Sunil Kamboj - Academia.edu (original) (raw)
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Papers by Sunil Kamboj
International Journal of Pharmaceutical Sciences Review and Research
The objective of the study is to evaluate the potential of novel vesicular drug carriers for bioa... more The objective of the study is to evaluate the potential of novel vesicular drug carriers for bioavailability enhancement. Novel vesicular drug delivery carriers intend to deliver the drug at a rate directed by need of body during the period of treatment, and channel the active entity to the site of action. Encapsulation of drug in vesicular structures prolongs the existence of drug in systemic circulation and reduces the toxicity, if selective uptake can be achieved. Vesicular drug delivery systems have been used to improve the therapeutic index, solubility, stability and rapid degradation of drug molecule. This system reduces the cost of therapy by bioavailability improvement of medication, especially in case of poorly soluble drugs. Thus a number of novel vesicular drug delivery systems have been developed that enhance the bioavailability and provide sustained or controlled release of drug. The focus of this review is to discuss various lipoidal and non-lipoidal vesicles with special emphasis on the bioavailability enhancement of drugs.
International Journal of Pharmaceutical Sciences Review and Research
Hydrazones is an important class of compounds for the development of novel drug moieties. Hydrazo... more Hydrazones is an important class of compounds for the development of novel drug moieties. Hydrazones consists of an azomethine -NHN=CH-proton which is responsible for the development of new drugs. Hydrazides and hydrazones leads to development of many bioactive heterocyclic compounds that are of wide interest. Therefore, many researchers synthesized various hydrazone compounds as important target structures and evaluated their biological activities. viz. antimicrobial, analgesic, anti-inflammatory, antioxidant, antiproliferative, antitubercular, antimalarial, anti-HIV, antiplatelet, anticonvulsant and anti-leishmanial activities. Hydrazones can be a potential lead for future developments to get safer and effective compounds. References of the most relevant literature published by various research scientists around the world are provided.
International Journal of Pharmaceutical Sciences Review and Research
The objective of the study is to evaluate the potential of novel vesicular drug carriers for bioa... more The objective of the study is to evaluate the potential of novel vesicular drug carriers for bioavailability enhancement. Novel vesicular drug delivery carriers intend to deliver the drug at a rate directed by need of body during the period of treatment, and channel the active entity to the site of action. Encapsulation of drug in vesicular structures prolongs the existence of drug in systemic circulation and reduces the toxicity, if selective uptake can be achieved. Vesicular drug delivery systems have been used to improve the therapeutic index, solubility, stability and rapid degradation of drug molecule. This system reduces the cost of therapy by bioavailability improvement of medication, especially in case of poorly soluble drugs. Thus a number of novel vesicular drug delivery systems have been developed that enhance the bioavailability and provide sustained or controlled release of drug. The focus of this review is to discuss various lipoidal and non-lipoidal vesicles with special emphasis on the bioavailability enhancement of drugs.
International Journal of Pharmaceutical Sciences Review and Research
Hydrazones is an important class of compounds for the development of novel drug moieties. Hydrazo... more Hydrazones is an important class of compounds for the development of novel drug moieties. Hydrazones consists of an azomethine -NHN=CH-proton which is responsible for the development of new drugs. Hydrazides and hydrazones leads to development of many bioactive heterocyclic compounds that are of wide interest. Therefore, many researchers synthesized various hydrazone compounds as important target structures and evaluated their biological activities. viz. antimicrobial, analgesic, anti-inflammatory, antioxidant, antiproliferative, antitubercular, antimalarial, anti-HIV, antiplatelet, anticonvulsant and anti-leishmanial activities. Hydrazones can be a potential lead for future developments to get safer and effective compounds. References of the most relevant literature published by various research scientists around the world are provided.