conservation of the Yangtze finless porpoise (YFP; Neophocaena asiaeorientalis), a Critically Endangered freshwater cetacean. The major challenges for IRDs are habitat degradation, habitat fragmentation, and several types of industrial and agricultural pollutants. Worsening climatic changes, illegal fishing, and overfishing are additional threats. The construction of several barrages has fragmented the population into several short segments, some of which are too small for the IRDs to survive. In some segments, the population status of the IRD is unkno...

Clinical Genetics, 2021

Congenital cranial dysinnervation disorders (CCDDs) are a heterogeneous group of neurodevelopment... more Congenital cranial dysinnervation disorders (CCDDs) are a heterogeneous group of neurodevelopmental phenotypes caused by a primary disturbance of innervation due to deficient, absent, or misguided cranial nerves. Although some CCDDs genes are known, several clinical phenotypes and their aetiologies remain to be elucidated. We describe a 12‐year‐old boy with hypotonia, developmental delay, sensorineural hearing loss, and keratoconjunctivitis due to lack of corneal reflex. He had a long expressionless face, severe oromotor dysfunction, bilateral agenesis/severe hypoplasia of the VIII nerve with marked atresia of the internal auditory canals and cochlear labyrinth malformation. Trio‐exome sequencing identified a homozygous loss of function variant in the NEUROG1 gene (NM_006161.2: c.202G > T, p.Glu68*). NEUROG1 is considered a causal candidate for CCDDs based on (i) the previous report of a patient with a homozygous gene deletion and developmental delay, deafness due to absent bilat...

Arabian Journal of Chemistry, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Frontiers in Bioengineering and Biotechnology, 2021

Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or w... more Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individual’s quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemotherapeutic approaches, which may cause complications and bear side effects, the surgical reconstruction involves the implantation of external materials such as ceramics, metals, and different other materials as bone substitutes. Compared to the synthetic substitutes, the use of biomaterials could be an ideal choice for bone regeneration owing to their renewability, non-toxicity, and non-immunoge...

Journal of the American Society of Nephrology, 2020

BackgroundCongenital anomalies of the kidney and urinary tract (CAKUT) are one of the most common... more BackgroundCongenital anomalies of the kidney and urinary tract (CAKUT) are one of the most common malformations identified in the fetal stage. Bilateral renal agenesis (BRA) represents the most severe and fatal form of CAKUT. Only three genes have been confirmed to have a causal role in humans (ITGA8, GREB1L, and FGF20).MethodsGenome sequencing within a diagnostic setting and combined data repository analysis identified a novel gene.ResultsTwo patients presented with BRA, detected during the prenatal period, without additional recognizable malformations. They had parental consanguinity and similarly affected, deceased siblings, suggesting autosomal recessive inheritance. Evaluation of homozygous regions in patient 1 identified a novel, nonsense variant in GFRA1 (NM_001348097.1:c.676C>T, p.[Arg226*]). We identified 184 patients in our repository with renal agenesis and analyzed their exome/genome data. Of these 184 samples, 36 were from patients who presented with isolated renal a...

Saudi Pharmaceutical Journal, 2020

COVID-19 has created havoc in the world by causing thousands of demises in a short period of time... more COVID-19 has created havoc in the world by causing thousands of demises in a short period of time. Up till now, several attempts have been made for potential therapeutics against SARS-COV2. In this retrospective, single-center study, we extracted data from 122 COVID-19, RT-PCR confirmed patients. who were treated with a new treatment strategy of lianhuaqingwen with Arbidol Hydrochloride. The patients were either asymptomatic or had mild symptoms for COVID-19 disease. Of 122 patients 21 (17.21%) patients developed severe conditions of COVID-19, while total 111 (90.9%) experienced mild symptoms such as fever in 93 (76.22%) patients, cough in 23 (20.17%) and muscle pain were observed in total 8 (7%) patients. Furthermore our newly applied drugs combination (Lianhuaqingwen and Arbidol Hydrochloride) showed therapeutic effects in 5-7 days in patients with mild symptoms with 98% recovery rate. These results indicate that COVID-19 patients with mild symptoms can be treated with Lianhuaqingwen and Arbidol Hydrochloride. However, extensive clinical investigations are required to confirm the effectiveness of these drugs.

Journal of Advanced Research, 2021

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Current Nanoscience, 2021

Glioblastoma is one of the fatal and aggressive types of brain tumors. The current standard treat... more Glioblastoma is one of the fatal and aggressive types of brain tumors. The current standard treatment for glioblastoma multiform (GBM) is surgical resection coupled with radiotherapy and chemotherapy. Although ample research has been performed, and multiple novel pharmacological approaches have been investigated for developing effective therapeutic drugs for treating GBM, the success of extending the survival of the patient is notably low. The unique barrier limiting GBM treatment is the presence of the blood-brain barrier (BBB), and most of the chemotherapeutic drugs fail to cross it due to their high molecular weight and large size. The currently used chemo drugs for GBM have poor penetration ability to the brain and cause off-target toxicity due to a high dose for maintaining drug concentration at the tumor site. The use of nanomaterial composites for co-delivery of multiple therapeutic drugs offers several advantages by encompassing the aforementioned obstacles. In this review, ...

Journal of Infection and Public Health, 2020

Journal of Molecular Structure, 2020

Abstract In this paper, we investigate the prediction power of all the well-known distance-based ... more Abstract In this paper, we investigate the prediction power of all the well-known distance-based molecular structure descriptors in the literature for 22 lower polycyclic aromatic hydrocarbons (PAHs). The standard enthalpy/heat of formation is chosen to be the representative of thermal properties, whereas, the normal boiling point is selected to represent intermolecular and van-der-Waals type interactions. First, we present a computational technique to compute distance-based, eccentricity-based, degree-distance-based and degree based topological descriptors. The proposed method extends certain existing techniques in the literature. The proposed method is used to compute various distance-based descriptors for the 22 PAHs and then we develop the regression models with their normal boiling point and standard enthalpy of formation. Experimental results reveal some unexpected outcomes as the correlation ability of some well-known distance-based descriptors such as the Wiener and the Szeged indices is rather weak. Unlike their reputation among researchers, the second atomic-bond connectivity index and the fourth geometric-arithmetic index yield the best performance with correlation coefficients greater than 0.95. The results warrant further usage of the second atom-bond connectivity index in the structure-activity and structure-property models. Our study contributes towards slowing down the proliferation of distance-based topological descriptors.

Infection Control & Hospital Epidemiology, 2020

Journal of Clinical Microbiology, 2020

The new decade of the 21 st century (2020) started with the emergence of a novel coronavirus know... more The new decade of the 21 st century (2020) started with the emergence of a novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in humans. The source of origin, transmission to humans, and mechanisms associated with the pathogenicity of SARS-CoV-2 are not yet clear, however, its resemblance to SARS-CoV and several other bat coronaviruses was recently confirmed through genome sequencing-related studies.

International Journal of Biological Sciences, 2019

Disruption of the circadian rhythm is a risk factor for cancer, while glioma is a leading contrib... more Disruption of the circadian rhythm is a risk factor for cancer, while glioma is a leading contributor to mortality worldwide. Substantial efforts are being undertaken to decrypt underlying molecular pathways. Our understanding of the mechanisms through which disrupted circadian rhythm induces glioma development and progression is incomplete. We, therefore, examined changes in the expression of glioma-related genes in the mouse brain after chronic jetlag (CJL) exposure. A total of 22 candidate tumor suppressor (n= 14) and oncogenes (n= 8) were identified and analyzed for their interaction with clock genes. Both the control and CJL groups were investigated for the expression of candidate genes in the nucleus accumbens, hippocampus, prefrontal cortex, hypothalamus, and striatum of wild type, Bmal1-/and Cry1/2 double knockout male mice. We found significant variations in the expression of candidate tumor suppressor and oncogenes in the brain tissues after CJL treatment in the wild type, Bmal1-/and Cry1/2 double knockout mice. In response to CJL treatment, some of the genes were regulated in the wild type, Bmal1-/and Cry1/2 similarly. However, the expression of some of the genes indicated their association with the functional clock. Overall, our result suggests a link between CJL and gliomas risk at least partially dependent on the circadian clock. However, further studies are needed to investigate the molecular mechanism associated with CJL and gliomas.

Biodiversity and Conservation, 2017

The China Pakistan Economic Corridor (CPEC) targets the less developed areas of Pakistan and Chin... more The China Pakistan Economic Corridor (CPEC) targets the less developed areas of Pakistan and China. In this way underdeveloped and deprived areas come into the road map of new era of holistic development. In the current study, the local community perception towards the socioeconomic impact of CPEC projects was examined in different regions of Gilgit Baltistan (GB). The primary data was collected from three main divisions of GB i.e. Gilgit, Skardu and Hunza and samples of one hundred and twenty respondents were interviewed. The data from the above regions were collected and was analysed using N-vivo software for thematic analysis, with the aim to present the perception of local people regarding the ongoing projects of CPEC. The study consists of socioeconomic indicators with qualitative in nature and its various dimensions including education, tourism, businesses, constitutional rights and their living standard. According to the study findings, it is obvious that CPEC is having a beneficial impact on socioeconomic condition of the GB. By having new opportunities to the local people of GB in various aspects i.e. economic, political and social, this would help them for their sustainable development and capacity building.

International journal of biological sciences, 2018

The circadian system maintains the main aspects of physiological and behavioral processes. Both c... more The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rhythmic cycle. The disrupted circadian rhythm and disregulated sleep affect an organism's health, thereby causing several disorders including cancer, depression and cardiac disorders. Considering the role of clock genes and environmental factors, extensive investigation is required focusing on pathways involved in development of life-threatening disorders. This review identifies the major risks and associated factors related with disruption in circadian system and sleep.